期刊
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
卷 10, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fcell.2022.934331
关键词
dual targeting; Endoplasmic reticulum; peroxisome; targeting signal; Mitochondria
资金
- DAAD
- Center for Synthetic Microbiology, Marburg
- DFG
- Philipps-Universitaet Marburg [FR-3586/2-1]
- Deutsche Forschungsgemeinschaft (DFG, German Research Foundation)
In this review, we discuss the shared proteins between peroxisomes and other cellular compartments, the mechanisms of dual targeting, their regulation, and functional consequences. Characterization of dual targeting is fundamental for understanding the integration of peroxisomes into the metabolic and regulatory circuits of eukaryotic cells.
Peroxisomes are eukaryotic organelles with critical functions in cellular energy and lipid metabolism. Depending on the organism, cell type, and developmental stage, they are involved in numerous other metabolic and regulatory pathways. Many peroxisomal functions require factors also relevant to other cellular compartments. Here, we review proteins shared by peroxisomes and at least one different site within the cell. We discuss the mechanisms to achieve dual targeting, their regulation, and functional consequences. Characterization of dual targeting is fundamental to understand how peroxisomes are integrated into the metabolic and regulatory circuits of eukaryotic cells.
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