期刊
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
卷 10, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fcell.2022.908790
关键词
macrophage; heart failure; cardiomyopathy; phenotype; resident macrophages
资金
- National Natural Science Foundation of China
- [81870193]
Macrophages play a crucial role in cardiomyopathy and understanding their molecular mechanisms helps in understanding the development of the disease. Targeted therapy on macrophages has shown promise in experimental studies, but there are challenges and considerations for clinical translation.
Cardiomyopathy is a major cause of heart failure, leading to systolic and diastolic dysfunction and promoting adverse cardiac remodeling. Macrophages, as key immune cells of the heart, play a crucial role in inflammation and fibrosis. Moreover, exogenous and cardiac resident macrophages are functionally and phenotypically different during cardiac injury. Although experimental evidence has shown that macrophage-targeted therapy is promising in cardiomyopathy, clinical translation remains challenging. In this article, the molecular mechanism of macrophages in cardiomyopathy has been discussed in detail based on existing literature. The issues and considerations of clinical treatment strategies for myocardial fibrosis has also been analyzed.
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