期刊
GUT MICROBES
卷 14, 期 1, 页码 -出版社
TAYLOR & FRANCIS INC
DOI: 10.1080/19490976.2022.2134689
关键词
Bacteria-bacteria interaction; bacteria-host interaction; gut bacterial extracellular vesicles; intestinal dysbiosis; intestinal microenvironment
资金
- Natural Science Foundation of China [32000081]
- Anhui Provincial Natural Science Foundation [1908085QC120]
- Natural Science Foundation of Anhui Higher Education Institutions of China [KJ2019A0040]
- Open Fund for Discipline Construction, Institute of Physical Science and Information Technology of Anhui University
- Outstanding Talents Program of Anhui University, China
- Doctoral Scientific Research Foundation of Anhui University
Intestinal microenvironment dysbiosis is a major cause of various diseases, and the use of gut bacteria-derived extracellular vesicles (GBEVs) shows potential in treatment. Understanding the role of GBEVs in bacteria-host communication is crucial for developing effective clinical strategies.
Intestinal microenvironment dysbiosis is one of the major causes of diseases, such as obesity, diabetes, inflammatory bowel disease, and colon cancer. Microbiota-based strategies have excellent clinical potential in the treatment of repetitive and refractory diseases; however, the underlying regulatory mechanisms remain elusive. Identification of the internal regulatory mechanism of the gut microbiome and the interaction mechanisms involving bacteria-host is essential to achieve precise control of the gut microbiome and obtain effective clinical data. Gut bacteria-derived extracellular vesicles (GBEVs) are lipid bilayer nanoparticles secreted by the gut microbiota and are considered key players in bacteria-bacteria and bacteria-host communication. This review focusses on the role of GBEVs in gut microbiota interactions and bacteria-host communication, and the potential clinical applications of GBEVs.
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