4.7 Article

Release of VAMP5-positive extracellular vesicles by retinal Muller glia in vivo

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Review Cell Biology

In sickness and in health: The functional role of extracellular vesicles in physiology and pathology in vivo Part I: Health and Normal Physiology

Abi G. Yates et al.

Summary: Previously considered cellular debris, extracellular vesicles (EVs) are now recognized as mediators of physiological and pathological functions in the body. They have the ability to transfer nucleic acids and proteins between distant organs, interact with target cells through their surface proteins, and play a role in health and disease through vesicle-bound lipids. EVs are crucial in the pathogenesis of diseases and the maintenance of system and organ homeostasis.

JOURNAL OF EXTRACELLULAR VESICLES (2022)

Article Biochemistry & Molecular Biology

Release of extracellular vesicle miR-494-3p by ARPE-19 cells with impaired mitochondria

J. Y. Ahn et al.

Summary: The study showed that miR-494-3p is enriched in ARPE-19 cell mitochondria, and knockdown of miR-494-3p affects mitochondrial function, with elevated levels of miR-494-3p in EVs released indicating impaired mitochondrial capacity.

BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS (2021)

Review Physiology

GLIAL CONNEXINS AND PANNEXINS IN THE HEALTHY AND DISEASED BRAIN

Christian Giaume et al.

Summary: Over the past few decades, research has shown that glial cells interact dynamically with neurons, impacting their activity and survival. Connexins and pannexins play a key role in these interactions, and understanding their function can provide insights into neuronal behavior and aid in the development of therapeutic strategies for brain diseases.

PHYSIOLOGICAL REVIEWS (2021)

Review Cell Biology

Primary cilia biogenesis and associated retinal ciliopathies

Holly Y. Chen et al.

Summary: The primary cilium is a microtubule-based organelle that senses external environment and modulates diverse signaling pathways in different cell types and tissues; ciliopathies are a spectrum of clinical entities caused by aberrant ciliogenesis or ciliary transport, leading to overlapping yet highly variable phenotypes; dysfunction and degeneration of light sensing photoreceptors in the retina are highly penetrant in ciliopathies.

SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY (2021)

Review Cell Biology

Glia-Derived Extracellular Vesicles: Role in Central Nervous System Communication in Health and Disease

Cristiana Pistono et al.

Summary: Glial cells play a crucial role in maintaining correct neuronal functionality and restoring balance in the central nervous system. Extracellular vesicles (EVs) released by glial cells, including astrocytes, oligodendrocytes, and microglia, have diverse effects on neurons and CNS homeostasis, with both neuroprotective and detrimental effects. Further research and evaluation of EVs are needed for their potential therapeutic application in neurological disorders.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2021)

Article Ophthalmology

Descriptive analysis of Fibulin-3 and the extracellular vesicle marker, Alix, in drusen from a small cohort of postmortem human eyes

Stephanie L. Grillo et al.

Summary: The study found an association between Fibulin-3 (Fib3) and drusen as well as extracellular vesicles (EVs), showing different distribution patterns in age-related macular degeneration (AMD).

EXPERIMENTAL EYE RESEARCH (2021)

Article Ophthalmology

Age-related increase of let-7 family microRNA in rat retina and vitreous

Priscilla Sayami Akamine et al.

Summary: The study found expression of the let-7 miRNA family in the vitreous and retina of rats, with most let-7 members significantly upregulated in the vitreous during development. Only let-7b and let-7c showed similar expression patterns in the retina as well. The increase of let-7b and let-7c in aging vitreous, along with their targeting of Has2 mRNA, may play a role in modulating hyaluronan content during the aging process.

EXPERIMENTAL EYE RESEARCH (2021)

Review Biochemistry & Molecular Biology

Brain-Derived Extracellular Vesicles in Health and Disease: A Methodological Perspective

Santra Brenna et al.

Summary: Extracellular vesicles (EVs) are double membrane structures released by various cell types that transport lipids, proteins, and genetic material to recipient cells, influencing their phenotype. In the central nervous system, EVs play crucial roles, with potential as biomarkers and therapeutic tools in neurological diseases.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

Article Ophthalmology

CD63+ extracellular vesicles from retinal pigment epithelial cells participate in crosstalk with macrophages in the innate inflammatory axis

Yohei Otsuki et al.

Summary: This study aimed to investigate the role of extracellular vesicles (EV) secreted by murine primary retinal pigment epithelial (mpRPE) cells in cell-to-cell communication with macrophages, revealing that the increased presence of EV in macrophages can lead to the production of cytokines and chemotactic proteins, thereby participating in ocular inflammation.

EXPERIMENTAL EYE RESEARCH (2021)

Article Cell Biology

Extracellular vesicles released by human retinal pigment epithelium mediate increased polarised secretion of drusen proteins in response to AMD stressors

Miguel Flores-Bellver et al.

Summary: The study shows that extracellular vesicles secreted by RPE cells are enriched in proteins associated with AMD pathophysiology, exhibiting distinctive directional secretion modes under homeostatic conditions and differential modulation in response to AMD stressors. This suggests a finely-tuned mechanism regulating the secretion of drusen-associated proteins via EVs.

JOURNAL OF EXTRACELLULAR VESICLES (2021)

Review Biochemistry & Molecular Biology

Astrocyte Gliotransmission in the Regulation of Systemic Metabolism

Cahue De Bernardis Murat et al.

Summary: Normal brain function heavily relies on the appropriate functioning of astrocytes, which not only provide substrate support to neuronal demand, but also regulate various physiological processes, such as cerebral vascular remodeling, glucose sensing, feeding, and circadian rhythms, for maintaining whole-body energy availability and behavior-related responses. Understanding the mechanisms of astrocyte-released gliotransmitters is crucial for elucidating the distinct roles of these glial cells in the neuroendocrine control of metabolism.

METABOLITES (2021)

Article Neurosciences

Interneuronal exchange and functional integration of synaptobrevin via extracellular vesicles

A. Alejandro Vilcaes et al.

Summary: Recent studies have found that extracellular vesicles secreted by neurons contain specific proteins that can rapidly integrate into the synaptic vesicle cycle of host neurons via a specific process, regulating neurotransmission and rescuing synaptic transmission in certain cases.

NEURON (2021)

Review Ophthalmology

Prospects for the application of Muller glia and their derivatives in retinal regenerative therapies

K. Eastlake et al.

Summary: Neural cell death is the main cause of blindness in retinal degenerative diseases, with recent stem cell research and the identification of Muller glial cells providing hope for potential therapies. However, there is currently no evidence to suggest that they promote regeneration in humans.

PROGRESS IN RETINAL AND EYE RESEARCH (2021)

Article Cell Biology

Exosome-Mediated Delivery of the Neuroprotective Peptide PACAP38 Promotes Retinal Ganglion Cell Survival and Axon Regeneration in Rats With Traumatic Optic Neuropathy

Tian Wang et al.

Summary: Traumatic optic neuropathy (TON) is characterized by optic nerve damage resulting in vision loss, with limited treatment options. Pituitary adenylate cyclase-activating polypeptide 38 (PACAP38) has shown promise as a therapeutic agent. Using rat retinal ganglion cell (RGC) exosomes as delivery vesicles for PACAP38 (EXOPACAP38) demonstrated improved uptake efficiency and potential for promoting RGC survival, nerve fiber layer thickness, axon regeneration, and optic nerve function in a rat TON model. EXOPACAP38 may offer therapeutic implications for TON patients.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2021)

Article Biochemistry & Molecular Biology

Nanotube-like processes facilitate material transfer between photoreceptors

Aikaterini A. Kalargyrou et al.

Summary: Recent research has shown that neuronal communication can involve the transfer of cytoplasmic and membrane-bound molecules between neurons, leading to gain-of-function in the recipient cells. Through transplantation and culturing experiments, it was demonstrated for the first time that photoreceptor neurons in mammals can form open-end nanotube-like processes.

EMBO REPORTS (2021)

Article Ophthalmology

Mitochondrial miRNA494-3p in extracellular vesicles participates in cellular interplay of iPS-Derived human retinal pigment epithelium with macrophages

Atsushi Mukai et al.

Summary: This study explored new molecular targets for therapy in human model systems by analyzing the interaction between extracellular vesicle miRs secreted by human retinal pigment epithelium cells and macrophages. The findings suggest that miR494-3p may serve as a potential molecular target for diagnosis and therapy of age-related macular degeneration.

EXPERIMENTAL EYE RESEARCH (2021)

Review Biochemistry & Molecular Biology

Living Proof of Activity of Extracellular Vesicles in the Central Nervous System

Shadi Mahjoum et al.

Summary: EVs play a crucial role in facilitating communication between cells in the CNS, influencing a wide range of physiological processes. While current research is mainly focused on in vitro studies, new methods and techniques are opening up possibilities for studying the role of EVs in the CNS in vivo.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

Review Cell Biology

Diverse plasma membrane protrusions act as platforms for extracellular vesicle shedding

Kirsi Rilla

Summary: Plasma membrane curvature plays a crucial role in regulating cellular phenotype and extensions like filopodia and microvilli support various cellular functions. There is emerging evidence that cellular plasma membrane protrusions act as specialized platforms for the budding of extracellular vesicles (EVs).

JOURNAL OF EXTRACELLULAR VESICLES (2021)

Review Biochemistry & Molecular Biology

Exocytosis in Astrocytes

Aleksandra Mielnicka et al.

Summary: Astrocytes, once considered simple brain glue, have been found to be dynamic partners involved in brain metabolism and influencing communication between neurons. Their communication with neurons is diverse, with regulated exocytosis receiving the most attention. Astrocytes possess complex vesicular organelles and molecular mechanisms that regulate exocytosis.

BIOMOLECULES (2021)

Review Biochemistry & Molecular Biology

Microglial Extracellular Vesicles as Vehicles for Neurodegeneration Spreading

Ines Dinis Aires et al.

Summary: Microglial cells are important for maintaining neuronal homeostasis in the central nervous system, while chronic neuroinflammation plays a role in neurodegenerative diseases. Extracellular vesicles, such as apoptotic bodies, microvesicles, and exosomes, are involved in intercellular communication and may regulate microglial cell function. Understanding the role of microglial extracellular vesicles could provide insights into the mechanisms underlying neurodegeneration.

BIOMOLECULES (2021)

Article Medicine, General & Internal

Differences in the Quantity and Composition of Extracellular Vesicles in the Aqueous Humor of Patients with Retinal Neovascular Diseases

Yai-Ping Hsiao et al.

Summary: Extracellular vesicles (EVs), including exosomes, were found in higher amounts in patients with retinal neovascular diseases compared to the control group. The study identified three subtypes of exosomes and showed differences in their distribution depending on the type of disease. This research indicates the potential of exosomes in the diagnosis and therapy of retinal neovascular diseases.

DIAGNOSTICS (2021)

Article Biochemistry & Molecular Biology

Proteomic Analysis Reveals Key Proteins in Extracellular Vesicles Cargo Associated with Idiopathic Pulmonary Fibrosis In Vitro

Juan Manuel Velazquez-Enriquez et al.

Summary: IPF is a chronic, progressive, irreversible, and highly fatal disease characterized by the dysregulation of fibroblast and myofibroblast activation. Proteins contained within EVs cargo derived from IPF cell lines play key roles in the pathogenesis of the disease, as revealed by proteomic analysis. These findings suggest a potential therapeutic target for IPF treatment.

BIOMEDICINES (2021)

Review Neurosciences

Glia of the human retina

Andreas Reichenbach et al.

Review Multidisciplinary Sciences

The biology, function, and biomedical applications of exosomes

Raghu Kalluri et al.

SCIENCE (2020)

Review Neurosciences

SNARE-Mediated Exocytosis in Neuronal Development

Fabio L. Urbina et al.

FRONTIERS IN MOLECULAR NEUROSCIENCE (2020)

Review Neurosciences

The contribution of glial cells to Huntington's disease pathogenesis

Daniel K. Wilton et al.

NEUROBIOLOGY OF DISEASE (2020)

Review Neurosciences

Astrocyte Crosstalk in CNS Inflammation

Mathias Linnerbauer et al.

NEURON (2020)

Review Neurosciences

Lactate Transporters Mediate Glia-Neuron Metabolic Crosstalk in Homeostasis and Disease

Mithilesh Kumar Jha et al.

FRONTIERS IN CELLULAR NEUROSCIENCE (2020)

Review Cell Biology

Neuron-Glia Interactions in Neurodevelopmental Disorders

Yoo Sung Kim et al.

Review Nanoscience & Nanotechnology

Roles of Exosomes in Ocular Diseases

Jia Liu et al.

INTERNATIONAL JOURNAL OF NANOMEDICINE (2020)

Review Cell Biology

More Than Mortar: Glia as Architects of Nervous System Development and Disease

Ines Lago-Baldaia et al.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2020)

Article Ophthalmology

Cd9 Protects Photoreceptors from Injury and Potentiates Edn2 Expression

Toshiro Iwagawa et al.

INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE (2020)

Article Ophthalmology

Analysis of Adult Neural Retina Extracellular Vesicle Release, RNA Transport and Proteomic Cargo

Jason Mighty et al.

INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE (2020)

Article Biochemistry & Molecular Biology

Reassessment of Exosome Composition

Dennis K. Jeppesen et al.

Article Biochemistry & Molecular Biology

g:Profiler: a web server for functional enrichment analysis and conversions of gene lists (2019 update)

Uku Raudvere et al.

NUCLEIC ACIDS RESEARCH (2019)

Review Neurosciences

Emerging roles of extracellular vesicles in neurodegenerative disorders

Yang You et al.

NEUROBIOLOGY OF DISEASE (2019)

Article Biochemistry & Molecular Biology

Vesiclepedia 2019:a compendium of RNA, proteins, lipids and metabolites in extracellular vesicles

Mohashin Pathan et al.

NUCLEIC ACIDS RESEARCH (2019)

Review Medicine, Research & Experimental

Glia-derived exosomes: Promising therapeutic targets

He Li et al.

LIFE SCIENCES (2019)

Review Neurosciences

Astroglia-Derived ATP Modulates CNS Neuronal Circuits

Peter Illes et al.

TRENDS IN NEUROSCIENCES (2019)

Article Anatomy & Morphology

Loss of VAMP5 in mice results in duplication of the ureter and insufficient expansion of the lung

Maiko Ikezawa et al.

DEVELOPMENTAL DYNAMICS (2018)

Review Biochemistry & Molecular Biology

Cholesterol and the journey of extracellular vesicles

Frank W. Pfrieger et al.

JOURNAL OF LIPID RESEARCH (2018)

Article Ophthalmology

Liquid Biopsy of Vitreous Reveals an Abundant Vesicle Population Consistent With the Size and Morphology of Exosomes

Yuanjun Zhao et al.

TRANSLATIONAL VISION SCIENCE & TECHNOLOGY (2018)

Article Cell Biology

Photoreceptor discs form through peripherin-dependent suppression of ciliary ectosome release

Raquel Y. Salinas et al.

JOURNAL OF CELL BIOLOGY (2017)

Article Neurosciences

Anatomy and spatial organization of Muller glia in mouse retina

Jingjing Wang et al.

JOURNAL OF COMPARATIVE NEUROLOGY (2017)

Article Biochemistry & Molecular Biology

Exosomal MicroRNA-15a Transfer from the Pancreas Augments Diabetic Complications by Inducing Oxidative Stress

Tengku Ain Kamalden et al.

ANTIOXIDANTS & REDOX SIGNALING (2017)

Review Neurosciences

Extracellular vesicles round off communication in the nervous system

Vivian Budnik et al.

NATURE REVIEWS NEUROSCIENCE (2016)

Article Multidisciplinary Sciences

Proteomic comparison defines novel markers to characterize heterogeneous populations of extracellular vesicle subtypes

Joanna Kowal et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2016)

Article Biochemistry & Molecular Biology

Active endocannabinoids are secreted on extracellular membrane vesicles

Martina Gabrielli et al.

EMBO REPORTS (2015)

Article Biotechnology & Applied Microbiology

StringTie enables improved reconstruction of a transcriptome from RNA-seq reads

Mihaela Pertea et al.

NATURE BIOTECHNOLOGY (2015)

Article Biochemical Research Methods

HISAT: a fast spliced aligner with low memory requirements

Daehwan Kim et al.

NATURE METHODS (2015)

Article Neurosciences

Serotonin Stimulates Secretion of Exosomes from Microglia Cells

Konstantin Glebov et al.

Article Biochemistry & Molecular Biology

C-elegans Ciliated Sensory Neurons Release Extracellular Vesicles that Function in Animal Communication

Juan Wang et al.

CURRENT BIOLOGY (2014)

Article Biochemical Research Methods

Exosomal Proteins in the Aqueous Humor as Novel Biomarkers in Patients with Neovascular Age-related Macular Degeneration

Gum-Yong Kang et al.

JOURNAL OF PROTEOME RESEARCH (2014)

Article Biochemistry & Molecular Biology

The Cilium Secretes Bioactive Ectosomes

Christopher R. Wood et al.

CURRENT BIOLOGY (2013)

Article Biochemistry & Molecular Biology

Exosomes from Retinal Astrocytes Contain Antiangiogenic Components That Inhibit Laser-induced Choroidal Neovascularization

Amir Reza Hajrasouliha et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2013)

Article Biochemistry & Molecular Biology

Neuronal Exosomal miRNA-dependent Translational Regulation of Astroglial Glutamate Transporter GLT1

Lydie Morel et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2013)

Article Biochemistry & Molecular Biology

Neurotransmitter-Triggered Transfer of Exosomes Mediates Oligodendrocyte-Neuron Communication

Carsten Fruehbeis et al.

PLOS BIOLOGY (2013)

Article Biochemistry & Molecular Biology

Sphingolipid-modulated Exosome Secretion Promotes Clearance of Amyloid-β by Microglia

Kohei Yuyama et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2012)

Article Biochemical Research Methods

Fiji: an open-source platform for biological-image analysis

Johannes Schindelin et al.

NATURE METHODS (2012)

Article Neurosciences

Relevance of Exocytotic Glutamate Release from Retinal Glia

Michal Slezak et al.

NEURON (2012)

Article Neurosciences

Release of exosomes from differentiated neurons and its regulation by synaptic glutamatergic activity

Gaelle Lachenal et al.

MOLECULAR AND CELLULAR NEUROSCIENCE (2011)

Article Nanoscience & Nanotechnology

Sizing and phenotyping of cellular vesicles using Nanoparticle Tracking Analysis

Rebecca A. Dragovic et al.

NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE (2011)

Article Biochemical Research Methods

TopHat: discovering splice junctions with RNA-Seq

Cole Trapnell et al.

BIOINFORMATICS (2009)

Review Oncology

Trafficking and function of the tetraspanin CD63

Maaike S. Pols et al.

EXPERIMENTAL CELL RESEARCH (2009)

Article Biochemical Research Methods

Universal sample preparation method for proteome analysis

Jacek R. Wisniewski et al.

NATURE METHODS (2009)

Review Multidisciplinary Sciences

Membrane Fusion: Grappling with SNARE and SM Proteins

Thomas C. Sudhof et al.

SCIENCE (2009)

Article Biochemical Research Methods

Semi-supervised learning for peptide identification from shotgun proteomics datasets

Lukas Kall et al.

NATURE METHODS (2007)

Article Neurosciences

Exosomes are released by cultured cortical neurones

J Fauré et al.

MOLECULAR AND CELLULAR NEUROSCIENCE (2006)

Article Multidisciplinary Sciences

Carbonic anhydrase XIV is enriched in specific membrane domains of retinal pigment epithelium, Muller cells, and astrocytes

EA Nagelhus et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)