Non-invasive monitoring of autophagy

The flux of autophagosomes in heart tissue can be detected in live mice via the fluorescence and magnetic resonance properties of intravenously injected iron oxide nanoparticles decorated with fluorescent peptides cleavable by lysosomal cathepsins.

Automated summary

The flux of autophagosomes in heart tissue can be detected in live mice using fluorescent peptides cleavable by lysosomal cathepsins, which are decorated on intravenously injected iron oxide nanoparticles with fluorescence and magnetic resonance properties.