The Effects of Prenatal Diet on Calf Performance and Perspectives for Fetal Programming Studies: A Meta-Analytical Investigation

Simple Summary Prenatal nutrition can reshape an animal's developmental trajectory, with persistent long-term consequences for the progeny. In prenatal life, the effects induced by the intrauterine conditions can be expressed as changes in offspring growth and meat quality. Thus, there are diverse sources of variations that contribute to the variations reported for fetal-programming responses in beef cattle, making it difficult to interpret and apply the results. In this sense, finding a common factor among the studies with which to group them may offer an opportunity to quantify the fetal-programming effects holistically and to obtain more applicable responses. With the increasing number of publications, it is important to summarize the quantitative measurements available in the scientific literature. In the present study, data from 35 publications were used. We verified that there is a gap related to the effects of maternal nutrition to females, at the beginning of gestation, and in zebu and crossbred animals, indicating new perspectives for future fetal-programming studies. In summary, our findings highlight an association between prenatal energy and protein supply and its effects on the offspring birth weight, weaning weight, and the daily weight gain of pregnant beef cows during pregnancy. This meta-analysis aimed to identify knowledge gaps in the scientific literature on future fetal-programming studies and to investigate the factors that determine the performance of beef cows and their offspring. A dataset composed of 35 publications was used. The prenatal diet, body weight (BW), average daily gain (ADG) during pregnancy, and calf sex were elicited as possible modulators of the beef cows and their offspring performance. Then, the correlations between these variables and the outcomes of interest were investigated. A mixed multiple linear regression procedure was used to evaluate the relationships between the responses and all the possible explanatory variables. A knowledge gap was observed in studies focused on zebu animals, with respect to the offspring sex and the consequences of prenatal nutrition in early pregnancy. The absence of studies considering the possible effects promoted by the interactions between the different stressors' sources during pregnancy was also detected. A regression analysis showed that prenatal diets with higher levels of protein improved the ADG of pregnant beef cows and that heavier cows give birth to heavier calves. Variations in the BW at weaning were related to the BW at birth and calf sex. Therefore, this research reinforces the importance of monitoring the prenatal nutrition of beef cows.

Automated summary

Prenatal nutrition has long-term consequences on animal development and progeny. This study aimed to summarize and identify knowledge gaps in fetal-programming studies in beef cattle using data from 35 publications. The findings showed an association between prenatal energy and protein supply and offspring birth weight, weaning weight, and daily weight gain of pregnant beef cows. However, there is a lack of research on zebu animals, offspring sex, and the effects of interactions between different stressors during pregnancy.