Analgesia during Parturition in Domestic Animals: Perspectives and Controversies on Its Use

Simple Summary Although the pain associated with parturition performs the primary physiological function of maintaining frequent, strong myometrial contractions, its biological consequences can affect the health of both mother and fetus. Whilst analgesic therapy may be recommended to avoid pain, the evidence indicates that the mechanisms of some analgesic drugs can interfere with the biological process of labor. Opioids and non-steroidal anti-inflammatory drugs have been shown to indirectly inhibit myometrial contractions by decreasing oxytocin secretion, while local analgesics decrease the number of contractions, although its intensity increases, improving maternal performance. This article analyzes the physiological role of pain during labor and the use and efficacy of opioids, non-steroidal anti-inflammatory drugs, and local analgesics in treatments to manage parturition in domestic mammals. This article analyzes the physiological role of pain during parturition in domestic animals, discusses the controversies surrounding the use of opioids, non-steroidal anti-inflammatory drugs (NSAIDs), and local analgesics as treatments during labor, and presents the advantages and disadvantages for mother and offspring. Labor is a potentially stressful and painful event, due to the contractions that promote expulsion of the fetus. During labor, neurotransmitters such as the prostaglandins contribute to the sensitization of oxytocin receptors in the myometrium and the activation of nociceptive fibers, thus supporting the physiological role of pain. Endogenously, the body secretes opioid peptides that modulate harmful stimuli and, at the same time, can inhibit oxytocin's action in the myometrium. Treating pain during the different stages of parturition is an option that can help prevent such consequences as tachycardia, changes in breathing patterns, and respiratory acidosis, all of which can harm the wellbeing of offspring. However, studies have found that some analgesics can promote myometrial contractility, increase expulsion time, affect fetal circulation, and alter mother-offspring recognition due to hypnotic effects. Other data, however, indicate that reducing the number of uterine contractions with analgesics increases their potency, thus improving maternal performance. Managing pain during labor requires understanding the tocolytic properties of analgesics and their advantages in preventing the consequences of pain.

Automated summary

This article examines the physiological role of pain during parturition in domestic animals and discusses the controversies surrounding the use of opioids, non-steroidal anti-inflammatory drugs (NSAIDs), and local analgesics as treatments during labor. The use of analgesics during labor can have both advantages and disadvantages for the mother and offspring, and managing pain during this process requires understanding the properties of different analgesics.