Preclinical-to-clinical innovations in stem cell therapies for liver regeneration

Acute and chronic liver diseases are the major cause of high morbidity and mortality globally. Liver trans-plantation is a widely used therapeutic option for liver failure. However, the shortage of availability of liver donors has encouraged research on the alternative approach to liver regeneration. Cell-based regenerative medicine is the best alternative therapy to cater to this need. To date, advanced preclinical approaches have been undertaken on stem cell differentiation and their use in liver tissue engineering for generating effica-cious and promising regenerative therapies. Advancements in the bioengineering of stem cells, and organoid generation are the way forward to efficient therapies against liver injury. This review summarizes the recent approaches for stem cell therapy-based liver regeneration and their proof of concepts for clinical application, bioengineering liver organoids to alleviate the liver failure caused due to chronic liver diseases.(c) 2022 Elsevier Masson SAS. All rights reserved.

Automated summary

Acute and chronic liver diseases are leading causes of illness and death worldwide. While liver transplantation is a commonly used treatment for liver failure, the scarcity of liver donors has prompted the exploration of alternative approaches, such as cell-based regenerative medicine. Recent advancements in stem cell differentiation and liver tissue engineering have shown promise in generating effective therapies for liver regeneration. The development of bioengineered liver organoids holds great potential in treating liver injuries caused by chronic liver diseases.