☆ 4.6 Article

Amphiphile-CpG vaccination induces potent lymph node activation and COVID-19 immunity in mice and non-human primates

NPJ VACCINES (2022)

相关参考文献

注意：仅列出部分参考文献，下载原文获取全部文献信息。

Article Biochemistry & Molecular Biology

SARS-CoV-2 vaccination induces immunological T cell memory able to cross-recognize variants from Alpha to Omicron

Alison Tarke et al.

Summary: T cell responses induced by different vaccine platforms cross-recognize early SARS-CoV-2 variants, while memory B cells and neutralizing antibodies show significant decreases. The majority of memory T cell responses are preserved against variants, with lower recognition of Omicron by memory B cells.

CELL (2022)

添加到收藏夹

Article Infectious Diseases

Community transmission and viral load kinetics of the SARS-CoV-2 delta (B.1.617.2) variant in vaccinated and unvaccinated individuals in the UK: a prospective, longitudinal, cohort study

Anika Singanayagam et al.

Summary: Vaccination reduces the risk of delta variant infection and accelerates viral clearance. However, fully vaccinated individuals with breakthrough infections may still have similar peak viral loads as unvaccinated cases and can efficiently transmit the infection.

LANCET INFECTIOUS DISEASES (2022)

添加到收藏夹

Article Multidisciplinary Sciences

Omicron extensively but incompletely escapes Pfizer BNT162b2 neutralization

Sandile Cele et al.

Summary: The study found that the Omicron variant has reduced neutralizing effectiveness in individuals vaccinated with Pfizer BNT162b2, but those who had previously been infected with SARS-CoV-2 showed better neutralization against Omicron.

NATURE (2022)

添加到收藏夹

Article Multidisciplinary Sciences

Omicron escapes the majority of existing SARS-CoV-2 neutralizing antibodies

Yunlong Cao et al.

Summary: The Omicron variant of SARS-CoV-2 contains 15 mutations in the receptor-binding domain, leading to evasion of over 85% of tested neutralizing antibodies. Different epitope groups of neutralizing antibodies are affected to varying degrees by single mutations of Omicron. Antibodies targeting the conserved region of sarbecovirus remain most effective against Omicron.

NATURE (2022)

添加到收藏夹

Article Biochemistry & Molecular Biology

Neutralizing antibodies against the SARS-CoV-2 Omicron variant BA.1 following homologous and heterologous CoronaVac or BNT162b2 vaccination

Samuel M. S. Cheng et al.

Summary: Specific antibody levels against the SARS-CoV-2 Omicron variant decrease significantly after two doses of BNT162b2 or CoronaVac vaccines, but can be markedly increased with a booster dose of BNT162b2. Individuals who previously received two doses of BNT162b2 or CoronaVac showed reduced serum antibody titers against Omicron, while a BNT162b2 booster dose increased the antibody levels in the majority of individuals. This suggests mRNA vaccine boosters may be necessary in countries primarily using CoronaVac vaccines to combat the spread of Omicron.

NATURE MEDICINE (2022)

添加到收藏夹

Article Biochemistry & Molecular Biology

Humoral and cellular immune memory to four COVID-19 vaccines

Zeli Zhang et al.

Summary: Multiple COVID-19 vaccines have successfully protected against symptomatic cases and deaths. Comparisons of T cell, B cell, and antibody responses to different vaccines can provide insights into protective immunity against COVID-19, particularly immune memory. mRNA vaccines and Ad26.COV2.S induced strong T cell responses, while mRNA vaccines showed substantial declines in antibodies.

CELL (2022)

添加到收藏夹

Article Multidisciplinary Sciences

Modeling of waning immunity after SARS-CoV-2 vaccination and influencing factors

Laura Perez-Alos et al.

Summary: This study examines the dynamics of immunological markers after the first dose of SARS-CoV-2 vaccination in a cohort of healthcare professionals in Denmark. The results suggest that natural infection leads to higher antibody responses, and the decline of IgG levels varies depending on factors such as age, sex, T-cell response, previous infection, and interval between vaccine doses.

NATURE COMMUNICATIONS (2022)

添加到收藏夹

Article Microbiology

SARS-CoV-2-specific T-cell epitope repertoire in convalescent and mRNA-vaccinated individuals

Julia Lang-Meli et al.

Summary: The study found that T cells predominantly targeted non-spike epitopes in convalescent individuals, while there was a broader spike-specific T-cell response in vaccinees. The spike-specific CD8(+) T-cell responses play a crucial role in combating variant viruses.

NATURE MICROBIOLOGY (2022)

添加到收藏夹

Review Immunology

COVID-19 Vaccines and SARS-CoV-2 Transmission in the Era of New Variants: A Review and Perspective

Jasmine R. Marcelin et al.

Summary: COVID-19 vaccines provide definite prevention and significant reduction in morbidity and mortality from coronavirus 2 infection. However, newer variants show lower vaccine protection against infection and attenuation of vaccine effects on transmission. Challenges in determining the magnitude of transmission reduction include accurate linkage of infections to vaccine status and timing, especially within households.

OPEN FORUM INFECTIOUS DISEASES (2022)

添加到收藏夹

Review Immunology

The germinal centre B cell response to SARS-CoV-2

Brian J. Laidlaw et al.

Summary: The GC response is crucial in establishing durable and broad immunity against SARS-CoV-2, with emerging evidence suggesting new approaches to modulate GC response and long-term immune responses induced by vaccines. Importantly, GC B cell responses persist for at least 6 months in some individuals following SARS-CoV-2 vaccination.

NATURE REVIEWS IMMUNOLOGY (2022)

添加到收藏夹

Article Multidisciplinary Sciences

Spike mutation D614G alters SARS-CoV-2 fitness

Jessica A. Plante et al.

Summary: The D614G substitution in the SARS-CoV-2 spike protein enhances viral replication and infectivity in human lung epithelial cells, primary airway tissues, and hamsters. This variant may increase transmission in the upper respiratory tract and doesn't seem to significantly reduce vaccine efficacy. Further research on therapeutic antibodies targeting the circulating G614 virus is recommended.

NATURE (2021)

添加到收藏夹

Article Biochemistry & Molecular Biology

Evaluating the Effects of SARS-CoV-2 Spike Mutation D614G on Transmissibility and Pathogenicity

Erik Volz et al.

Summary: The study suggests a positive selection for the SARS-CoV-2 spike protein variant D614G in the UK, but no evidence of differences in COVID-19 mortality or clinical severity in patients infected with this variant. 614G is associated with higher viral load and younger age of patients compared to 614D.

CELL (2021)

添加到收藏夹

Article Medicine, General & Internal

Safety and efficacy of the ChAdOx1 nCoV-19 vaccine (AZD1222) against SARS-CoV-2: an interim analysis of four randomised controlled trials in Brazil, South Africa, and the UK

Merryn Voysey et al.

Summary: The ChAdOx1 nCoV-19 vaccine has been shown to have an acceptable safety profile and effectiveness against symptomatic COVID-19, with higher efficacy observed in the group that received a low dose followed by a standard dose.

LANCET (2021)

添加到收藏夹

Article Medicine, General & Internal

Waning Immune Humoral Response to BNT162b2 Covid-19 Vaccine over 6 Months

Einav G. Levin et al.

Summary: A study in Israel revealed that waning immunity after receiving two doses of the BNT162b2 vaccine led to an increase in the incidence of SARS-CoV-2 infection. Levels of spike-binding IgG and neutralizing antibodies decreased more significantly in men, individuals aged 65 or older, and immunosuppressed individuals in a longitudinal study involving nearly 4000 healthcare workers.

NEW ENGLAND JOURNAL OF MEDICINE (2021)

添加到收藏夹

Editorial Material Medicine, General & Internal

Urgent needs of low-income and middle-income countries for COVID-19 vaccines and therapeutics

J. Peter Figueroa et al.

LANCET (2021)

添加到收藏夹

Article Multidisciplinary Sciences

Antibody resistance of SARS-CoV-2 variants B.1.351 and B.1.1.7

Pengfei Wang et al.

Summary: The COVID-19 pandemic has had global repercussions, with promising vaccines and monoclonal antibody therapies. However, newly detected variants of SARS-CoV-2 present challenges to these treatment options.

NATURE (2021)

添加到收藏夹

Article Multidisciplinary Sciences

A lymph node-targeted Amphiphile vaccine induces potent cellular and humoral immunity to SARS-CoV-2

Martin P. Steinbuck et al.

Summary: The AMP-CpG adjuvant efficiently delivers CpG to lymph nodes, inducing high levels of antigen-specific T cells and generating diverse T helper 1 (TH1) cytokines. Immunization with AMP-CpG also leads to strong antibodies that neutralize Spike-2-ACE2 receptor binding, with significantly higher titers than natural convalescent patient COVID-19 responses.

SCIENCE ADVANCES (2021)

添加到收藏夹

Review Microbiology

Potential SARS-CoV-2 Immune Correlates of Protection in Infection and Vaccine Immunization

Yongjun Sui et al.

Summary: Robust immune responses are crucial in combating COVID-19, with high levels of antibodies and Th1 responses being able to prevent viral transmission and disease progression. In addition to genetic and innate immune factors, trained immunity and local mucosal immunity also play a role in reducing infection risk and mitigating disease severity.

PATHOGENS (2021)

添加到收藏夹

Article Biochemistry & Molecular Biology

SARS-CoV-2 variants B.1.351 and P.1 escape from neutralizing antibodies

Markus Hoffmann et al.

Summary: The emerging SARS-CoV-2 variants may exhibit resistance to existing neutralizing antibodies and treatments, which could have significant implications for pandemic containment efforts.

CELL (2021)

添加到收藏夹

Article Biochemistry & Molecular Biology

Transmission, infectivity, and neutralization of a spike L452R SARS-CoV-2 variant

Xianding Deng et al.

Summary: A new SARS-CoV-2 variant named B.1.427/B.1.429 was identified in California, with increased transmissibility and carrying three mutations in spike protein, including L452R substitution. The variant emerged in May 2020 and became predominant in sequenced cases from September 2020 to January 2021. In vivo viral shedding was increased and antibody neutralization decreased, calling for further investigation.

CELL (2021)

添加到收藏夹

Article Medicine, General & Internal

Efficacy of ChAdOx1 nCoV-19 (AZD1222) vaccine against SARS-CoV-2 variant of concern 202012/01 (B.1.1.7): an exploratory analysis of a randomised controlled trial

Katherine R. W. Emary et al.

Summary: A post-hoc analysis was conducted on the efficacy of the ChAdOx1 nCoV-19 vaccine against the B.1.1.7 variant of SARS-CoV-2 in the UK. The vaccine showed reduced neutralisation activity against the B.1.1.7 variant in vitro, but still demonstrated efficacy against the B.1.1.7 variant of the virus.

LANCET (2021)

添加到收藏夹

Article Medicine, General & Internal

Efficacy of NVX-CoV2373 Covid-19 Vaccine against the B.1.351 Variant

V. Shinde et al.

Summary: The NVX-CoV2373 vaccine showed efficacy in preventing Covid-19, with higher vaccine efficacy observed among HIV-negative participants. Most infections were caused by the B.1.351 variant.

NEW ENGLAND JOURNAL OF MEDICINE (2021)

添加到收藏夹

Article Biochemistry & Molecular Biology

Evidence for increased breakthrough rates of SARS-CoV-2 variants of concern in BNT162b2-mRNA-vaccinated individuals

Talia Kustin et al.

Summary: Breakthrough SARS-CoV-2 infections post-vaccination may be caused by B.1.1.7 or B.1.351 variants, indicating the importance of robust vaccination. Reduced vaccine effectiveness against these variants was observed in the study, highlighting the need for continued surveillance and enhanced vaccination efforts.

NATURE MEDICINE (2021)

添加到收藏夹

Review Immunology

The CD83 Molecule - An Important Immune Checkpoint

Linda Grosche et al.

FRONTIERS IN IMMUNOLOGY (2020)

添加到收藏夹

Article Biochemistry & Molecular Biology

Tracking Changes in SARS-CoV-2 Spike: Evidence that D614G Increases Infectivity of the COVID-19 Virus

Bette Korber et al.

CELL (2020)

添加到收藏夹

Article Immunology

The receptor-binding domain of the viral spike protein is an immunodominant and highly specific target of antibodies in SARS-CoV-2 patients

Lakshmanane Premkumar et al.

SCIENCE IMMUNOLOGY (2020)

添加到收藏夹

Article Multidisciplinary Sciences

SARS-CoV-2-specific T cell immunity in cases of COVID-19 and SARS, and uninfected controls

Nina Le Bert et al.

NATURE (2020)

添加到收藏夹

Article Immunology

BATF3 programs CD8+T cell memory

Marco A. Ataide et al.

NATURE IMMUNOLOGY (2020)

添加到收藏夹

Article Biochemical Research Methods

Quantification of SARS-CoV-2 neutralizing antibody by a pseudotyped virus-based assay

Jianhui Nie et al.

NATURE PROTOCOLS (2020)

添加到收藏夹

Article Multidisciplinary Sciences

Enhanced CAR-T cell activity against solid tumors by vaccine boosting through the chimeric receptor

Leyuan Ma et al.

SCIENCE (2019)

添加到收藏夹

Article Oncology

Enhancement of Peptide Vaccine Immunogenicity by Increasing Lymphatic Drainage and Boosting Serum Stability

Kelly D. Moynihan et al.

CANCER IMMUNOLOGY RESEARCH (2018)

添加到收藏夹

Article Immunology

Transient Surface CCR5 Expression by Naive CD8+ T Cells within Inflamed Lymph Nodes Is Dependent on High Endothelial Venule Interaction and Augments Th Cell-Dependent Memory Response

David Askew et al.

JOURNAL OF IMMUNOLOGY (2016)

添加到收藏夹

Review Biotechnology & Applied Microbiology

From sewer to saviour - targeting the lymphatic system to promote drug exposure and activity

Natalie L. Trevaskis et al.

NATURE REVIEWS DRUG DISCOVERY (2015)

添加到收藏夹

Article Immunology

T cell-mediated immune response to respiratory coronaviruses

Rudragouda Channappanavar et al.

IMMUNOLOGIC RESEARCH (2014)

添加到收藏夹

Article Multidisciplinary Sciences

Structure-based programming of lymph-node targeting in molecular vaccines

Haipeng Liu et al.

NATURE (2014)

添加到收藏夹

Article Chemistry, Multidisciplinary

Membrane Anchored Immunostimulatory Oligonucleotides for In Vivo Cell Modification and Localized Immunotherapy

Haipeng Liu et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2011)

添加到收藏夹

Article Immunology

Dynamic imaging of chemokine-dependent CD8(+) T cell help for CD8(+) T cell responses

Stephanie Hugues et al.

NATURE IMMUNOLOGY (2007)

添加到收藏夹

Article Immunology

High affinity germinal center B cells are actively selected into the plasma cell compartment

Tri Giang Phan et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2006)

添加到收藏夹

Article Multidisciplinary Sciences

Chemokines enhance immunity by guiding naive CD8+ T cells to sites of CD4 T cell-dendritic cell interaction

F Castellino et al.

NATURE (2006)

添加到收藏夹

Review Biotechnology & Applied Microbiology

Therapeutic potential of Toll-like receptor 9 activation

Arthur M. Krieg

NATURE REVIEWS DRUG DISCOVERY (2006)

添加到收藏夹

Article Biochemistry & Molecular Biology

Spontaneous formation of nucleic acid-based nanoparticles is responsible for high interferon-α induction by CpG-A in plasmacytoid dendritic cells

M Kerkmann et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2005)

添加到收藏夹

Article Immunology

SIGIRR, a negative regulator of Toll-like receptor-interleukin 1 receptor signaling

D Wald et al.

NATURE IMMUNOLOGY (2003)

添加到收藏夹

© Peeref 2019-2024. All rights reserved.