Antimicrobial Perspectives of Active SiO2FexOy/ZnO Composites

The antibacterial activity of zinc oxide particles has received significant interest worldwide, especially through the implementation of technology to synthesize particles in the nanometer range. This study aimed to determine the antimicrobial efficacy of silica-based iron oxide matrix (SiO2FexOy) synthesized with various amounts of ZnO (SiO2FexOyZnO) against various pathogens. It is observed that, with the addition of ZnO to the system, the average size of the porosity of the material increases, showing increasingly effective antibacterial properties. Zinc-iron-silica oxide matrix composites were synthesized using the sol-gel method. The synthesized materials were investigated physicochemically to highlight their structural properties, through scanning electron microscopy (SEM), Energy Dispersive X-ray Spectroscopy (EDX), and Fourier-transform infrared spectroscopy (FT-IR). At the same time, surface area, pore size and total pore volume were determined for materials synthesized using the Brunauer-Emmett-Teller (BET) method. Although the material with 0.0001 g ZnO (600 m(2)/g) has the highest specific surface area, the best antimicrobial activity was obtained for the material with 1.0 g ZnO, when the average pore volume is the largest (similar to 8 nm) for a specific surface of 306 m(2)/g. This indicates that the main role in the antibacterial effect has reactive oxygen species (ROS) generated by the ZnO that are located in the pores of the composite materials. The point of zero charge (pH(pZc)) is a very important parameter for the characterization of materials that indicate the acid-base behaviour. The pH(pZc) value varies between 4.9 and 6.3 and is influenced by the amount of ZnO with which the iron-silica oxide matrix is doped. From the antimicrobial studies carried out, it was found that for S. aureus the total antibacterial effect was obtained at the amount of 1.0 g ZnO. For Gram-negative bacteria, a total antibacterial effect was observed in S. flexneri (for the material with 0.1 g ZnO), followed by E. coli (for 1.0 g ZnO). For P. aeruginosa, the maximum inhibition rate obtained for the material with 1.0 g ZnO was approximately 49%.

Automated summary

The antibacterial activity of zinc oxide particles has attracted significant attention worldwide. This study synthesized silica-based iron oxide matrix composites with different amounts of zinc oxide and evaluated their antimicrobial efficacy against various pathogens. The results showed that adding zinc oxide to the system increased the average porosity size of the material and enhanced its antibacterial properties.