4.7 Article

Crystal Engineering of Ionic Cocrystals Sustained by Azolium center dot center dot center dot Azole Heterosynthons

期刊

PHARMACEUTICS
卷 14, 期 11, 页码 -

出版社

MDPI
DOI: 10.3390/pharmaceutics14112321

关键词

crystal engineering; ionic cocrystals; charge-assisted hydrogen bond; azolium; azole; supramolecular heterosynthon

资金

  1. Science Foundation Ireland (SFI) through Synthesis and Solid State Pharmaceutical Centre (SSPC) [12/RC/2275_P2, 16/IA/4624]

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This article discusses the crystal engineering of ionic cocrystals composed of azole functional groups. Through data mining and structural characterization of new ICCs, insights into the hierarchy of NH+···N supramolecular heterosynthons were obtained, highlighting their importance in cocrystal design.
Crystal engineering of multi-component molecular crystals, cocrystals, is a subject of growing interest, thanks in part to the potential utility of pharmaceutical cocrystals as drug substances with improved properties. Whereas molecular cocrystals (MCCs) are quite well studied from a design perspective, ionic cocrystals (ICCs) remain relatively underexplored despite there being several recently FDA-approved drug products based upon ICCs. Successful cocrystal design strategies typically depend on strong and directional noncovalent interactions between coformers, as exemplified by hydrogen bonds. Understanding of the hierarchy of such interactions is key to successful outcomes in cocrystal design. We herein address the crystal engineering of ICCs comprising azole functional groups, particularly imidazoles and triazoles, which are commonly encountered in biologically active molecules. Specifically, azoles were studied for their propensity to serve as coformers with strong organic (trifluoroacetic acid and p-toluenesulfonic acid) and inorganic (hydrochloric acid, hydrobromic acid and nitric acid) acids to gain insight into the hierarchy of NH+center dot center dot center dot N (azolium-azole) supramolecular heterosynthons. Accordingly, we combined data mining of the Cambridge Structural Database (CSD) with the structural characterization of 16 new ICCs (11 imidazoles, 4 triazoles, one imidazole-triazole). Analysis of the new ICCs and 66 relevant hits archived in the CSD revealed that supramolecular synthons between identical azole rings (A(+)B(-)A) are much more commonly encountered, 71, than supramolecular synthons between different azole rings (A(+)B(-)C), 11. The average NH+center dot center dot center dot N distance found in the new ICCs reported herein is 2.697(3) angstrom and binding energy calculations suggested that hydrogen bond strengths range from 31-46 kJ mol(-1). The azolium-triazole ICC (A(+)B(-)C) was obtained via mechanochemistry and differed from the other ICCs studied as there was no NH+center dot center dot center dot N hydrogen bonding. That the CNC angles in imidazoles and 1,2,4-triazoles are sensitive to protonation, the cationic forms having larger (approximately 4.4 degrees) values than comparable neutral rings, was used as a parameter to distinguish between protonated and neutral azole rings. Our results indicate that ICCs based upon azolium-azole supramolecular heterosynthons are viable targets, which has implications for the development of new azole drug substances with improved properties.

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