Autologous Marrow Mesenchymal Stem Cell Driving Bone Regeneration in a Rabbit Model of Femoral Head Osteonecrosis

Article Orthopedics

A novel model of traumatic femoral head necrosis in rats developed by microsurgical technique

Yongxiang Lv et al.

Summary: The study successfully established an original and highly selective rat model in which traumatic osteonecrosis of the femoral head was induced by surgical deprivation of the anterior-superior retinacular vasculature.

BMC MUSCULOSKELETAL DISORDERS (2022)

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Review Orthopedics

Osteonecrosis of the Femoral Head

Gary George et al.

Summary: Osteonecrosis of the femoral head is a progressive and debilitating condition with a variety of causes, and total hip arthroplasty is the definitive treatment. Further research, including large patient registries, is needed to better understand this condition.

JOURNAL OF THE AMERICAN ACADEMY OF ORTHOPAEDIC SURGEONS GLOBAL RESEARCH AND REVIEWS (2022)

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Review Environmental Sciences

Avascular Necrosis of Femoral Head-Overview and Current State of the Art

Wojciech Konarski et al.

Summary: Avascular necrosis of the femoral head is a condition caused by disruption of blood supply. Diagnosis can be established based on patients' complaints, medical history, and radiographic findings. There is currently no consensus on the treatment of this disease, with non-surgical methods recommended for early-stage patients and surgery recommended for advanced cases.

INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH (2022)

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Article Multidisciplinary Sciences

Construction and validation of steroid-induced rabbit osteonecrosis model

Tongtong Zhu et al.

Summary: Osteonecrosis is a common orthopedic disease that can result in joint collapse without timely treatment. The clinical use of high-dose steroids is a common cause of osteonecrosis. Currently, there is a lack of standardized protocol for constructing osteonecrosis animal models, and the survival and model formation rates are unsatisfactory. This study successfully established a rabbit model of osteonecrosis by optimizing the construction protocol.

METHODSX (2022)

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Article Endocrinology & Metabolism

Type VI Collagen Regulates Endochondral Ossification in the Temporomandibular Joint

Taishi Komori et al.

Summary: This study investigates the role of type VI collagen in temporomandibular joint (TMJ) cartilage and finds that it is crucial for endochondral ossification in the TMJ. Alpha 2(VI) deficiency leads to abnormal chondrocyte differentiation and maturation, and alters gene expression profiles related to cell cycle and extracellular matrix (ECM) organization. The study also suggests deregulation of bone morphogenetic protein 2 (BMP2) activity during chondrocyte differentiation.

JBMR PLUS (2022)

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Article Surgery

Effect of vascularized periosteum on revitalization of massive bone isografts: An experimental study in a rabbit model

David Barastegui et al.

Summary: This study conducted in rabbits found that the association of vascularized periosteum to a massive bone isograft accelerates bone graft substitution into newly formed bone, but does not lead to bone graft revitalization.

MICROSURGERY (2021)

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Article Orthopedics

Strategies to Identify Mesenchymal Stromal Cells in Minimally Manipulated Human Bone Marrow Aspirate Concentrate Lack Consensus

Severin Ruoss et al.

Summary: In this study, five strategies for identifying MSCs were compared in clinical-grade BMAC-MSCs and cultured MSCs. The findings suggest a need for liberalized methods to identify any MSCs in fresh human BMAC, as well as a lack of consensus at the single cell transcriptome and protein expression levels.

AMERICAN JOURNAL OF SPORTS MEDICINE (2021)

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Article Cell & Tissue Engineering

Reprogrammed mesenchymal stem cells derived from iPSCs promote bone repair in steroid-associated osteonecrosis of the femoral head

Meiling Zhou et al.

Summary: The study demonstrated that reprogramming ONFH-BMSCs to iPSC-MSCs could reverse abnormal proliferation, differentiation, and DNA methylation patterns, and transplantation of iPSC-MSCs effectively promoted bone repair and angiogenesis in the necrosis area of the femoral head.

STEM CELL RESEARCH & THERAPY (2021)

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Article Medicine, General & Internal

Osteonecrosis of the Femoral Head Safely Healed with Autologous, Expanded, Bone Marrow-Derived Mesenchymal Stromal Cells in a Multicentric Trial with Minimum 5 Years Follow-Up

Enrique Gomez-Barrena et al.

Summary: The study demonstrated the safety and early efficacy of treating early femoral head osteonecrosis with autologous mesenchymal stromal cells (MSC) expanded from bone marrow. Results showed that 80% of patients maintained head sphericity and showed bone regeneration at 2 years, with 19% converting to total hip replacement (THR) after 5 years.

JOURNAL OF CLINICAL MEDICINE (2021)

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Review Medicine, General & Internal

Osteonecrosis of the Femoral Head: an Updated Review of ARCO on Pathogenesis, Staging and Treatment

Jeremy T. Hines et al.

Summary: Non-traumatic osteonecrosis of the femoral head (ONFH) predominantly affects adults younger than 50 years, leading to femoral head collapse and hip arthritis. The use of corticosteroids for leukemia and organ transplantation has contributed to the increasing prevalence of ONFH.

JOURNAL OF KOREAN MEDICAL SCIENCE (2021)

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Article Immunology

Comparing the chondrogenic potential of rabbit mesenchymal stem cells derived from the infrapatellar fat pad, periosteum & bone marrow

Karthikeyan Rajagopal et al.

Summary: The study demonstrated that rabbit bone marrow mesenchymal stem cells (BM-MSCs) had superior chondrogenic potential for cartilage repair compared to MSCs from other sources.

INDIAN JOURNAL OF MEDICAL RESEARCH (2021)

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Article Chemistry, Multidisciplinary

Histopathological Signatures of the Femoral Head in Patients with Osteonecrosis and Potential Applications in a Multi-Targeted Approach: A Pilot Study

Giovanna Desando et al.

APPLIED SCIENCES-BASEL (2020)

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Article

Cell therapy for posttraumatic shoulder osteonecrosis

J. Hernigou et al.

Morphologie (2020)

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Review Cell & Tissue Engineering

Stem cell therapy for osteonecrosis of femoral head: Opportunities and challenges

Yingxing Xu et al.

REGENERATIVE THERAPY (2020)

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Review Immunology

Inflammation, Bone Healing and Osteonecrosis: From Bedside to Bench

Stuart B. Goodman et al.

JOURNAL OF INFLAMMATION RESEARCH (2020)

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Article Cell & Tissue Engineering

Impact of HOXB7 overexpression on human adipose-derived mesenchymal progenitors

Elisabetta Manuela Foppiani et al.

STEM CELL RESEARCH & THERAPY (2019)

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Review Cell & Tissue Engineering

Concise Review: Challenges in Clinical Development of Mesenchymal Stromal/Stem Cells

Ilenia Mastrolia et al.

STEM CELLS TRANSLATIONAL MEDICINE (2019)

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Article Orthopedics

Osteonecrosis of the femoral head: pathophysiology and current concepts of treatment

Daniel Petek et al.

EFORT OPEN REVIEWS (2019)

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Review Orthopedics

Animal models of steroid-induced osteonecrosis of the femoral head-a comprehensive research review up to 2018

Jianzhong Xu et al.

INTERNATIONAL ORTHOPAEDICS (2018)

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Article Multidisciplinary Sciences

Potency Biomarker Signature Genes from Multiparametric Osteogenesis Assays: Will cGMP Human Bone Marrow Mesenchymal Stromal Cells Make Bone?

Alba Murgia et al.

PLOS ONE (2016)

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Article Cell & Tissue Engineering

Analysis of new bone, cartilage, and fibrosis tissue in healing murine allografts using whole slide imaging and a new automated histomorphometric algorithm

Longze Zhang et al.

Bone Research (2016)

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Review Medicine, General & Internal

Mesenchymal stem/stromal cells as a delivery platform in cell and gene therapies

Naomi D'souza et al.

BMC MEDICINE (2015)

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Article Orthopedics

iNOS expression and osteocyte apoptosis in idiopathic, non-traumatic osteonecrosis

Jun Wang et al.

ACTA ORTHOPAEDICA (2015)

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Article Cell Biology

Visualization of Different Tissues Involved in Endochondral Ossification With Alcian Blue Hematoxylin and Orange G/Eosin Counterstain

Jessica R. Nowalk et al.

JOURNAL OF HISTOTECHNOLOGY (2014)

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Article Rheumatology

Regenerative effects of transplanting autologous mesenchymal stem cells on corticosteroid-induced osteonecrosis in rabbits

Hiroyuki Matsuya et al.

Modern Rheumatology (2014)

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Article Cell & Tissue Engineering

Transportation Conditions for Prompt Use of Ex Vivo Expanded and Freshly Harvested Clinical-Grade Bone Marrow Mesenchymal Stromal/Stem Cells for Bone Regeneration

Elena Veronesi et al.

TISSUE ENGINEERING PART C-METHODS (2014)

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Article Biochemistry & Molecular Biology

Adipose stromal/stem cells assist fat transplantation reducing necrosis and increasing graft performance

Maria Serena Piccinno et al.

APOPTOSIS (2013)

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Article Anatomy & Morphology

Isolation, characterization and the multi-lineage differentiation potential of rabbit bone marrow-derived mesenchymal stem cells

Sik-Loo Tan et al.

JOURNAL OF ANATOMY (2013)

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Article Multidisciplinary Sciences

The Therapeutic Effect of Negative Pressure in Treating Femoral Head Necrosis in Rabbits

Yin-gang Zhang et al.

PLOS ONE (2013)

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Article Multidisciplinary Sciences

HIF-1α Transgenic Bone Marrow Cells Can Promote Tissue Repair in Cases of Corticosteroid-Induced Osteonecrosis of the Femoral Head in Rabbits

Hao Ding et al.

PLOS ONE (2013)

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Article Multidisciplinary Sciences

Autologous Bone-Marrow Mesenchymal Stem Cell Implantation and Endothelial Function in a Rabbit Ischemic Limb Model

Shinsuke Mikami et al.

PLOS ONE (2013)

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Article Orthopedics

The effect of core decompression on local expression of BMP-2, PPAR-γ and bone regeneration in the steroid-induced femoral head osteonecrosis

Wei Wang et al.

BMC MUSCULOSKELETAL DISORDERS (2012)

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Article Multidisciplinary Sciences

HGF-Transgenic MSCs Can Improve the Effects of Tissue Self-Repair in a Rabbit Model of Traumatic Osteonecrosis of the Femoral Head

Qian Wen et al.

PLOS ONE (2012)

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Article Cell Biology

Early spontaneous immortalization and loss of plasticity of rabbit bone marrow mesenchymal stem cells

N. Ahmadbeigi et al.

CELL PROLIFERATION (2011)

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Article Engineering, Biomedical

Micro-CT-based bone ceramic scaffolding and its performance after seeding with mesenchymal stem cells for repair of load-bearing bone defect in canine femoral head

Jiang Peng et al.

JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS (2011)

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Adipose-Derived Mesenchymal Stem Cells as Stable Source of Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand Delivery for Cancer Therapy

Giulia Grisendi et al.

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GMP-manufactured density gradient media for optimized mesenchymal stromal/stem cell isolation and expansion

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CYTOTHERAPY (2010)

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Article Endocrinology & Metabolism

Treatment of experimental osteonecrosis of the hip in adult rabbits with a single local injection of recombinant human FGF-2 microspheres

Yutaka Kuroda et al.

JOURNAL OF BONE AND MINERAL METABOLISM (2010)

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Modulating Endochondral Ossification of Multipotent Stromal Cells for Bone Regeneration

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Review Hematology

Buffy-coat-derived pooled platelet concentrates and apheresis platelet concentrates: which product type should be preferred?

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Restoration and reversible expansion of the osteoblastic hematopoietic stem cell niche after marrow radioablation

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Endochondral ossification is required for haematopoietic stem-cell niche formation

Charles K. F. Chan et al.

NATURE (2009)

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Article Orthopedics

Total THA in adult osteonecrosis related to sickle cell disease

Philippe Hernigou et al.

CLINICAL ORTHOPAEDICS AND RELATED RESEARCH (2008)

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Article Rheumatology

Dose Effects of Corticosteroids on the Development of Osteonecrosis in Rabbits

Goro Motomura et al.

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Article Biology

Erythrocyte lysis in isotonic solution of ammonium chloride: Theoretical modeling and experimental verification

Andrey V. Chernyshev et al.

JOURNAL OF THEORETICAL BIOLOGY (2008)

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Article Rheumatology

Prevention of corticosteroid-induced osteonecrosis in rabbits by intra-bone marrow injection of autologous bone marrow cells

T. Asada et al.

RHEUMATOLOGY (2008)

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Article Engineering, Biomedical

Injectable biodegradable hydrogel composites for rabbit marrow mesenchymal stem cell and growth factor delivery for cartilage tissue engineering

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BM cells giving rise to MSC in culture have a heterogeneous CD34 and CD45 phenotype

S. Kaiser et al.

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Article Rheumatology

Effects of different corticosteroids on the development of osteonecrosis in rabbits

K Miyanishi et al.

RHEUMATOLOGY (2005)

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Estimation of bone matrix apparent stiffness variation caused by osteocyte lacunar size and density

YN Yeni et al.

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Autologous Marrow Mesenchymal Stem Cell Driving Bone Regeneration in a Rabbit Model of Femoral Head Osteonecrosis

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