Chitosan-G-Glycidyl Methacrylate/Au Nanocomposites Promote Accelerated Skin Wound Healing

Herein, we report the synthesis of Au nanoparticles (AuNPs) in chitosan (CTS) solution by chemically reducing HAuCl4. CTS was further functionalized with glycidyl methacrylate (chitosan-gglycidyl methacrylate/AuNP, CTS-g-GMA/AuNP) to improve the mechanical properties for cellular regeneration requirements of CTS-g-GMA/AuNP. Our nanocomposites promote excellent cellular viability and have a positive effect on cytokine regulation in the inflammatory and anti-inflammatory response of skin cells. After 40 days of nanocomposite exposure to a skin wound, we showed that our films have a greater skin wound healing capacity than a commercial film (TheraForm (R)), and the presence of the collagen allows better cosmetic ave aspects in skin regeneration in comparison with a nanocomposite with an absence of this protein. Electrical percolation phenomena in such nanocomposites were used as guiding tools for the best nanocomposite performance. Our results suggest that chitosan-based Au nanocomposites show great potential for skin wound repair.

Automated summary

In this study, we synthesized Au nanoparticles (AuNPs) in chitosan (CTS) solution through chemical reduction of HAuCl4. CTS was further functionalized with glycidyl methacrylate (chitosan-g-glycidyl methacrylate/AuNP, CTS-g-GMA/AuNP) to improve the mechanical properties for cellular regeneration. Our nanocomposites showed excellent cellular viability and had a positive effect on cytokine regulation in the inflammatory and anti-inflammatory response of skin cells. After 40 days, the nanocomposite films exhibited better skin wound healing capacity and cosmetic aspects in comparison with a commercial film and the presence of collagen in the nanocomposite played a significant role in enhancing the overall regeneration effect of skin. Electrical percolation phenomena were utilized to optimize the performance of nanocomposites. Overall, chitosan-based Au nanocomposites showed great potential for skin wound repair.