期刊
PHARMACEUTICS
卷 14, 期 10, 页码 -出版社
MDPI
DOI: 10.3390/pharmaceutics14102242
关键词
methylene blue; gold nanorods; graphene oxide; diagnosis; phototherapy
资金
- Korean Ministry of Education, Science Technology [2016R1D1A3B0201175615]
- Grand Information Technology Research Center Program through the Institute of Information & Communications Technology Planning & Evaluation (IITP) - Ministry of Science and ICT (MSIT), Korea [IITP-2022-2020-0-01612]
- Basic Science Research Program through the National Research Foundation of Korea (NRF) - Ministry of Education [NRF-2022R1I1A1A01068693]
Photo-nanotheranostics integrates near-infrared light-triggered diagnostics and therapeutics, promising early detection and precise treatment of cancer. In this study, mesoporous silica-coated gold nanorods on graphene oxide loaded with methylene blue were developed as an all-in-one photo-nanotheranostic agent for imaging-guided photothermal therapy and photodynamic therapy. The nanomaterial showed a high photothermal conversion efficiency and strong SERS effect, allowing accurate cancer cell detection and prolonged therapy.
Photo-nanotheranostics integrates near-infrared (NIR) light-triggered diagnostics and therapeutics, which are combined into a novel all-in-one phototheranostic nanomaterial that holds great promise for the early detection and precise treatment of cancer. In this study, we developed methylene blue-loaded mesoporous silica-coated gold nanorods on graphene oxide (MB-GNR@mSiO(2)-GO) as an all-in-one photo-nanotheranostic agent for intracellular surface-enhanced Raman scattering (SERS) imaging-guided photothermal therapy (PTT)/photodynamic therapy (PDT) for cancer. Amine functionalization of the MB-GNR@mSiO(2) surfaces was performed using 3-aminopropyltriethoxysilane (APTES), which was well anchored on the carboxyl groups of graphene oxide (GO) nanosheets uniformly, and showed a remarkably higher photothermal conversion efficiency (48.93%), resulting in outstanding PTT/PDT for cancer. The in vitro photothermal/photodynamic effect of MB-GNR@mSiO(2)-GO with laser irradiation showed significantly reduced cell viability (6.32%), indicating that MB-GNR@mSiO(2)-GO with laser irradiation induced significantly more cell deaths. Under laser irradiation, MB-GNR@mSiO(2)-GO showed a strong SERS effect, which permits accurate cancer cell detection by SERS imaging. Subsequently, the same Raman laser can focus on highly detected MDA-MB-23l cells for a prolonged time to perform PTT/PDT. Therefore, MB-GNR@mSiO(2)-GO has great potential for precise SERS imaging-guided synergistic PTT/PDT for cancer.
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