期刊
PHARMACEUTICS
卷 14, 期 9, 页码 -出版社
MDPI
DOI: 10.3390/pharmaceutics14091907
关键词
AC biosuceptometry; magnetic nanoparticles; cirrhosis-associated rat hepatocarcinogenesis; nanotechnology
资金
- Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP) [2013/07699-0, 2021/06405-9, 2021/09829-4, 2019/11277-0]
- Conselho Nacional de Pesquisas e Desenvolvimento Tecnologico (CNPq) [312074/20189, 311074/2018]
- German Academic Exchange program DAAD
- Brazilian CAPES-PROBRAL [57446914, 88887.198747/2018-00, 888 81.198748/2018-01]
This study aimed to assess the impact of cirrhosis-associated hepatocarcinogenesis on the biodistribution of hepatic magnetic nanoparticles (MNPs). The results showed that the uptake of MNPs in the liver is compromised during cirrhosis due to reduced blood flow and impaired liver function caused by scar tissue.
Since magnetic nanoparticles (MNPs) have been used as multifunctional probes to diagnose and treat liver diseases in recent years, this study aimed to assess how the condition of cirrhosis-associated hepatocarcinogenesis alters the biodistribution of hepatic MNPs. Using a real-time image acquisition approach, the distribution profile of MNPs after intravenous administration was monitored using an AC biosusceptometry (ACB) assay. We assessed the biodistribution profile based on the ACB images obtained through selected regions of interest (ROIs) in the heart and liver position according to the anatomical references previously selected. The signals obtained allowed for the quantification of pharmacokinetic parameters, indicating that the uptake of hepatic MNPs is compromised during liver cirrhosis, since scar tissue reduces blood flow through the liver and slows its processing function. Since liver monocytes/macrophages remained constant during the cirrhotic stage, the increased intrahepatic vascular resistance associated with impaired hepatic sinusoidal circulation was considered the potential reason for the change in the distribution of MNPs.
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