4.7 Article

Effect of the Silica-Magnetite Nanocomposite Coating Functionalization on the Doxorubicin Sorption/Desorption

期刊

PHARMACEUTICS
卷 14, 期 11, 页码 -

出版社

MDPI
DOI: 10.3390/pharmaceutics14112271

关键词

nanocomposites; Fe3O4 nanoparticles; SiO2; PMIDA; doxorubicin; sorption; desorption; DFT calculations

资金

  1. Ministry of Science and Higher Education of the Russian Federation [075-15-2020-777]

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A series of new composite materials based on Fe3O4 magnetic nanoparticles coated with SiO2 were synthesized, and the performance of these materials in drug loading and delivery systems was explored theoretically and experimentally. The study showed that the use of PMIDA can increase the SiO2 content in the Fe3O4@SiO2 composites and enhance the loading of Dox drug. In addition, quantum chemical calculations revealed the binding mechanism of Dox to the functional groups on the surface of the nanoparticles.
A series of new composite materials based on Fe3O4 magnetic nanoparticles coated with SiO2 (or aminated SiO2) were synthesized. It has been shown that the use of N-(phosphonomethyl)iminodiacetic acid (PMIDA) to stabilize nanoparticles before silanization ensures the increased content of a SiO2 phase in the Fe3O4@SiO2 nanocomposites (NCs) in comparison with materials obtained under similar conditions, but without PMIDA. It has been demonstrated for the first time that the presence of PMIDA on the surface of NCs increases the level of Dox loading due to specific binding, while surface modification with 3-aminopropylsilane, on the contrary, significantly reduces the sorption capacity of materials. These regularities were in accordance with the results of quantum chemical calculations. It has been shown that the energies of Dox binding to the functional groups of NCs are in good agreement with the experimental data on the Dox sorption on these NCs. The mechanisms of Dox binding to the surface of NCs were proposed: simultaneous coordination of Dox on the PMIDA molecule and silanol groups at the NC surface leads to a synergistic effect in Dox binding. The synthesized NCs exhibited pH-dependent Dox release, as well as dose-dependent cytotoxicity in in vitro experiments. The cytotoxic effects of the studied materials correspond to their calculated IC50 values. NCs with a SiO2 shell obtained using PMIDA exhibited the highest effect. At the same time, the presence of PMIDA in NCs makes it possible to increase the Dox loading, as well as to reduce its desorption rate, which may be useful in the design of drug delivery vehicles with a prolonged action. We believe that the data obtained can be further used to develop stimuli-responsive materials for targeted cancer chemotherapy.

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