4.6 Article

Cardiovascular disease and risk of lung cancer incidence and mortality: A nationwide matched cohort study

期刊

FRONTIERS IN ONCOLOGY
卷 12, 期 -, 页码 -

出版社

FRONTIERS MEDIA SA
DOI: 10.3389/fonc.2022.950971

关键词

cardiovascular disease; lung cancer; incidence; mortality; survival

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资金

  1. Independent Research Fund Denmark [DFF-6110-00019B, 9039-00010B, 1030-00012B]
  2. Nordic Cancer Union [R275-A15770, R278-A15877]
  3. Karen Elise Jensens Fond (2016)
  4. Novo Nordisk Fonden [NNF18OC0052029]
  5. Shanghai Rising-Star Program [21QA1401300]
  6. National Natural Science Foundation of China [82073570, 82173612]
  7. Shanghai Municipal Natural Science Foundation [22ZR1414900]
  8. Shanghai Municipal Science and Technology Major Project [ZD2021CY001]

向作者/读者索取更多资源

The study found that patients with cardiovascular disease (CVD) are more likely to develop lung cancer and have a higher risk of lung cancer mortality, especially those with heart disease and vascular disease. Individuals diagnosed with CVD in middle adulthood have a higher risk of developing lung cancer.
PurposePrevious studies have suggested a link between cardiovascular disease (CVD) and the subsequent development of lung cancer. However, empirical evidence on the association of CVDs, particularly type-specific CVDs, with lung cancer incidence and survival remains limited. MethodsThe cohort study included 306,285 patients with CVD and 1,222,140 individuals without CVD. We performed stratified Cox regression to estimate the hazard ratio (HR). ResultsDuring up to 42 years of follow-up, 243 (0.08%) and 537 (0.04%) participants were diagnosed with lung cancer among CVD patients and matched individuals, respectively. Patients with CVD had a 67% increased risk of lung cancer (HR: 1.67, 95% confidence interval [CI]: 1.42-1.96). The increased risks were observed in patients with heart disease (1.93, 1.30-2.85), vascular disease (1.88, 1.35-2.61), and hypertensive disease (1.46, 1.15-1.85), respectively. Patients with CVD had a 95% increased risk of lung cancer mortality (1.95, 1.50-2.55), particularly vascular disease (3.24, 1.74-6.02) and heart disease (2.29, 1.23-4.26). Patients with CVD diagnosed in middle adulthood (>40 years old) tended to have a higher incidence risk (3.44, 2.28-5.19) and mortality (3.67, 1.80-7.46) than those diagnosed at younger ages. ConclusionsOur findings on the association of CVD diagnosis, especially heart and vascular disease, with increased risk of lung cancer incidence and mortality suggest that CVD contributes to the development and worsening of lung cancer survival. In particular, people with CVD diagnosed in middle adulthood (>40 years old) would benefit from early preventive evaluation and screening for lung cancer.

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