4.6 Review

The oncogenic roles of JC polyomavirus in cancer

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Article Oncology

The Oncogenic Effects, Pathways, and Target Molecules of JC Polyoma Virus T Antigen in Cancer Cells

Hua-Chuan Zheng et al.

Summary: JC polyoma virus (JCPyV) plays a significant role in various cellular processes such as proliferation, metabolism, migration, and invasion. Overexpression of T-antigen leads to activation of oncogenes and signaling pathways, resulting in a more aggressive phenotype of cancer cells.

FRONTIERS IN ONCOLOGY (2022)

Article Urology & Nephrology

Outcomes of Living Kidney Donor Candidates and Living Kidney Recipient Candidates with JC Polyomavirus and BK Polyomavirus Viruria

Sara Querido et al.

Summary: Recent data has shown a potential protective association between JCV viruria and chronic kidney disease, with JCV viruria having a positive impact on reducing the risk of proteinuria. This concept of protective association is extrapolated to a South European population, warranting further research into its potential benefits.

INTERNATIONAL JOURNAL OF NEPHROLOGY (2021)

Article Oncology

The differential presence of human polyomaviruses, JCPyV and BKPyV, in prostate cancer and benign prostate hypertrophy tissues

Chenghuang Shen et al.

Summary: The study investigated the potential association between the prevalence of JCPyV or BKPyV and prostate cancer in Taiwan. Results showed that JCPyV/BKPyV DNA prevalence was higher in prostate cancer tissues compared to benign samples, and that PC cells were more susceptible to JCPyV infection. Patients with high levels of prostate-specific antigen and Gleason scores were at a higher risk of viral infection, suggesting a potential link between JCPyV infection and prostate cancer progression.

BMC CANCER (2021)

Article Virology

Human neurotropic polyomavirus, JC virus, agnoprotein targets mitochondrion and modulates its functions

Reshu Saxena et al.

Summary: The study reveals that the JC virus's regulatory protein Agno targets mitochondria and affects their functions. The mitochondrial targeting sequence (MTS) of Agno and its dimerization domain play crucial roles in this process. Furthermore, the study shows that Agno-positive cells exhibit reduced mitochondrial membrane potential, respiration rates, ATP production, as well as increased ROS production and Ca2+ uptake by the mitochondria.

VIROLOGY (2021)

Article Virology

Induction of Brain Tumors by the Archetype Strain of Human Neurotropic JCPyV in a Transgenic Mouse Model

Luis Del Valle et al.

Summary: JC Virus (JCPyV) is a human neurotropic virus that causes progressive multifocal leukoencephalopathy. Different strains of JCPyV are determined by mutations in the regulatory region, with the strain associated with PML containing two 98 base pair repeats.

VIRUSES-BASEL (2021)

Article Multidisciplinary Sciences

A multi-omic investigation of male lower urinary tract symptoms: Potential role for JC virus

Samuel Thomas et al.

Summary: There was a significant association found between the presence of JC virus in urine and a diagnosis of LUTS. Urine metabolomics analysis identified dysregulation of metabolites associated with key LUTS processes.

PLOS ONE (2021)

Article Virology

IFNα and β Mediated JCPyV Suppression through C/EBPβ-LIP Isoform

Dana May et al.

Summary: The study found that interferons can negatively regulate JC virus transcription and replication by inducing C/EBPβ-LIP.

VIRUSES-BASEL (2021)

Article Clinical Neurology

Mutations in the John Cunningham virus VP1 gene could predispose to the development of progressive multifocal leukoencephalopathy in multiple sclerosis patients undergoing treatment with natalizumab

J. Flores et al.

Summary: The study aimed to identify mutations along the JC virus VP1 gene in MS patients undergoing treatment with NTZ and correlate them with the anti-JC virus antibody index.

MULTIPLE SCLEROSIS AND RELATED DISORDERS (2021)

Article Microbiology

The Small t Antigen of JC Virus Antagonizes RIG-I-Mediated Innate Immunity by Inhibiting TRIM25's RNA Binding Ability

Cindy Chiang et al.

Summary: JCV infection in human astrocytes is controlled by innate immune sensors RIG-I and cGAS, with the small t antigen of JCV acting as an interferon antagonist. This highlights how JCV and related viruses manipulate innate immune pathways, potentially sparking research into novel therapies.
Article Biochemistry & Molecular Biology

Teriflunomide Inhibits JCPyV Infection and Spread in Glial Cells and Choroid Plexus Epithelial Cells

Bethany A. O'Hara et al.

Summary: The study found that teriflunomide can inhibit the infection and spread of JC polyomavirus in glial and choroid plexus epithelial cells. JC polyomavirus DNA was detected in a high proportion of RRMS patients, but not in the cerebrospinal fluid.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

Article Biochemistry & Molecular Biology

The Oncogenic Roles of JC Virus T Antigen in Breast Carcinogenesis

Hua-chuan Zheng et al.

Summary: The study revealed an association between JC virus T antigen and clinical pathological parameters of breast cancer, suggesting a potentially important oncogenic role for T antigen in breast carcinogenesis. JC virus T antigen could serve as a molecular marker for differentiation and aggressive behaviors in breast cancer.

FRONTIERS IN MOLECULAR BIOSCIENCES (2021)

Review Infectious Diseases

Association between JC virus and colorectal cancer: systematic review and meta-analysis

Rasoul Shavaleh et al.

INFECTIOUS DISEASES (2020)

Review Biochemistry & Molecular Biology

The Role of the JC Virus in Central Nervous System Tumorigenesis

Nicholas Ahye et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

Article Transplantation

JC Virus-Related Progressive Multifocal Leukoencephalopathy After Living-Donor Liver Transplant: A Rare Case

Archana Rastogi et al.

EXPERIMENTAL AND CLINICAL TRANSPLANTATION (2019)

Article Virology

JC Polyomavirus Entry by Clathrin-Mediated Endocytosis Is Driven by β-Arrestin

Colleen L. Mayberry et al.

JOURNAL OF VIROLOGY (2019)

Article Biochemistry & Molecular Biology

JCPyV-Induced MAPK Signaling Activates Transcription Factors during Infection

Jeanne K. DuShane et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)

Article Biochemistry & Molecular Biology

Nuclear Magnetic Resonance Structure of the Human Polyoma JC Virus Agnoprotein

Pascale Coric et al.

JOURNAL OF CELLULAR BIOCHEMISTRY (2017)

Article Immunology

CPT11 prevents virus replication in JCI cells persistently infected with JC polyomavirus

Souichi Nukuzuma et al.

MICROBIOLOGY AND IMMUNOLOGY (2017)

Article Multidisciplinary Sciences

Pur-Alpha Induces JCV Gene Expression and Viral Replication by Suppressing SRSF1 in Glial Cells

Ilker Kudret Sariyer et al.

PLOS ONE (2016)

Article Biochemistry & Molecular Biology

Oligomerization of neutral peptides derived from the JC virus agnoprotein through a cysteine residue

Koushi Hidaka et al.

AMINO ACIDS (2015)

Review Clinical Neurology

Novel syndromes associated with JC virus infection of neurons and meningeal cells: no longer a gray area

Dhanashri P. Miskin et al.

CURRENT OPINION IN NEUROLOGY (2015)

Article Multidisciplinary Sciences

IFN-Gamma Inhibits JC Virus Replication in Glial Cells by Suppressing T-Antigen Expression

Francesca Isabella De-Simone et al.

PLOS ONE (2015)

Article Virology

TNF-α Stimulates Efficient JC Virus Replication in Neuroblastoma Cells

Souichi Nukuzuma et al.

JOURNAL OF MEDICAL VIROLOGY (2014)

Article Multidisciplinary Sciences

Activation of c-Myc and Cyclin D1 by JCV T-Antigen and β-Catenin in Colon Cancer

Michael J. Ripple et al.

PLOS ONE (2014)

Article Virology

Suppressive effect of PARP-1 inhibitor on JC virus replication in vitro

Souichi Nukuzuma et al.

JOURNAL OF MEDICAL VIROLOGY (2013)

Article Biotechnology & Applied Microbiology

JC virus granule cell neuronopathy is associated with VP1 C terminus mutants

Xin Dang et al.

JOURNAL OF GENERAL VIROLOGY (2012)

Article Multidisciplinary Sciences

JC Virus T-Antigen Regulates Glucose Metabolic Pathways in Brain Tumor Cells

Evan Noch et al.

PLOS ONE (2012)

Article Multidisciplinary Sciences

Bag3-Induced Autophagy Is Associated with Degradation of JCV Oncoprotein, T-Ag

Ilker Kudret Sariyer et al.

PLOS ONE (2012)

Article Microbiology

Hexadecyloxypropyl-Cidofovir (CMX001) Suppresses JC Virus Replication in Human Fetal Brain SVG Cell Cultures

Zhi-Gang Jiang et al.

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2010)

Article Biochemistry & Molecular Biology

Large T Antigen Promotes JC Virus Replication in G2-arrested Cells by Inducing ATM- and ATR-mediated G2 Checkpoint Signaling

Yasuko Orba et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2010)

Article Virology

Viral Infection In Bone Marrow Transplants: Is JC Virus Involved?

Monica Mischitelli et al.

JOURNAL OF MEDICAL VIROLOGY (2010)

Article Virology

Role of N-Linked Glycosylation of the 5-HT2A Receptor in JC Virus Infection

Melissa S. Maginnis et al.

JOURNAL OF VIROLOGY (2010)

Article Microbiology

The Human Polyoma JC Virus Agnoprotein Acts as a Viroporin

Tadaki Suzuki et al.

PLOS PATHOGENS (2010)

Article Infectious Diseases

Mapping the history and current situation of research on John Cunningham virus - a bibliometric analysis

Hua-chuan Zheng et al.

BMC INFECTIOUS DISEASES (2009)

Article Multidisciplinary Sciences

JC Virus Mediates Invasion and Migration in Colorectal Metastasis

Alexander Link et al.

PLOS ONE (2009)

Article Biochemistry & Molecular Biology

A novel role of Rac1 GTPase in JCV T-antigen-mediated β-catenin stabilization

R. Bhattacharyya et al.

ONCOGENE (2007)

Article Anatomy & Morphology

Detection of the JC virus genome in lung cancers: Possible role of the T-antigen in lung oncogenesis

Hekmat Osman Abdel-Aziz et al.

APPLIED IMMUNOHISTOCHEMISTRY & MOLECULAR MORPHOLOGY (2007)

Article Oncology

Oncogenic role of JC virus in lung cancer

H. Zheng et al.

JOURNAL OF PATHOLOGY (2007)

Article Cell Biology

Interplay between the retinobrastoma related pRb2/p130 and E2F-4 and-5 in relation to JCV-TAg

Valentina Caracciolo et al.

JOURNAL OF CELLULAR PHYSIOLOGY (2007)

Article Oncology

High JC virus load in gastric cancer and adjacent non-cancerous mucosa

Yoshihiro Murai et al.

CANCER SCIENCE (2007)

Article Virology

JC virus minor capsid proteins Vp2 and Vp3 are essential for virus propagation

M. L. Gasparovic et al.

JOURNAL OF VIROLOGY (2006)

Article Clinical Neurology

Detection of JC virus DNA sequences in brain tumors in pediatric patients

H Okamoto et al.

JOURNAL OF NEUROSURGERY (2005)

Article Biochemistry & Molecular Biology

Interaction between JCV large T-antigen and β-catenin

DD Gan et al.

ONCOGENE (2004)

Article Virology

Role of JC virus agnoprotein in DNA repair

A Darbinyan et al.

JOURNAL OF VIROLOGY (2004)

Article Biochemistry & Molecular Biology

Nuclear entry mechanism of the human polyomavirus JC virus-like particle - Role of importins and the nuclear pore complex

QM Qu et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2004)

Article Virology

JC virus-induced changes in cellular gene expression in primary human astrocytes

S Radhakrishnan et al.

JOURNAL OF VIROLOGY (2003)

Article Neurosciences

JC virus agnoprotein colocalizes with tubulin

S Endo et al.

JOURNAL OF NEUROVIROLOGY (2003)

Article Neurosciences

Role of the environment in the transmission of JC virus

S Bofill-Mas et al.

JOURNAL OF NEUROVIROLOGY (2003)

Article Biochemistry & Molecular Biology

Insulin receptor substrate 1 translocation to the nucleus by the human JC virus T-antigen

A Lassak et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2002)

Article Chemistry, Medicinal

Transcriptional regulation of the glial cell-specific JC virus by p53

HS Kim et al.

ARCHIVES OF PHARMACAL RESEARCH (2002)