Impact of skeletal muscle loss during conversion therapy on clinical outcomes in lavage cytology positive patients with gastric cancer

Article Geriatrics & Gerontology

Impact of preoperative sarcopenia on postoperative complications and prognosis of gastric cancer resection: A meta-analysis of cohort studies

Fei Chen et al.

Summary: Preoperative sarcopenia increases the risk of postoperative complications and reduces the overall survival rate in patients undergoing gastrectomy for gastric cancer.

ARCHIVES OF GERONTOLOGY AND GERIATRICS (2022)

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Article Oncology

Clinical impact of gastrectomy for gastric cancer patients with positive lavage cytology without gross peritoneal dissemination

Hiroshi Kobayashi et al.

Summary: Gastrectomy does not significantly improve the survival time of patients with P0CY1 gastric cancer. Surgeons should prioritize chemotherapy as the initial treatment.

JOURNAL OF SURGICAL ONCOLOGY (2022)

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Article Nutrition & Dietetics

Postoperative Loss of Skeletal Muscle Mass Predicts Poor Survival After Gastric Cancer Surgery

Shanjun Tan et al.

Summary: This study investigated the link between postoperative loss of skeletal muscle mass and survival following gastric cancer surgery, finding that patients with postoperative skeletal muscle index loss >= 5% had poorer overall survival and disease-free survival. Further research is needed to determine whether stabilizing or enhancing skeletal muscle mass after surgery improves survival outcomes.

FRONTIERS IN NUTRITION (2022)

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Article Oncology

Neoadjuvant intraperitoneal and systemic paclitaxel combined with apatinib and S-1 chemotherapy for conversion therapy in gastric cancer patients with positive exfoliative cytology: a prospective study

Ping'an Ding et al.

Summary: In this study, neoadjuvant intraperitoneal and systemic paclitaxel chemotherapy combined with apatinib and S-1 treatment showed promising results in increasing the FCC negative rate of P0CY1 gastric cancer patients. The treatment led to high ORR and DCR after 3 cycles of conversion therapy, with a significant percentage of patients undergoing R0 surgical resection.

JOURNAL OF GASTROINTESTINAL ONCOLOGY (2021)

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Article Multidisciplinary Sciences

Optimal body size adjustment of L3 CT skeletal muscle area for sarcopenia assessment

Brian A. Derstine et al.

Summary: The study suggests adjusting for height and BMI to accurately assess muscle loss, with SMA(HT) recommended for height adjustment and the z(SMA(HT)) score recommended for optimal height and BMI adjustment, to provide unbiased assessments of relative L3 skeletal muscle area across different body sizes.

SCIENTIFIC REPORTS (2021)

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Article Geriatrics & Gerontology

Sarcopenia and major complications in patients undergoing oncologic colon surgery

Michael Schneider et al.

Summary: This study found that lower muscle quality (SMRA) may be a better predictor of adverse outcomes than muscle quantity (SMA and SMI) after oncologic colon surgery. Factors such as major surgery, intraoperative blood loss, and intraoperative complications may be associated with major complications.

JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE (2021)

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Article Nutrition & Dietetics

Influence of body composition, muscle strength, and physical performance on the postoperative complications and survival after radical gastrectomy for gastric cancer: A comprehensive analysis from a large-scale prospective study

Qian-Tong Dong et al.

Summary: This study revealed a complex correlation among body composition parameters, muscle strength, and gait speed in patients undergoing radical gastrectomy for gastric cancer. Grip strength and skeletal muscle index were independently predictive of postoperative complications, while skeletal muscle density and gait speed had independent predictive value for overall survival and disease-free survival.

CLINICAL NUTRITION (2021)

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Article Oncology

The impact of body composition on short-term outcomes of neoadjuvant chemotherapy with gemcitabine plus S-1 in patients with resectable pancreatic cancer

Tsuyoshi Takeda et al.

Summary: This retrospective study evaluated the impact of body composition on short-term outcomes of NAC GS in resectable pancreatic cancer patients, and found sarcopenia to be significantly associated with lower body mass index and total adipose tissue index, but not with completion rate of NAC, adverse events, and tolerance.

JAPANESE JOURNAL OF CLINICAL ONCOLOGY (2021)

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Article Oncology

Impact of preoperative chemotherapy as initial treatment for advanced gastric cancer with peritoneal metastasis limited to positive peritoneal lavage cytology (CY1) or localized peritoneal metastasis (P1a): a multi-institutional retrospective study

Toshifumi Yamaguchi et al.

Summary: This study investigated the efficacy of preoperative chemotherapy as initial treatment in GC patients with CY1 and/or P1a. Results showed that preoperative chemotherapy did not provide a survival benefit for GC patients with CY1 and/or P1a, but showed favorable survival in patients who converted to P0 and CY0.

GASTRIC CANCER (2021)

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Article Oncology