DUSP1 promotes muscle atrophy by inhibiting myocyte differentiation in cachectic patients

Article Cell Biology

MiR-337-3p confers protective effect on facet joint osteoarthritis by targeting SKP2 to inhibit DUSP1 ubiquitination and inactivate MAPK pathway

Shengsheng Jian et al.

Summary: MiR-337-3p plays a protective role in facet joint osteoarthritis by negatively targeting SKP2 to suppress DUSP1 ubiquitination and inactivate the p38 MAPK pathway.

CELL BIOLOGY AND TOXICOLOGY (2023)

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Article Geriatrics & Gerontology

Human pancreatic tumour organoid-derived factors enhance myogenic differentiation

Rianne D. W. Vaes et al.

Summary: The study revealed that factors derived from pancreatic tumor organoids alter the kinetics of myogenesis, potentially contributing to impaired muscle mass maintenance in cancer cachexia.

JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE (2022)

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Article Geriatrics & Gerontology

Ovarian cancer ascites induces skeletal muscle wasting in vitro and reflects sarcopenia in patients

Jorne Ubachs et al.

Summary: This study evaluated the impact of factors present in ascites on protein metabolism in skeletal muscle cells, finding lower protein synthesis, potentially higher protein breakdown rates, and increased NF-kappa B activity in cells exposed to ascites from sarcopenic ovarian cancer patients. These changes correlated with clinical muscle measures and suggest that ascites could be a new tool for studying drivers of tissue wasting in ovarian cancer.

JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE (2022)

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Review Cell Biology

Muscular contraction's therapeutic potential for cancer-induced wasting

Justin P. Hardee et al.

Summary: Skeletal muscle atrophy and dysfunction are significant factors contributing to increased morbidity and mortality in cancer patients. The complex pathophysiology of cachexia involves disruptions to the systemic cancer environment and interactions with various tissues. This article provides an overview of the current understanding of how resistance-type exercise impacts mechanisms involved in cancer-induced muscle wasting, particularly focusing on the role of IL-6 and gp130 receptors. The authors also discuss the gaps in knowledge and future research directions to improve preclinical studies and translate findings to human patients with cancer.

AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY (2022)

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Review Oncology

Understanding the common mechanisms of heart and skeletal muscle wasting in cancer cachexia

Valentina Rausch et al.

Summary: Cachexia is a severe complication of cancer characterized by progressive muscle and adipose tissue atrophy, resulting in weight loss, reduced quality of life, and shortened life expectancy. Cardiac muscle plays a significant role in cachexia, as cancer patients often experience cardiac abnormalities and heart failure symptoms. The lack of effective treatments underscores the need for further understanding of the underlying mechanisms, particularly the metabolic and proteolytic alterations in skeletal and cardiac muscles.

ONCOGENESIS (2021)

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Article Geriatrics & Gerontology

Biomarkers related to fatty acid oxidative capacity are predictive for continued weight loss in cachectic cancer patients

Silvia Catanese et al.

Summary: Cancer patients undergoing systemic treatment showed significant alterations in amino acid levels and acylcarnitine patterns, which could be predictive for weight loss. Baseline acylcarnitine analysis was valuable in studying energy metabolism related to cancer cachexia. Pathway analyses indicated the involvement of serine/glycine and tryptophan pathways in this condition.

JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE (2021)

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Article Medicine, General & Internal

The ERG1A K+ Channel Is More Abundant in Rectus abdominis Muscle from Cancer Patients Than that from Healthy Humans

Sandra Zampieri et al.

Summary: The study demonstrates that ERG1A is present in human skeletal muscle, with levels increasing in healthy older adults and higher in older cancer patients. Moreover, the abundance of ERG1A protein significantly increases in muscle atrophy or cancer cachexia conditions, suggesting a potential association with muscle loss in humans.

DIAGNOSTICS (2021)

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Article Cell Biology

MRTF-A regulates myoblast commitment to differentiation by targeting PAX7 during muscle regeneration

Ruhui Song et al.

Summary: The study reveals that MRTF-A plays crucial roles in myoblast commitment to differentiation by binding to its distal CArG box, contributing to PAX7-mediated myoblast self-renewal, proliferation, and differentiation. Overexpression of MRTF-A promotes myoblast proliferation while inhibiting cell differentiation, leading to decreased muscle regeneration.

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2021)

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Article Oncology

Control of Skeletal Muscle Atrophy Associated to Cancer or Corticosteroids by Ceramide Kinase

Federica Pierucci et al.

Summary: In summary, skeletal muscle mass wasting is a serious condition that significantly impacts disease prognosis and life expectancy. This study demonstrates the crucial role of the CerK/C1P axis in skeletal muscle mass associated with cancer or corticosteroids.

CANCERS (2021)

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Article Cell Biology

Phosphorylation of Dynamin-Related Protein 1 (DRP1) Regulates Mitochondrial Dynamics and Skeletal Muscle Wasting in Cancer Cachexia

Xiangyu Mao et al.

Summary: Patients with cachexia exhibit noticeable mitochondrial abnormalities and muscle loss, with an imbalance in mitochondrial dynamics potentially contributing to muscle atrophy. Regulation of DRP1 could ameliorate these abnormalities caused by cachexia.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2021)

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Article Biochemistry & Molecular Biology

Dual-Specificity Phosphatase 1 (DUSP1) Has a Central Role in Redox Homeostasis and Inflammation in the Mouse Cochlea

Jose M. Bermudez-Munoz et al.

Summary: DUSP1 plays a critical role in controlling the cross-talk between oxidative stress and inflammation in sensorineural hearing loss. Knockout of Dusp1 gene in mice accelerates SNHL progression and triggers inflammation, redox imbalance, and hair cell death. N-acetylcysteine treatment delays the onset of SNHL, mitigates cochlear damage, and improves redox balance.

ANTIOXIDANTS (2021)

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Review Biochemistry & Molecular Biology

Metabolic Remodeling in Skeletal Muscle Atrophy as a Therapeutic Target

Alessandra Renzini et al.

Summary: The skeletal muscle, as a highly responsive tissue, undergoes metabolic changes in response to external demand. Various atrophic conditions, such as aging, ALS, and cancer-induced cachexia, lead to muscle wasting through different molecular signaling pathways. Nutritional interventions and physical exercise have been shown to be effective tools for counteracting muscle wasting in atrophic conditions.

METABOLITES (2021)

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Review Biochemistry & Molecular Biology