期刊
FRONTIERS IN ONCOLOGY
卷 12, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fonc.2022.975981
关键词
neutrophils; immunotherapy; immune checkpoints; NETs; EMT
类别
资金
- NIH/NCI
- IU Simon Comprehensive Cancer Center
- [R01 CA221158-05]
- [R01 CA224493-04]
- [R01 CA240952-02]
- [P30CA082709]
This review provides an update on the contribution of neutrophils in immune suppression and tumor progression. It discusses the molecular pathways through which neutrophils assist cancer progression and orchestrate immune evasion, as well as the potential of neutrophil antagonism to enhance the efficacy of immune checkpoint blockade therapy.
Neutrophils, the most copious leukocytes in human blood, play a critical role in tumorigenesis, cancer progression, and immune suppression. Recently, neutrophils have attracted the attention of researchers, immunologists, and oncologists because of their potential role in orchestrating immune evasion in human diseases including cancer, which has led to a hot debate redefining the contribution of neutrophils in tumor progression and immunity. To make this debate fruitful, this review seeks to provide a recent update about the contribution of neutrophils in immune suppression and tumor progression. Here, we first described the molecular pathways through which neutrophils aid in cancer progression and orchestrate immune suppression/evasion. Later, we summarized the underlying molecular mechanisms of neutrophil-mediated therapy resistance and highlighted various approaches through which neutrophil antagonism may heighten the efficacy of the immune checkpoint blockade therapy. Finally, we have highlighted several unsolved questions and hope that answering these questions will provide a new avenue toward immunotherapy revolution.
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