Multifunctionality of Calebin A in inflammation, chronic diseases and cancer

Chronic diseases including cancer have high case numbers as well as mortality rates. The efficient treatment of chronic diseases is a major ongoing medical challenge worldwide, because of their complexity and many inflammatory pathways such as JNK, p38/MAPK, MEK/ERK, JAK/STAT3, PI3K and NF-kappa B among others being implicated in their pathogenesis. Together with the versatility of chronic disease classical mono-target therapies are often insufficient. Therefore, the anti-inflammatory as well as anti-cancer capacities of polyphenols are currently investigated to complement and improve the effect of classical anti-inflammatory drugs, chemotherapeutic agents or to overcome drug resistance of cancer cells. Currently, research on Calebin A, a polyphenolic component of turmeric (Curcuma longa), is becoming of growing interest with regard to novel treatment strategies and has already been shown health-promoting as well as anti-tumor properties, including anti-oxidative and anti-inflammatory effects, in diverse cancer cells. Within this review, we describe already known anti-inflammatory activities of Calebin A via modulation of NF-kappa B and its associated signaling pathways, linked with TNF-alpha, TNF-beta and COX-2 and further summarize Calebin A's tumor-inhibiting properties that are known up to date such as reduction of cancer cell viability, proliferation as well as metastasis. We also shed light on possible future prospects of Calebin A as an anti-cancer agent.

Automated summary

Chronic diseases, including cancer, have high case numbers and mortality rates. The complexity and involvement of various inflammatory pathways in their pathogenesis make the efficient treatment of chronic diseases a global medical challenge. Current research focuses on exploring the anti-inflammatory and anti-cancer properties of polyphenols, such as Calebin A from turmeric, to complement and enhance the effects of conventional anti-inflammatory drugs and chemotherapeutic agents.