☆ 4.6 Article

Histone lysine methylation patterns in prostate cancer microenvironment infiltration: Integrated bioinformatic analysis and histological validation

FRONTIERS IN ONCOLOGY (2022)

相关参考文献

注意：仅列出部分参考文献，下载原文获取全部文献信息。

Article Oncology

Cancer statistics, 2022

Rebecca L. Siegel et al.

Summary: Each year, the American Cancer Society compiles data on cancer occurrence and outcomes in the United States. The latest data shows that breast and prostate cancer progress has stagnated, while lung cancer has shown improvements in survival rates. Lung cancer incidence for advanced disease has declined while localized-stage rates have increased, resulting in higher survival rates. Mortality patterns align with incidence trends, with lung cancer deaths declining rapidly, breast cancer deaths slowing, and prostate cancer deaths stabilizing.

CA-A CANCER JOURNAL FOR CLINICIANS (2022)

添加到收藏夹

Article Oncology

Construction of a risk prediction model using m6A RNA methylation regulators in prostate cancer: comprehensive bioinformatic analysis and histological validation

Yongjun Quan et al.

Summary: This study evaluated the m6A modification patterns in prostate cancer patients and constructed a risk prediction model using m6A RNA regulators. The results showed that m6A modification patterns have a significant impact on prostate cancer progression.

CANCER CELL INTERNATIONAL (2022)

添加到收藏夹

Article Urology & Nephrology

Inherited TP53 Variants and Risk of Prostate Cancer

Kara N. Maxwell et al.

Summary: Complementary analysis of prostate cancer incidence in LFS males and gTP53 prevalence in prostate cancer cohorts suggests that gTP53 predisposes to aggressive prostate cancer. Prostate cancer should be considered as part of LFS screening protocols and TP53 should be considered in germline prostate cancer susceptibility testing.

EUROPEAN UROLOGY (2022)

添加到收藏夹

Article Cell Biology

Enhanced autophagy and NFE2L2/NRF2 pathway activation in SPOP mutation-driven prostate cancer

Kun Gao et al.

Summary: This study reveals a negative regulatory role of SPOP in autophagy and NFE2L2 pathway activation. The study found that SPOP induces non-degradative ubiquitination of SQSTM1, thereby suppressing autophagy and NFE2L2 pathway activation. The PCa-associated SPOP mutants lose the capacity to ubiquitinate SQSTM1 and instead enhance autophagy and the antioxidant response in a dominant-negative manner.

AUTOPHAGY (2022)

添加到收藏夹

Article Oncology

SPOP-mutant prostate cancer: Translating fundamental biology into patient care

Tiziano Bernasocchi et al.

Summary: Comprehensive cancer genome studies have identified genetically-defined subtypes of prostate cancer with distinct truncal driver mutations, which are linked to specific biological features and therapeutic vulnerabilities.

CANCER LETTERS (2022)

添加到收藏夹

Article Oncology

Stemness-related LncRNA pair signature for predicting therapy response in gastric cancer

Quan Jiang et al.

Summary: This study successfully established a signature based on 13 differentially expressed lncRNA pairs, which could predict survival and sensitivity to chemotherapy and immunotherapy in gastric cancer patients. Validation in two cohorts confirmed the practicality and predictive potential of the signature.

BMC CANCER (2021)

添加到收藏夹

Article Oncology

UHRF1 promotes androgen receptor-regulated CDC6 transcription and anti-androgen receptor drug resistance in prostate cancer through KDM4C-Mediated chromatin modifications

Yingxue Gao et al.

Summary: UHRF1 and CDC6, oncogenes that play critical roles in therapeutic resistance, are upregulated simultaneously in prostate cancer, where UHRF1 promotes CDC6 transcription controlled by AR through chromatin modification, contributing to anti-AR drug resistance and worse survival. Targeting both AR and UHRF1 simultaneously could be a novel and promising therapeutic approach for prostate cancer.

CANCER LETTERS (2021)

添加到收藏夹

Article Oncology

DNMT3A epigenetically regulates key microRNAs involved in epithelial-to-mesenchymal transition in prostate cancer

Monica Mancini et al.

Summary: The study demonstrates that the interaction between DNMT3A and miRNAs plays a central role in the EMT process of prostate cancer, with key miRNAs such as the miR-200 family, miR-205, and miR-203 being down-regulated and hyper-methylated. Differential expression of DNMT3A isoforms and a regulatory feedback loop between miR-429 and DNMT3A were also identified during EMT. Additionally, miR-429 was shown to target DNMT3A and modulate the expression of EMT factors.

CARCINOGENESIS (2021)

添加到收藏夹

Article Urology & Nephrology

The Mutational Landscape of Metastatic Castration-sensitive Prostate Cancer: The Spectrum Theory Revisited

Matthew P. Deek et al.

Summary: Somatic mutational profiles across the spectrum of metastatic castration-sensitive prostate cancer reveal associations between TP53 mutations and clinical outcomes in patients with oligometastasis, indicating a potential biological definition of oligometastasis beyond numerical classifications. Mutation analysis in TP53 and DNA double-strand break repair genes may help predict the number of metastases and clinical outcomes in patients with mCSPC.

EUROPEAN UROLOGY (2021)

添加到收藏夹

Review Biochemistry & Molecular Biology

Epigenetic modulation of antitumor immunity for improved cancer immunotherapy

Enyong Dai et al.

Summary: Epigenetic mechanisms play important roles in cancer initiation and immune cell function, with the potential to impact tumor microenvironment and therapeutic efficacy by modulating immune cell populations and promoting transcriptional and metabolic reprogramming. By regulating immune-associated genes and immune checkpoint molecules, epigenetic modulating agents can enhance tumor immunogenicity and facilitate anti-tumor immune responses.

MOLECULAR CANCER (2021)

添加到收藏夹

Article Biotechnology & Applied Microbiology

Analysis of RNA m6A methylation regulators and tumour immune cell infiltration characterization in prostate cancer

Yue Zhao et al.

Summary: Recent studies have shown the potential roles of RNA N6-methyladenosine (m(6)A) modification in tumor microenvironment (TME) cell infiltration. The expression of different m(6)A regulators within prostate cancer is related to genetic variation, alternative splicing, tumor mutational burden (TMB) and TME, and can predict TME scores and prognosis. CD8 T cells play a crucial role in immune cell intersection and are strongly correlated with immune associated gene sets in prostate cancer.

ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY (2021)

添加到收藏夹

Article Biochemistry & Molecular Biology

m6A regulator-mediated methylation modification patterns and tumor microenvironment infiltration characterization in gastric cancer

Bo Zhang et al.

MOLECULAR CANCER (2020)

添加到收藏夹

Article Biochemistry & Molecular Biology

Identification of a distinct luminal subgroup diagnosing and stratifying early stage prostate cancer by tissue-based single-cell RNA sequencing

Xiaoshi Ma et al.

MOLECULAR CANCER (2020)

添加到收藏夹

Article Genetics & Heredity

Chromatin binding of FOXA1 is promoted by LSD1-mediated demethylation in prostate cancer

Shuai Gao et al.

NATURE GENETICS (2020)

添加到收藏夹

Editorial Material Genetics & Heredity

Targeting LSD1 and FOXA1 in prostate cancer

Soleilmane Omarjee et al.

NATURE GENETICS (2020)

添加到收藏夹

Editorial Material Urology & Nephrology

DOT1L in prostate cancer

Tim Thomas

NATURE REVIEWS UROLOGY (2020)

添加到收藏夹

Article Multidisciplinary Sciences

Histone methyltransferase DOT1L coordinates AR and MYC stability in prostate cancer

R. Vatapalli et al.

NATURE COMMUNICATIONS (2020)

添加到收藏夹

Article Biochemistry & Molecular Biology

Inhibition of enhancer of zeste homolog 2 (EZH2) overcomes enzalutamide resistance in castration-resistant prostate cancer

Yunfeng Bai et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2019)

添加到收藏夹

Article Oncology

Polycomb group proteins EZH2 and EED directly regulate androgen receptor in advanced prostate cancer

Qipeng Liu et al.

INTERNATIONAL JOURNAL OF CANCER (2019)

添加到收藏夹

Article Medicine, Research & Experimental

Integrated Analysis of Genetic Abnormalities of the Histone Lysine Methyltransferases in Prostate Cancer

Yangjun Zhang et al.

MEDICAL SCIENCE MONITOR (2019)

添加到收藏夹

Article Cell Biology

SUV420H2 is an epigenetic regulator of epithelial/mesenchymal states in pancreatic cancer

Manuel Viotti et al.

JOURNAL OF CELL BIOLOGY (2018)

添加到收藏夹

Review Biochemistry & Molecular Biology

Understanding the tumor immune microenvironment (TIME) for effective therapy

Mikhail Binnewies et al.

NATURE MEDICINE (2018)

添加到收藏夹

Article Oncology

Epigenetic Reprogramming with Antisense Oligonucleotides Enhances the Effectiveness of Androgen Receptor Inhibition in Castration-Resistant Prostate Cancer

Lanbo Xiao et al.

CANCER RESEARCH (2018)

添加到收藏夹

Article Multidisciplinary Sciences

NSD2 is a conserved driver of metastatic prostate cancer progression

Alvaro Aytes et al.

NATURE COMMUNICATIONS (2018)

添加到收藏夹

Article Cell Biology

Polycomb- and Methylation-Independent Roles of EZH2 as a Transcription Activator

Jung Kim et al.

CELL REPORTS (2018)

添加到收藏夹

Review Multidisciplinary Sciences

Elements of cancer immunity and the cancer-immune set point

Daniel S. Chen et al.

NATURE (2017)

添加到收藏夹

Article Multidisciplinary Sciences

Rb1 and Trp53 cooperate to suppress prostate cancer lineage plasticity, metastasis, and antiandrogen resistance

Sheng Yu Ku et al.

SCIENCE (2017)

添加到收藏夹

Article Cell Biology

Pan-cancer Immunogenomic Analyses Reveal Genotype-Immunophenotype Relationships and Predictors of Response to Checkpoint Blockade

Pornpimol Charoentong et al.

CELL REPORTS (2017)

添加到收藏夹

Review Biochemistry & Molecular Biology

Writing, erasing and reading histone lysine methylations

Kwangbeom Hyun et al.

EXPERIMENTAL AND MOLECULAR MEDICINE (2017)

添加到收藏夹

Article Oncology

N-Myc Induces an EZH2-Mediated Transcriptional Program Driving Neuroendocrine Prostate Cancer

Etienne Dardenne et al.

CANCER CELL (2016)

添加到收藏夹

Article Biochemistry & Molecular Biology

Divergent clonal evolution of castration-resistant neuroendocrine prostate cancer

Himisha Beltran et al.

NATURE MEDICINE (2016)

添加到收藏夹

Article Oncology

Standardizing the definition of adverse pathology for lower risk men undergoing radical prostatectomy

Michael A. Kozminski et al.

UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS (2016)

添加到收藏夹

Article Medicine, General & Internal

Patterns of Immune Infiltration in Breast Cancer and Their Clinical Implications: A Gene-Expression-Based Retrospective Study

H. Raza Ali et al.

PLOS MEDICINE (2016)

添加到收藏夹

Article Pathology

Cancer stem cell markers in prostate cancer: an immunohistochemical study of ALDH1, SOX2 and EZH2

Admire Matsika et al.

PATHOLOGY (2015)

添加到收藏夹

Article Biochemical Research Methods

GSVA: gene set variation analysis for microarray and RNA-Seq data

Sonja Haenzelmann et al.

BMC BIOINFORMATICS (2013)

添加到收藏夹

Article Oncology

Histone Lysine-Specific Methyltransferases and Demethylases in Carcinogenesis: New Targets for Cancer Therapy and Prevention

Xuejiao Tian et al.

CURRENT CANCER DRUG TARGETS (2013)

添加到收藏夹

Article Oncology

SMYD3 as an Oncogenic Driver in Prostate Cancer by Stimulation of Androgen Receptor Transcription

Cheng Liu et al.

JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE (2013)

添加到收藏夹

Review Biochemistry & Molecular Biology

Microenvironmental regulation of tumor progression and metastasis

Daniela F. Quail et al.

NATURE MEDICINE (2013)

添加到收藏夹

Article Oncology

Collaboration of Kras and Androgen Receptor Signaling Stimulates EZH2 Expression and Tumor-Propagating Cells in Prostate Cancer

Houjian Cai et al.

CANCER RESEARCH (2012)

添加到收藏夹

Review Biochemistry & Molecular Biology

Histone Lysine Methylation Dynamics: Establishment, Regulation, and Biological Impact

Joshua C. Black et al.

MOLECULAR CELL (2012)

添加到收藏夹

Review Genetics & Heredity

Histone methylation: a dynamic mark in health, disease and inheritance

Eric L. Greer et al.

NATURE REVIEWS GENETICS (2012)

添加到收藏夹

Article Medicine, General & Internal

Safety, Activity, and Immune Correlates of Anti-PD-1 Antibody in Cancer

Suzanne L. Topalian et al.

NEW ENGLAND JOURNAL OF MEDICINE (2012)

添加到收藏夹

Article Biochemistry & Molecular Biology

The SRA protein UHRF1 promotes epigenetic crosstalks and is involved in prostate cancer progression

F. Babbio et al.

ONCOGENE (2012)

添加到收藏夹

Article Multidisciplinary Sciences

EZH2 Oncogenic Activity in Castration-Resistant Prostate Cancer Cells Is Polycomb-Independent

Kexin Xu et al.

SCIENCE (2012)

添加到收藏夹

Review Cell Biology

Regulation of chromatin by histone modifications

Andrew J. Bannister et al.

CELL RESEARCH (2011)

添加到收藏夹

Review Biochemistry & Molecular Biology

Histone arginine methylation

Alessandra Di Lorenzo et al.

FEBS LETTERS (2011)

添加到收藏夹

Article Urology & Nephrology

Predicting 15-Year Prostate Cancer Specific Mortality After Radical Prostatectomy

Scott E. Eggener et al.

JOURNAL OF UROLOGY (2011)

添加到收藏夹

Article Multidisciplinary Sciences

Systematic RNA interference reveals that oncogenic KRAS-driven cancers require TBK1

David A. Barbie et al.

NATURE (2009)

添加到收藏夹

Review Multidisciplinary Sciences

The complex language of chromatin regulation during transcription

Shelley L. Berger

NATURE (2007)

添加到收藏夹

Review Biochemistry & Molecular Biology

Chromatin modifications and their function

Tony Kouzarides

CELL (2007)

添加到收藏夹

Review Biochemistry & Molecular Biology

The role of chromatin during transcription

Bing Li et al.

CELL (2007)

添加到收藏夹

Review Cell Biology

The diverse functions of histone lysine methylation

C Martin et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2005)

添加到收藏夹

Review Biochemistry & Molecular Biology

The nucleosome: From genomic organization to genomic regulation

S Khorasanizadeh

CELL (2004)

添加到收藏夹

Review Multidisciplinary Sciences

Translating the histone code

T Jenuwein et al.

SCIENCE (2001)

添加到收藏夹

© Peeref 2019-2024. All rights reserved.