Clinical relevance of the combined analysis of circulating tumor cells and anti-tumor T-cell immunity in metastatic breast cancer patients

Article Oncology

Circulating Tumor Cell Transcriptomics as Biopsy Surrogates in Metastatic Breast Cancer

Alexander Ring et al.

Summary: RNA-Seq of CTCs can serve as a surrogate biomarker for breast cancer macrometastasis, providing clinically relevant insights into disease biology and clinically actionable targets.

ANNALS OF SURGICAL ONCOLOGY (2022)

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Article Oncology

Neoadjuvant Chemotherapy and Immunotherapy in Luminal B-like Breast Cancer: Results of the Phase II GIADA Trial

Maria Vittoria Dieci et al.

Summary: This study explored the role of immunotherapy in hormone receptor-positive, HER2-negative breast cancer. The results showed that Luminal B-like breast cancer patients had a higher rate of pathologic complete response to sequential anthracyclines and anti-PD-1 treatment. Tumor-infiltrating lymphocytes, immune-related gene-expression signatures, and specific immune cell subpopulations were closely associated with pathologic complete response.

CLINICAL CANCER RESEARCH (2022)

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Review Immunology

Revealing Clonal Responses of Tumor-Reactive T-Cells Through T Cell Receptor Repertoire Analysis

Hiroyasu Aoki et al.

Summary: CD8(+) T cells are crucial for the antitumor immune response. TCR repertoire analysis allows for a better understanding of the response of tumor-specific T cells in the tumor microenvironment.

FRONTIERS IN IMMUNOLOGY (2022)

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Article Oncology

Changes in T-cell subsets and clonal repertoire during chemoimmunotherapy with pembrolizumab and paclitaxel or capecitabine for metastatic triple-negative breast cancer

Brie Chun et al.

Summary: This study investigates the effects of pembrolizumab combined with paclitaxel or capecitabine on T-cell subsets in triple-negative breast cancer patients. The results show that these treatments result in similar lymphodepletions across peripheral T-cell subsets and do not alter T-cell clonal diversity. The findings contribute to our understanding of the impact of chemoimmunotherapy on the immune system.

JOURNAL FOR IMMUNOTHERAPY OF CANCER (2022)

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Review Oncology

Breast Cancer Tumor Microenvironment and Molecular Aberrations Hijack Tumoricidal Immunity

Huey-Jen Lin et al.

Summary: Immune therapy plays a crucial role in cancer research, but the emergence of resistant clones can lead to treatment failure. Understanding molecular, cellular, and microenvironmental aberrations is essential for uncovering mechanisms of resistance.

CANCERS (2022)

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Review Oncology

Functional analysis of circulating tumour cells: the KEY to understand the biology of the metastatic cascade

Zahra Eslami-S et al.

Summary: Metastasis formation is the main cause of cancer-related death in patients with solid tumors. This process involves the escape of cancer cells from the primary tumor to the bloodstream, where they become circulating tumor cells (CTCs). Only a small subgroup of CTCs will survive and colonize distant sites. Analyzing these metastasis-competent CTCs is challenging due to their low concentration in peripheral blood, but a few research groups have successfully expanded CTCs in vitro and in vivo to serve as models for comprehensive analysis. These models have revealed the complexity and variability of the metastatic cascade, opening new avenues for diagnostic and therapeutic advancements.

BRITISH JOURNAL OF CANCER (2022)

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Review Oncology

Evaluation of the TCR Repertoire as a Predictive and Prognostic Biomarker in Cancer: Diversity or Clonality?

Andrea Aran et al.

Summary: The study of TCR repertoire in cancer patients is important for understanding the anti-tumoural response, predicting prognosis, and determining response to immune checkpoint inhibitor therapies. The TCR repertoire is influenced by various factors and can provide valuable insights for modulating immune responses and predicting outcomes.

CANCERS (2022)

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Review Oncology

Potential Predictive and Prognostic Value of Biomarkers Related to Immune Checkpoint Inhibitor Therapy of Triple-Negative Breast Cancer

Qiaorui Tan et al.

Summary: Triple-negative breast cancer (TNBC) is an aggressive subtype of breast cancer with poor prognosis and limited effective treatment options. Immunotherapy based on immune checkpoint inhibition shows promise, but its efficacy varies among TNBC patients. Therefore, identifying predictive biomarkers for immunotherapy response is crucial.

FRONTIERS IN ONCOLOGY (2022)

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Review Medicine, General & Internal

De novo and recurrent metastatic breast cancer - A systematic review of population-level changes in survival since 1995

S. J. Lord et al.

Summary: The impact of advances in breast cancer care on survival rates is inconsistent for metastatic breast cancer. The overall survival of de novo metastatic breast cancer has improved since 1995, while recurrent metastatic breast cancer has shown no significant change in survival rates. There are also variations in survival rates based on age, hormone receptor, and HER2 subgroup.

ECLINICALMEDICINE (2022)

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Article Oncology

Circulating T-Cell Repertoires Correlate With the Tumor Response in Patients With Breast Cancer Receiving Neoadjuvant Chemotherapy

Gengxi Cai et al.

Summary: This study aimed to explore the dynamic change of T-cell repertoire and its clinical value in evaluating the tumor response in patients with breast cancer receiving neoadjuvant chemotherapy (NAC). Through high-throughput T-cell receptor (TCR)-beta sequencing, it was found that the diversity of TCR repertoires was associated with age and clinical stage of the patients. In addition, some characteristics of TCR repertoires that correlated with clinical response were identified, which might provide useful information for tailoring therapeutic regimens during the early cycle of NAC.

JCO PRECISION ONCOLOGY (2022)

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Article Oncology

Efficacy of Circulating Tumor Cell Count-Driven vs Clinician-Driven First-line Therapy Choice in Hormone Receptor-Positive, ERBB2-Negative Metastatic Breast Cancer The STIC CTC Randomized Clinical Trial

Francois-Clement Bidard et al.

Summary: The study suggests that high circulating tumor cell count can be a reliable biomarker for guiding the choice between chemotherapy and endocrine therapy as first-line treatment for hormone receptor-positive, ERBB2-negative metastatic breast cancer.

JAMA ONCOLOGY (2021)

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Article Oncology

Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

Hyuna Sung et al.

Summary: The global cancer burden in 2020 saw an estimated 19.3 million new cancer cases and almost 10.0 million cancer deaths. Female breast cancer surpassed lung cancer as the most commonly diagnosed cancer, while lung cancer remained the leading cause of cancer death. These trends are expected to rise in 2040, with transitioning countries experiencing a larger increase compared to transitioned countries due to demographic changes and risk factors associated with globalization and a growing economy. Efforts to improve cancer prevention measures and provision of cancer care in transitioning countries will be crucial for global cancer control.

CA-A CANCER JOURNAL FOR CLINICIANS (2021)

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Article

Circulating low density neutrophils of breast cancer patients are associated with their worse prognosis due to the impairment of T cell responses

Diana P. Saraiva et al.

Oncotarget (2021)

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Review Oncology

Liquid Biopsy: From Discovery to Clinical Application

Catherine Alix-Panabieres et al.

Summary: CTC and ctDNA have been recognized as promising biomarkers with various clinical applications, including early cancer detection and therapeutic monitoring. However, challenges such as standardization and validation of clinical effectiveness need to be addressed in this dynamic field of translational cancer research.

CANCER DISCOVERY (2021)

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Article Oncology

Is There One Key Step in the Metastatic Cascade?

Antoine M. Dujon et al.

Summary: This study uses a framework similar to the Drake equation to investigate the metastatic cascade of cancer cells, highlighting the importance of the half-life of circulating tumor cells in reducing the risk of metastasis.

CANCERS (2021)

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Review Biochemistry & Molecular Biology

Circulating Tumor Cells as a Tool to Untangle the Breast Cancer Heterogeneity Issue

Tania Rossi et al.

Summary: Breast cancer is characterized by high heterogeneity, with circulating tumor cells playing a crucial role in metastasis. While CTCs have shown promise as a liquid biopsy for studying cancer progression and guiding treatment, they are not currently used in clinical practice for personalized medicine.

BIOMEDICINES (2021)

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Article Medicine, General & Internal

Breast cancer induces systemic immune changes on cytokine signaling in peripheral blood monocytes and lymphocytes

Lei Wang et al.

EBIOMEDICINE (2020)

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Article Oncology

Clinical Relevance of Immune Checkpoints on Circulating Tumor Cells in Breast Cancer

Maria A. Papadaki et al.

CANCERS (2020)

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Editorial Material Medicine, General & Internal

Breast cancer is a systemic disease optimally treated by a multidisciplinary team

Nadia Harbeck

NATURE REVIEWS DISEASE PRIMERS (2020)

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Article Oncology

Outcomes of Observation vs Stereotactic Ablative Radiation for Oligometastatic Prostate Cancer The ORIOLE Phase 2 Randomized Clinical Trial

Ryan Phillips et al.

JAMA ONCOLOGY (2020)

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Article Oncology

Dysmetabolic Circulating Tumor Cells Are Prognostic in Metastatic Breast Cancer

Giulia Brisotto et al.

CANCERS (2020)

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Article Biochemistry & Molecular Biology

Analysis of circulating breast cancer cell heterogeneity and interactions with peripheral blood mononuclear cells

Heather M. Brechbuhl et al.

MOLECULAR CARCINOGENESIS (2020)

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Review Oncology

The clinical use of circulating tumor cells (CTCs) enumeration for staging of metastatic breast cancer (MBC): International expert consensus paper

Massimo Cristofanilli et al.

CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY (2019)

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Review Oncology

Liquid biopsy in the era of immuno-oncology: is it ready for prime-time use for cancer patients?

P. Hofman et al.

ANNALS OF ONCOLOGY (2019)

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Article Immunology

Examining Peripheral and Tumor Cellular Immunome in Patients With Cancer

Eda K. Holl et al.

FRONTIERS IN IMMUNOLOGY (2019)

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Article Oncology

Characteristics and prognostic significance of profiling the peripheral blood T-cell receptor repertoire in patients with advanced lung cancer

Yang-Yang Liu et al.

INTERNATIONAL JOURNAL OF CANCER (2019)

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Article Oncology

Higher Absolute Lymphocyte Counts Predict Lower Mortality from Early-Stage Triple-Negative Breast Cancer

Anosheh Afghahi et al.

CLINICAL CANCER RESEARCH (2018)

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Article Medicine, General & Internal

Global surveillance of trends in cancer survival 2000-14 (CONCORD-3): analysis of individual records for 37 513 025 patients diagnosed with one of 18 cancers from 322 population-based registries in 71 countries

Claudia Allemani et al.

LANCET (2018)

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Article Oncology

Tumour-infiltrating lymphocytes and prognosis in different subtypes of breast cancer: a pooled analysis of 3771 patients treated with neoadjuvant therapy

Carsten Denkert et al.

LANCET ONCOLOGY (2018)

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Article Oncology

Circulating CD8+ T-cell repertoires reveal the biological characteristics of tumors and clinical responses to chemotherapy in breast cancer patients

Kai-Rong Lin et al.

CANCER IMMUNOLOGY IMMUNOTHERAPY (2018)

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Article Oncology

The prognostic and predictive value of tumor-infiltrating lymphocytes and hematologic parameters in patients with breast cancer

Kwan Ho Lee et al.

BMC CANCER (2018)

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Review Medicine, General & Internal

The Interplay between Circulating Tumor Cells and the Immune System: From Immune Escape to Cancer Immunotherapy

Kevin Leone et al.

DIAGNOSTICS (2018)

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Article Oncology

Research needs in breast cancer

F. Cardoso et al.

ANNALS OF ONCOLOGY (2017)

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Review Oncology

Circulating and disseminated tumour cells - mechanisms of immune surveillance and escape

Malte Mohme et al.

NATURE REVIEWS CLINICAL ONCOLOGY (2017)

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Article Biotechnology & Applied Microbiology

Overview of methodologies for T-cell receptor repertoire analysis

Elisa Rosati et al.

BMC BIOTECHNOLOGY (2017)

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Review Oncology

Clinical relevance of host immunity in breast cancer: from TILs to the clinic

Peter Savas et al.

NATURE REVIEWS CLINICAL ONCOLOGY (2016)

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Article Oncology

Clonal expansion of antitumor T cells in breast cancer correlates with response to neoadjuvant chemotherapy

Jae-Hyun Park et al.

INTERNATIONAL JOURNAL OF ONCOLOGY (2016)

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Article Oncology

Circulating Tumor Cells (CTC) Are Associated with Defects in Adaptive Immunity in Patients with Inflammatory Breast Cancer

M. Mego et al.

JOURNAL OF CANCER (2016)

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Article Medicine, Research & Experimental

Improved Natural Killer cell activity and retained anti-tumor CD8+ T cell responses contribute to the induction of a pathological complete response in HER2-positive breast cancer patients undergoing neoadjuvant chemotherapy

E. Muraro et al.

JOURNAL OF TRANSLATIONAL MEDICINE (2015)

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Article Oncology

Frequent expression of PD-L1 on circulating breast cancer cells

Martine Mazel et al.

MOLECULAR ONCOLOGY (2015)

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Article Oncology

Immune monitoring technology primer: the enzyme-linked immunospot (Elispot) and Fluorospot assay

Sylvia Janetzki

JOURNAL FOR IMMUNOTHERAPY OF CANCER (2015)

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Review Oncology

En Route to Metastasis: Circulating Tumor Cell Clusters and Epithelial-to-Mesenchymal Transition

Nicola Aceto et al.

TRENDS IN CANCER (2015)

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Article Oncology

Co-expression of MET and CD47 is a novel prognosticator for survival of luminal-type breast cancer patients

Irene Baccelli et al.

ONCOTARGET (2014)

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Review Immunology

Immunosequencing: applications of immune repertoire deep sequencing

Harlan Robins

CURRENT OPINION IN IMMUNOLOGY (2013)

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Article Biotechnology & Applied Microbiology

Identification of a population of blood circulating tumor cells from breast cancer patients that initiates metastasis in a xenograft assay

Irene Baccelli et al.

NATURE BIOTECHNOLOGY (2013)

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Article Multidisciplinary Sciences

Using synthetic templates to design an unbiased multiplex PCR assay

Christopher S. Carlson et al.

NATURE COMMUNICATIONS (2013)

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Article Oncology

Platelet-Derived MHC Class I Confers a Pseudonormal Phenotype to Cancer Cells That Subverts the Antitumor Reactivity of Natural Killer Immune Cells

Theresa Placke et al.

CANCER RESEARCH (2012)

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Article Oncology

Relationship Between Lymphocytopenia and Circulating Tumor Cells as Prognostic Factors for Overall Survival in Metastatic Breast Cancer

Ugo De Giorgi et al.

CLINICAL BREAST CANCER (2012)

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Article Oncology

Lymphopenia combined with low TCR diversity (divpenia) predicts poor overall survival in metastatic breast cancer patients

Manuarii Manuel et al.

ONCOIMMUNOLOGY (2012)

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Article Oncology

The seed and soil hypothesis revisited-The role of tumor-stroma interactions in metastasis to different organs

Robert R. Langley et al.

INTERNATIONAL JOURNAL OF CANCER (2011)

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Article Oncology

A different immunologic profile characterizes patients with HER-2-overexpressing and HER-2-negative locally advanced breast cancer: implications for immune-based therapies

Elena Muraro et al.

BREAST CANCER RESEARCH (2011)

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Article Hematology

Comprehensive assessment of T-cell receptor β-chain diversity in αβ T cells

Harlan S. Robins et al.

BLOOD (2009)

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Article Oncology

Identification of HLA-A3-restricted CD8+T cell epitopes derived from mammaglobin-A, a tumor-associated antigen of human breast cancer

A Jaramillo et al.

INTERNATIONAL JOURNAL OF CANCER (2002)

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Clinical relevance of the combined analysis of circulating tumor cells and anti-tumor T-cell immunity in metastatic breast cancer patients

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