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YTHDC2 Promotes Malignant Phenotypes of Breast Cancer Cells

JOURNAL OF ONCOLOGY (2022)

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Article Cell Biology

YTHDC2 control of gametogenesis requires helicase activity but not m6A binding

Yuhki Saito et al.

Summary: In this study, the researchers investigated how the N-6-methyladenosine (m(6)A) reader and RNA helicase YTHDC2 regulate gene expression during meiosis. They found that YTHDC2 can bind transcripts independent of m(6)A status and regulate gene expression through distinct mechanisms during multiple stages of meiosis. Mutation of the m(6)A-binding pocket of YTHDC2 had no effect on gametogenesis, suggesting that YTHDC2's function is m(6)A-independent. However, mutation in the ATPase motif of YTHDC2 blocked meiotic prophase I progression, causing sterility.

GENES & DEVELOPMENT (2022)

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Article Multidisciplinary Sciences

The m6A reader YTHDC2 is essential for escape from KSHV SOX-induced RNA decay

Daniel Macveigh-Fierro et al.

Summary: N6-methyladenosine (m6A) modifications play a significant role in modulating viral and host transcripts during Kaposi's sarcoma-associated herpesvirus (KSHV) lytic infection. The presence of m6A modification in IL-6 mRNA confers resistance to viral endoribonuclease SOX, and this modification recruits m6A reader YTHDC2 for the escape of the IL-6 transcript.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2022)

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Article Clinical Neurology

Identification of N6-methyladenosine-related lncRNAs for patients with primary glioblastoma

Wen Wang et al.

Summary: This study identified four m(6)a-related prognostic lncRNAs in patients with pGBM, with the low-risk group showing longer survival compared to the high-risk group. Different m(6)a statuses were associated with histologic grade and survival outcomes in glioma. Functional annotation revealed enrichment of genes related to immune response, apoptosis, and RNA metabolism regulation.

NEUROSURGICAL REVIEW (2021)

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Article Gastroenterology & Hepatology

N6-Methyladenosine Reader Protein YT521-B Homology Domain-Containing 2 Suppresses Liver Steatosis by Regulation of mRNA Stability of Lipogenic Genes

Bing Zhou et al.

Summary: In this study, it was found that m(6)A enrichment and mRNA expression of lipogenic genes were increased in leptin-receptor-deficient mice. The m(6)A reader, Ythdc2, was down-regulated in obese mice and NAFLD patients, and its suppression in lean mice led to TG accumulation while overexpression in obese mice improved liver steatosis and insulin resistance. This suggests that Ythdc2 plays a crucial role in regulating hepatic lipogenesis and TG homeostasis, presenting a potential target for treating obesity-related NAFLD.

HEPATOLOGY (2021)

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Article Toxicology

N6-methyladenosine reader YTHDC2 and eraser FTO may determine hepatocellular carcinoma prognoses after transarterial chemoembolization

Jiandong Liu et al.

Summary: Transarterial chemoembolization (TACE) has improved overall survival of unresectable hepatocellular carcinoma (HCC) patients, but some show no response to TACE. Functional SNPs in m(6)A-regulating genes, particularly in YTHDC2 and FTO, were found to be associated with prognosis in TACE-treated HCC patients in a Chinese Han population. This suggests m(6)A-regulating genes could be potential targets to enhance therapeutic strategies for unresectable HCC patients.

ARCHIVES OF TOXICOLOGY (2021)

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Article Multidisciplinary Sciences

N6-methyladenosine modification of HCV RNA genome regulates cap-independent IRES-mediated translation via YTHDC2 recognition

Geon-Woo Kim et al.

Summary: The m(6)A modification of the HCV RNA genome plays a crucial role in IRES-dependent translation, with the m(6)A reader protein YTHDC2 being essential for recognizing and supporting HCV translation initiation. This study highlights the functional significance of m(6)A modification and YTHDC2 in HCV IRES-dependent translation initiation, providing potential therapeutic targets for interfering with the infectious process.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2021)

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Article Oncology

RNA m6A Methylation Regulators Subclassify Luminal Subtype in Breast Cancer

Lin Yang et al.

Summary: This study comprehensively explores the characteristics of m(6)A regulators in breast cancer and their correlation with prognosis, highlighting the unique features of the basal-like subtype compared to other subtypes.

FRONTIERS IN ONCOLOGY (2021)

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Review Cell Biology

Linking the YTH domain to cancer: the importance of YTH family proteins in epigenetics

Rongkai Shi et al.

Summary: N6-methyladenosine (m6A) is the most prevalent and reversible modification of mRNA in mammalian cells, and YTH family proteins, as the main readers of m6A modification, play important roles in m6A research by recognizing and binding m6A-containing RNA through their YTH domain. The crystal structure of the YTH domain has been resolved, highlighting the crucial roles of conserved residues in the specific recognition of m6A-modified RNAs. Upstream and downstream targets have been identified in different cancer types, emphasizing the significance of YTH family proteins in m6A regulation.

CELL DEATH & DISEASE (2021)

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Article Oncology

N6-methyladenosine RNA methylation regulators contribute to the progression of prostate cancer

Qunying Wu et al.

Summary: The study found that METTL3, METTL14, ALKBH5, FTO, YTHDC2, YTHDF1, and YTHDF2 were abnormally expressed in prostate cancer and related to Gleason classification. Changes in m(6)A levels may contribute to the development and progression of prostate cancer.

JOURNAL OF CANCER (2021)

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Article Oncology

m6A Reader YTHDC2 Promotes Radiotherapy Resistance of Nasopharyngeal Carcinoma via Activating IGF1R/AKT/S6 Signaling Axis

Jun-Ju He et al.

FRONTIERS IN ONCOLOGY (2020)

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Article Oncology

Downregulation ofm6AreaderYTHDC2promotes tumor progression and predicts poor prognosis in non-small cell lung cancer

Shulei Sun et al.

THORACIC CANCER (2020)

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Review Cell Biology

Reading, writing and erasing mRNA methylation

Sara Zaccara et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2019)

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Article Multidisciplinary Sciences

m6A in mRNA coding regions promotes translation via the RNA helicase-containing YTHDC2

Yuanhui Mao et al.

NATURE COMMUNICATIONS (2019)

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Review Cell Biology

Reading, writing and erasing mRNA methylation

Sara Zaccara et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2019)

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Article Biochemistry & Molecular Biology

Essential role of METTL3-mediated m6A modification in glioma stem-like cells maintenance and radioresistance

A. Visvanathan et al.

ONCOGENE (2018)

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Article Cell & Tissue Engineering

METTL14 Inhibits Hematopoietic Stem/Progenitor Differentiation and Promotes Leukemogenesis via mRNA m6A Modification

Hengyou Weng et al.

CELL STEM CELL (2018)

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Article Biochemistry & Molecular Biology

The m(6)A reader protein YTHDC2 interacts with the small ribosomal subunit and the 5 '-3 ' exoribonuclease XRN1

Jens Kretschmer et al.

RNA (2018)

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Article Biology

ketu mutant mice uncover an essential meiotic function for the ancient RNA helicase YTHDC2

Devanshi Jain et al.

ELIFE (2018)

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Review Genetics & Heredity

YTH Domain: A Family of N-6-methyladenosine (m(6)A) Readers

Shanhui Liao et al.

GENOMICS PROTEOMICS & BIOINFORMATICS (2018)

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Article Biochemistry & Molecular Biology

Regulation of m6 A Transcripts by the 3' → 5' RNA Helicase YTHDC2 Is Essential for a Successful Meiotic Program in the Mammalian Germline

Magdalena Natalia Wojtas et al.

MOLECULAR CELL (2017)

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Article Biology

The conserved RNA helicase YTHDC2 regulates the transition from proliferation to differentiation in the germline

Alexis S. Bailey et al.

ELIFE (2017)

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Article Cell Biology

Ythdc2 is an N6-methyladenosine binding protein that regulates mammalian spermatogenesis

Phillip J. Hsu et al.

CELL RESEARCH (2017)

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Article Oncology

RNA helicase YTHDC2 promotes cancer metastasis via the enhancement of the efficiency by which HIF-1α mRNA is translated

Atsushi Tanabe et al.

CANCER LETTERS (2016)

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Article Multidisciplinary Sciences

Implementation of meiosis prophase I programme requires a conserved retinoid-independent stabilizer of meiotic transcripts

Emilie Abby et al.

NATURE COMMUNICATIONS (2016)

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Article Cell & Tissue Engineering

m6A RNA Modification Controls Cell Fate Transition in Mammalian Embryonic Stem Cells

Pedro J. Batista et al.

CELL STEM CELL (2014)

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Article Genetics & Heredity

Transcriptional machinery of TNF-α-inducible YTH domain containing 2 (YTHDC2) gene

Atsushi Tanabe et al.

GENE (2014)

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Article Multidisciplinary Sciences

Cyclosporin A Associated Helicase-Like Protein Facilitates the Association of Hepatitis C Virus RNA Polymerase with Its Cellular Cyclophilin B

Kengo Morohashi et al.

PLOS ONE (2011)

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Review Oncology

Choosing the right cell line for breast cancer research

Deborah L. Holliday et al.

BREAST CANCER RESEARCH (2011)

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