☆ 4.6 Review

Tumor-Infiltrating Dendritic Cells: Decisive Roles in Cancer Immunosurveillance, Immunoediting, and Tumor T Cell Tolerance

CELLS (2022)

相关参考文献

注意：仅列出部分参考文献，下载原文获取全部文献信息。

Article Gastroenterology & Hepatology

Hypoxia-driven immunosuppression by Treg and type-2 conventional dendritic cells in HCC

Sheena Suthen et al.

Summary: This study analyzed the immune landscapes of hypoxic regions in hepatocellular carcinoma (HCC) and identified enriched immune subsets, including regulatory T cells, M2 macrophages, and HLA-DRlo cDC2, in hypoxia-high tumor regions. In contrast, hypoxia-low tumor regions showed an abundance of active granzyme B-hi PD-1(lo) CD8(+) T cells, indicating a relatively active immune landscape. The up-regulation of cancer-associated genes in tumor tissues and immunosuppressive genes in tumor-infiltrating leukocytes supported a highly pro-tumorigenic network in hypoxic HCC.

HEPATOLOGY (2022)

添加到收藏夹

Article Biochemistry & Molecular Biology

Amateur antigen-presenting cells in the tumor microenvironment

Laurel B. Darragh et al.

Summary: Presentation of tumor antigens is a crucial step in generating an effective antitumor immune response. Recent evidence suggests that besides professional antigen-presenting cells, other cells in the tumor microenvironment are also capable of presenting tumor antigens, potentially playing a significant role in priming an antitumor immune response. This new perspective on antigen presentation supports the development of novel immunotherapies to enhance T cell priming.

MOLECULAR CARCINOGENESIS (2022)

添加到收藏夹

Article Biochemistry & Molecular Biology

Quiescent cancer cells resist T cell attack by forming an immunosuppressive niche

Pilar Baldominos et al.

Summary: This study discovered that in primary breast cancer, tumor cells that resist T cell attack are quiescent and form clusters with reduced immune infiltration. These quiescent cancer cells show superior tumorigenic capacity and higher expression of chemotherapy resistance and stemness genes. Single-cell RNA sequencing revealed differential phenotypes in infiltrating cells based on their intra-tumor location, and uncovered hypoxia-induced immune-suppressive programs. The findings suggest that eliminating quiescent cancer cells holds the promise to counteract immunotherapy resistance and prevent disease recurrence in TNBC.

CELL (2022)

添加到收藏夹

Review Oncology

The Role of Type-2 Conventional Dendritic Cells in the Regulation of Tumor Immunity

Yasuyuki Saito et al.

Summary: This review outlines the role of type-2 conventional dendritic cells (cDC2s) in antitumor immunity and summarizes the latest progress in cancer vaccination and cDC2-targeted cancer immunotherapy.

CANCERS (2022)

添加到收藏夹

Review Immunology

Dendritic Cell Regulation of T Helper Cells

Xiangyun Yin et al.

Summary: Dendritic cells play a crucial role in sensing the microenvironment and shaping the adaptive immune response. They consist of several subsets that regulate T lymphocyte differentiation and determine distinct CD4(+) T helper cell differentiation outcomes. The intrinsic properties of DC subsets, local tissue microenvironments, and interactions with other immune cells contribute to Th cell differentiation during homeostasis and inflammation.

ANNUAL REVIEW OF IMMUNOLOGY, VOL 39 (2021)

添加到收藏夹

Article Biochemistry & Molecular Biology

A pan-cancer single-cell transcriptional atlas of tumor infiltrating myeloid cells

Sijin Cheng et al.

Summary: This study conducted a pan-cancer analysis of single myeloid cells from 210 patients across 15 human cancer types, revealing distinct features of TIMs in different cancer types. For example, mast cells in nasopharyngeal cancer were associated with better prognosis, and pro-angiogenic TAMs showed diverse markers across different cancer types. The composition of TIMs appeared to be linked with certain features of somatic mutations and gene expressions.

CELL (2021)

添加到收藏夹

Review Oncology

Type I IFN Activating Type I Dendritic Cells for Antitumor Immunity

Yong Liang et al.

Summary: Immune checkpoint inhibitors are successful immunotherapy modalities that enhance CD8(+) T-cell responses. Recent studies have found that cross-priming of conventional type 1 dendritic cells (cDC1) plays a crucial role in initiating CD8(+) T-cell responses during tumor progression, as well as in immunotherapy-mediated reactivation of tumor-specific CD8(+) T cells for tumor regression. Inducing type I IFNs within tumors can overcome innate immune resistance and activate antitumor adaptive immunity.

CLINICAL CANCER RESEARCH (2021)

添加到收藏夹

Review Immunology

Regulatory Dendritic Cells, T Cell Tolerance, and Dendritic Cell Therapy for Immunologic Disease

Sara Ness et al.

Summary: Dendritic cells are antigen-presenting cells that interact with T cells to regulate adaptive immune responses. Under certain conditions, dendritic cells can develop into anti-inflammatory cells, inducing immunologic tolerance. Studies have shown that regulatory dendritic cells induce T cell tolerance by suppressing effector T cells and inducing regulatory T cells.

FRONTIERS IN IMMUNOLOGY (2021)

添加到收藏夹

Article Biology

Redefining innate natural antibodies as important contributors to anti-tumor immunity

Kavita Rawat et al.

Summary: The study highlights the important role of B cells and natural antibodies in the early defense against tumors and precancerous cells, which may have been overlooked due to the popular use of a single B cell-deficient mouse model.

ELIFE (2021)

添加到收藏夹

Review Immunology

The Role of Plasmacytoid Dendritic Cells in Cancers

Binhui Zhou et al.

Summary: Plasmacytoid dendritic cells (pDCs) are a special subtype of dendritic cells that produce massive amounts of type I interferon (IFN-I) and play a pivotal role in antiviral immunity. However, in many types of cancer, tumor-infiltrating pDCs do not respond to Toll-like receptor (TLR) stimulation, leading to reduced IFN-alpha production and promoting tumor growth.

FRONTIERS IN IMMUNOLOGY (2021)

添加到收藏夹

Editorial Material Immunology

Lymphoid stromal cells proGrem dendritic cell homeostasis

Antonio P. Baptista et al.

Summary: Single-cell technologies have revealed the critical role of Grem1(+) fibroblastic reticular cells (FRCs) as niche cells in secondary lymphoid organs, contributing to the homeostasis of resident dendritic cells and T cell immunity.

NATURE IMMUNOLOGY (2021)

添加到收藏夹

Article Multidisciplinary Sciences

TIM4 expression by dendritic cells mediates uptake of tumor-associated antigens and anti-tumor responses

Giulia Maria Piperno et al.

Summary: Loss of TIM4 expression in lung tumor-associated cDC1 leads to inefficient uptake of cell-associated antigens and reduced activation of CD8+ T cells in advanced lung tumors. This contributes to immune surveillance and anti-tumor immune responses.

NATURE COMMUNICATIONS (2021)

添加到收藏夹

Article Immunology

Effective Cytotoxicity of Dendritic Cells against Established T Cell Lymphomas in Mice

Sigrid Dubois et al.

Summary: The bone marrow-derived dendritic cells showed effective killing of T cell lymphomas in mice, with the cytotoxicity being mediated by NO metabolites. The study suggests that dendritic cell adaptive immunotherapy can be used as a treatment against T cell lymphomas in mice.

JOURNAL OF IMMUNOLOGY (2021)

添加到收藏夹

Review Biochemistry & Molecular Biology

Antigen presentation by mouse monocyte-derived cells: Re-evaluating the concept of monocyte-derived dendritic cells

Alice Coillard et al.

Summary: This study reviews the research on mouse mo-DC, evaluates the in vivo evidence for monocyte-derived antigen-presenting cells, and proposes that mo-DC may present antigens to effector T cells locally in tissues, playing a complementary role to cDCs.

MOLECULAR IMMUNOLOGY (2021)

添加到收藏夹

Article Oncology

Site-Dependent Immune Escape Due to Impaired Dendritic Cell Cross-Priming

Mark S. Diamond et al.

Summary: The study focused on T-cell surveillance of murine pancreatic adenocarcinoma cells expressing neoantigen and found that immune escape can occur in a tissue-specific manner. Tumor outgrowth in the pancreas and peritoneum was associated with reduced CD8T-cell priming by cDC1, which could be restored through CD40 agonist treatment. This highlights the importance of addressing microenvironmental barriers for successful combination immunotherapies.

CANCER IMMUNOLOGY RESEARCH (2021)

添加到收藏夹

Review Immunology

Corneal Nerves, CD11c+ Dendritic Cells and Their Impact on Ocular Immune Privilege

Jerry Y. Niederkorn

Summary: The eye and the brain have limited regenerative capacities, making them vulnerable to immune-mediated inflammation. Immune privilege is a condition sustained by physiological, anatomical, and regulatory processes that restrict immune responses and inflammation in these organs.

FRONTIERS IN IMMUNOLOGY (2021)

添加到收藏夹

Review Immunology

Genetic models of human and mouse dendritic cell development and function

David A. Anderson et al.

Summary: Genetic models of mouse DC development have helped in understanding the functions of different DC subsets, with classical DCs having specific roles in pathogen detection and cytokine production, while plasmacytoid DCs mainly detect viral infections and produce type I interferon.

NATURE REVIEWS IMMUNOLOGY (2021)

添加到收藏夹

Article Immunology

Dendritic cells license regulatory B cells to produce IL-10 and mediate suppression of antigen-specific CD8 T cells

Joanne Boldison et al.

CELLULAR & MOLECULAR IMMUNOLOGY (2020)

添加到收藏夹

Article Oncology

Dendritic Cell Paucity Leads to Dysfunctional Immune Surveillance in Pancreatic Cancer

Samarth Hegde et al.

CANCER CELL (2020)

添加到收藏夹

Article Biochemistry & Molecular Biology

Tumor-Derived Retinoic Acid Regulates Intratumoral Monocyte Differentiation to Promote Immune Suppression

Samir Devalaraja et al.

CELL (2020)

添加到收藏夹

Review Immunology

Wnt Signaling Cascade in Dendritic Cells and Regulation of Anti-tumor Immunity

Amol Suryawanshi et al.

FRONTIERS IN IMMUNOLOGY (2020)

添加到收藏夹

Article Immunology

Merocytic Dendritic Cells Compose a Conventional Dendritic Cell Subset with Low Metabolic Activity

Cindy Audiger et al.

JOURNAL OF IMMUNOLOGY (2020)

添加到收藏夹

Article Immunology

Cancer cell CCR2 orchestrates suppression of the adaptive immune response

Miriam R. Fein et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2020)

添加到收藏夹

Review Oncology

Dendritic cell biology and its role in tumor immunotherapy

Yingying Wang et al.

JOURNAL OF HEMATOLOGY & ONCOLOGY (2020)

添加到收藏夹

Article Multidisciplinary Sciences

Immune suppressive landscape in the human esophageal squamous cell carcinoma microenvironment

Yingxia Zheng et al.

NATURE COMMUNICATIONS (2020)

添加到收藏夹

Review Immunology

Dendritic cells in cancer immunology and immunotherapy

Stefanie K. Wculek et al.

NATURE REVIEWS IMMUNOLOGY (2020)

添加到收藏夹

Review Cell Biology

Human in vivo-differentiated monocyte-derived dendritic cells

Tsing-Lee Tang-Huau et al.

SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY (2019)

添加到收藏夹

Review Cell Biology

Plasmacytoid pre-dendritic cells (pDC): from molecular pathways to function and disease association

Solana Alculumbre et al.

SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY (2019)

添加到收藏夹

Review Immunology

Antigen presentation by dendritic cells for B cell activation

William R. Heath et al.

CURRENT OPINION IN IMMUNOLOGY (2019)

添加到收藏夹

Review Immunology

Beyond cDC1: Emerging Roles of DC Crosstalk in Cancer Immunity

Rajkumar Noubade et al.

FRONTIERS IN IMMUNOLOGY (2019)

添加到收藏夹

Review Immunology

Current Concepts on 6-sulfo LacNAc Expressing Monocytes (slanMo)

Fareed Ahmad et al.

FRONTIERS IN IMMUNOLOGY (2019)

添加到收藏夹

Review Immunology

Targeting Conventional Dendritic Cells to Fine-Tune Antibody Responses

Demo Yemane Tesfaye et al.

FRONTIERS IN IMMUNOLOGY (2019)

添加到收藏夹

Review Immunology

Induction of Tolerance and Immunity by Dendritic Cells: Mechanisms and Clinical Applications

Jitka Fucikova et al.

FRONTIERS IN IMMUNOLOGY (2019)

添加到收藏夹

Article Cell Biology

Human Tolerogenic Dendritic Cells Regulate Immune Responses through Lactate Synthesis

Eros Marin et al.

CELL METABOLISM (2019)

添加到收藏夹

Review Immunology

Plasmacytoid Dendritic Cells: Development, Regulation, and Function

Boris Reizis

IMMUNITY (2019)

添加到收藏夹

Review Immunology

Role of Tumor-Mediated Dendritic Cell Tolerization in Immune Evasion

Nicholas C. DeVito et al.

FRONTIERS IN IMMUNOLOGY (2019)

添加到收藏夹

Article Immunology

Non-small Cell Lung Cancer Cells Modulate the Development of Human CD1c+ Conventional Dendritic Cell Subsets Mediated by CD103 and CD205

Yong Lu et al.

FRONTIERS IN IMMUNOLOGY (2019)

添加到收藏夹

Review Immunology

Are Conventional Type 1 Dendritic Cells Critical for Protective Antitumor Immunity and How?

Jean-Charles Cancel et al.

FRONTIERS IN IMMUNOLOGY (2019)

添加到收藏夹

Article Medicine, Research & Experimental

CD91 on dendritic cells governs immunosurveillance of nascent, emerging tumors

Abigail L. Sedlacek et al.

JCI INSIGHT (2019)

添加到收藏夹

Review Cell Biology

Dendritic cell subsets

Christophe Macri et al.

SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY (2018)

添加到收藏夹

Article Cell Biology

Development, Diversity, and Function of Dendritic Cells in Mouse and Human

David A. Anderson et al.

COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY (2018)

添加到收藏夹

Review Immunology

Human dendritic cell subsets: an update

Matthew Collin et al.

IMMUNOLOGY (2018)

添加到收藏夹

Review Immunology

Dendritic Cell-Based Cancer Vaccines

Patricia M. Santos et al.

JOURNAL OF IMMUNOLOGY (2018)

添加到收藏夹

Review Immunology

Plasmacytoid dendritic cell in immunity and cancer

Dana Mitchell et al.

JOURNAL OF NEUROIMMUNOLOGY (2018)

添加到收藏夹

Review Immunology

Dendritic cells in the regulation of immunity and inflammation

Cheng Qian et al.

SEMINARS IN IMMUNOLOGY (2018)

添加到收藏夹

Article Oncology

Quantitative and functional alterations of 6-sulfo LacNac dendritic cells in multiple myeloma

Baptiste Lamarthee et al.

ONCOIMMUNOLOGY (2018)

添加到收藏夹

Review Immunology

Dendritic Cells and CD8 T Cell Immunity in Tumor Microenvironment

Chunmei Fu et al.

FRONTIERS IN IMMUNOLOGY (2018)

添加到收藏夹

Review Oncology

The Role of Type 1 Conventional Dendritic Cells in Cancer Immunity

Jan P. Boettcher et al.

TRENDS IN CANCER (2018)

添加到收藏夹

Article Oncology

Autologous Dendritic Cells Pulsed with Allogeneic Tumor Cell Lysate in Mesothelioma: From Mouse to Human

Joachim G. J. V. Aerts et al.

CLINICAL CANCER RESEARCH (2018)

添加到收藏夹

Article Oncology

Dendritic Cells Enhance Polyfunctionality of Adoptively Transferred T Cells That Target Cytomegalovirus in Glioblastoma

Elizabeth A. Reap et al.

CANCER RESEARCH (2018)

添加到收藏夹

Review Cell Biology

Dendritic cell-based immunotherapy

Rachel L. Sabado et al.

CELL RESEARCH (2017)

添加到收藏夹

Article Oncology

Dendritic Cell Vaccination Enhances Immune Responses and Induces Regression of HER2pos DCIS Independent of Route: Results of Randomized Selection Design Trial

Lea Lowenfeld et al.

CLINICAL CANCER RESEARCH (2017)

添加到收藏夹

Review Cell Biology

Heterogeneity, functional specialization and differentiation of monocyte-derived dendritic cells

Kevin V. Chow et al.

IMMUNOLOGY AND CELL BIOLOGY (2017)

添加到收藏夹

Article Oncology

Vaccination with poly (IC: LC) and peptide-pulsed autologous dendritic cells in patients with pancreatic cancer

Shikhar Mehrotra et al.

JOURNAL OF HEMATOLOGY & ONCOLOGY (2017)

添加到收藏夹

Article Hematology

Dendritic cell vaccination as postremission treatment to prevent or delay relapse in acute myeloid leukemia

Sebastien Anguille et al.

BLOOD (2017)

添加到收藏夹

Review Immunology

Hematologic neoplasms: Dendritic cells vaccines in motion

Domenico Galati et al.

CLINICAL IMMUNOLOGY (2017)

添加到收藏夹

Article Oncology

Immune Responses and Long-Term Disease Recurrence Status After Telomerase-Based Dendritic Cell Immunotherapy in Patients With Acute Myeloid Leukemia

Hanna J. Khoury et al.

CANCER (2017)

添加到收藏夹

Article Oncology

Phase I Trial of Intratumoral Injection of CCL21 Gene-Modified Dendritic Cells in Lung Cancer Elicits Tumor-Specific Immune Responses and CD8+ T-cell Infiltration

Jay M. Lee et al.

CLINICAL CANCER RESEARCH (2017)

添加到收藏夹

Review Immunology

Monocyte differentiation and antigen-presenting functions

Claudia V. Jakubzick et al.

NATURE REVIEWS IMMUNOLOGY (2017)

添加到收藏夹

Article Oncology

Dendritic Cell-Based Immunotherapy: State of the Art and Beyond

Kalijn F. Bol et al.

CLINICAL CANCER RESEARCH (2016)

添加到收藏夹

Article Oncology

Phase II randomised trial of autologous tumour lysate dendritic cell plus best supportive care compared with best supportive care in pre-treated advanced colorectal cancer patients

Miguel Caballero-Banos et al.

EUROPEAN JOURNAL OF CANCER (2016)

添加到收藏夹

Review Medicine, Research & Experimental

Dendritic cell-derived exosomes for cancer therapy

Jonathan M. Pitt et al.

JOURNAL OF CLINICAL INVESTIGATION (2016)

添加到收藏夹

Article Oncology

Phase II Study of Autologous Monocyte-Derived mRNA Electroporated Dendritic Cells (TriMixDC-MEL) Plus Ipilimumab in Patients With Pretreated Advanced Melanoma

Sofie Wilgenhof et al.

JOURNAL OF CLINICAL ONCOLOGY (2016)

添加到收藏夹

Review Cell Biology

Dendritic cells and monocyte-derived cells: Two complementary and integrated functional systems

Andreas Schlitzer et al.

SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY (2015)

添加到收藏夹

Article Oncology

Phase I/II clinical trial of dendritic-cell based immunotherapy (DCVAC/PCa) combined with chemotherapy in patients with metastatic, castration-resistant prostate cancer

Michal Podrazil et al.

ONCOTARGET (2015)

添加到收藏夹

Review Immunology

The multifaceted biology of plasmacytoid dendritic cells

Melissa Swiecki et al.

NATURE REVIEWS IMMUNOLOGY (2015)

添加到收藏夹

Review Immunology

Type I interferons in anticancer immunity

Laurence Zitvogel et al.

NATURE REVIEWS IMMUNOLOGY (2015)

添加到收藏夹

Review Biochemistry & Molecular Biology

Dendritic cell maturation: functional specialization through signaling specificity and transcriptional programming

Marc Dalod et al.

EMBO JOURNAL (2014)

添加到收藏夹

Review Oncology

Clinical use of dendritic cells for cancer therapy

Sebastien Anguille et al.

LANCET ONCOLOGY (2014)

添加到收藏夹

Article Oncology

Molecular programming of steady-state dendritic cells: impact on autoimmunity and tumor immune surveillance

Dylan J. Johnson et al.

RENAISSANCE OF CANCER IMMUNOTHERAPY (2013)

添加到收藏夹

Review Immunology

T-cell tolerance in cancer

Roza Nurieva et al.

IMMUNOTHERAPY (2013)

添加到收藏夹

Review Immunology

Innate and adaptive immune cells in the tumor microenvironment

Thomas F. Gajewski et al.

NATURE IMMUNOLOGY (2013)

添加到收藏夹

Review Immunology

Decisions About Dendritic Cells: Past, Present, and Future

Ralph M. Steinman

ANNUAL REVIEW OF IMMUNOLOGY, VOL 30 (2012)

添加到收藏夹

Review Oncology

Cross-talk between myeloid-derived suppressor cells (MDSC), macrophages, and dendritic cells enhances tumor-induced immune suppression

Suzanne Ostrand-Rosenberg et al.

SEMINARS IN CANCER BIOLOGY (2012)

添加到收藏夹

Review Oncology

Cancer immunotherapy via dendritic cells

Karolina Palucka et al.

NATURE REVIEWS CANCER (2012)

添加到收藏夹

Article Hematology

Regulatory dendritic cells program generation of interleukin-4-producing alternative memory CD4 T cells with suppressive activity

Xiongfei Xu et al.

BLOOD (2011)

添加到收藏夹

Article Oncology

Quantitative and Functional Alterations of Plasmacytoid Dendritic Cells Contribute to Immune Tolerance in Ovarian Cancer

Sana Intidhar Labidi-Galy et al.

CANCER RESEARCH (2011)

添加到收藏夹

Article Immunology

Mast Cells Condition Dendritic Cells to Mediate Allograft Tolerance

Victor C. de Vries et al.

IMMUNITY (2011)

添加到收藏夹

Review Oncology

The immunoregulatory mechanisms of carcinoma for its survival and development

Caigan Du et al.

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2011)

添加到收藏夹

Article Immunology

Tumor-Infiltrating Programmed Death Receptor-1+ Dendritic Cells Mediate Immune Suppression in Ovarian Cancer

James Krempski et al.

JOURNAL OF IMMUNOLOGY (2011)

添加到收藏夹

Review Multidisciplinary Sciences

Development of Monocytes, Macrophages, and Dendritic Cells

Frederic Geissmann et al.

SCIENCE (2010)

添加到收藏夹

Article Immunology

The surface protein TIGIT suppresses T cell activation by promoting the generation of mature immunoregulatory dendritic cells

Xin Yu et al.

NATURE IMMUNOLOGY (2009)

添加到收藏夹

Review Immunology

Cancer immunotherapy by dendritic cells

Cornelis J. M. Melief

IMMUNITY (2008)

添加到收藏夹

Review Immunology

Human dendritic cells: Potent antigen-presenting cells at the crossroads of innate and adaptive immunity

M Rossi et al.

JOURNAL OF IMMUNOLOGY (2005)

添加到收藏夹

Review Immunology

Monocyte-derived dendritic cells

B León et al.

SEMINARS IN IMMUNOLOGY (2005)

添加到收藏夹

Review Immunology

Plasmacytoid dendritic cells in immunity

M Colonna et al.

NATURE IMMUNOLOGY (2004)

添加到收藏夹

Review Immunology

IDO expression by dendritic cells: Tolerance and tryptophan catabolism

AL Mellor et al.

NATURE REVIEWS IMMUNOLOGY (2004)

添加到收藏夹

© Peeref 2019-2024. All rights reserved.