☆ 4.6 Article

Transplantation of Human Induced Pluripotent Stem Cell-Derived Neural Progenitor Cells Promotes Forelimb Functional Recovery after Cervical Spinal Cord Injury

CELLS (2022)

相关参考文献

注意：仅列出部分参考文献，下载原文获取全部文献信息。

Review Cell & Tissue Engineering

Human stem cell models of neurodegeneration: From basic science of amyotrophic lateral sclerosis to clinical translation

Elisa Giacomelli et al.

Summary: This article evaluates the status of using induced pluripotent stem cells (iPSCs) to model neurodegenerative diseases, focusing on amyotrophic lateral sclerosis (ALS) as an example. It discusses the methods and challenges associated with deriving and using disease-relevant neuronal and glial lineages.

CELL STEM CELL (2022)

添加到收藏夹

Article Cell & Tissue Engineering

Modulation by DREADD reveals the therapeutic effect of human iPSC-derived neuronal activity on functional recovery after spinal cord injury

Takahiro Kitagawa et al.

Summary: By inhibiting the neuronal activity of grafted cells, it was found that locomotor function in spinal cord injury mice significantly decreased. Trans-synaptic tracing revealed the integration of graft neurons into the host motor circuitry. These results indicate the importance of engrafting functionally competent neurons for the recovery from spinal cord injury.

STEM CELL REPORTS (2022)

添加到收藏夹

Article Cell Biology

Human induced pluripotent stem cells integrate, create synapses and extend long axons after spinal cord injury

Nicolas Stoflet Lavoie et al.

Summary: This study explores interventions using cells differentiated from induced pluripotent stem cells in animal models to treat neural injury. The transplanted cells survive and differentiate into neurons and glia, filling the lesion cavity and expressing spinal cord transcriptional programs. The transplanted cells integrate well with host cells, forming synapses and myelinating axons that extend across the injury site.

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2022)

添加到收藏夹

Article Cell & Tissue Engineering

Human iPSC-Derived Neural Models for Studying Alzheimer's Disease: from Neural Stem Cells to Cerebral Organoids

Martin Barak et al.

Summary: Induced pluripotent stem cells (iPSCs) have been widely used in the past two decades to study human neural development, disease modeling, and in vitro drug discovery. In the field of Alzheimer's disease (AD), iPSC-based models have been used to investigate molecular mechanisms and test potential drugs. This review summarizes the differentiation strategies of iPSCs into neuronal and glial cell types and cerebral organoids, and their applications in AD modeling and drug discovery.

STEM CELL REVIEWS AND REPORTS (2022)

添加到收藏夹

Review Cell & Tissue Engineering

Review of the Current Trends in Clinical Trials Involving Induced Pluripotent Stem Cells

Jennifer Yejean Kim et al.

Summary: Research on global clinical trials revealed that the USA leads in nontherapeutic trials with large participation numbers, while Japan takes the lead in therapeutic trials with smaller participant numbers. Studies on disorders of the circulatory system, as well as the nervous and visual systems, are particularly notable.

STEM CELL REVIEWS AND REPORTS (2022)

添加到收藏夹

Article Cell & Tissue Engineering

hiPSC-derived NSCs effectively promote the functional recovery of acute spinal cord injury in mice

Desheng Kong et al.

Summary: The study shows that using human iPSC-derived neural stem cells can promote neural functional recovery in mice with acute SCI, while also reducing fibrosis, glial scar formation, and inflammation.

STEM CELL RESEARCH & THERAPY (2021)

添加到收藏夹

Article Cell Biology

Long-term selective stimulation of transplanted neural stem/progenitor cells for spinal cord injury improves locomotor function

Momotaro Kawai et al.

Summary: Research shows that chemogenetic stimulation of transplanted hiPSC-NS/PCs enhances cell activity and promotes neuron-to-neuron interactions, leading to increased expression of synapse-related genes and proteins in surrounding host tissues. This prevents atrophy of the injured spinal cord and improves locomotor function in a rodent model of SCI, providing a new strategy for enhancing the efficacy of cell transplantation therapy for spinal cord injury.

CELL REPORTS (2021)

添加到收藏夹

Review Cell & Tissue Engineering

Neuronal cell-based medicines from pluripotent stem cells: Development, production, and preclinical assessment

Yun Sun et al.

Summary: The use of human pluripotent stem cell-derived neural cells to replace degenerating cells in the treatment of brain function degeneration shows promising potential, but there are still challenges in both preclinical and clinical stages.

STEM CELLS TRANSLATIONAL MEDICINE (2021)

添加到收藏夹

Article Cell & Tissue Engineering

LOTUS overexpression via ex vivo gene transduction further promotes recovery of motor function following human iPSC-NS/PC transplantation for contusive spinal cord injury

Shuhei Ito et al.

Summary: The lentiviral transduction of LOTUS gene into hiPSC-NS/PCs shows promising effects in enhancing cell survival, promoting neurite extension, and improving motor function recovery in a mouse model of subacute SCI.

STEM CELL REPORTS (2021)

添加到收藏夹

Review Cell Biology

Pluripotent Stem Cells for Spinal Cord Injury Repair

Maria Martin-Lopez et al.

Summary: Spinal cord injury is a devastating condition that greatly impacts patients' quality of life, with cell therapy showing promising therapeutic potential, particularly with the use of stem cells.

CELLS (2021)

添加到收藏夹

Article Cell & Tissue Engineering

First-in-human clinical trial of transplantation of iPSC-derived NS/PCs in subacute complete spinal cord injury: Study protocol

Keiko Sugai et al.

Summary: Our group has conducted extensive studies on the use of human induced pluripotent cell-derived neural stem/progenitor cell grafts in models of spinal cord injury. We are preparing to initiate a first-in-human clinical study in subacute SCI patients. The study aims to assess safety and preliminary evidence of impact on neurological function and quality-of-life outcomes.

REGENERATIVE THERAPY (2021)

添加到收藏夹

Review Cell Biology

Induced pluripotent stem cell technology for spinal cord injury: a promising alternative therapy

Yu Li et al.

Summary: Spinal cord injury presents a significant challenge in trauma repair due to its difficulty and increasing morbidity. Stem cell therapy, particularly induced pluripotent stem cells, holds great potential in treating spinal cord injury by differentiating into precursor cells of various neural cell types at the injury site.

NEURAL REGENERATION RESEARCH (2021)

添加到收藏夹

Article Cell & Tissue Engineering

In vivo monitoring of remnant undifferentiated neural cells following human iPS cell-derived neural stem/progenitor cells transplantation

Yuji Taninnoto et al.

STEM CELLS TRANSLATIONAL MEDICINE (2020)

添加到收藏夹

Article Neurosciences

Reaching and Grasping Training Improves Functional Recovery After Chronic Cervical Spinal Cord Injury

Chrystine Gallegos et al.

FRONTIERS IN CELLULAR NEUROSCIENCE (2020)

添加到收藏夹

Article Neurosciences

Cell therapy for spinal cord injury by using human iPSC-derived region-specific neural progenitor cells

Keita Kajikawa et al.

MOLECULAR BRAIN (2020)

添加到收藏夹

Article Multidisciplinary Sciences

Grafted human induced pluripotent stem cells improve the outcome of spinal cord injury: modulation of the lesion microenvironment

Tamas Bellak et al.

SCIENTIFIC REPORTS (2020)

添加到收藏夹

Review Cell Biology

Human Pluripotent Stem Cells-Based Therapies for Neurodegenerative Diseases: Current Status and Challenges

Elizabeth Ford et al.

CELLS (2020)

添加到收藏夹

Article Critical Care Medicine

Clinical Outcomes from a Multi-Center Study of Human Neural Stem Cell Transplantation in Chronic Cervical Spinal Cord Injury

Allan D. Levi et al.

JOURNAL OF NEUROTRAUMA (2019)

添加到收藏夹

Article Biotechnology & Applied Microbiology

Hypoimmunogenic derivatives of induced pluripotent stem cells evade immune rejection in fully immunocompetent allogeneic recipients

Tobias Deuse et al.

NATURE BIOTECHNOLOGY (2019)

添加到收藏夹

Article Neurosciences

Astrocytes migrate from human neural stem cell grafts and functionally integrate into the injured rat spinal cord

Brian V. Lien et al.

EXPERIMENTAL NEUROLOGY (2019)

添加到收藏夹

Article Multidisciplinary Sciences

Generation of hypoimmunogenic human pluripotent stem cells

Xiao Han et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2019)

添加到收藏夹

Review Biochemistry & Molecular Biology

The Challenge of Bringing iPSCs to the Patient

Maria del Carmen Ortuno-Costela et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)

添加到收藏夹

Review Cell & Tissue Engineering

Cell therapy for spinal cord injury using induced pluripotent stem cells

Narihito Nagoshi et al.

REGENERATIVE THERAPY (2019)

添加到收藏夹

Review Immunology

Engineering universal cells that evade immune detection

Robert Lanza et al.

NATURE REVIEWS IMMUNOLOGY (2019)

添加到收藏夹

Article Neurosciences

Apolipoprotein E as a novel therapeutic neuroprotection target after traumatic spinal cord injury

Xiaoxin Cheng et al.

EXPERIMENTAL NEUROLOGY (2018)

添加到收藏夹

Article Multidisciplinary Sciences

Injured adult motor and sensory axons regenerate into appropriate organotypic domains of neural progenitor grafts

Jennifer N. Dulin et al.

NATURE COMMUNICATIONS (2018)

添加到收藏夹

Article Medicine, Research & Experimental

Prolonged human neural stem cell maturation supports recovery in injured rodent CNS

Paul Lu et al.

JOURNAL OF CLINICAL INVESTIGATION (2017)

添加到收藏夹

Article Clinical Neurology

Human Neural Stem Cell Transplantation in Chronic Cervical Spinal Cord Injury: Functional Outcomes at 12 Months in a Phase II Clinical Trial

George M. Ghobrial et al.

NEUROSURGERY (2017)

添加到收藏夹

Article Cell & Tissue Engineering

Human neural progenitors derived from integration-free iPSCs for SCI therapy

Ying Liu et al.

STEM CELL RESEARCH (2017)

添加到收藏夹

Article Medicine, Research & Experimental

One-Step piggyBac Transposon-Based CRISPR/Cas9 Activation of Multiple Genes

Shenglan Li et al.

MOLECULAR THERAPY-NUCLEIC ACIDS (2017)

添加到收藏夹

Article Biochemistry & Molecular Biology

Spinal cord reconstitution with homologous neural grafts enables robust corticospinal regeneration

Ken Kadoya et al.

NATURE MEDICINE (2016)

添加到收藏夹

Article Neurosciences

Long-Distance Axonal Growth from Human Induced Pluripotent Stem Cells after Spinal Cord Injury

Paul Lu et al.

NEURON (2014)

添加到收藏夹

Article Biochemistry & Molecular Biology

Transplantation of D15A-Expressing Glial-Restricted-Precursor-Derived Astrocytes Improves Anatomical and Locomotor Recovery after Spinal Cord Injury

Chunling Fan et al.

INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES (2013)

添加到收藏夹

Article Biochemistry & Molecular Biology

Long-Distance Growth and Connectivity of Neural Stem Cells after Severe Spinal Cord Injury

Paul Lu et al.

CELL (2012)

添加到收藏夹

Article Multidisciplinary Sciences

Pre-Evaluated Safe Human iPSC-Derived Neural Stem Cells Promote Functional Recovery after Spinal Cord Injury in Common Marmoset without Tumorigenicity

Yoshiomi Kobayashi et al.

PLOS ONE (2012)

添加到收藏夹

Article Cell & Tissue Engineering

Chromatin Insulator Elements Block Transgene Silencing in Engineered Human Embryonic Stem Cell Lines at a Defined Chromosome 13 Locus

Chad C. MacArthur et al.

STEM CELLS AND DEVELOPMENT (2012)

添加到收藏夹

Article Neurosciences

Transgenic Targeting of Recombinant Rabies Virus Reveals Monosynaptic Connectivity of Specific Neurons

Aldis P. Weible et al.

JOURNAL OF NEUROSCIENCE (2010)

添加到收藏夹

Article Neurosciences

Transplantation of Ciliary Neurotrophic Factor-Expressing Adult Oligodendrocyte Precursor Cells Promotes Remyelination and Functional Recovery after Spinal Cord Injury

Qilin Cao et al.

JOURNAL OF NEUROSCIENCE (2010)

添加到收藏夹

Article Multidisciplinary Sciences

Induced pluripotent stem cell lines derived from human somatic cells

Junying Yu et al.

SCIENCE (2007)

添加到收藏夹

Article Biochemistry & Molecular Biology

Induction of pluripotent stem cells from adult human fibroblasts by defined factors

Kazutoshi Takahashi et al.

CELL (2007)

添加到收藏夹

Article Biochemistry & Molecular Biology

Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors

Kazutoshi Takahashi et al.

CELL (2006)

添加到收藏夹

Article Critical Care Medicine

Behavioral and histological characterization of unilateral cervical spinal cord contusion injury in rats

JC Gensel et al.

JOURNAL OF NEUROTRAUMA (2006)

添加到收藏夹

Article Neurosciences

Functional and electrophysiological changes after graded traumatic spinal cord injury in adult rat

QL Cao et al.

EXPERIMENTAL NEUROLOGY (2005)

添加到收藏夹

Article Developmental Biology

CD44 expression identifies astrocyte-restricted precursor cells

Y Liu et al.

DEVELOPMENTAL BIOLOGY (2004)

添加到收藏夹

Article Neurosciences

Differentiation of engrafted neuronal-restricted precursor cells is inhibited in the traumatically injured spinal cord

QL Cao et al.

EXPERIMENTAL NEUROLOGY (2002)

添加到收藏夹

Article Neurosciences

Transplants of fibroblasts genetically modified to express BDNF promote axonal regeneration from supraspinal neurons following chronic spinal cord injury

Y Jin et al.

EXPERIMENTAL NEUROLOGY (2002)

添加到收藏夹

Article Biochemical Research Methods

Cortical and subcortical lesions impair skilled walking in the ladder rung walking test: a new task to evaluate fore- and hindlimb stepping, placing, and co-ordination

GA Metz et al.

JOURNAL OF NEUROSCIENCE METHODS (2002)

添加到收藏夹

Article Neurosciences

Functional regeneration of chronically injured sensory afferents into adult spinal cord after neurotrophin gene therapy

MI Romero et al.

JOURNAL OF NEUROSCIENCE (2001)

添加到收藏夹

Article Clinical Neurology

Presence and significance of CD-95 (Fas/APO1) expression after spinal cord injury

M Zurita et al.

JOURNAL OF NEUROSURGERY (2001)

添加到收藏夹

Article Neurosciences

Pluripotent stem cells engrafted into the normal or lesioned adult rat spinal cord are restricted to a glial lineage

QL Cao et al.

EXPERIMENTAL NEUROLOGY (2001)

添加到收藏夹

Article Multidisciplinary Sciences

Functional regeneration of sensory axone into the adult spinal cord

MS Ramer et al.

NATURE (2000)

添加到收藏夹

Article Clinical Neurology

Fibroblasts genetically modified to produce BDNF support regrowth of chronically injured serotonergic axons

Y Jin et al.

NEUROREHABILITATION AND NEURAL REPAIR (2000)

添加到收藏夹

© Peeref 2019-2024. All rights reserved.