相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。The Expression of TRIM6 Activates the mTORC1 Pathway by Regulating the Ubiquitination of TSC1-TSC2 to Promote Renal Fibrosis
Weiwei Liu et al.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2021)
Evidence for Lysosomal Dysfunction within the Epidermis in Psoriasis and Atopic Dermatitis
Kim Klapan et al.
JOURNAL OF INVESTIGATIVE DERMATOLOGY (2021)
Tsc1 regulates tight junction independent of mTORC1
Mingqiang Lai et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2021)
Stability of tuberous sclerosis complex 2 is controlled by methylation at R1457 and R1459
Seishu Gen et al.
SCIENTIFIC REPORTS (2020)
Tuberous sclerosis: a review of the past, present, and future
Sanem Pinar Uysal et al.
TURKISH JOURNAL OF MEDICAL SCIENCES (2020)
Lysosome Alterations in the Human Epithelial Cell Line HaCaT and Skin Specimens: Relevance to Psoriasis
Katarzyna Bochenska et al.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)
Lysosomes Support the Degradation, Signaling, and Mitochondrial Metabolism Necessary for Human Epidermal Differentiation
Christine L. Monteleon et al.
JOURNAL OF INVESTIGATIVE DERMATOLOGY (2018)
Systemic Inflammation and Cardiovascular Comorbidity in Psoriasis Patients: Causes and Consequences
Wolf-Henning Boehncke
FRONTIERS IN IMMUNOLOGY (2018)
The tuberous sclerosis complex subunit TBC1D7 is stabilized by Akt phosphorylation-mediated 14-3-3 binding
James P. Madigan et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2018)
Epidermal mTORC1 Signaling Contributes to the Pathogenesis of Psoriasis and Could Serve as a Therapeutic Target
Claudia Buerger
FRONTIERS IN IMMUNOLOGY (2018)
A mechanistic target of rapamycin complex 1/2 (mTORC1)/V-Akt murine thymoma viral oncogene homolog 1 (AKT1)/cathepsin H axis controls filaggrin expression and processing in skin, a novel mechanism for skin barrier disruption in patients with atopic dermatitis
Aishath S. Naeem et al.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2017)
Inflammation dependent mTORC1 signaling interferes with the switch from keratinocyte proliferation to differentiation
Claudia Buerger et al.
PLOS ONE (2017)
Blocking mTOR Signalling with Rapamycin Ameliorates Imiquimod-induced Psoriasis in Mice
Claudia Buerger et al.
ACTA DERMATO-VENEREOLOGICA (2017)
TSC2 N-terminal lysine acetylation status affects to its stability modulating mTORC1 signaling and autophagy
Ana Garcia-Aguilar et al.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH (2016)
Constitutive Autophagy and Nucleophagy during Epidermal Differentiation
Olufolake Akinduro et al.
JOURNAL OF INVESTIGATIVE DERMATOLOGY (2016)
Combination of everolimus and tacrolimus: a potentially effective regimen for recalcitrant psoriasis
Kai-Che Wei et al.
DERMATOLOGIC THERAPY (2015)
Spatial Control of the TSC Complex Integrates Insulin and Nutrient Regulation of mTORC1 at the Lysosome
Suchithra Menon et al.
CELL (2014)
Regulation of TORC1 in Response to Amino Acid Starvation via Lysosomal Recruitment of TSC2
Constantinos Demetriades et al.
CELL (2014)
Mammalian target of rapamycin and its downstream signalling components are activated in psoriatic skin
C. Buerger et al.
BRITISH JOURNAL OF DERMATOLOGY (2013)
Downregulation of 14-3-3β and 14-3-3ζ in lesions of psoriasis vulgaris
X. Man et al.
CLINICAL AND EXPERIMENTAL DERMATOLOGY (2013)
The IL-23/T17 pathogenic axis in psoriasis is amplified by keratinocyte responses
Michelle A. Lowes et al.
TRENDS IN IMMUNOLOGY (2013)
Interleukin-1β Interferes with Epidermal Homeostasis through Induction of Insulin Resistance: Implications for Psoriasis Pathogenesis
Claudia Buerger et al.
JOURNAL OF INVESTIGATIVE DERMATOLOGY (2012)
TBC1D7 Is a Third Subunit of the TSC1-TSC2 Complex Upstream of mTORC1
Christian C. Dibble et al.
MOLECULAR CELL (2012)
Heterogeneity of Inflammatory and Cytokine Networks in Chronic Plaque Psoriasis
William R. Swindell et al.
PLOS ONE (2012)
Gene Expression in Skin and Lymphoblastoid Cells: Refined Statistical Method Reveals Extensive Overlap in cis-eQTL Signals
Jun Ding et al.
AMERICAN JOURNAL OF HUMAN GENETICS (2010)
Ragulator-Rag Complex Targets mTORC1 to the Lysosomal Surface and Is Necessary for Its Activation by Amino Acids
Yasemin Sancak et al.
CELL (2010)
A Characterization of the expression of 14-3-3 isoforms in psoriasis, basal cell carcinoma, atopic dermatitis and contact dermatitis
Line Raaby et al.
DERMATOLOGY REPORTS (2010)
A complex interplay between Akt, TSC2 and the two mTOR complexes
Jingxiang Huang et al.
BIOCHEMICAL SOCIETY TRANSACTIONS (2009)
Rapamycin selectively inhibits expression of an inducible keratin (K6a) in human keratinocytes and improves symptoms in pachyonychia congenita patients
Robyn P. Hickerson et al.
JOURNAL OF DERMATOLOGICAL SCIENCE (2009)
The TSC1-TSC2 complex: a molecular switchboard controlling cell growth
Jingxiang Huang et al.
BIOCHEMICAL JOURNAL (2008)
Pam (Protein associated with Myc) functions as an E3 Ubiquitin ligase and regulates TSC/mTOR signaling
Sangyeul Han et al.
CELLULAR SIGNALLING (2008)
E3 ubiquitin ligase E6AP-mediated TSC2 turnover in the presence and absence of HPV16 E6
Li Zheng et al.
GENES TO CELLS (2008)
Pathogenesis and therapy of psoriasis
Michelle A. Lowes et al.
NATURE (2007)
Severe psoriasis treated with a new macrolide: everolimus
E. Frigerio et al.
BRITISH JOURNAL OF DERMATOLOGY (2007)
TSC1 stabilizes TSC2 by inhibiting the interaction between TSC2 and the HERC1 ubiquitin ligase
H Chong-Kopera et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2006)
Phosphorylation and functional inactivation of TSC2 by Erk: Implications for tuberous sclerosis and cancer pathogenesis
Li Ma et al.
CELL (2006)
Phosphorylation and functional inactivation of TSC2 by Erk: Implications for tuberous sclerosis and cancer pathogenesis
L Ma et al.
CELL (2005)
Treatment of psoriasis with topical sirolimus: preclinical development and a randomized, double-blind trial
AD Ormerod et al.
BRITISH JOURNAL OF DERMATOLOGY (2005)
Tumor-promoting phorbol esters and activated Ras inactivate the tuberous sclerosis tumor suppressor complex via p90 ribosomal S6 kinase
PP Roux et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2004)
Rheb binds tuberous sclerosis complex 2 (TSC2) and promotes S6 kinase activation in a rapamycin- and farnesylation-dependent manner
AF Castro et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
Rheb GTPase is a direct target of TSC2 GAP activity and regulates mTOR signaling
K Inoki et al.
GENES & DEVELOPMENT (2003)
Insulin activation of Rheb, a mediator of mTOR/S6K/4E-BP signaling, is inhibited by TSC1 and 2
A Garami et al.
MOLECULAR CELL (2003)
Akt activation promotes degradation of tuberin and FOXO3a via the proteasome
DR Plas et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
14-3-3β binds to and negatively regulates the tuberous sclerosis complex 2 (TSC2) tumor suppressor gene product, tuberin
SD Shumway et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
Regulation of TSC2 by 14-3-3 binding
Y Li et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2002)
Akt regulates growth by directly phosphorylating Tsc2
CJ Potter et al.
NATURE CELL BIOLOGY (2002)
TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling
K Inoki et al.
NATURE CELL BIOLOGY (2002)
Identification of the tuberous sclerosis complex-2 tumor suppressor gene product tuberin as a target of the phosphoinositide 3-Kinase/Akt pathway
BD Manning et al.
MOLECULAR CELL (2002)
Efficacy of sirolimus (rapamycin) administered concomitantly with a subtherapeutic dose of cyclosporin in the treatment of severe psoriasis: a randomized controlled trial
S Reitamo et al.
BRITISH JOURNAL OF DERMATOLOGY (2001)