期刊
CELLS
卷 11, 期 18, 页码 -出版社
MDPI
DOI: 10.3390/cells11182852
关键词
miRNA; abnormal expression; tumor; regulatory mechanism
类别
资金
- Program for High-level Innovative Talents in Guizhou Province [QKH-RC-2016-4031]
- National Natural Science Foundation of China [32160178, 82160503, 81960509]
- Project of the Guizhou Provincial Department of Science and Technology [QKH-JC2018-1428, QKHZC-2020-4Y156]
- Program for New Century Excellent Talents in University, Ministry of Education of China [NCET-12-0661]
- Collaborative Innovation Center of Chinese Ministry of Education [2020-39]
- Project of the Zunyi Science and Technology Bureau [ZKH-HZ-2021-193]
- Program for Excellent Young Talents of Zunyi Medical University [15ZY-001]
MicroRNAs (miRNAs) regulate gene expression in various biological processes and are closely associated with tumorigenesis. MiRNA-based cancer gene therapy shows promising anti-tumor effects and is a new field in cancer treatment. Understanding the regulatory mechanisms of miRNA can benefit the development of gene therapy and clinical outcome in cancer patients.
MicroRNAs (miRNAs) are widely present in many organisms and regulate the expression of genes in various biological processes such as cell differentiation, metabolism, and development. Numerous studies have shown that miRNAs are abnormally expressed in tumor tissues and are closely associated with tumorigenesis. MiRNA-based cancer gene therapy has consistently shown promising anti-tumor effects and is recognized as a new field in cancer treatment. So far, some clinical trials involving the treatment of malignancies have been carried out; however, studies of miRNA-based cancer gene therapy are still proceeding slowly. Therefore, furthering our understanding of the regulatory mechanisms of miRNA can bring substantial benefits to the development of miRNA-based gene therapy or other combination therapies and the clinical outcome of patients with cancer. Recent studies have revealed that the aberrant expression of miRNA in tumors is associated with promoter sequence mutation, epigenetic alteration, aberrant RNA modification, etc., showing the complexity of aberrant expression mechanisms of miRNA in tumors. In this paper, we systematically summarized the regulation mechanisms of miRNA expression in tumors, with the aim of providing assistance in the subsequent elucidation of the role of miRNA in tumorigenesis and the development of new strategies for tumor prevention and treatment.
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