期刊
CELLS
卷 11, 期 21, 页码 -出版社
MDPI
DOI: 10.3390/cells11213352
关键词
mGlu5; plasticity; hippocampus; spatial learning; long-term memory; positive allosteric modulators; negative allosteric modulators
类别
资金
- Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) grant [SFB 1280/A04, 316803389]
mGlu5 plays a significant role in hippocampal synaptic plasticity, which is associated with knowledge acquisition and retention. Normal mGlu5 function is crucial for these processes.
The metabotropic glutamate (mGlu) receptor family consists of group I receptors (mGlu1 and mGlu5) that are positively coupled to phospholipase-C and group II (mGlu2 and mGlu3) and III receptors (mGlu4-8) that are negatively coupled to adenylyl cyclase. Of these, mGlu5 has emerged as a key factor in the induction and maintenance of persistent (>24 h) forms of hippocampal synaptic plasticity. Studies in freely behaving rodents have revealed that mGlu5 plays a pivotal role in the stabilisation of hippocampal long-term potentiation (LTP) and long-term depression (LTD) that are tightly associated with the acquisition and retention of knowledge about spatial experience. In this review article we shall address the state of the art in terms of the role of mGlu5 in forms of hippocampal synaptic plasticity related to experience-dependent information storage and present evidence that normal mGlu5 function is central to these processes.
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