☆ 4.6 Article

Modulation of Neutrophil Activity by Soluble Complement Cleavage Products-An In-Depth Analysis

CELLS (2022)

相关参考文献

注意：仅列出部分参考文献，下载原文获取全部文献信息。

Review Hematology

Advancing therapeutic complement inhibition in hematologic diseases: PNH and beyond

Eleni Gavriilaki et al.

Summary: This review provides an update on the targeting of complement in hematologic diseases, covering topics such as complement biology, activation and therapeutic inhibition in complement-mediated hematologic diseases, hematologic entities under investigation for complement inhibition, and other complement-related disorders of potential interest to hematologists.

BLOOD (2022)

添加到收藏夹

Review Immunology

C3-targeted host-modulation approaches to oral inflammatory conditions

Tetsuhiro Kajikawa et al.

Summary: Periodontitis, if not properly treated, can lead to tooth loss and affect overall health. This review focuses on the potential use of a complement-targeting drug called AMY-101 in the treatment of periodontal disease and peri-implant inflammatory conditions.

SEMINARS IN IMMUNOLOGY (2022)

添加到收藏夹

Article Multidisciplinary Sciences

Genetic evidence that uptake of the fluorescent analog 2NBDG occurs independently of known glucose transporters

Lucas J. D'Souza et al.

Summary: 2NBDG, a derivative of glucose, is widely used to visualize glucose uptake in cells. However, its uptake is not necessarily related to glucose transport and is promoted by an unknown mechanism.

PLOS ONE (2022)

添加到收藏夹

Review Urology & Nephrology

Immunopathophysiology of trauma-related acute kidney injury

David A. C. Messerer et al.

Summary: Physical trauma can lead to acute kidney injury, triggered by various causes including hemorrhagic shock, rhabdomyolysis, nephrotoxic drugs, and infectious complications. The complex immunopathophysiological response results in kidney circulatory disturbances, functional impairment, and inflammation, exacerbating multi-organ dysfunction.

NATURE REVIEWS NEPHROLOGY (2021)

添加到收藏夹

Review Biochemistry & Molecular Biology

Ion and Water Transport in Neutrophil Granulocytes and Its Impairment during Sepsis

David Alexander Christian Messerer et al.

Summary: Neutrophil granulocytes play a crucial role in innate immunity but can lead to cellular dysfunction and multiple organ failure when excessively stimulated. Following stimulation, they respond with defined physiological patterns involving ion and water fluxes. Ion transport proteins are critical for the immune functions of neutrophils.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

添加到收藏夹

Review Cell Biology

Complement Receptors and Their Role in Leukocyte Recruitment and Phagocytosis

Sofie Vandendriessche et al.

Summary: The complement system plays a crucial role in controlling microorganisms and removing dead cells, while also stimulating adaptive immune responses and tissue regeneration. Complement receptors on leukocytes and parenchymal cells are essential for recognizing complement-derived molecules and promoting immune responses.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2021)

添加到收藏夹

Article Immunology

Interleukin 8 Elicits Rapid Physiological Changes in Neutrophils That Are Altered by Inflammatory Conditions

Stefan Bernhard et al.

Summary: The response of neutrophils to IL-8 is dependent on specific ion channels and transporters, and can be impaired by LPS. This study provides new mechanistic insights into the interaction between IL-8 and neutrophils during systemic inflammation.

JOURNAL OF INNATE IMMUNITY (2021)

添加到收藏夹

Article Biochemistry & Molecular Biology

Simultaneous Measurement of Changes in Neutrophil Granulocyte Membrane Potential, Intracellular pH, and Cell Size by Multiparametric Flow Cytometry

Alexander Elias Paul Stratmann et al.

Summary: Neutrophils respond to proinflammatory stimuli by changing their membrane potential, intracellular pH, and cellular size. This study introduces a method using multiparametric flow cytometry to quantify these changes and improve time resolution for monitoring rapid changes within seconds. The findings may contribute to a better understanding of neutrophils in health and disease, potentially leading to novel diagnostic and prognostic approaches.

BIOMEDICINES (2021)

添加到收藏夹

Article Medicine, General & Internal

Sutimlimab in Cold Agglutinin Disease

Alexander Roeth et al.

Summary: In patients with cold agglutinin disease, treatment with sutimlimab rapidly halted hemolysis, increased hemoglobin levels, and reduced fatigue by selectively inhibiting activity in the classic complement pathway.

NEW ENGLAND JOURNAL OF MEDICINE (2021)

添加到收藏夹

Article Multidisciplinary Sciences

The neutrotime transcriptional signature defines a single continuum of neutrophils across biological compartments

Ricardo Grieshaber-Bouyer et al.

Summary: Neutrophils exhibit a single developmental spectrum, ranging from immature pre-neutrophils in the bone marrow to mature neutrophils in the blood and spleen. Inflammation affects neutrophil transcriptional states, leading to varying transcriptional activities at different sites.

NATURE COMMUNICATIONS (2021)

添加到收藏夹

Review Immunology

Neutrophils in COVID-19

Nico Reusch et al.

Summary: Research has found that the immune deviation of neutrophils in COVID-19 patients and promising therapeutic attempts to target them are crucial for understanding and treating the disease.

FRONTIERS IN IMMUNOLOGY (2021)

添加到收藏夹

Article Immunology

Activation of Neutrophil Granulocytes by Platelet-Activating Factor Is Impaired During Experimental Sepsis

Stefan Hug et al.

Summary: Platelet-activating factor (PAF) plays a crucial role in the systemic inflammatory response, particularly in sepsis. This study investigates the changes in neutrophil cellular responses induced by PAF during sepsis, focusing on membrane potential, intracellular pH, and cellular swelling. The study found that in a pathological environment, the response of neutrophils to PAF was altered, with exposure to lipopolysaccharide leading to diminished intracellular alkalization and neutrophil size changes. These findings suggest that an impaired physiological response of neutrophils to PAF stimulation may contribute to the development of neutrophil dysfunction in sepsis.

FRONTIERS IN IMMUNOLOGY (2021)

添加到收藏夹

Review Immunology

Complement as driver of systemic inflammation and organ failure in trauma, burn, and sepsis

Marco Mannes et al.

Summary: The complement system is an ancient defense system that can be activated after acute injuries to aid in regeneration, but uncontrolled activation may contribute to disease progression and multi-organ dysfunction.

SEMINARS IN IMMUNOPATHOLOGY (2021)

添加到收藏夹

Review Medicine, Research & Experimental

Rationale for targeting complement in COVID-19

Anastasia Polycarpou et al.

EMBO MOLECULAR MEDICINE (2020)

添加到收藏夹

Article Immunology

Animal-Free Human Whole Blood Sepsis Model to Study Changes in Innate Immunity

David Alexander Christian Messerer et al.

FRONTIERS IN IMMUNOLOGY (2020)

添加到收藏夹

Article Cell Biology

Complement C5a Alters the Membrane Potential of Neutrophils during Hemorrhagic Shock

David A. C. Messerer et al.

MEDIATORS OF INFLAMMATION (2018)

添加到收藏夹

Review Immunology

Innate immune responses to trauma

Markus Huber-Lang et al.

NATURE IMMUNOLOGY (2018)

添加到收藏夹

Review Immunology

The critical role of C5a as an initiator of neutrophil-mediated autoimmune inflammation of the joint and skin

Christian D. Sadik et al.

SEMINARS IN IMMUNOLOGY (2018)

添加到收藏夹

Review Immunology

Neutrophils in Tissue Trauma of the Skin, Bone, and Lung: Two Sides of the Same Coin

A. Kovtun et al.

JOURNAL OF IMMUNOLOGY RESEARCH (2018)

添加到收藏夹

Review Immunology

Update on Neutrophil Function in Severe Inflammation

Esmaeil Mortaz et al.

FRONTIERS IN IMMUNOLOGY (2018)

添加到收藏夹

Article Immunology

Complement C5a Functions as a Master Switch for the pH Balance in Neutrophils Exerting Fundamental Immunometabolic Effects

Stephanie Denk et al.

JOURNAL OF IMMUNOLOGY (2017)

添加到收藏夹

Article Immunology

Complement C5a-Induced Changes in Neutrophil Morphology During Inflammation

S. Denk et al.

SCANDINAVIAN JOURNAL OF IMMUNOLOGY (2017)

添加到收藏夹

Article Urology & Nephrology

Complement Activation Induces Neutrophil Adhesion and Neutrophil-Platelet Aggregate Formation on Vascular Endothelial Cells

Magdalena Riedl et al.

KIDNEY INTERNATIONAL REPORTS (2017)

添加到收藏夹

Review Immunology

The intimate and controversial relationship between voltage-gated proton channels and the phagocyte NADPH oxidase

Thomas E. DeCoursey

IMMUNOLOGICAL REVIEWS (2016)

添加到收藏夹

Article Pathology

Effect of Blood Sampling, Processing, and Storage on the Measurement of Complement Activation Biomarkers

Shangbin Yang et al.

AMERICAN JOURNAL OF CLINICAL PATHOLOGY (2015)

添加到收藏夹

Review Immunology

Is the Complement Activation Product C3a a Proinflammatory Molecule? Re-evaluating the Evidence and the Myth

Liam G. Coulthard et al.

JOURNAL OF IMMUNOLOGY (2015)

添加到收藏夹

Review Immunology

C4a: An Anaphylatoxin in Name Only

Scott R. Barnum

JOURNAL OF INNATE IMMUNITY (2015)

添加到收藏夹

Review Biotechnology & Applied Microbiology

Complement, a target for therapy in inflammatory and degenerative diseases

B. Paul Morgan et al.

NATURE REVIEWS DRUG DISCOVERY (2015)

添加到收藏夹

Review Rheumatology

The multifactorial role of neutrophils in rheumatoid arthritis

Helen L. Wright et al.

NATURE REVIEWS RHEUMATOLOGY (2014)

添加到收藏夹

Review Immunology

Neutrophil recruitment and function in health and inflammation

Elzbieta Kolaczkowska et al.

NATURE REVIEWS IMMUNOLOGY (2013)

添加到收藏夹

Review Pharmacology & Pharmacy

International Union of Pharmacology. LXXXVII. Complement Peptide C5a, C4a, and C3a Receptors

Andreas Klos et al.

PHARMACOLOGICAL REVIEWS (2013)

添加到收藏夹

Article Immunology

C5a Receptor-Dependent Cell Activation by Physiological Concentrations of Desarginated C5a: Insights from a Novel Label-Free Cellular Assay

Edimara S. Reis et al.

JOURNAL OF IMMUNOLOGY (2012)

添加到收藏夹

Review Microbiology

THE COMPLEMENT SYSTEM: HISTORY, PATHWAYS, CASCADE AND INHIBITORS

P. N. Nesargikar et al.

EUROPEAN JOURNAL OF MICROBIOLOGY AND IMMUNOLOGY (2012)

添加到收藏夹

Article Hematology

C5a-mediated neutrophil dysfunction is RhoA-dependent and predicts infection in critically ill patients

Andrew Conway Morris et al.

BLOOD (2011)

添加到收藏夹

Review Cell Biology

The complement system

J. Vidya Sarma et al.

CELL AND TISSUE RESEARCH (2011)

添加到收藏夹

Article Immunology

Serum concentrations of complement anaphylatoxins and proinflammatory mediators in patients with 2009 H1N1 influenza

Rieko Ohta et al.

MICROBIOLOGY AND IMMUNOLOGY (2011)

添加到收藏夹

Review Pharmacology & Pharmacy

Function, structure and therapeutic potential of complement C5a receptors

P. N. Monk et al.

BRITISH JOURNAL OF PHARMACOLOGY (2007)

添加到收藏夹

Review Immunology

The dark side of C5A in sepsis

PA Ward

NATURE REVIEWS IMMUNOLOGY (2004)

添加到收藏夹

Article Biochemistry & Molecular Biology

Interactions between NADPH oxidase and voltage-gated proton channels: why electron transport depends on proton transport

TE DeCoursey

FEBS LETTERS (2003)

添加到收藏夹

Article Multidisciplinary Sciences

The voltage dependence of NADPH oxidase reveals why phagocytes need proton channels

TE DeCoursey et al.

NATURE (2003)

添加到收藏夹

Article Biochemistry & Molecular Biology

The orphan receptor C5L2 has high affinity binding sites for complement fragments C5a and C5a des-Arg(74)

SA Cain et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2002)

添加到收藏夹

Article Immunology

Requirements for C5a receptor-mediated IL-4 and IL-13 production and leukotriene C4 generation in human basophils

S Eglite et al.

JOURNAL OF IMMUNOLOGY (2000)

添加到收藏夹

© Peeref 2019-2024. All rights reserved.