4.6 Review

Metformin Prevents or Delays the Development and Progression of Osteoarthritis: New Insight and Mechanism of Action

期刊

CELLS
卷 11, 期 19, 页码 -

出版社

MDPI
DOI: 10.3390/cells11193012

关键词

metformin; osteoarthritis; type 2 diabetes; AMPK; SIRT1

资金

  1. National Key R&D Program of China [2019YFA0111900]
  2. National Natural Science Foundation of China [81874030, 81902303, 82072506]
  3. Guangdong Basic and Applied Basic Research Foundation [2020A1515011046, 2021A1515220030]
  4. Provincial Clinical Medical Technology Innovation Project of Hunan [2020SK53709]
  5. Shenzhen Science and Technology Project [RCBS20200714114856299, RCYX20210609103902019]
  6. Innovation-Driven Project of Central South University [2020CX045]

向作者/读者索取更多资源

This review comprehensively summarizes the current research progress on metformin as a proposed drug for the prevention or treatment of osteoarthritis, including its molecular mechanism and clinical significance.
For over 60 years, metformin has been widely prescribed by physicians to treat type 2 diabetes. Along with more in-depth research on metformin and its molecular mechanism in recent decades, metformin has also been proposed as an effective drug to prevent or delay musculoskeletal disorders, including osteoarthritis (OA). The occurrence and development of OA are deemed to be associated with the impaired mitochondrial functions of articular chondrocytes. Metformin can activate the pathways and expressions of both AMPK and SIRT1 so as to protect the mitochondrial function of chondrocytes, thereby promoting osteoblast production. Moreover, the clinical significance of the metformin combination therapy in preventing OA has also been demonstrated. This review aimed to comprehensively summarize the current research progress on metformin as a proposed drug for OA prevention or treatment.

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