4.6 Article

Dysregulated Neutrophil Phenotype and Function in Hospitalised Non-ICU COVID-19 Pneumonia

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Immunology

Impaired Degradation of Neutrophil Extracellular Traps: A Possible Severity Factor of Elderly Male COVID-19 Patients

Nicole de Buhr et al.

Summary: In this study, the levels of NET markers and DNase activity were examined in COVID-19 patients compared to healthy controls. The findings showed that COVID-19 patients had increased levels of NET markers in their plasma, with higher levels observed in male patients. Additionally, COVID-19 patients exhibited increased DNase activity compared to healthy controls. Importantly, there was a negative correlation between DNase activity and the age of male patients. The antimicrobial peptide LL-37 was also found to be correlated with NET marker levels in male COVID-19 patients, suggesting its potential role in the risk of NET-associated thrombosis in this population.

JOURNAL OF INNATE IMMUNITY (2022)

Article Immunology

Increased Peripheral Blood Neutrophil Activation Phenotypes and Neutrophil Extracellular Trap Formation in Critically Ill Coronavirus Disease 2019 (COVID-19) Patients: A Case Series and Review of the Literature

Jorge A. Masso-Silva et al.

Summary: Recent research indicates that COVID-19 patients exhibit increased neutrophil levels in both blood and lung tissue, with activated neutrophils correlating with disease severity. Neutrophils in COVID-19 patients show functional changes, including enhanced neutrophil extracellular trap formation, phagocytosis, and oxidative burst, suggesting a more aggressive antimicrobial and proinflammatory response.

CLINICAL INFECTIOUS DISEASES (2022)

Article Critical Care Medicine

Impairment of neutrophil functions and homeostasis in COVID-19 patients: association with disease severity

Chloe Loyer et al.

Summary: This study reveals that COVID-19 patients have continuously activated neutrophils in their blood, which are associated with endothelial and vascular activation. Additionally, COVID-19 patients have aging-angiogenic neutrophil subsets and reduced oxidative burst response to bacterial stimuli. Moreover, COVID-19 patients who died exhibit more severe neutrophil exhaustion and impaired oxidative burst response.

CRITICAL CARE (2022)

Article Biochemistry & Molecular Biology

Large-Scale Multi-omic Analysis of COVID-19 Severity

Katherine A. Overmyer et al.

Summary: The study conducted RNA-seq and high-resolution mass spectrometry on blood samples from COVID-19-positive and COVID-19-negative patients, identifying molecular features associated with disease severity and outcomes, offering pathophysiological insights and therapeutic suggestions. The observed dysregulation of platelet function, blood coagulation, acute phase response, and endotheliopathy further illuminated the unique COVID-19 phenotype. The findings are presented through a web-based tool enabling interactive exploration and machine learning prediction of COVID-19 severity.

CELL SYSTEMS (2021)

Review Cell Biology

Aging in COVID-19: Vulnerability, immunity and intervention

Yiyin Chen et al.

Summary: The COVID-19 pandemic originating from Wuhan in December 2019 has had far-reaching health and socioeconomic impacts worldwide. The disease caused by SARS-CoV-2 is highly heterogeneous, with age, gender, and comorbidities playing key roles in disease severity and outcomes. Aging and dysregulation of immune function are thought to contribute to the increased vulnerability of older adults to severe COVID-19. Further research on immune responses to SARS-CoV-2 infection, particularly in different age groups, is crucial for understanding disease heterogeneity and developing effective vaccines.

AGEING RESEARCH REVIEWS (2021)

Article Critical Care Medicine

Tissue-Specific Immunopathology in Fatal COVID-19

David A. Dorward et al.

Summary: In fatal COVID-19 cases, abnormal immune responses were found primarily in the lung and reticuloendothelial system, which were not clearly associated with the virus. Tissue-specific immunopathology in COVID-19 implicates a significant role of immune-mediated, virus-independent mechanisms in severe disease.

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2021)

Article Genetics & Heredity

Disease severity-specific neutrophil signatures in blood transcriptomes stratify COVID-19 patients

Anna C. Aschenbrenner et al.

Summary: This study provides novel insights into distinct molecular subgroups or phenotypes that are not simply explained by clinical parameters. Whole blood transcriptomes are shown to be extremely informative for COVID-19 as they capture the major drivers of disease severity, granulocytes.

GENOME MEDICINE (2021)

Article Immunology

Inflammatory profiles across the spectrum of disease reveal a distinct role for GM-CSF in severe COVID-19

Ryan S. Thwaites et al.

Summary: The study found that levels of inflammatory cytokines and chemokines gradually increased with the severity of COVID-19, with IL-6 and GM-CSF playing central roles in the pathogenesis of the disease. Comparisons with samples from fatal influenza patients revealed that GM-CSF was prominent only in COVID-19, further identifying key factors that characterize and distinguish severe and fatal COVID-19.

SCIENCE IMMUNOLOGY (2021)

Review Immunology

Neutrophils and COVID-19: Active Participants and Rational Therapeutic Targets

Jon Hazeldine et al.

Summary: Approximately 20% of individuals infected with SARS-CoV-2 may progress to severe respiratory complications, with a hyperactive and dysregulated immune response potentially underpinning the development of severe disease, particularly through the involvement of neutrophils. Evaluating the number, maturity status and function of circulating neutrophils at hospital admission shows promise as a prognostic tool for early identification of patients at risk of clinical deterioration. Targeting neutrophils as a potential therapeutic strategy for severe COVID-19 warrants further investigation, given the limited specific treatments currently available.

FRONTIERS IN IMMUNOLOGY (2021)

Review Respiratory System

The role of co-infections and secondary infections in patients with COVID-19

Charles Feldman et al.

Summary: The current review provides an extensive look at the prevalence of co-infections and superinfections in patients with COVID-19, highlighting their potential impact on the severity and outcome of the disease. However, a clear distinction between the two types of infections is often lacking in the literature.

PNEUMONIA (2021)

Article Cardiac & Cardiovascular Systems

Neutrophil extracellular traps and thrombosis in COVID-19

Yu Zuo et al.

Summary: Studies on COVID-19 patients have shown dysregulated coagulation and high risk of thrombotic events. Elevated levels of neutrophils and NETs in COVID-19 patients may be associated with thrombosis, requiring further investigation and novel prevention approaches.

JOURNAL OF THROMBOSIS AND THROMBOLYSIS (2021)

Article Immunology

Kinetics of peripheral blood neutrophils in severe coronavirus disease 2019

Mieke Metzemaekers et al.

Summary: Our study explores the characteristics of neutrophils in severe COVID-19 patients, showing increased plasma concentrations of G-CSF and CXCL8 upon ICU admission, indicating emergency myelopoiesis. COVID-19 neutrophils were hyper-responsive to CXCL8 and CXCL12, suggesting an increased activation state in the circulation.

CLINICAL & TRANSLATIONAL IMMUNOLOGY (2021)

Review Respiratory System

Neutrophils in community-acquired pneumonia: parallels in dysfunction at the extremes of age

Frances Susanna Grudzinska et al.

THORAX (2020)

Review Biochemistry & Molecular Biology

Neutrophil Metabolic Shift during Their Lifecycle: Impact on Their Survival and Activation

Louise Injarabian et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

Article Biochemistry & Molecular Biology

Imbalanced Host Response to SARS-CoV-2 Drives Development of COVID-19

Daniel Blanco-Melo et al.

Article Biochemistry & Molecular Biology

Proteomic and Metabolomic Characterization of COVID-19 Patient Sera

Bo Shen et al.

Article Biochemistry & Molecular Biology

Severe COVID-19 Is Marked by a Dysregulated Myeloid Cell Compartment

Jonas Schulte-Schrepping et al.

Article Biochemistry & Molecular Biology

Ultra-High-Throughput Clinical Proteomics Reveals Classifiers of COVID-19 Infection

Christoph B. Messner et al.

CELL SYSTEMS (2020)

Article Medicine, General & Internal

Vascular occlusion by neutrophil extracellular traps in COVID-19

Moritz Leppkes et al.

EBIOMEDICINE (2020)

Article Medicine, Research & Experimental

Neutrophil extracelluar traps in COVID-19

Yu Zuo et al.

JCI INSIGHT (2020)

Article Virology

Clinical features and short-term outcomes of 221 patients with COVID-19 in Wuhan, China

Guqin Zhang et al.

JOURNAL OF CLINICAL VIROLOGY (2020)

Article Multidisciplinary Sciences

Association of COVID-19 inflammation with activation of the C5a-C5aR1 axis

Julien Carvelli et al.

NATURE (2020)

Article Biochemistry & Molecular Biology

A single-cell atlas of the peripheral immune response in patients with severe COVID-19

Aaron J. Wilk et al.

NATURE MEDICINE (2020)

Article Virology

Co-infection with respiratory pathogens among COVID-2019 cases

Xiaojuan Zhu et al.

VIRUS RESEARCH (2020)

Article Medicine, Research & Experimental

Complement and tissue factor-enriched neutrophil extracellular traps are key drivers in COVID-19 immunothrombosis

Panagiotis Skendros et al.

JOURNAL OF CLINICAL INVESTIGATION (2020)

Article Immunology

SARS-CoV-2-triggered neutrophil extracellular traps mediate COVID-19 pathology

Flavio Protasio Veras et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2020)

Review Immunology

PI3Kδ Inhibition as a Potential Therapeutic Target in COVID-19

Giuseppe Palma et al.

FRONTIERS IN IMMUNOLOGY (2020)

Article Immunology

Excessive Neutrophils and Neutrophil Extracellular Traps in COVID-19

Jun Wang et al.

FRONTIERS IN IMMUNOLOGY (2020)

Review Biochemistry & Molecular Biology

NETosis: Molecular Mechanisms, Role in Physiology and Pathology

N. V. Vorobjeva et al.

BIOCHEMISTRY-MOSCOW (2020)

Article Critical Care Medicine

Simvastatin Improves Neutrophil Function and Clinical Outcomes in Pneumonia A Pilot Randomized Controlled Clinical Trial

Elizabeth Sapey et al.

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2019)

Article Immunology

Effect of Adhesion and Substrate Elasticity on Neutrophil Extracellular Trap Formation

Luise Erpenbeck et al.

FRONTIERS IN IMMUNOLOGY (2019)

Article Cell Biology

Sepsis Induces a Dysregulated Neutrophil Phenotype That Is Associated with Increased Mortality

Jaimin M. Patel et al.

MEDIATORS OF INFLAMMATION (2018)

Review Physiology

Neutrophil: A Cell with Many Roles in Inflammation or Several Cell Types?

Carlos Rosales

FRONTIERS IN PHYSIOLOGY (2018)

Article Critical Care Medicine

Vitamin D to Prevent Lung Injury Following EsophagectomyA Randomized, Placebo-Controlled Trial*

Dhruv Parekh et al.

CRITICAL CARE MEDICINE (2018)

Review Cell Biology

Neutrophils in the lung: the first responders

Gurpreet Kaur Aulakh

CELL AND TISSUE RESEARCH (2018)

Review Immunology

Neutrophil extracellular traps in immunity and disease

Venizelos Papayannopoulos

NATURE REVIEWS IMMUNOLOGY (2018)

Review Immunology

Neutrophils to the ROScue: Mechanisms of NADPH Oxidase Activation and Bacterial Resistance

Giang T. Nguyen et al.

FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY (2017)

Article Critical Care Medicine

Pulmonary Infections in the Elderly Lead to Impaired Neutrophil Targeting, Which Is Improved by Simvastatin

Elizabeth Sapey et al.

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2017)

Article Cell Biology

Neutrophil extracellular traps release induced by Leishmania: role of PI3Kγ, ERK, PI3Kσ, PKC, and [Ca2+]

Thiago DeSouza-Vieira et al.

JOURNAL OF LEUKOCYTE BIOLOGY (2016)

Review Cell Biology

Neutrophils in viral infections: Current concepts and caveats

Ioanna E. Galani et al.

JOURNAL OF LEUKOCYTE BIOLOGY (2015)

Review Immunology

Statin therapy and autoimmune disease: from protein prenylation to immunomodulation

J Greenwood et al.

NATURE REVIEWS IMMUNOLOGY (2006)

Article Immunology

Phagocytosis by neutrophils

WL Lee et al.

MICROBES AND INFECTION (2003)

Review Cell Biology

Roles of PI3Ks in leukocyte chemotaxis and phagocytosis

L Stephens et al.

CURRENT OPINION IN CELL BIOLOGY (2002)

Article Medicine, Research & Experimental

Transient expression of IL-1β induces acute lung injury and chronic repair leading to pulmonary fibrosis

M Kolb et al.

JOURNAL OF CLINICAL INVESTIGATION (2001)