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The Transient Receptor Potential Melastatin 2 (TRPM2) Channel Contributes to β-Amyloid Oligomer-Related Neurotoxicity and Memory Impairment
Valeriy G. Ostapchenko et al.
JOURNAL OF NEUROSCIENCE (2015)
Peripheral Oxidative Stress Markers in Individuals with Alzheimer's Disease with or without Cerebrovascular Disease
Hirokuni Hatanaka et al.
JOURNAL OF THE AMERICAN GERIATRICS SOCIETY (2015)
Astrocytes and microglia but not neurons preferentially generate N-terminally truncated Aβ peptides
Timo Jan Oberstein et al.
NEUROBIOLOGY OF DISEASE (2015)
The Glymphatic System: A Beginner's Guide
Nadia Aalling Jessen et al.
NEUROCHEMICAL RESEARCH (2015)
Brain Amyloid-Beta Fragment Signatures in Pathological Ageing and Alzheimer's Disease by Hybrid Immunoprecipitation Mass Spectrometry
Erik Portelius et al.
NEURODEGENERATIVE DISEASES (2015)
Investigation of A phosphorylated at serine 8 (pA) in Alzheimer's disease, dementia with Lewy bodies and vascular dementia
E. L. Ashby et al.
NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY (2015)
Genetic Association Between APP, ADAM10 Gene Polymorphism, and Sporadic Alzheimer's Disease in the Chinese Population
Fan Zeng et al.
NEUROTOXICITY RESEARCH (2015)
White Matter Degeneration in Atypical Alzheimer Disease
Francesca Caso et al.
RADIOLOGY (2015)
Impact of amyloid β aggregate maturation on antibody treatment in APP23 mice
Karthikeyan Balakrishnan et al.
ACTA NEUROPATHOLOGICA COMMUNICATIONS (2015)
The Chemerin Receptor CMKLR1 is a Functional Receptor for Amyloid-β Peptide
Lei Peng et al.
JOURNAL OF ALZHEIMERS DISEASE (2015)
Small Aβ1-42 Oligomer-Induced Membrane Depolarization of Neuronal and Microglial Cells: Role of N-Methyl-D-Aspartate Receptors
Ramune Morkuniene et al.
JOURNAL OF NEUROSCIENCE RESEARCH (2015)
Enemy attraction: bacterial agonists for leukocyte chemotaxis receptors
Dominik Alexander Bloes et al.
NATURE REVIEWS MICROBIOLOGY (2015)
Increased Number of Plasma B Cells Producing Autoantibodies Against Aβ42 Protofibrils in Alzheimer's Disease
Sofia Sollvander et al.
JOURNAL OF ALZHEIMERS DISEASE (2015)
Amylin: Pharmacology, Physiology, and Clinical Potential
Debbie L. Hay et al.
PHARMACOLOGICAL REVIEWS (2015)
Double Negative (IgG+IgD-CD27-) B Cells are Increased in a Cohort of Moderate-Severe Alzheimer's Disease Patients and Show a Pro-Inflammatory Trafficking Receptor Phenotype
Matteo Bulati et al.
JOURNAL OF ALZHEIMERS DISEASE (2015)
Focusing the amyloid cascade hypothesis on N-truncated Abeta peptides as drug targets against Alzheimer's disease
Thomas A. Bayer et al.
ACTA NEUROPATHOLOGICA (2014)
R47H TREM2 variant increases risk of typical early-onset Alzheimer's disease but not of prion or frontotemporal dementia
Catherine F. Slattery et al.
ALZHEIMERS & DEMENTIA (2014)
Simultaneous Determination of Post-Translational Racemization and Isomerization of N-Terminal Amyloid-β in Alzheimer's Brain Tissues by Covalent Chiral Derivatized Ultraperformance Liquid Chromatography Tandem Mass Spectrometry
Koichi Inoue et al.
ANALYTICAL CHEMISTRY (2014)
Autophagy in microglia degrades extracellular β-amyloid fibrils and regulates the NLRP3 inflammasome
Mi-Hyang Cho et al.
AUTOPHAGY (2014)
High molecular mass assemblies of amyloid-β oligomers bind prion protein in patients with Alzheimer's disease
Frank Dohler et al.
BRAIN (2014)
Biochemical stages of amyloid-β peptide aggregation and accumulation in the human brain and their association with symptomatic and pathologically preclinical Alzheimer's disease
Ajeet Rijal Upadhaya et al.
BRAIN (2014)
Microglia convert aggregated amyloid-β into neurotoxic forms through the shedding of microvesicles
P. Joshi et al.
CELL DEATH AND DIFFERENTIATION (2014)
Prion protein facilitates synaptic vesicle release by enhancing release probability
Susan W. Robinson et al.
HUMAN MOLECULAR GENETICS (2014)
Insights into the physiological function of the β-amyloid precursor protein: beyond Alzheimer's disease
Edgar Dawkins et al.
JOURNAL OF NEUROCHEMISTRY (2014)
Microglia receptors and their implications in the response to amyloid β for Alzheimer's disease pathogenesis
Deborah Doens et al.
JOURNAL OF NEUROINFLAMMATION (2014)
The amyloid state and its association with protein misfolding diseases
Tuomas P. J. Knowles et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2014)
Study on Aβ34 biology and detection in transgenic mice brains
Celine Caillava et al.
NEUROBIOLOGY OF AGING (2014)
Activated Scavenger Receptor A Promotes Glial Internalization of Aβ
He Zhang et al.
PLOS ONE (2014)
TREM-2 Promotes Macrophage-Mediated Eradication of Pseudomonas aeruginosa via a PI3K/Akt Pathway
M. Zhu et al.
SCANDINAVIAN JOURNAL OF IMMUNOLOGY (2014)
TREM2 mutations implicated in neurodegeneration impair cell surface transport and phagocytosis
Gernot Kleinberger et al.
SCIENCE TRANSLATIONAL MEDICINE (2014)
Truncated and modified amyloid-beta species
Markus P. Kummer et al.
ALZHEIMERS RESEARCH & THERAPY (2014)
Oligodendrocyte Precursor Cells Modulate the Neuronal Network by Activity-Dependent Ectodomain Cleavage of Glial NG2
Dominik Sakry et al.
PLOS BIOLOGY (2014)
Innate immune activation in neurodegenerative disease
Michael T. Heneka et al.
NATURE REVIEWS IMMUNOLOGY (2014)
N-truncated amyloid β (Aβ) 4-42 forms stable aggregates and induces acute and long-lasting behavioral deficits
Yvonne Bouter et al.
ACTA NEUROPATHOLOGICA (2013)
Intracellular accumulation of aggregated pyroglutamate amyloid beta: convergence of aging and Aβ pathology at the lysosome
Line De Kimpe et al.
AGE (2013)
Pyroglutamate-3 Amyloid-β Deposition in the Brains of Humans, Non-Human Primates, Canines, and Alzheimer Disease-Like Transgenic Mouse Models
Jeffrey L. Frost et al.
AMERICAN JOURNAL OF PATHOLOGY (2013)
Mild Cognitive Impairment Due to Alzheimer Disease in the Community
Ronald C. Petersen et al.
ANNALS OF NEUROLOGY (2013)
Shuttling Protein Nucleolin Is a Microglia Receptor for Amyloid Beta Peptide 1-42
Daisuke Ozawa et al.
BIOLOGICAL & PHARMACEUTICAL BULLETIN (2013)
Microglia Promote Learning-Dependent Synapse Formation through Brain-Derived Neurotrophic Factor
Christopher N. Parkhurst et al.
CELL (2013)
The amyloid precursor protein: A biochemical enigma in brain development, function and disease
Natalia N. Nalivaeva et al.
FEBS LETTERS (2013)
Sequential Proteolytic Processing of the Triggering Receptor Expressed on Myeloid Cells-2 (TREM2) Protein by Ectodomain Shedding and γ-Secretase-dependent Intramembranous Cleavage
Patrick Wunderlich et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2013)
P2Y4 Receptor-Mediated Pinocytosis Contributes to Amyloid Beta-Induced Self-Uptake by Microglia
Hui-quan Li et al.
MOLECULAR AND CELLULAR BIOLOGY (2013)
NLRP3 is activated in Alzheimer's disease and contributes to pathology in APP/PS1 mice
Michael T. Heneka et al.
NATURE (2013)
CD36 coordinates NLRP3 inflammasome activation by facilitating intracellular nucleation of soluble ligands into particulate ligands in sterile inflammation
Frederick J. Sheedy et al.
NATURE IMMUNOLOGY (2013)
Altered synapses and gliotransmission in Alzheimer's disease and AD model mice
Stanislaw Mitew et al.
NEUROBIOLOGY OF AGING (2013)
TREM2 is associated with the risk of Alzheimer's disease in Spanish population
Bruno A. Benitez et al.
NEUROBIOLOGY OF AGING (2013)
Alzheimer's Disease Risk Gene CD33 Inhibits Microglial Uptake of Amyloid Beta
Ana Griciuc et al.
NEURON (2013)
TREM2 Variants in Alzheimer's Disease
Rita Guerreiro et al.
NEW ENGLAND JOURNAL OF MEDICINE (2013)
Correction: The Pathogenic Aβ43 Is Enriched in Familial and Sporadic Alzheimer Disease
Anna Sandebring et al.
PLoS One (2013)
Cerebrospinal Aβ11-x and 17-x levels as indicators of mild cognitive impairment and patients' stratification in Alzheimer's disease
J-D Abraham et al.
TRANSLATIONAL PSYCHIATRY (2013)
Ammonium hydroxide treatment of Aβ produces an aggregate free solution suitable for biophysical and cell culture characterization
Timothy M. Ryan et al.
PEERJ (2013)
The regulation of AβPP expression by RNA-binding proteins
Cara J. Westmark et al.
AGEING RESEARCH REVIEWS (2012)
β-Amyloid protein (Aβ) and human amylin regulation of apoptotic genes occurs through the amylin receptor
Jack H. Jhamandas et al.
APOPTOSIS (2012)
The Metalloprotease Meprin β Generates Amino Terminal-truncated Amyloid β Peptide Species
Jessica Bien et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2012)
Phosphorylation of Amyloid-β Peptide at Serine 8 Attenuates Its Clearance via Insulin-degrading and Angiotensin-converting Enzymes
Sathish Kumar et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2012)
Blood markers of oxidative stress in Alzheimer's disease
Alice Skoumalova et al.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2012)
TLR2 Is a Primary Receptor for Alzheimer's Amyloid β Peptide To Trigger Neuroinflammatory Activation
Shirong Liu et al.
JOURNAL OF IMMUNOLOGY (2012)
An online nano-LC-ESI-FTICR-MS method for comprehensive characterization of endogenous fragments from amyloid β and amyloid precursor protein in human and cat cerebrospinal fluid
Gunnar Brinkmalm et al.
JOURNAL OF MASS SPECTROMETRY (2012)
Involvement of formyl peptide receptors in receptor for advanced glycation end products (RAGE) - and amyloid beta 1-42-induced signal transduction in glial cells
Alexander Slowik et al.
MOLECULAR NEURODEGENERATION (2012)
The toxic Aβ oligomer and Alzheimer's disease: an emperor in need of clothes
Iryna Benilova et al.
NATURE NEUROSCIENCE (2012)
Characterization of cerebrospinal fluid aminoterminally truncated and oxidized amyloid-β peptides
Mirko Bibl et al.
PROTEOMICS CLINICAL APPLICATIONS (2012)
A Paravascular Pathway Facilitates CSF Flow Through the Brain Parenchyma and the Clearance of Interstitial Solutes, Including Amyloid β
Jeffrey J. Iliff et al.
SCIENCE TRANSLATIONAL MEDICINE (2012)
Molecular consequences of amyloid precursor protein and presenilin mutations causing autosomal-dominant Alzheimer's disease
Sascha Weggen et al.
ALZHEIMERS RESEARCH & THERAPY (2012)
A partially folded structure of amyloid-beta(1-40) in an aqueous environment
Subramanian Vivekanandan et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2011)
Binding studies of truncated variants of the Aβ peptide to the V-domain of the RAGE receptor reveal Aβ residues responsible for binding
Emilia Gospodarska et al.
BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS (2011)
SR-A/MARCO-mediated ligand delivery enhances intracellular TLR and NLR function, but ligand scavenging from cell surface limits TLR4 response to pathogens
Subhankar Mukhopadhyay et al.
BLOOD (2011)
Astrocyte TLR4 Activation Induces a Proinflammatory Environment Through the Interplay Between MyD88-Dependent NFκB Signaling, MAPK, and Jak1/Stat1 Pathways
Roser Gorina et al.
GLIA (2011)
Overexpression of Glutaminyl Cyclase, the Enzyme Responsible for Pyroglutamate Aβ Formation, Induces Behavioral Deficits, and Glutaminyl Cyclase Knock-out Rescues the Behavioral Phenotype in 5XFAD Mice
Sadim Jawhar et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2011)
Prion Protein Interacts with BACE1 Protein and Differentially Regulates Its Activity toward Wild Type and Swedish Mutant Amyloid Precursor Protein
Heledd H. Griffiths et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2011)
Large Quantities of Aβ Peptide Are Constitutively Released during Amyloid Precursor Protein Metabolism in Vivo and in Vitro
Abhay Moghekar et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2011)
The contribution of activated astrocytes to Aβ production: Implications for Alzheimer's disease pathogenesis
Jie Zhao et al.
JOURNAL OF NEUROINFLAMMATION (2011)
TLR4 mutation reduces microglial activation, increases Aβ deposits and exacerbates cognitive deficits in a mouse model of Alzheimer's disease
Min Song et al.
JOURNAL OF NEUROINFLAMMATION (2011)
Microglial MAC1 receptor and PI3K are essential in mediating β-amyloid peptide-induced microglial activation and subsequent neurotoxicity
Dan Zhang et al.
JOURNAL OF NEUROINFLAMMATION (2011)
Crystal Structure of the Amyloid-β p3 Fragment Provides a Model for Oligomer Formation in Alzheimer's Disease
Victor A. Streltsov et al.
JOURNAL OF NEUROSCIENCE (2011)
The Role of Microglia in the Healthy Brain
Marie-Eve Tremblay et al.
JOURNAL OF NEUROSCIENCE (2011)
Replication of EPHA1 and CD33 associations with late-onset Alzheimer's disease: a multi-centre case-control study
Minerva M. Carrasquillo et al.
MOLECULAR NEURODEGENERATION (2011)
Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease
Adam C. Naj et al.
NATURE GENETICS (2011)
Common variants at ABCA7, MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer's disease
Paul Hollingworth et al.
NATURE GENETICS (2011)
Potent amyloidogenicity and pathogenicity of Aβ43
Takashi Saito et al.
NATURE NEUROSCIENCE (2011)
A novel pathway for amyloid precursor protein processing
Erik Portelius et al.
NEUROBIOLOGY OF AGING (2011)
Alzheimer's disease as homeostatic responses to age-related myelin breakdown
George Bartzokis
NEUROBIOLOGY OF AGING (2011)
Pyroglutamate-Aβ 3 and 11 colocalize in amyloid plaques in Alzheimer's disease cerebral cortex with pyroglutamate-Aβ 11 forming the central core
Christopher P. Sullivan et al.
NEUROSCIENCE LETTERS (2011)
Genetic Variant of the Scavenger Receptor BI in Humans
Menno Vergeer et al.
NEW ENGLAND JOURNAL OF MEDICINE (2011)
Site-specific characterization of threonine, serine, and tyrosine glycosylations of amyloid precursor protein/amyloid β-peptides in human cerebrospinal fluid
Adnan Halim et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2011)
Synaptic Pruning by Microglia Is Necessary for Normal Brain Development
Rosa C. Paolicelli et al.
SCIENCE (2011)
Oligodendrocytes: biology and pathology
Monika Bradl et al.
ACTA NEUROPATHOLOGICA (2010)
Astrocytes: biology and pathology
Michael V. Sofroniew et al.
ACTA NEUROPATHOLOGICA (2010)
Mass spectrometric characterization of brain amyloid beta isoform signatures in familial and sporadic Alzheimer's disease
Erik Portelius et al.
ACTA NEUROPATHOLOGICA (2010)
NOX Activity Is Increased in Mild Cognitive Impairment
Annadora J. Bruce-Keller et al.
ANTIOXIDANTS & REDOX SIGNALING (2010)
Biomarkers of oxidative damage and inflammation in Alzheimer's disease
Douglas Galasko et al.
BIOMARKERS IN MEDICINE (2010)
RAGE-dependent signaling in microglia contributes to neuroinflammation, Aβ accumulation, and impaired learning/memory in a mouse model of Alzheimer's disease
Fang Fang et al.
FASEB JOURNAL (2010)
The Class A Scavenger Receptor, Macrophage Receptor with Collagenous Structure, Is the Major Phagocytic Receptor for Clostridium sordellii Expressed by Human Decidual Macrophages
Tennille Thelen et al.
JOURNAL OF IMMUNOLOGY (2010)
The Common Architecture of Cross-β Amyloid
Thomas R. Jahn et al.
JOURNAL OF MOLECULAR BIOLOGY (2010)
Association between the RAGE G82S polymorphism and Alzheimer's disease
Keshen Li et al.
JOURNAL OF NEURAL TRANSMISSION (2010)
Pyroglutamate Abeta pathology in APP/PS1KI mice, sporadic and familial Alzheimer's disease cases
Oliver Wirths et al.
JOURNAL OF NEURAL TRANSMISSION (2010)
Association of the RAGE G82S polymorphism with Alzheimer's disease
Jonny Daborg et al.
JOURNAL OF NEURAL TRANSMISSION (2010)
Microglial activation depends on beta-amyloid conformation: role of the formylpeptide receptor 2
Tony Heurtaux et al.
JOURNAL OF NEUROCHEMISTRY (2010)
Functional and physical interactions between formyl-peptide-receptors and scavenger receptor MARCO and their involvement in amyloid beta 1-42-induced signal transduction in glial cells
Lars-Ove Brandenburg et al.
JOURNAL OF NEUROCHEMISTRY (2010)
Memory Impairment in Transgenic Alzheimer Mice Requires Cellular Prion Protein
David A. Gimbel et al.
JOURNAL OF NEUROSCIENCE (2010)
Norepinephrine Promotes Microglia to Uptake and Degrade Amyloid β Peptide through Upregulation of Mouse Formyl Peptide Receptor 2 and Induction of Insulin-Degrading Enzyme
Yan Kong et al.
JOURNAL OF NEUROSCIENCE (2010)
Glial and neuronal control of brain blood flow
David Attwell et al.
NATURE (2010)
CD36 ligands promote sterile inflammation through assembly of a Toll-like receptor 4 and 6 heterodimer
Cameron R. Stewart et al.
NATURE IMMUNOLOGY (2010)
Evidence that γ-secretase mediates oxidative stress-induced β-secretase expression in Alzheimer's disease
Dong-Gyu Jo et al.
NEUROBIOLOGY OF AGING (2010)
Expression and Signaling of Formyl-Peptide Receptors in the Brain
Fabio Cattaneo et al.
NEUROCHEMICAL RESEARCH (2010)
Genome-wide analysis reveals novel genes influencing temporal lobe structure with relevance to neurodegeneration in Alzheimer's disease
Jason L. Stein et al.
NEUROIMAGE (2010)
Functional characterization of two human receptor activity-modifying protein 3 variants
Richard J. Bailey et al.
PEPTIDES (2010)
Synthetic amyloid-β oligomers impair long-term memory independently of cellular prion protein
Claudia Balducci et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)
Association between NMDA receptor subunit 2b gene polymorphism and Alzheimer's disease in Chinese Han population in Shanghai
Chao Chen et al.
NEUROSCIENCE BULLETIN (2010)
Pyroglutamate Formation Influences Solubility and Amyloidogenicity of Amyloid Peptides
Dagmar Schlenzig et al.
BIOCHEMISTRY (2009)
Polymorphism of Alzheimer's Aβ17-42 (p3) Oligomers: The Importance of the Turn Location and Its Conformation
Yifat Miller et al.
BIOPHYSICAL JOURNAL (2009)
Genetic Variation in N-Methyl-D-Aspartate Receptor Subunit NR3A but Not NR3B Influences Susceptibility to Alzheimer's Disease
Hsin-Ping Liu et al.
DEMENTIA AND GERIATRIC COGNITIVE DISORDERS (2009)
Degradation of Amyloid β Protein by Purified Myelin Basic Protein
Mei-Chen Liao et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2009)
Cutting Edge: NF-κB Activating Pattern Recognition and Cytokine Receptors License NLRP3 Inflammasome Activation by Regulating NLRP3 Expression
Franz G. Bauernfeind et al.
JOURNAL OF IMMUNOLOGY (2009)
Interleukin-1β enhances nucleotide-induced and α-secretase-dependent amyloid precursor protein processing in rat primary cortical neurons via up-regulation of the P2Y2 receptor
Qiongman Kong et al.
JOURNAL OF NEUROCHEMISTRY (2009)
Aβ43 is more frequent than Aβ40 in amyloid plaque cores from Alzheimer disease brains
Hedvig Welander et al.
JOURNAL OF NEUROCHEMISTRY (2009)
Aminopeptidase A contributes to the N-terminal truncation of amyloid β-peptide
Jean Sevalle et al.
JOURNAL OF NEUROCHEMISTRY (2009)
Distinct fractional Aβ release patterns in human mononuclear phagocytes
Juan Manuel Maier et al.
JOURNAL OF NEUROIMMUNOLOGY (2009)
Amyloid Precursor Protein Mediates a Tyrosine Kinase-Dependent Activation Response in Endothelial Cells
Susan A. Austin et al.
JOURNAL OF NEUROSCIENCE (2009)
CD14 and Toll-Like Receptors 2 and 4 Are Required for Fibrillar Aβ-Stimulated Microglial Activation
Erin G. Reed-Geaghan et al.
JOURNAL OF NEUROSCIENCE (2009)
Resting Microglia Directly Monitor the Functional State of Synapses In Vivo and Determine the Fate of Ischemic Terminals
Hiroaki Wake et al.
JOURNAL OF NEUROSCIENCE (2009)
RAGE (Receptor for Advanced Glycation Endproducts), RAGE Ligands, and their role in Cancer and Inflammation
Louis J. Sparvero et al.
JOURNAL OF TRANSLATIONAL MEDICINE (2009)
Microglial activation and amyloid deposition in mild cognitive impairment A PET study
A. Okello et al.
NEUROLOGY (2009)
Factors associated with resistance to dementia despite high Alzheimer disease pathology
D. Erten-Lyons et al.
NEUROLOGY (2009)
Association between NR2B subunit gene (GRIN2B) promoter polymorphisms and sporadic Alzheimer's disease in the North Chinese population
Hanqiu Jiang et al.
NEUROSCIENCE LETTERS (2009)
Prions: Protein Aggregation and Infectious Diseases
Adriano Aguzzi et al.
PHYSIOLOGICAL REVIEWS (2009)
Tripartite synapses: astrocytes process and control synaptic information
Gertrudis Perea et al.
TRENDS IN NEUROSCIENCES (2009)
DNA damage-inducing agents elicit γ-secretase activation mediated by oxidative stress
S. M. Jin et al.
CELL DEATH AND DIFFERENTIATION (2008)
A soluble form of the receptor for advanced glycation endproducts (RAGE) is produced by proteolytic cleavage of the membrane-bound form by the sheddase a disintegrin and metalloprotease 10 (ADAM10)
Angela Raucci et al.
FASEB JOURNAL (2008)
p3 peptide, a truncated form of Aβ devoid of synaptotoxic effect, does not assemble into soluble oligomers
Fabienne Dulin et al.
FEBS LETTERS (2008)
Increased expression of the γ-secretase components presenilin-1 and nicastrin in activated astrocytes and microglia following traumatic brain injury
Yasmine Nadler et al.
GLIA (2008)
Receptor for Advanced Glycation End Products Is Subjected to Protein Ectodomain Shedding by Metalloproteinases
Ling Zhang et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2008)
Interleukin-1β up-regulates TACE to enhance α-cleavage of APP in neurons:: resulting decrease in Aβ production
Yuriko Tachida et al.
JOURNAL OF NEUROCHEMISTRY (2008)
Inhibition of glutaminyl cyclase prevents pGlu-Aβ formation after intracortical/hippocampal microinjection in vivo/in situ
Stephen Schilling et al.
JOURNAL OF NEUROCHEMISTRY (2008)
Toll-like receptor 4-dependent upregulation of cytokines in a transgenic mouse model of Alzheimer's disease
Jing-Ji Jin et al.
JOURNAL OF NEUROINFLAMMATION (2008)
Amyloid β protein dimer-containing human CSF disrupts synaptic plasticity:: Prevention by systemic passive immunization
Igor Klyubin et al.
JOURNAL OF NEUROSCIENCE (2008)
Toll-like receptor 2 acts as a natural innate immune receptor to clear amyloid β1-42 and delay the cognitive decline in a mouse model of Alzheimer's disease
Karine L. Richard et al.
JOURNAL OF NEUROSCIENCE (2008)
Expression of the receptor for advanced glycation end products in Oligodendrocytes in response to oxidative stress
Jingdong Qin et al.
JOURNAL OF NEUROSCIENCE RESEARCH (2008)
Amyloid-β protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory
Ganesh M. Shankar et al.
NATURE MEDICINE (2008)
Involvement of formyl-peptide-receptor-like-1 and phospholipase D in the internalization and signal transduction of amyloid beta 1-42 in glial cells
L. -O. Brandenburg et al.
NEUROSCIENCE (2008)
DIFFERENTIAL EXPRESSION OF FIVE MEMBERS OF THE ADAM FAMILY IN THE DEVELOPING CHICKEN BRAIN
J. Lin et al.
NEUROSCIENCE (2008)
Cellular prion protein regulates β-secretase cleavage of the Alzheimer's amyloid precursor protein
Edward T. Parkin et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)
Sustained hippocampal IL-1β overexpression mediates chronic neuroinflammation and ameliorates Alzheimer plaque pathology
Solomon S. Shaftel et al.
JOURNAL OF CLINICAL INVESTIGATION (2007)
Aspects of β-amyloid as a biomarker for Alzheimer's disease
Ulf Andreasson et al.
BIOMARKERS IN MEDICINE (2007)
The Alzheimer's peptides Aβ40 and 42 adopt distinct conformations in water:: A combined MD/NMR study
Nikolaos G. Sgourakis et al.
JOURNAL OF MOLECULAR BIOLOGY (2007)
Internalization of PrP106-126 by the formyl-peptide-receptor-like-1 in glial cells
Lars-Ove Brandenburg et al.
JOURNAL OF NEUROCHEMISTRY (2007)
Resolvin E1 selectively interacts with leukotriene B4 receptor BLT1 and ChemR23 to regulate inflammation
Makoto Arita et al.
JOURNAL OF IMMUNOLOGY (2007)
Association of the Gly82Ser polymorphism in the receptor for advanced glycation end products (RAGE) gene with circulating levels of soluble RAGE and inflammatory markers in nondiabetic and nonobese Koreans
Yangsoo Jang et al.
METABOLISM-CLINICAL AND EXPERIMENTAL (2007)
Role of the toll-like receptor 4 in neuro-inflammation in Alzheimer's disease
Silke Walter et al.
CELLULAR PHYSIOLOGY AND BIOCHEMISTRY (2007)
The cellular prion protein (PrPC): Its physiological function and role in disease
Laura Westergard et al.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2007)
Formyl peptide receptors: A promiscuous subfamily of G protein-coupled receptors controlling immune responses
Isabelle Migeotte et al.
CYTOKINE & GROWTH FACTOR REVIEWS (2006)
High sensitivity analysis of amyloid-beta peptide composition in amyloid deposits from human and PS2APP mouse brain
A. Guentert et al.
NEUROSCIENCE (2006)
Role of toll-like receptor signalling in Aβ uptake and clearance
Kazuki Tahara et al.
BRAIN (2006)
Intraneuronal β-amyloid aggregates, neurodegeneration, and neuron loss in transgenic mice with five familial Alzheimer's disease mutations:: Potential factors in amyloid plaque formation
Holly Oakley et al.
JOURNAL OF NEUROSCIENCE (2006)
Inhibition of glutaminyl cyclase alters pyroglutamate formation in mammalian cells
Holger Cynis et al.
BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS (2006)
Effects of solvent on the structure of the Alzheimer amyloid-β(25-35) peptide
Guanghong Wei et al.
BIOPHYSICAL JOURNAL (2006)
Aβ42-driven cerebral amyloidosis in transgenic mice reveals early and robust pathology
Rebecca Radde et al.
EMBO REPORTS (2006)
Possible role of scavenger receptor SRCL in the clearance of amyloid-β in Alzheimer's disease.
Kenji Nakamura et al.
JOURNAL OF NEUROSCIENCE RESEARCH (2006)
Equimolar production of amyloid β-protein and amyloid precursor protein intracellular domain from β-carboxyl-terminal fragment by β-secretase
Nobuto Kakuda et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2006)
Toll-like receptors in central nervous system glial inflammation and homeostasis
T Kielian
JOURNAL OF NEUROSCIENCE RESEARCH (2006)
A specific amyloid-β protein assembly in the brain impairs memory
S Lesné et al.
NATURE (2006)
Astrocyte-endothelial interactions at the blood-brain barrier
NJ Abbott et al.
NATURE REVIEWS NEUROSCIENCE (2006)
Solvent and mutation effects on the nucleation of amyloid β-protein folding
L Cruz et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)
BACE1, a major determinant of selective vulnerability of the brain to amyloid-β amyloidogenesis, is essential for cognitive, emotional, and synaptic functions
FM Laird et al.
JOURNAL OF NEUROSCIENCE (2005)
Recombinant prion protein induces rapid polarization and development of synapses in embryonic rat hippocampal neurons in vitro
J Kanaani et al.
JOURNAL OF NEUROCHEMISTRY (2005)
MARCO is the major binding receptor for unopsonized particles and bacteria on human alveolar macrophages
MS Arredouani et al.
JOURNAL OF IMMUNOLOGY (2005)
Prion protein (PrPc) promotes β-amyloid plaque formation
KA Schwarze-Eicker et al.
NEUROBIOLOGY OF AGING (2005)
Structure of the cross-β spine of amyloid-like fibrils
R Nelson et al.
NATURE (2005)
Resting microglial cells are highly dynamic surveillants of brain parenchyma in vivo
A Nimmerjahn et al.
SCIENCE (2005)
Natural oligomers of the amyloid-protein specifically disrupt cognitive function
JP Cleary et al.
NATURE NEUROSCIENCE (2005)
CD36 overexpression in human brain correlates with β-amyloid deposition but not with Alzheimer's disease
R Ricciarelli et al.
FREE RADICAL BIOLOGY AND MEDICINE (2004)
Amyloid precursor protein mediates proinflammatory activation of monocytic lineage cells
CM Sondag et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
TRPM2 channel opening in response to oxidative stress is dependent on activation of poly(ADP-ribose) polymerase
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BRITISH JOURNAL OF PHARMACOLOGY (2004)
Pauling and Corey's α-pleated sheet structure may define the prefibrillar amyloidogenic intermediate in amyloid disease
RS Armen et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2004)
LRP/amyloid β-peptide interaction mediates differential brain efflux of Aβ isoforms
R Deane et al.
NEURON (2004)
Microglial phagocytosis of fibrillar β-amyloid through a β1 integrin-dependent mechanism
J Koenigsknecht et al.
JOURNAL OF NEUROSCIENCE (2004)
The LPS receptor (CD14) links innate immunity with Alzheimer's disease
K Fassbender et al.
FASEB JOURNAL (2004)
Cerebrospinal Fluid Profile of Amyloid beta Peptides in Patients with Alzheimer's Disease Determined by Protein Biochip Technology
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NEURODEGENERATIVE DISEASES (2004)
Neprilysin regulates amyloid beta peptide levels
RA Marr et al.
JOURNAL OF MOLECULAR NEUROSCIENCE (2004)
Loss of TGF-β1 leads to increased neuronal cell death and microgliosis in mouse brain
TC Brionne et al.
NEURON (2003)
Aβ protofibrils possess a stable core structure resistant to hydrogen exchange
I Kheterpal et al.
BIOCHEMISTRY (2003)
Tissue-specific expression patterns of the RAGE receptor and its soluble forms - a result of regulated alternative splicing?
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BIOCHIMICA ET BIOPHYSICA ACTA-GENE STRUCTURE AND EXPRESSION (2003)
CD36 mediates the innate host response to β-amyloid
JB El Khoury et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2003)
Truncated beta-amyloid peptide species in pre-clinical Alzheimer's disease as new targets for the vaccination approach
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JOURNAL OF NEUROCHEMISTRY (2003)
β-amyloid racemized at the Ser26 residue in the brains of patients with Alzheimer disease:: Implications in the pathogenesis of Alzheimer disease
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JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY (2003)
Association of the 3′ UTR transcription factor LBP-1c/CP2/LSF polymorphism with late-onset Alzheimer's disease
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AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS (2003)
Changes in expression of amyloid precursor protein and interleukin-1β after experimental traumatic brain injury in rats
JR Ciallella et al.
JOURNAL OF NEUROTRAUMA (2002)
Conversion of PrP to a self-perpetuating PrPSc-like conformation in the cytosol
JY Ma et al.
SCIENCE (2002)
Solution structure of the Alzheimer amyloid β-peptide (1-42) in an apolar microenvironment -: Similarity with a virus fusion domain
O Crescenzi et al.
EUROPEAN JOURNAL OF BIOCHEMISTRY (2002)
Characterization of recombinant soluble macrophage scavenger receptor MARCO
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JOURNAL OF BIOLOGICAL CHEMISTRY (2002)
Aβ 17-42 in Alzheimer's disease activates JNK and caspase-8 leading to neuronal apoptosis
WL Wei et al.
BRAIN (2002)
Oligomeric and fibrillar species of amyloid-β peptides differentially affect neuronal viability
KN Dahlgren et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2002)
Oxidative stress increases expression and activity of BACE in NT2 neurons
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NEUROBIOLOGY OF DISEASE (2002)
Prion protein is secreted in soluble forms in the epididymal fluid and proteolytically processed and transported in seminal plasma
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BIOLOGY OF REPRODUCTION (2002)
Highly conserved and disease-specific patterns of carboxyterminally truncated Aβ peptides 1-37/38/39 in addition to 1-40/42 in Alzheimer's disease and in patients with chronic neuroinflammation
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JOURNAL OF NEUROCHEMISTRY (2002)
CD36, a class B scavenger receptor, is expressed on microglia in Alzheimer's disease brains and can mediate production of reactive oxygen species in response to beta-amyloid fibrils
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AMERICAN JOURNAL OF PATHOLOGY (2002)
Association analysis for the genetic variants of the NMDA receptor subunit 2b and Alzheimer's disease
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DEMENTIA AND GERIATRIC COGNITIVE DISORDERS (2002)
β amyloid peptide (Aβ42) is internalized via the G-protein-coupled receptor FPRL1 and forms fibrillar aggregates in macrophages
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FASEB JOURNAL (2001)
Hematologically important mutations: Leukocyte adhesion deficiency
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BLOOD CELLS MOLECULES AND DISEASES (2001)
Oxidation of aβ and plaque biogenesis in Alzheimer's disease and Down syndrome
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NEUROBIOLOGY OF DISEASE (2001)
Involvement of microglial receptor for advanced glycation endproducts (RAGE) in Alzheimer's disease: Identification of a cellular activation mechanism
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EXPERIMENTAL NEUROLOGY (2001)
Amyloid-β induces chemotaxis and oxidant stress by acting at formylpeptide receptor 2, a G protein-coupled receptor expressed in phagocytes and brain
HL Tiffany et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2001)
Antioxidant defences and oxidative stress markers in erythrocytes and plasma from normally nourished elderly Alzheimer patients
I Bourdel-Marchasson et al.
AGE AND AGEING (2001)
Amyloid-β peptide fragments p3 and p4 induce pro-inflammatory cytokine and chemokine production in vitro and in vivo
AM Szczepanik et al.
JOURNAL OF NEUROCHEMISTRY (2001)
Scavenger receptor class B type I (SR-BI) mediates adhesion of neonatal murine microglia to fibrillar β-amyloid
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JOURNAL OF NEUROIMMUNOLOGY (2001)
BACE1 is the major β-secretase for generation of Aβ peptides by neurons
HB Cai et al.
NATURE NEUROSCIENCE (2001)
Amyloid β42 activates a G-protein-coupled chemoattractant receptor, FPR-Like-1
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JOURNAL OF NEUROSCIENCE (2001)
Aβ peptide immunization reduces behavioural impairment and plaques in a model of Alzheimer's disease
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NATURE (2000)
Amyloid fibril formation by Aβ16-22, a seven-residue fragment of the Alzheimer's β-amyloid peptide, and structural characterization by solid state NMR
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BIOCHEMISTRY (2000)
Peripherally administered antibodies against amyloid β-peptide enter the central nervous system and reduce pathology in a mouse model of Alzheimer disease
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NATURE MEDICINE (2000)
Amyloid precursor protein gene isoforms in Alzheimer's disease and other neurodegenerative disorders
PK Panegyres et al.
JOURNAL OF THE NEUROLOGICAL SCIENCES (2000)
Cell mediators of inflammation in the Alzheimer disease brain
H Akiyama et al.
ALZHEIMER DISEASE & ASSOCIATED DISORDERS (2000)
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