期刊
CANCERS
卷 14, 期 18, 页码 -出版社
MDPI
DOI: 10.3390/cancers14184495
关键词
CTRP1; NF-kappa B; metastasis; tumor progression
类别
资金
- National Research Foundation of Korea (NRF) - Korean government [2019R1A2C1006511, 2020R1I1A1A01051824]
- National Research Foundation of Korea [2019R1A2C1006511, 2020R1I1A1A01051824] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
CTRP1 plays a critical role in tumor progression, and knockout of CTRP1 gene can inhibit cell proliferation, invasion, and tumor growth. Elevated levels of CTRP1 are associated with poor prognosis.
C1q and TNF-related 1 (C1QTNF1/CTRP1) is an adiponectin-associated protein belonging to the C1q/TNF-related protein family. Recent studies have shown that the C1q and TNF-related protein (CTRP) family is involved in cancer progression; however, the specific role of CTRP1 in tumor progression has not yet been elucidated. To examine the role of CTRP1 in tumor progression, we generated CTRP1 knockout A549 and HCT116 cell lines, which reduced the expression levels of nuclear factor (NF)-kappa B-dependent and metastasis-promoting transcripts. We demonstrated that CTRP1 knockout inhibited the cell proliferation and invasion and tumor growth. Finally, database analysis showed that CTRP1 expression was upregulated in metastatic cancers and elevated levels of CTRP1 were associated with poor prognosis. These results suggest that CTRP1 expression contributes to NF-kappa B signaling and promotes tumor progression.
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