4.6 Article

Increased Density of Growth Differentiation Factor-15+Immunoreactive M1/M2 Macrophages in Prostate Cancer of Different Gleason Scores Compared with Benign Prostate Hyperplasia

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Review Biochemistry & Molecular Biology

Pathophysiological role of growth differentiation factor 15 (GDF15) in obesity, cancer, and cachexia

Jawed Akhtar Siddiqui et al.

Summary: Growth differentiation factor 15 or macrophage inhibitory cytokine-1 (GDF15/MIC-1) is a divergent member of the transforming growth factor beta superfamily and has diverse pathophysiological roles in cancers, cardiometabolic disorders, and other diseases. Its role in cancer development and progression is complicated and depends on the specific cancer type and stage, and its mechanisms are related to its receptor GFRAL.

CYTOKINE & GROWTH FACTOR REVIEWS (2022)

Article Biochemistry & Molecular Biology

Identification of immune-based prostate cancer subtypes using mRNA expression

Jukun Song et al.

Summary: This study examined immune cell profiling in prostate cancer, identifying multiple molecular subtypes and investigating their specific clinical characteristics and functional enrichment. Algorithms were used to predict clinical responses and potential chemotherapeutic targets. Results showed an association between a specific subtype and advanced PCa, which was more likely to respond to immunotherapy.

BIOSCIENCE REPORTS (2021)

Review Cell Biology

The Importance of Exosomal PD-L1 in Cancer Progression and Its Potential as a Therapeutic Target

Lingxiao Ye et al.

Summary: The binding of PD-L1 with its receptor PD-1 can deactivate cytotoxic T lymphocytes, facilitating immune escape of tumors. Exosomal PD-L1 derived from tumor cells is implicated in drug resistance. The potential of circulating exosomal PD-L1 as a clinical indicator and therapeutic targeting strategies are discussed, including inhibiting exosome biogenesis or secretion.
Article Andrology

Semen sampling as a simple, noninvasive surrogate for prostate health screening

Gisela Lorente et al.

Summary: The potential of ejaculate screening in prostate cancer, differentiation between vasectomy and prostate pathology using specific small RNAs, and the development of a noninvasive test for monitoring prostate health are supported by the study.

SYSTEMS BIOLOGY IN REPRODUCTIVE MEDICINE (2021)

Article Oncology

The immune checkpoint regulator PD-L1 expression are associated with clinical progression in prostate cancer

Juan He et al.

Summary: This study found that PD-L1 expression is significantly higher in prostate cancer cases compared to benign tissues, while PD-1 expression showed no significant difference. PD-L1 expression correlated with Gleason score and may be associated with the progression of prostate cancer.

WORLD JOURNAL OF SURGICAL ONCOLOGY (2021)

Article Oncology

Investigation of Neural Microenvironment in Prostate Cancer in Context of Neural Density, Perineural Invasion, and Neuroendocrine Profile of Tumors

Dawid Sigorski et al.

Summary: The study revealed differences in neural parameters between prostate cancer and benign prostate, with a heterogeneous neural network in PCa. Higher neural density was observed in the surrounding and invasive front of the tumor. NPY expression, neuroendocrine differentiation, and ERG status were found to be related to ND and PNI. The findings provide evidence for autocrine and paracrine interactions in the neural microenvironment of prostate cancer.

FRONTIERS IN ONCOLOGY (2021)

Article Oncology

Cancer statistics, 2020

Rebecca L. Siegel et al.

CA-A CANCER JOURNAL FOR CLINICIANS (2020)

Review Urology & Nephrology

Tumour innervation and neurosignalling in prostate cancer

Brayden March et al.

NATURE REVIEWS UROLOGY (2020)

Review Cell Biology

Complexity of Neural Component of Tumor Microenvironment in Prostate Cancer

Aleksandra Sejda et al.

PATHOBIOLOGY (2020)

Review Endocrinology & Metabolism

GDF15: A Hormone Conveying Somatic Distress to the Brain

Samuel M. Lockhart et al.

ENDOCRINE REVIEWS (2020)

Article Oncology

Growth differentiation factor 15 (GDF15) in cancer cell metastasis: from the cells to the patients

Anna Spanopoulou et al.

CLINICAL & EXPERIMENTAL METASTASIS (2020)

Review Cell Biology

Nerves in the Tumor Microenvironment: Origin and Effects

Wenjun Wang et al.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2020)

Article Oncology

Immune infiltration in renal cell carcinoma

Shichao Zhang et al.

CANCER SCIENCE (2019)

Article Oncology

UCHL1 loss alters the cell cycle in metastatic pancreatic neuroendocrine tumors

Brendan M. Finnerty et al.

ENDOCRINE-RELATED CANCER (2019)

Review Oncology

Tumor Neurobiology and the War of Nerves in Cancer

Sam Faulkner et al.

CANCER DISCOVERY (2019)

Article Oncology

Growth and differentiation factor 15 regulates PD-L1 expression in glioblastoma

Haiqin Peng et al.

CANCER MANAGEMENT AND RESEARCH (2019)

Review Immunology

Interaction of neurotransmitters and neurochemicals with lymphocytes

Daniel Kerage et al.

JOURNAL OF NEUROIMMUNOLOGY (2019)

Article Pathology

Neuroendocrine tumors of the prostate

Samson W. Fine

MODERN PATHOLOGY (2018)

Review Immunology

Mast Cell, the Neglected Member of the Tumor Microenvironment: Role in Breast Cancer

Angelica Aponte-Lopez et al.

JOURNAL OF IMMUNOLOGY RESEARCH (2018)

Review Medicine, Research & Experimental

The evolving relationship of wound healing and tumor stroma

Deshka S. Foster et al.

JCI INSIGHT (2018)

Article Biochemistry & Molecular Biology

Neuroendocrine Cells of the Prostate Derive from the Neural Crest

Jaroslaw Szczyrba et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2017)

Article Medicine, Research & Experimental

Histopathology of Prostate Cancer

Peter A. Humphrey

COLD SPRING HARBOR PERSPECTIVES IN MEDICINE (2017)

Review Oncology

Immune Cell Population in Ovarian Tumor Microenvironment

Dong Li Cai et al.

JOURNAL OF CANCER (2017)

Review Oncology

Nerve-Cancer Cell Cross-talk: A Novel Promoter of Tumor Progression

Phillip Jobling et al.

CANCER RESEARCH (2015)

Article Endocrinology & Metabolism

Reduced Expression of GDF-15 Is Associated With Atrophic Inflammatory Lesions of the Prostate

James R. Lambert et al.

PROSTATE (2015)

Review Pharmacology & Pharmacy

The diverse roles of nonsteroidal anti-inflammatory drug activated gene (NAG-1/GDF15) in cancer

Xingya Wang et al.

BIOCHEMICAL PHARMACOLOGY (2013)

Review Oncology

Growth/differentiation factor-15: prostate cancer suppressor or promoter?

P. Vanhara et al.

PROSTATE CANCER AND PROSTATIC DISEASES (2012)

Review Biochemical Research Methods

Ubiquitin C-Terminal Hydrolase L1 in Tumorigenesis

Jennifer Hurst-Kennedy et al.

BIOCHEMISTRY RESEARCH INTERNATIONAL (2012)

Article Endocrinology & Metabolism

Human prostate cancer cells express neuroendocrine cell markers PGP 9.5 and chromogranin A

Aaron Leiblich et al.

PROSTATE (2007)

Article Biochemistry & Molecular Biology

Tumor-induced anorexia and weight loss are mediated by the TGF-β superfamily cytokine MIC-1

Heiko Johnen et al.

NATURE MEDICINE (2007)

Article Medicine, General & Internal

Expression profiling of PC-3 cell line variants and comparison of MIC-I transcript levels in benign and malignant prostate

L. Patrikainen et al.

EUROPEAN JOURNAL OF CLINICAL INVESTIGATION (2007)

Article Multidisciplinary Sciences

Large-scale delineation of secreted protein biomarkers overexpressed in cancer tissue and serum

JB Welsh et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2003)