☆ 4.6 Review

Changing Landscape in the Treatment of Adult Acute Lymphoblastic Leukemia (ALL)

CANCERS (2022)

相关参考文献

注意：仅列出部分参考文献，下载原文获取全部文献信息。

Article Oncology

Disease Burden Affects Outcomes in Pediatric and Young Adult B-Cell Lymphoblastic Leukemia After Commercial Tisagenlecleucel: A Pediatric Real-World Chimeric Antigen Receptor Consortium Report

Liora M. Schultz et al.

Summary: Commercial tisagenlecleucel demonstrates efficacy and tolerability in patients with relapsed and refractory B-ALL. The study finds that high disease burden is associated with inferior overall survival, event-free survival, and increased toxicity.

JOURNAL OF CLINICAL ONCOLOGY (2022)

添加到收藏夹

Article Oncology

Prognostic impact of chromosomal abnormalities and copy number alterations in adult B-cell precursor acute lymphoblastic leukaemia: a UKALL14 study

Anthony Moorman et al.

Summary: Chromosomal abnormalities have a significant prognostic impact on patients with B-cell precursor ALL, with specific abnormalities like KMT2A-AFF1, complex karyotype, and low hypodiploidy/near-triploidy associated with poor outcomes. Patients with BCR-ABL1 have similar outcomes to others, while JAK-STAT abnormalities are linked to a high relapse rate of 56%.

LEUKEMIA (2022)

添加到收藏夹

Article Hematology

CD34+CD19-CD22+ B-cell progenitors may underlie phenotypic escape in patients treated with CD19-directed therapies

Clara Bueno et al.

Summary: CD19-directed immunotherapies have greatly improved the treatment of B-cell acute lymphoblastic leukemia (B-ALL). However, many patients still experience relapse. This study reveals the presence of pre-leukemic CD34(+)CD19(-)CD22(+) cells, which may contribute to phenotypic escape after CD19-directed immunotherapies.

BLOOD (2022)

添加到收藏夹

Review Oncology

The 5th edition of the World Health Organization Classification of Haematolymphoid Tumours: Lymphoid Neoplasms

Rita Alaggio et al.

Summary: This article provides an overview of the upcoming 5th edition of the World Health Organization classification of lymphoid tumors, highlighting changes from the previous edition such as reorganization of entities, modification of nomenclature, revision of diagnostic criteria, deletion of entities, introduction of new entities, and inclusion of tumor-like lesions.

LEUKEMIA (2022)

添加到收藏夹

Article Hematology

Early autologous and allogeneic peripheral blood stem cell transplantation for adult patients with acute B and T cell precursor neoplasms: a 12-year single center experience

Normann Steiner et al.

Summary: This study retrospectively analyzed the outcomes of early autologous and allogeneic stem cell transplantation in lymphoblastic leukemia patients. The 10-year overall survival rates were 45% after autologous transplantation and 58% after allogeneic transplantation.

ANNALS OF HEMATOLOGY (2021)

添加到收藏夹

Article Hematology

A multicenter total therapy strategy for de novo adult Philadelphia chromosome positive acute lymphoblastic leukemia patients: final results of the GIMEMA LAL1509 protocol

Sabina Chiaretti et al.

Summary: The study showed that long-term survival can be achieved in adult Philadelphia chromosome positive acute lymphoblastic leukemia patients with a total-therapy strategy based on chemotherapy-free induction and, in complete molecular responders, without further systemic chemotherapy. Patients with additional copy number aberrations exhibited worse survival outcomes, highlighting the importance of screening for these abnormalities in diagnostic work-up.

HAEMATOLOGICA (2021)

添加到收藏夹

Article Oncology

Venetoclax and navitoclax in Combination with Chemotherapy in Patients with Relapsed or Refractory Acute Lymphoblastic Leukemia and Lymphoblastic Lymphoma

Vinod A. Pullarkat et al.

Summary: In this phase I study, combining venetoclax with low-dose navitoclax and chemotherapy showed good tolerability and promising efficacy in patients with relapsed/refractory acute lymphoblastic leukemia or lymphoblastic lymphoma. Responses were observed in patients across histologic and genomic subtypes, even in those who had failed stem cell transplant therapies.

CANCER DISCOVERY (2021)

添加到收藏夹

Article Hematology

KTE-X19 anti-CD19 CAR T-cell therapy in adult relapsed/refractory acute lymphoblastic leukemia: ZUMA-3 phase 1 results

Bijal D. Shah et al.

Summary: The ZUMA-3 study evaluated the efficacy and safety of KTE-X19 in adults with relapsed/refractory B-cell acute lymphoblastic leukemia. The treatment showed a high response rate and tolerable safety profile, with revised adverse event management strategies helping to optimize the risk-benefit ratio.

BLOOD (2021)

添加到收藏夹

Article Hematology

Chemotherapy or allogeneic transplantation in high-risk Philadelphia chromosome-negative adult lymphoblastic leukemia

Josep-Maria Ribera et al.

Summary: The study evaluated the outcomes of high-risk Ph- adult ALL patients treated with chemotherapy or allo-HSCT, finding that avoiding allo-HSCT for patients with adequate MRD response does not affect outcomes.

BLOOD (2021)

添加到收藏夹

Article Hematology

Molecular classification improves risk assessment in adult BCR-ABL1-negative B-ALL

Elisabeth Paietta et al.

Summary: Genomic analysis in adults with B-lineage acute lymphoblastic leukemia revealed distinct survival outcomes associated with different genetic subtypes, highlighting the potential for future therapeutic benefits based on genomic characteristics.

BLOOD (2021)

添加到收藏夹

Article Oncology

Hyper-CVAD plus ofatumumab versus hyper-CVAD plus rituximab as frontline therapy in adults with Philadelphia chromosome-negative acute lymphoblastic leukemia: A propensity score analysis

Koji Sasaki et al.

Summary: The study compared the efficacy of different treatment regimens in patients with acute lymphoblastic leukemia, showing that hyper-CVAD + ofatumumab was more effective than hyper-CVAD + Rituximab in patients with Philadelphia chromosome-negative ALL.

CANCER (2021)

添加到收藏夹

Article Medicine, General & Internal

KTE-X19 for relapsed or refractory adult B-cell acute lymphoblastic leukaemia: phase 2 results of the single-arm, open-label, multicentre ZUMA-3 study

Bijal D. Shah et al.

Summary: KTE-X19 demonstrated a high rate of complete remission or complete remission with incomplete haematological recovery in adult patients with relapsed or refractory B-precursor acute lymphoblastic leukaemia. Median overall survival was not reached in responding patients, and the therapy showed a manageable safety profile. These findings suggest that KTE-X19 has the potential to provide long-term clinical benefit to these patients.

LANCET (2021)

添加到收藏夹

Review Genetics & Heredity

T-Cell Acute Lymphoblastic Leukemia: Biomarkers and Their Clinical Usefulness

Valentina Bardelli et al.

Summary: T-ALL is an immature lymphoid tumor affecting bone marrow, lymphoid organs, etc. It is a heterogeneous disease caused by multiple genetic abnormalities.

GENES (2021)

添加到收藏夹

Article Oncology

Blinatumomab compared with standard of care for the treatment of adult patients with relapsed/refractory Philadelphia chromosome-positive B-precursor acute lymphoblastic leukemia

Alessandro Rambaldi et al.

CANCER (2020)

添加到收藏夹

Review Biochemistry & Molecular Biology

Minimal Residual Disease Detection in Acute Lymphoblastic Leukemia

Aaron Kruse et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

添加到收藏夹

Review Oncology

Novel Therapies in the Treatment of Adult Acute Lymphoblastic Leukemia

Alexander Gavralidis et al.

CURRENT HEMATOLOGIC MALIGNANCY REPORTS (2020)

添加到收藏夹

Article Medicine, General & Internal

Dasatinib-Blinatumomab for Ph-Positive Acute Lymphoblastic Leukemia in Adults

Robin Foa et al.

NEW ENGLAND JOURNAL OF MEDICINE (2020)

添加到收藏夹

Meeting Abstract Hematology

Reduced-Intensity Chemotherapy with Mini-Hyper-CVD Plus Inotuzumab Ozogamicin, with or without Blinatumomab, in Older Adults with Newly Diagnosed Philadelphia Chromosome-Negative Acute Lymphoblastic Leukemia: Results from a Phase II Study

Nicholas J. Short et al.

BLOOD (2020)

添加到收藏夹

Meeting Abstract Hematology

Interim Results of the Phase I/II Study of the Ponatinib, Venetoclax and Dexamethasone for Patients with Relapsed or Refractory Philadelphia Chromosome-Positive Acute Lymphoblastic Leukemia

Nicholas J. Short et al.

BLOOD (2020)

添加到收藏夹

Article Hematology

Blinatumomab for Acute Lymphoblastic Leukemia Relapse after Allogeneic Hematopoietic Stem Cell Transplantation

Anthony S. Stein et al.

BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION (2019)

添加到收藏夹

Review Biochemistry & Molecular Biology

Next-Generation Sequencing in Acute Lymphoblastic Leukemia

Nicoletta Coccaro et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)

添加到收藏夹

Meeting Abstract Hematology

Phase II Study of the Hyper-CVAD Regimen in Combination with Ofatumumab (HCVAD-O) As Frontline Therapy for Adult Patients (pts) with CD20-Positive B-Cell Acute Lymphoblastic Leukemia (B-ALL)

Guillaume Richard-Carpentier et al.

BLOOD (2019)

添加到收藏夹

Meeting Abstract Hematology

Updated Results from the Phase II Study of Hyper-CVAD in Sequential Combination with Blinatumomab in Newly Diagnosed Adults with B-Cell Acute Lymphoblastic Leukemia (B-ALL)

Guillaume Richard-Carpentier et al.

BLOOD (2019)

添加到收藏夹

Review Biophysics

Hematopoietic stem cell transplantation for adults with Philadelphia chromosome-negative acute lymphoblastic leukemia in first remission: a position statement of the European Working Group for Adult Acute Lymphoblastic Leukemia (EWALL) and the Acute Leukemia Working Party of the European Society for Blood and Marrow Transplantation (EBMT)

Sebastian Giebel et al.

BONE MARROW TRANSPLANTATION (2019)

添加到收藏夹

Meeting Abstract Hematology

SWOG 1312 Final Results: A Phase 1 Trial of Inotuzumab in Combination with CVP (Cyclophosphamide, Vincristine, Prednisone) for Relapsed/ Refractory CD22+Acute Leukemia

Anjali S. Advani et al.

BLOOD (2019)

添加到收藏夹

Meeting Abstract Hematology

Long-Term Safety and Efficacy of Hyper-CVAD Plus Ponatinib As Frontline Therapy for Adults with Philadelphia Chromosome-Positive Acute Lymphoblastic Leukemia

Nicholas J. Short et al.

BLOOD (2019)

添加到收藏夹

Article Biochemistry & Molecular Biology

Discovery of a ZIP7 inhibitor from a Notch pathway screen

Erin Nolin et al.

NATURE CHEMICAL BIOLOGY (2019)

添加到收藏夹

Review Hematology

Toxicities of CD19 CAR-T cell immunotherapy

Alexandre V. Hirayama et al.

AMERICAN JOURNAL OF HEMATOLOGY (2019)

添加到收藏夹

Article Hematology

Minimal residual disease level predicts outcome in adults with Ph-negative B-precursor acute lymphoblastic leukemia

Nicola Goekbuget et al.

HEMATOLOGY (2019)

添加到收藏夹

Review Oncology

Managing CNS disease in adults with acute lymphoblastic leukemia

Richard A. Larson

LEUKEMIA & LYMPHOMA (2018)

添加到收藏夹

Article Oncology

Inotuzumab ozogamicin in combination with low-intensity chemotherapy for older patients with Philadelphia chromosome-negative acute lymphoblastic leukaemia: a single-arm, phase 2 study

Hagop Kantarjian et al.

LANCET ONCOLOGY (2018)

添加到收藏夹

Article Medicine, General & Internal

Long-Term Follow-up of CD19 CAR Therapy in Acute Lymphoblastic Leukemia

Jae H. Park et al.

NEW ENGLAND JOURNAL OF MEDICINE (2018)

添加到收藏夹

Article Medicine, General & Internal

Tisagenlecleucel in Children and Young Adults with B-Cell Lymphoblastic Leukemia

S. L. Maude et al.

NEW ENGLAND JOURNAL OF MEDICINE (2018)

添加到收藏夹

Review Oncology

Acute lymphoblastic leukemia and lymphoblastic lymphoma in adolescents and young adults

Jennifer L. McNeer et al.

PEDIATRIC BLOOD & CANCER (2018)

添加到收藏夹

Review Oncology

Pediatric-Inspired Treatment Regimens for Adolescents and Young Adults With Philadelphia Chromosome-Negative Acute Lymphoblastic Leukemia A Review

Stuart E. Siegel et al.

JAMA ONCOLOGY (2018)

添加到收藏夹

Review Hematology

Treatment of young adults with Philadelphia-negative acute lymphoblastic leukemia and lymphoblastic lymphoma: Hyper-CVAD vs. pediatric-inspired regimens

Stuart E. Siegel et al.

AMERICAN JOURNAL OF HEMATOLOGY (2018)

添加到收藏夹

Meeting Abstract Hematology

Sequential Combination of Low-Intensity Chemotherapy (Mini-hyper-CVD) Plus Inotuzumab Ozogamicin with or without Blinatumomab in Patients with Relapsed/Refractory Philadelphia Chromosome-Negative Acute Lymphoblastic Leukemia (ALL): A Phase 2 Trial

Koji Sasaki et al.

BLOOD (2018)

添加到收藏夹

Meeting Abstract Hematology

Results of SWOG 1318: A Phase 2 Trial of Blinatumomab Followed By Pomp (Prednisone, Vincristine, Methotrexate, 6-Mercaptopurine) Maintenance in Elderly Patients with Newly Diagnosed Philadelphia Chromosome Negative B-Cell Acute Lymphoblastic Leukemia

Anjali S. Advani et al.

BLOOD (2018)

添加到收藏夹

Article Hematology

Hyper-CVAD plus nelarabine in newly diagnosed adult T-cell acute lymphoblastic leukemia and T-lymphoblastic lymphoma

Yasmin Abaza et al.

AMERICAN JOURNAL OF HEMATOLOGY (2018)

添加到收藏夹

Article Medicine, General & Internal

Blinatumomab versus Chemotherapy for Advanced Acute Lymphoblastic Leukemia

Hagop Kantarjian et al.

NEW ENGLAND JOURNAL OF MEDICINE (2017)

添加到收藏夹

Article Oncology

Safety and Efficacy of Blinatumomab in Combination With a Tyrosine Kinase Inhibitor for the Treatment of Relapsed Philadelphia Chromosome-positive Leukemia

Rita Assi et al.

CLINICAL LYMPHOMA MYELOMA & LEUKEMIA (2017)

添加到收藏夹

Article Hematology

Dasatinib and low-intensity chemotherapy in elderly patients with Philadelphia chromosome-positive ALL

Philippe Rousselot et al.

BLOOD (2016)

添加到收藏夹

Article Hematology

International reference analysis of outcomes in adults with B-precursor Ph-negative relapsed/refractory acute lymphoblastic leukemia

Nicola Goekbuget et al.

HAEMATOLOGICA (2016)

添加到收藏夹

Article Medicine, General & Internal

Adult Acute Lymphoblastic Leukemia

Shilpa Paul et al.

MAYO CLINIC PROCEEDINGS (2016)

添加到收藏夹

Article Medicine, General & Internal

Rituximab in B-Lineage Adult Acute Lymphoblastic Leukemia

Sebastien Maury et al.

NEW ENGLAND JOURNAL OF MEDICINE (2016)

添加到收藏夹

Article Medicine, General & Internal

Inotuzumab Ozogamicin versus Standard Therapy for Acute Lymphoblastic Leukemia

Hagop M. Kantarjian et al.

NEW ENGLAND JOURNAL OF MEDICINE (2016)

添加到收藏夹

Article Hematology

International reference analysis of outcomes in adults with B-precursor Ph-negative relapsed/refractory acute lymphoblastic leukemia

Nicola Goekbuget et al.

HAEMATOLOGICA (2016)

添加到收藏夹

Article Education, Scientific Disciplines

T-cell acute lymphoblastic leukemia

Elizabeth A. Raetz et al.

HEMATOLOGY-AMERICAN SOCIETY OF HEMATOLOGY EDUCATION PROGRAM (2016)

添加到收藏夹

Article Hematology

Randomized study of reduced-intensity chemotherapy combined with imatinib in adults with Ph-positive acute lymphoblastic leukemia

Yves Chalandon et al.

BLOOD (2015)

添加到收藏夹

Review Hematology

Minimal residual disease diagnostics in acute lymphoblastic leukemia: need for sensitive, fast, and standardized technologies

Jacques J. M. van Dongen et al.

BLOOD (2015)

添加到收藏夹

Article Oncology

Long-term follow-up of a phase 2 study of chemotherapy plus dasatinib for the initial treatment of patients with Philadelphia chromosome-positive acute lymphoblastic leukemia

Farhad Ravandi et al.

CANCER (2015)

添加到收藏夹

Article Hematology

Final report of a phase II study of imatinib mesylate with hyper-CVAD for the front-line treatment of adult patients with Philadelphia chromosome-positive acute lymphoblastic leukemia

Naval Daver et al.

HAEMATOLOGICA (2015)

添加到收藏夹

Article Hematology

Final report of a phase II study of imatinib mesylate with hyper-CVAD for the front-line treatment of adult patients with Philadelphia chromosome-positive acute lymphoblastic leukemia

Naval Daver et al.

HAEMATOLOGICA (2015)

添加到收藏夹

Article Hematology

UKALLXII/ECOG2993: addition of imatinib to a standard treatment regimen enhances long-term outcomes in Philadelphia positive acute lymphoblastic leukemia

Adele K. Fielding et al.

BLOOD (2014)

添加到收藏夹

Article Hematology

SWOG S0910: a phase 2 trial of clofarabine/cytarabine/epratuzumab for relapsed/refractory acute lymphocytic leukaemia

Anjali S. Advani et al.

BRITISH JOURNAL OF HAEMATOLOGY (2014)

添加到收藏夹

Article Education, Scientific Disciplines

Chimeric antigen receptor T-cell therapy for ALL

Shannon L. Maude et al.

HEMATOLOGY-AMERICAN SOCIETY OF HEMATOLOGY EDUCATION PROGRAM (2014)

添加到收藏夹

Review Hematology

Central Nervous System Involvement in Adult Acute Lymphoblastic Leukemia: Diagnostic Tools, Prophylaxis, and Therapy

Maria Ilaria Del Principe et al.

MEDITERRANEAN JOURNAL OF HEMATOLOGY AND INFECTIOUS DISEASES (2014)

添加到收藏夹

Review Hematology

How I treat older patients with ALL

Nicola Goekbuget

BLOOD (2013)

添加到收藏夹

Article Oncology

Notch1 signaling is involved in regulating Foxp3 expression in T-ALL

Xiaodan Luo et al.

CANCER CELL INTERNATIONAL (2013)

添加到收藏夹

Article Oncology

Convergence of the ZMIZ1 and NOTCH1 Pathways at C-MYC in Acute T Lymphoblastic Leukemias

Lesley A. Rakowski et al.

CANCER RESEARCH (2013)

添加到收藏夹

Article Medicine, General & Internal

Acute lymphoblastic leukaemia

Hiroto Inaba et al.

LANCET (2013)

添加到收藏夹

Article Hematology

High single-drug activity of nelarabine in relapsed T-lymphoblastic leukemia/lymphoma offers curative option with subsequent stem cell transplantation

Nicola Goekbuget et al.

BLOOD (2011)

添加到收藏夹

Review Oncology

Central Nervous System Prophylaxis in Adults With Acute Lymphoblastic Leukemia Current and Emerging Therapies

Elias Jabbour et al.

CANCER (2010)

添加到收藏夹

Review Oncology

Adult Acute Lymphoblastic Leukemia Concepts and Strategies

Stefan Faderl et al.

CANCER (2010)

添加到收藏夹

Article Oncology

Chemoimmunotherapy With a Modified Hyper-CVAD and Rituximab Regimen Improves Outcome in De Novo Philadelphia Chromosome-Negative Precursor B-Lineage Acute Lymphoblastic Leukemia

Deborah A. Thomas et al.

JOURNAL OF CLINICAL ONCOLOGY (2010)

添加到收藏夹

Article Education, Scientific Disciplines

Minimal Residual Disease in Acute Lymphoblastic Leukemia

Dario Campana

HEMATOLOGY-AMERICAN SOCIETY HEMATOLOGY EDUCATION PROGRAM (2010)

添加到收藏夹

Article Hematology

Myeloablative allogeneic versus autologous stem cell transplantation in adult patients with acute lymphoblastic leukemia in first remission: a prospective sibling donor versus no-donor comparison

Jan J. Cornelissen et al.

BLOOD (2009)

添加到收藏夹

Article Hematology

Nelarabine induces complete remissions in adults with relapsed or refractory T-lineage acute lymphoblastic leukemia or lymphoblastic lymphoma: Cancer and Leukemia Group B study 19801

Daniel J. DeAngelo et al.

BLOOD (2007)

添加到收藏夹

Article Oncology

Chemoimmunotherapy with hyper-CVAD plus rituximab for the treatment of adult Burkitt and Burkitt-type lymphoma or acute lymphoblastic leukemia

DA Thomas et al.

CANCER (2006)

添加到收藏夹

Article Hematology

Clinical significance of minimal residual disease quantification in adult patients with standard-risk acute lymphoblastic leukemia

M Brüggemann et al.

BLOOD (2006)

添加到收藏夹

© Peeref 2019-2024. All rights reserved.