Recent Trends in Nanomedicine-Based Strategies to Overcome Multidrug Resistance in Tumors

Article Chemistry, Medicinal

Cationic liposomes co-deliver chemotherapeutics and siRNA for the treatment of breast cancer

Mingyuan Li et al.

Summary: In this study, paclitaxel, crizotinib, and Bcl-xL siRNA were co-loaded in cationic liposomes, which showed promising results as a delivery system for breast cancer treatment, with improved targeting efficiency and reduced side effects.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2022)

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Review Chemistry, Multidisciplinary

Engineered strategies to enhance tumor penetration of drug-loaded nanoparticles

Mohammad Souri et al.

Summary: Nanocarriers have been widely studied for anticancer drug delivery, with their clinical translation facing challenges due to inefficient accumulation and penetration in tumor microenvironment. Despite various strategies proposed to overcome these challenges, their success has been limited so far. Novel strategies such as transformable nanocarriers and transcellular transport of peptide-modified nanocarriers have emerged as potential advanced drug delivery systems.

JOURNAL OF CONTROLLED RELEASE (2022)

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Article Oncology

Current nano-therapeutic approaches ameliorating inflammation in cancer progression

Muneeb U. Rehman et al.

Summary: Cancer is a major cause of death worldwide, and nanomedicine has the potential to revolutionize cancer treatment. Nanotechnology allows for the development of specific drugs that target cancer cells and increase drug bioavailability. This review article discusses the advances in nanomedicine and the current clinical status of various nanomedicines, as well as their mechanisms of action.

SEMINARS IN CANCER BIOLOGY (2022)

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Article Chemistry, Multidisciplinary

Targeted Nanoparticle for Co-delivery of HER2 siRNA and a Taxane to Mirror the Standard Treatment of HER2+Breast Cancer: Efficacy in Breast Tumor and Brain Metastasis

Worapol Ngamcherdtrakul et al.

Summary: The first-line treatment of advanced and metastatic human epidermal growth factor receptor type 2 (HER2+) breast cancer requires a combination of two antibodies and a taxane. However, this treatment is expensive, time-consuming, and has limited efficacy. To overcome these limitations, a single therapeutic based on nanoparticles has been developed, which can co-deliver drugs and siRNA to specifically target HER2-positive breast cancer cells.

SMALL (2022)

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Article Biotechnology & Applied Microbiology

Co-delivery of STAT3 siRNA and methotrexate in breast cancer cells

Zahra Shakeran et al.

Summary: Co-delivery of methotrexate (MTX) and STAT3 siRNA using chitosan modified mesoporous silica nanoparticles (MSNs) showed significant reduction in breast cancer cell viability compared to single treatments alone. The cellular uptake of modified NPs was influenced by the dihydrofolate reductase (DHFR) receptor, and the protein corona composition on the NPs surface potentially modulated cellular uptake.

ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY (2022)

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Article Chemistry, Applied

Co-delivery of doxorubicin and siRNA by all-trans retinoic acid conjugated chitosan-based nanocarriers for multiple synergistic antitumor efficacy

Chang Liu et al.

Summary: In this study, double grafted TMC nanoparticles were developed for the co-delivery of DOX and siRNA, selectively inhibiting the proliferation of tumor cells and exhibiting superior in vivo and in vitro anti-tumor efficiency.

CARBOHYDRATE POLYMERS (2022)

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Article Chemistry, Physical

A targeted nanoplatform co-delivery of pooled siRNA and doxorubicin for reversing of multidrug resistance in breast cancer

Hongmei Liu et al.

Summary: This study aimed to develop a novel and facile strategy for preparing a highly efficient and safe gene and drug delivery system for multidrug-resistant (MDR) breast cancer. A targeted nanoplatform based on biodegradable boronic acid modified epsilon-polylysine was developed to co-deliver P-gp siRNA, Bcl-2 siRNA, and doxorubicin for overcoming MDR. The nanoplatform exhibited robust inhibitory effects against invasion, proliferation, and colony formation of MCF-7/ADR cells in vitro, and demonstrated ATP responsiveness. In vivo antitumor experiments showed significant inhibition of tumor growth and good biocompatibility with the targeted nanoplatform.

NANO RESEARCH (2022)

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Article Biochemistry & Molecular Biology

Precise engineering of cholesterol-loaded chitosan micelles as a promising nanocarrier system for co-delivery drug-siRNA for the treatment of gastric cancer therapy

Chenqu Wu et al.

Summary: This study demonstrates a self-assembled strategy for simultaneous delivery of the therapeutic drug salinomycin (SAL) and siRNA to cancer cells using chitosan nanoparticles. The siRNA@C-SAL showed superior cytotoxicity against gastric carcinoma cells without significant adverse effects in healthy mice. Thus, this improved drug delivery system with siRNA and hydrophobic drugs provides a potential strategy for the treatment of gastric cancer.

PROCESS BIOCHEMISTRY (2022)

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Article Biotechnology & Applied Microbiology

Multifunctional nanoparticles co-loaded with Adriamycin and MDR-targeting siRNAs for treatment of chemotherapy-resistant esophageal cancer

Xiangyang Zhang et al.

Summary: The development of multidrug resistance (MDR) in cancer chemotherapy is a major challenge. This study identified MVP and BCL2 as potential factors driving MDR in ESCC. A self-assembling nanoparticle platform was designed to deliver Adriamycin and siRNAs targeting MVP and BCL2, reducing drug efflux and promoting apoptosis. The nanoparticles effectively inhibited cancer cell growth and tumor development.

JOURNAL OF NANOBIOTECHNOLOGY (2022)

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Article Engineering, Biomedical

Codelivery of Paclitaxel and Parthenolide in Discoidal Bicelles for a Synergistic Anticancer Effect: Structure Matters

Armin Tahmasbi Rad et al.

Summary: The study designed structurally stable nanodiscoidal phospholipid bicelles capable of encapsulating anticancer drugs, exhibiting longer blood circulation, deeper tumor penetration, and increased tumor cell uptake compared to spherical particles.

ADVANCED NANOBIOMED RESEARCH (2022)

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Article Instruments & Instrumentation

Simultaneous delivery of anti-miRNA and docetaxel with supramolecular self-assembled chitosome for improving chemosensitivity of triple negative breast cancer cells

Xianfu Sun et al.

Summary: A novel chitosome nanovector, co-loading hydrophobic docetaxel and hydrophilic anti-miR-21, showed enhanced cellular transfection and stability against nucleases, leading to improved chemosensitivity of TNBC cells. The chitosome could be a promising candidate for simultaneous delivery of insoluble chemotherapeutic drugs and gene agents in TNBC therapy.

DRUG DELIVERY AND TRANSLATIONAL RESEARCH (2021)

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Review Chemistry, Multidisciplinary

Challenges and Opportunities in Cancer Drug Resistance

Richard A. Ward et al.

Summary: Recent years have seen significant progress in targeted cancer therapies, but drug resistance remains a common challenge. Researchers are exploring new approaches to overcome resistance, such as increasing drug selectivity and potency, using alternative chemical structures, changing mechanisms of action, and targeting allosteric pockets.

CHEMICAL REVIEWS (2021)

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Article Biophysics

Calcium phosphate-polymeric nanoparticle system for co-delivery of microRNA-21 inhibitor and doxorubicin

Vishnu Sriram et al.

Summary: Targeted combination therapy utilizing calcium phosphate-coated hybrid lipid-polymeric nanoparticles for co-delivery of miR-21i and Dox has shown synergistic effects in cancer treatment, with potential for overcoming drug resistance.

COLLOIDS AND SURFACES B-BIOINTERFACES (2021)

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Article Oncology

Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

Hyuna Sung et al.

Summary: The global cancer burden in 2020 saw an estimated 19.3 million new cancer cases and almost 10.0 million cancer deaths. Female breast cancer surpassed lung cancer as the most commonly diagnosed cancer, while lung cancer remained the leading cause of cancer death. These trends are expected to rise in 2040, with transitioning countries experiencing a larger increase compared to transitioned countries due to demographic changes and risk factors associated with globalization and a growing economy. Efforts to improve cancer prevention measures and provision of cancer care in transitioning countries will be crucial for global cancer control.

CA-A CANCER JOURNAL FOR CLINICIANS (2021)

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Article Chemistry, Multidisciplinary

Multivalent rubber-like RNA nanoparticles for targeted co-delivery of paclitaxel and MiRNA to silence the drug efflux transporter and liver cancer drug resistance

Hongzhi Wang et al.

Summary: Hepatocellular carcinoma (HCC) is the third leading cause of cancer-related death globally. Liver acts as a filter to detoxify chemicals, while liver cancer cells exhibit drug effluxion leading to chemoresistance. A new multivalent RNA nanoparticle, designed to target liver cancer cells, efficiently delivers therapeutics to the tumor site and shows potential in treating HCC.

JOURNAL OF CONTROLLED RELEASE (2021)

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Article Materials Science, Biomaterials

Targeted delivery of quercetin by nanoparticles based on chitosan sensitizing paclitaxel-resistant lung cancer cells to paclitaxel

Yonghong Wang et al.

Summary: The study showed that quercetin (QUE) could reverse the resistance of non-small cell lung cancer (NSCLC) to paclitaxel (PTX). By preparing targeted biodegradable cetuximab chitosan nanoparticles (Cet-CTS NPs) to deliver PTX and QUE, the growth of PTX-resistant tumor cells was successfully inhibited.

MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS (2021)

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Article Materials Science, Biomaterials

Stable W/O/W multiple nanoemulsion encapsulating natural tocotrienols and caffeic acid with cisplatin synergistically treated cancer cell lines (A549 and HEP G2) and reduced toxicity on normal cell line (HEK 293)

Revathi Raviadaran et al.

Summary: This study demonstrated that encapsulated tocotrienols and caffeic acid in water-in-oil-in-water with cisplatin synergistically improved therapeutic efficacy towards cancer cells, while reducing toxicity effects towards normal cells.

MATERIALS SCIENCE AND ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS (2021)

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Article Biotechnology & Applied Microbiology

Co-encapsulation of gemcitabine and tocotrienols in nanovesicles enhanced efficacy in pancreatic cancer

Geetha Maniam et al.

Summary: This study successfully synthesized niosomes co-encapsulating GEM and tocotrienols, and demonstrated their enhanced antiproliferative effects in Panc 10.05 cells. Niosomes significantly improved the cytotoxicity of the drug combination and showed higher cellular uptake of GEM, providing a new approach for the treatment of pancreatic cancer cells.

NANOMEDICINE (2021)

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Article Cell Biology

被撤回的出版物: Parthenolide Augments the Chemosensitivity of Non-small-Cell Lung Cancer to Cisplatin via the PI3K/AKT Signaling Pathway (Retracted article. See vol. 9, 2021)

Li-Mei Wu et al.

Summary: Although cisplatin-based chemotherapy can improve the prognosis of patients with non-small-cell lung cancer (NSCLC), chemotherapy resistance remains a major obstacle to curing the disease. Combining parthenolide (PTL) and cisplatin (DDP) has been shown to synergistically inhibit NSCLC growth by affecting the PI3K-AKT signaling pathway. This combination therapy may offer a new option for treating NSCLC.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2021)

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Article Oncology

Cancer statistics for the year 2020: An overview

Jacques Ferlay et al.

Summary: The study briefly reviews the methods and data sources used in compiling the IARC GLOBOCAN cancer statistics for 2020 and summarizes the main results. It estimated that there were nearly 19.3 million new cancer cases and almost 10 million cancer deaths worldwide in 2020, with the most commonly diagnosed cancers being female breast cancer and lung cancer, and the most common causes of cancer death being lung cancer and liver cancer.

INTERNATIONAL JOURNAL OF CANCER (2021)

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Review Pharmacology & Pharmacy

A Systematic Review of the Preventive and Therapeutic Effects of Naringin Against Human Malignancies

Maryam Ghanbari-Movahed et al.

Summary: Naringin, a natural flavonoid, has shown promising anti-tumor activity through modulation of various signaling pathways implicated in cancer initiation, promotion, and progression. Studies have demonstrated that treatment with naringin alone or in combination with other drugs can effectively suppress tumor growth, with naringin-metal complexes showing even greater anticancer effects. Further preclinical and clinical studies are warranted to explore the full potential of naringin as a candidate for cancer prevention and treatment.

FRONTIERS IN PHARMACOLOGY (2021)

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Article Cell & Tissue Engineering

Cisplatin and si-Notch1-Folic Acid-Conjugated Mesoporous Silica Nanoparticles Prevent Hepatocellular Carcinoma

Xiaoping Li et al.

Summary: The study investigated the combined effect of cisplatin with conjugated mesoporous silica nanoparticles on hepatocellular carcinoma (HCC). The Pt(IV) MNP/siNotch1 nanoparticles exhibited enhanced cytotoxicity and downregulated expression of Notch1 and cancer stem cells, while MNP/siNotch1 nanoparticles significantly suppressed cell proliferation and clonal formation. Co-delivery of cisplatin, si-Notch1, and folic acid conjugated MSN could inhibit the development of HCC, suggesting a potential novel treatment approach for the future.

JOURNAL OF BIOMATERIALS AND TISSUE ENGINEERING (2021)

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Article Medicine, Research & Experimental

Co-delivery of 5-fluorouracil and miRNA-34a mimics by host-guest self-assembly nanocarriers for efficacious targeted therapy in colorectal cancer patient-derived tumor xenografts

Jianbin Xu et al.

Summary: This study developed well-defined quantum dot-based multifunctional nanocarriers for co-delivery of chemotherapeutic drugs and nucleotide drugs to distinct targets in tumors, showing synergistic effects for colorectal cancer therapy. The research findings demonstrated the efficacy of this co-delivery system in inhibiting CRC cell proliferation and migration, as well as suppressing tumor growth in a CRC cell-derived tumor xenograft model.

THERANOSTICS (2021)

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Article Materials Science, Biomaterials

Nanobody-displaying porous silicon nanoparticles for the co-delivery of siRNA and doxorubicin

Terence Tieu et al.

Summary: This study investigates the use of biocompatible porous silicon nanoparticles for co-delivery of Doxorubicin and MRP1 siRNA, with nanobodies incorporated onto the nanoparticle surface to enhance the selectivity and retention of the delivery vehicle at the tumor site. This approach effectively downregulated MRP1 expression, leading to increased cytotoxicity in prostate cancer cells when both siRNA and Doxorubicin were delivered together.

BIOMATERIALS SCIENCE (2021)

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Article Instruments & Instrumentation

Co-delivery of cisplatin and siRNA through hybrid nanocarrier platform for masking resistance to chemotherapy in lung cancer

Vivek Patel et al.

Summary: The study demonstrated that co-loading siRNA with the drug in a nanocarrier improved the efficacy of cisplatin in NSCLC, showing increased cell uptake, cytotoxic potential, and gene knock-down. The optimized formulation also presented increased half-life, tumor regression, and reduced drug resistance, promising for current cisplatin-based treatments in NSCLC.

DRUG DELIVERY AND TRANSLATIONAL RESEARCH (2021)

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Article Pharmacology & Pharmacy

Combination and Co-delivery of Methotrexate and Curcumin: Preparation and In Vitro Cytotoxic Investigation on Glioma Cells

Basil Mujokoro et al.

JOURNAL OF PHARMACEUTICAL INNOVATION (2020)

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Article Medicine, Research & Experimental

Dual delivery nanoscale device for miR-451 and adriamycin co-delivery to combat multidrug resistant in bladder cancer

Shuguang Wei et al.

BIOMEDICINE & PHARMACOTHERAPY (2020)

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Article Biochemistry & Molecular Biology

Computer-aided drug design of small molecule inhibitors of the ERCC1-XPF protein-protein interaction

Francesco Gentile et al.

CHEMICAL BIOLOGY & DRUG DESIGN (2020)

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Review Pharmacology & Pharmacy

Improvement of conventional anti-cancer drugs as new tools against multidrug resistant tumors

Sabrina Dallavalle et al.

DRUG RESISTANCE UPDATES (2020)

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Article Biotechnology & Applied Microbiology

Engineered exosomes for targeted co-delivery of miR-21 inhibitor and chemotherapeutics to reverse drug resistance in colon cancer

Gaofeng Liang et al.

JOURNAL OF NANOBIOTECHNOLOGY (2020)

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Article Pharmacology & Pharmacy

Therapeutic e fficacy of thermosensitive Pluronic hydrogel for codelivery of resveratrol microspheres and cisplatin in the treatment of liver cancer ascites

Qian Wen et al.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2020)

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Article Cell Biology

EZH2-inhibitor DZNep enhances apoptosis of renal tubular epithelial cells in presence and absence of cisplatin

Si-qi Chen et al.

CELL DIVISION (2020)

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Article Pharmacology & Pharmacy

Preparation and characterization of parthenolide nanocrystals for enhancing therapeutic effects of sorafenib against advanced hepatocellular carcinoma

Pan Liang et al.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2020)

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Article Materials Science, Biomaterials

LHRH-conjugated, PEGylated, poly-lactide-co-glycolide nanocapsules for targeted delivery of combinational chemotherapeutic drugs Docetaxel and Quercetin for prostate cancer

Ajinkya A. Shitole et al.

MATERIALS SCIENCE AND ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS (2020)

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Article Biochemistry & Molecular Biology

Carbosilane Dendrimers Loaded with siRNA Targeting Nrf2 as a Tool to Overcome Cisplatin Chemoresistance in Bladder Cancer Cells

Leanne Ambrosio et al.

ANTIOXIDANTS (2020)

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Review Chemistry, Medicinal

Parthenolide as Cooperating Agent for Anti-Cancer Treatment of Various Malignancies

Malgorzata Sztiller-Sikorska et al.

PHARMACEUTICALS (2020)

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Review Oncology

Targeted lapatinib anti-HER2/ErbB2 therapy resistance in breast cancer: opportunities to overcome a difficult problem

Reema Wahdan-Alaswad et al.

CANCER DRUG RESISTANCE (2020)

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Article Pharmacology & Pharmacy

Co-delivery of resveratrol and docetaxel via polymeric micelles to improve the treatment of drug-resistant tumors

Xiong Guo et al.

ASIAN JOURNAL OF PHARMACEUTICAL SCIENCES (2019)

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Article Engineering, Biomedical

Dual responsive micelles capable of modulating miRNA-34a to combat taxane resistance in prostate cancer

Feng Lin et al.

BIOMATERIALS (2019)

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Article Pharmacology & Pharmacy

Polyamidoamine dendrimers-based nanomedicine for combination therapy with siRNA and chemotherapeutics to overcome multidrug resistance

Jiayi Pan et al.

EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS (2019)

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Article Chemistry, Multidisciplinary

Co-delivery of miR-181a and melphalan by lipid nanoparticles for treatment of seeded retinoblastoma

Seyed Nasrollah Tabatabaei et al.

JOURNAL OF CONTROLLED RELEASE (2019)

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Review Biochemistry & Molecular Biology

Targeting epigenetic modifications in cancer therapy: erasing the roadmap to cancer

Helai P. Mohammad et al.

NATURE MEDICINE (2019)

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Article Multidisciplinary Sciences

Novel mutations in the kinase domain of BCR-ABL gene causing imatinib resistance in chronic myeloid leukemia patients

Chodimella Chandrasekhar et al.

SCIENTIFIC REPORTS (2019)

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Review Oncology

The role and mechanisms of action of microRNAs in cancer drug resistance

Wengong Si et al.

CLINICAL EPIGENETICS (2019)

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Article Pharmacology & Pharmacy

Targeted Co-Delivery of siRNA and Methotrexate for Tumor Therapy via Mixed Micelles

Fei Hao et al.

PHARMACEUTICS (2019)

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Article Nanoscience & Nanotechnology

Co-Delivery of Gemcitabine and Mcl-1 SiRNA via Cationic Liposome-Based System Enhances the Efficacy of Chemotherapy in Pancreatic Cancer

Yanbing Wang et al.

JOURNAL OF BIOMEDICAL NANOTECHNOLOGY (2019)

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Article Biochemistry & Molecular Biology

Targeting interleukin-6 as a strategy to overcome stroma-induced resistance to chemotherapy in gastric cancer

In-Hye Ham et al.

MOLECULAR CANCER (2019)

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Article Biochemistry & Molecular Biology

Resveratrol chemosensitizes adriamycin-resistant breast cancer cells by modulating miR-122-5p

Wei Zhang et al.

JOURNAL OF CELLULAR BIOCHEMISTRY (2019)

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Article Oncology

Human Aquaporin-5 Facilitates Hydrogen Peroxide Permeation Affecting Adaption to Oxidative Stress and Cancer Cell Migration

Claudia Rodrigues et al.

CANCERS (2019)

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Review Pharmacology & Pharmacy

The multi-factorial nature of clinical multidrug resistance in cancer

Yehuda G. Assaraf et al.

DRUG RESISTANCE UPDATES (2019)

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Editorial Material Biochemistry & Molecular Biology

New Strategies to Overcome Resistance to Chemotherapy and Immune System in Cancer

Chiara Riganti et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)

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Article Biotechnology & Applied Microbiology

Functional exosome-mediated co-delivery of doxorubicin and hydrophobically modified microRNA 159 for triple-negative breast cancer therapy

Chunai Gong et al.

JOURNAL OF NANOBIOTECHNOLOGY (2019)

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Article Hematology

Treatment value of second-generation BCR-ABL1 tyrosine kinase inhibitors compared with imatinib to achieve treatment-free remission in patients with chronic myeloid leukaemia: a modelling study

Ya-Chen Tina Shih et al.

LANCET HAEMATOLOGY (2019)

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Review Multidisciplinary Sciences

A view on drug resistance in cancer

Neil Vasan et al.

NATURE (2019)

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Article Oncology

Major vault protein is a direct target of Notch1 signaling and contributes to chemoresistance in triple-negative breast cancer cells

Ying-Sheng Xiao et al.

CANCER LETTERS (2019)

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Review Biochemistry & Molecular Biology

Mutant p53 as a guardian of the cancer cell

Fiamma Mantovani et al.

CELL DEATH AND DIFFERENTIATION (2019)

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Article Chemistry, Medicinal

Design and synthesis of mixed micellar system for enhanced anticancer efficacy of Paclitaxel through its co-delivery with Naringin

Tooba Jabri et al.

DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY (2019)

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Article Nanoscience & Nanotechnology

Co-Delivery of Curcumin and Paclitaxel by Core-Shell Targeting Amphiphilic Copolymer to Reverse Resistance in the Treatment of Ovarian Cancer

Meng-Dan Zhao et al.

INTERNATIONAL JOURNAL OF NANOMEDICINE (2019)

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Review Biotechnology & Applied Microbiology

Epigenetic modifications of histones in cancer

Zibo Zhao et al.

GENOME BIOLOGY (2019)

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Article Pharmacology & Pharmacy

Co-encapsulation of docetaxel and cyclosporin A into SNEDDS to promote oral cancer chemotherapy

Weiping Cui et al.

DRUG DELIVERY (2019)

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Review Oncology

Drug resistance and combating drug resistance in cancer

Xuan Wang et al.

CANCER DRUG RESISTANCE (2019)

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Article Biotechnology & Applied Microbiology

Lipid nanoparticle-based co-delivery of epirubicin and BCL-2 siRNA for enhanced intracellular drug release and reversing multidrug resistance

Miao Yu et al.

ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY (2018)

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Article Nanoscience & Nanotechnology

Stimuli-Responsive Nanocarrier for Co-delivery of MiR-31 and Doxorubicin To Suppress High MtEF4 Cancer

Fang Wang et al.

ACS APPLIED MATERIALS & INTERFACES (2018)

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Article Nanoscience & Nanotechnology

Polyamino Acid Layer-by-Layer (LbL) Constructed Silica-Supported Mesoporous Titania Nanocarriers for Stimuli-Responsive Delivery of microRNA 708 and Paclitaxel for Combined Chemotherapy

Biki Gupta et al.

ACS APPLIED MATERIALS & INTERFACES (2018)

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Article Nanoscience & Nanotechnology

Overcoming Chemoresistance in Cancer via Combined MicroRNA Therapeutics with Anticancer Drugs Using Multifunctional Magnetic Core-Shell Nanoparticles

Perry T. Yin et al.

ACS APPLIED MATERIALS & INTERFACES (2018)

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Article Biochemistry & Molecular Biology

Co-Delivery of Doxorubicin and Anti-BCL-2 siRNA by pH-Responsive Polymeric Vector to Overcome Drug Resistance in In Vitro and In Vivo HepG2 Hepatoma Model

Weitong Sun et al.

BIOMACROMOLECULES (2018)

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Article Medicine, Research & Experimental

Drug metabolizing enzymes and their inhibitors' role in cancer resistance

Shelly Pathania et al.

BIOMEDICINE & PHARMACOTHERAPY (2018)

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Review Biochemistry & Molecular Biology

Cancer Treatment with Liposomes Based Drugs and Genes Co-delivery Systems

Chuanmin Zhang et al.

CURRENT MEDICINAL CHEMISTRY (2018)

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Article Nanoscience & Nanotechnology

Doxorubicin and anti-VEGF siRNA co-delivery via nano-graphene oxide for enhanced cancer therapy in vitro and in vivo

Qi Sun et al.

INTERNATIONAL JOURNAL OF NANOMEDICINE (2018)

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Article Biotechnology & Applied Microbiology

Effect of AQP-5 silencing by siRNA interference on chemosensitivity of breast cancer cells

Xueqing Li et al.

ONCOTARGETS AND THERAPY (2018)

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Article Materials Science, Biomaterials

Reduction/photo dual-responsive polymeric prodrug nanoparticles for programmed siRNA and doxorubicin delivery

Ming Wu et al.

BIOMATERIALS SCIENCE (2018)

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Article Nanoscience & Nanotechnology

Quercetin and doxorubicin co-delivery using mesoporous silica nanoparticles enhance the efficacy of gastric carcinoma chemotherapy

Jian Fang et al.

INTERNATIONAL JOURNAL OF NANOMEDICINE (2018)

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Article Oncology

Hsa-miRNA-143-3p Reverses Multidrug Resistance of Triple-Negative Breast Cancer by Inhibiting the Expression of Its Target Protein Cytokine-Induced Apoptosis Inhibitor 1 In Vivo

Yu Wei Deng et al.

JOURNAL OF BREAST CANCER (2018)

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Article Biochemistry & Molecular Biology

A nanomedicine approach enables co-delivery of cyclosporin A and gefitinib to potentiate the therapeutic efficacy in drug-resistant lung cancer

Weidong Han et al.

SIGNAL TRANSDUCTION AND TARGETED THERAPY (2018)

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Article Food Science & Technology

Anticancer effect of curcumin on breast cancer and stem cells

Hui-Tien Liu et al.

FOOD SCIENCE AND HUMAN WELLNESS (2018)

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Article Nanoscience & Nanotechnology

Doxorubicin@Bcl-2 siRNA Core@Shell Nanoparticles for Synergistic Anticancer Chemotherapy

Mengjiao Zhou et al.

ACS APPLIED BIO MATERIALS (2018)

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Review Biochemistry & Molecular Biology

Tumor-related interleukins: old validated targets for new anti-cancer drug development

Sarra Setrerrahmane et al.

MOLECULAR CANCER (2017)

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Article Oncology

Acquired Resistance with Epigenetic Alterations Under Long-Term Antiangiogenic Therapy for Hepatocellular Carcinoma

Yoshiteru Ohata et al.

MOLECULAR CANCER THERAPEUTICS (2017)

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Review Oncology

Novel strategies to prevent the development of multidrug resistance (MDR) in cancer

Jinglu Wang et al.

ONCOTARGET (2017)

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Article Multidisciplinary Sciences

Tumoral expression of drug and xenobiotic metabolizing enzymes in breast cancer patients of different ethnicities with implications to personalized medicine

Yan Li et al.

SCIENTIFIC REPORTS (2017)

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Article Nanoscience & Nanotechnology

ATRP Fabricated and Short Chain Polyethylenimine Grafted Redox Sensitive Polymeric Nanoparticles for Codelivery of Anticancer Drug and siRNA in Cancer Therapy

Chetan Nehate et al.

ACS APPLIED MATERIALS & INTERFACES (2017)

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Review Pharmacology & Pharmacy

The Different Mechanisms of Cancer Drug Resistance: A Brief Review

Behzad Mansoori et al.

ADVANCED PHARMACEUTICAL BULLETIN (2017)

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Article Biochemistry & Molecular Biology

The role of aquaporin-5 in cancer cell migration: A potential active participant

Helene H. Jensen et al.

INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY (2016)

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Article Biochemistry & Molecular Biology

Co-delivery with nano-quercetin enhances doxorubicin-mediated cytotoxicity against MCF-7 cells

Akbar Minaei et al.

MOLECULAR BIOLOGY REPORTS (2016)

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Article Chemistry, Multidisciplinary

Mixed Nanosized Polymeric Micelles as Promoter of Doxorubicin and miRNA-34a Co-Delivery Triggered by Dual Stimuli in Tumor Tissue

Giuseppina Salzano et al.

SMALL (2016)

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