相关参考文献
注意：仅列出部分参考文献，下载原文获取全部文献信息。Histone deacetylase 6 inhibitors with blood-brain barrier penetration as a potential strategy for CNS-Disorders therapy
Xiu Gu et al.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2022)
Safety and pharmacokinetics of Roscovitine (Seliciclib) in cystic fibrosis patients chronically infected with Pseudomonas aeruginosa, a randomized, placebo-controlled study
Laurent Meijer et al.
JOURNAL OF CYSTIC FIBROSIS (2022)
Src family kinases (SFKs): critical regulators of microglial homeostatic functions and neurodegeneration in Parkinson's and Alzheimer's diseases
Camila C. Portugal et al.
FEBS JOURNAL (2022)
Phenotypic drug discovery: recent successes, lessons learned and new directions
Fabien Vincent et al.
NATURE REVIEWS DRUG DISCOVERY (2022)
Overcoming the blood-brain barrier for the therapy of malignant brain tumor: current status and prospects of drug delivery approaches
Ksenia Mitusova et al.
JOURNAL OF NANOBIOTECHNOLOGY (2022)
Safety and pharmacokinetics of Roscovitine (Seliciclib) in cystic fibrosis patients chronically infected with Pseudomonas aeruginosa, a randomized, placebo-controlled study
Laurent Meijer et al.
JOURNAL OF CYSTIC FIBROSIS (2022)
Tideglusib attenuates growth of neuroblastoma cancer stem/progenitor cells in vitro and in vivo by specifically targeting GSK-3β
Hisham F. Bahmad et al.
PHARMACOLOGICAL REPORTS (2021)
The Role of CDK5 in Tumours and Tumour Microenvironments
Phuong Anh Do et al.
CANCERS (2021)
Molecular regulation of autophagy in a pro-inflammatory tumour microenvironment: New insight into the role of serum amyloid A
M. du Plessis et al.
CYTOKINE & GROWTH FACTOR REVIEWS (2021)
Receptor Tyrosine Kinase Signaling and Targeting in Glioblastoma Multiforme
Manali Tilak et al.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)
Low concentrations of vorinostat decrease EB1 expression in GBM cells and affect microtubule dynamics, cell survival and migration
Thomas Perez et al.
Oncotarget (2021)
Impact of Chaperone-Mediated Autophagy in Brain Aging: Neurodegenerative Diseases and Glioblastoma
Jaione Auzmendi-Iriarte et al.
FRONTIERS IN AGING NEUROSCIENCE (2021)
Tideglusib suppresses stem-cell-like features and progression of osteosarcoma by inhibiting GSK-3β/NOTCH1 signaling
Dandan Wei et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2021)
Tau Regulates Glioblastoma Progression, 3D Cell Organization, Growth and Migration via the PI3K-AKT Axis
Alessandra Pagano et al.
CANCERS (2021)
Tau oligomers accumulation sensitizes prostate cancer cells to docetaxel treatment
Stefano Martellucci et al.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY (2021)
Mutation-specific non-canonical pathway of PTEN as a distinct therapeutic target for glioblastoma
Seung Won Choi et al.
CELL DEATH & DISEASE (2021)
Acetylated tau inhibits chaperone-mediated autophagy and promotes tau pathology propagation in mice
Benjamin Caballero et al.
NATURE COMMUNICATIONS (2021)
Infrequent RAS mutation is not associated with specific histological phenotype in gliomas
Yasuhide Makino et al.
BMC CANCER (2021)
Current Status of Clinical Trials on Tau Immunotherapies
Changyi Ji et al.
DRUGS (2021)
Novel Therapeutic Approaches for Alzheimer's Disease: An Updated Review
Tien-Wei Yu et al.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)
The Radiosensitizing Effect of AZD0530 in Glioblastoma and Glioblastoma Stem-Like Cells
Hong Shik Yun et al.
MOLECULAR CANCER THERAPEUTICS (2021)
CDK5 Knockdown inhibits proliferation and induces apoptosis and Cell Cycle Arrest in Human Glioblastoma
Yan Zhou et al.
JOURNAL OF CANCER (2021)
The potential use of tideglusib as an adjuvant radio-therapeutic treatment for glioblastoma multiforme cancer stem-like cells
Jolie Bou-Gharios et al.
PHARMACOLOGICAL REPORTS (2021)
A small molecule transcription factor EB activator ameliorates beta-amyloid precursor protein and Tau pathology in Alzheimer's disease models
Ju-Xian Song et al.
AGING CELL (2020)
Proteomic and Genomic Changes in Tau Protein, Which Are Associated with Alzheimer's Disease after Ischemia-Reperfusion Brain Injury
Marzena Ulamek-Koziol et al.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)
Specific Degradation of Endogenous Tau Protein and Inhibition of Tau Fibrillation by Tanshinone IIA through the Ubiquitin- Proteasome Pathway
Nan Cai et al.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2020)
Fyn tyrosine kinase, a downstream target of receptor tyrosine kinases, modulates antiglioma immune responses
Andrea Comba et al.
NEURO-ONCOLOGY (2020)
Oligodendroglioma showing pleomorphic xanthoastrocytoma-like perivascular microlesion: With IDH1, TERT promoter mutation and 1p/19q codeletion detected in both components
Chiaki Murakami et al.
PATHOLOGY INTERNATIONAL (2020)
The IDH-TAU-EGFR triad defines the neovascular landscape of diffuse gliomas
Ricardo Gargini et al.
SCIENCE TRANSLATIONAL MEDICINE (2020)
Patient-derived tumor organoid predicts drugs response in glioblastoma: A step forward in personalized cancer therapy?
Herbert H-F Loong et al.
JOURNAL OF CLINICAL NEUROSCIENCE (2020)
Increased Tau Expression Correlates With IDH Mutation in Infiltrating Gliomas and Impairs Cell Migration
Satoshi Nakata et al.
JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY (2020)
Advances in the Knowledge of the Molecular Biology of Glioblastoma and Its Impact in Patient Diagnosis, Stratification, and Treatment
Belen Delgado-Martin et al.
ADVANCED SCIENCE (2020)
Perhexiline Demonstrates FYN-mediated Antitumor Activity in Glioblastoma
Shiva Kant et al.
MOLECULAR CANCER THERAPEUTICS (2020)
Tau immunotherapies: Lessons learned, current status and future considerations
L. A. Sandusky-Beltran et al.
NEUROPHARMACOLOGY (2020)
Protein Phosphatase 2A as a Drug Target in the Treatment of Cancer and Alzheimer's Disease
Hui Wei et al.
CURRENT MEDICAL SCIENCE (2020)
A Phase I Study of Dinaciclib in Combination With MK-2206 in Patients With Advanced Pancreatic Cancer
Adrian G. Murphy et al.
CTS-CLINICAL AND TRANSLATIONAL SCIENCE (2020)
HCK promotes glioblastoma progression by TGFβ signaling
Zhenlin Wang et al.
BIOSCIENCE REPORTS (2020)
P53 aggregation, interactions with tau, and impaired DNA damage response in Alzheimer's disease
Kathleen M. Farmer et al.
ACTA NEUROPATHOLOGICA COMMUNICATIONS (2020)
SRC Kinase in Glioblastoma: News from an Old Acquaintance
Claudia Cirotti et al.
CANCERS (2020)
The application of histone deacetylases inhibitors in glioblastoma
Rui Chen et al.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2020)
Tau affects P53 function and cell fate during the DNA damage response
Martina Sola et al.
COMMUNICATIONS BIOLOGY (2020)
Caffeoyl-Prolyl-Histidine Amide Inhibits Fyn and Alleviates Atopic Dermatitis-Like Phenotypes via Suppression of NF-κB Activation
Hayan Jeong et al.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)
Ethnic delineation of primary glioblastoma genome
Harim Koo et al.
CANCER MEDICINE (2020)
Degradation and Transmission of Tau by Autophagic-Endolysosomal Networks and Potential Therapeutic Targets for Tauopathy
Shanya Jiang et al.
FRONTIERS IN MOLECULAR NEUROSCIENCE (2020)
Tau reduction in aged mice does not impact Microangiopathy
Rachel E. Bennett et al.
ACTA NEUROPATHOLOGICA COMMUNICATIONS (2020)
HDAC6 ZnF UBP as the Modifier of Tau Structure and Function
Abhishek Ankur Balmik et al.
BIOCHEMISTRY (2020)
TDP-43 and Tau Oligomers in Alzheimer's Disease, Amyotrophic Lateral Sclerosis, and Frontotemporal Dementia
Mauro Montalbano et al.
NEUROBIOLOGY OF DISEASE (2020)
Glioblastoma Organoids: Pre-Clinical Applications and Challenges in the Context of Immunotherapy
Eliane Klein et al.
FRONTIERS IN ONCOLOGY (2020)
Emerging Evidences for an Implication of the Neurodegeneration-Associated Protein TAU in Cancer
Stephanie Papin et al.
BRAIN SCIENCES (2020)
Overcoming cancer therapeutic bottleneck by drug repurposing
Zhe Zhang et al.
SIGNAL TRANSDUCTION AND TARGETED THERAPY (2020)
Could Alzheimer's Disease Originate in the Periphery and If So How So?
Gerwyn Morris et al.
MOLECULAR NEUROBIOLOGY (2019)
Applications of Human Brain Organoids to Clinical Problems
H. Isaac Chen et al.
DEVELOPMENTAL DYNAMICS (2019)
Aberrant expression of the microtubule-associated protein tau is an independent prognostic feature in prostate cancer
Cornelia Schroeder et al.
BMC CANCER (2019)
A farnesyltransferase inhibitor activates lysosomes and reduces tau pathology in mice with tauopathy
Israel Hernandez et al.
SCIENCE TRANSLATIONAL MEDICINE (2019)
A walk through tau therapeutic strategies
Santosh Jadhav et al.
ACTA NEUROPATHOLOGICA COMMUNICATIONS (2019)
Glioblastoma heterogeneity and the tumour microenvironment: implications for preclinical research and development of new treatments
Sally L. Perrin et al.
BIOCHEMICAL SOCIETY TRANSACTIONS (2019)
Akt inhibitor SC66 promotes cell sensitivity to cisplatin in chemoresistant ovarian cancer cells through inhibition of COL11A1 expression
Yi-Hui Wu et al.
CELL DEATH & DISEASE (2019)
A p53/TIAF1/WWOX triad exerts cancer suppression but may cause brain protein aggregation due to p53/WWOX functional antagonism
Pei-Yi Chou et al.
CELL COMMUNICATION AND SIGNALING (2019)
Role of Tau as a Microtubule-Associated Protein: Structural and Functional Aspects
Pascale Barbier et al.
FRONTIERS IN AGING NEUROSCIENCE (2019)
Trends and Challenges in Tumor Anti-Angiogenic Therapies
Jozsef Jaszai et al.
CELLS (2019)
Phospho-Tau Protein Expression in the Cell Cycle of SH-SY5Y Neuroblastoma Cells: A Morphological Study
Paola Flores-Rodriguez et al.
JOURNAL OF ALZHEIMERS DISEASE (2019)
Nuclear Tau, p53 and Pin1 Regulate PARN-Mediated Deadenylation and Gene Expression
Jorge Baquero et al.
FRONTIERS IN MOLECULAR NEUROSCIENCE (2019)
Tau regulates the microtubule-dependent migration of glioblastoma cells via the Rho-ROCK signaling pathway
Gilles Breuzard et al.
JOURNAL OF CELL SCIENCE (2019)
Regulation of human glioma cell migration, tumor growth, and stemness gene expression using a Lck targeted inhibitor
J. P. Zepecki et al.
ONCOGENE (2019)
Regulation of in vivo dynein force production by CDK5 and 14-3-3ε and KIAAO528
Dail E. Chapman et al.
NATURE COMMUNICATIONS (2019)
14-3-3 zeta promotes gliomas cells invasion by regulating Snail through the PI3K/AKT signaling
Junjun Li et al.
CANCER MEDICINE (2019)
Tau immunotherapy: Hopes and hindrances
Koorosh Shahpasand et al.
HUMAN VACCINES & IMMUNOTHERAPEUTICS (2018)
Tau clearance improves astrocytic function and brain glutamate-glutamine cycle
Michaeline L. Hebron et al.
JOURNAL OF THE NEUROLOGICAL SCIENCES (2018)
Tau-targeting therapies for Alzheimer disease
Erin E. Congdon et al.
NATURE REVIEWS NEUROLOGY (2018)
Epidermal growth factor receptor and EGFRvIII in glioblastoma: signaling pathways and targeted therapies
Zhenyi An et al.
ONCOGENE (2018)
Tau induces blood vessel abnormalities and angiogenesis-related gene expression in P301L transgenic mice and human Alzheimer's disease
Rachel E. Bennett et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2018)
The interactions of p53 with tau and Aβ as potential therapeutic targets for Alzheimer's disease
Maja Jazvinscak Jembrek et al.
PROGRESS IN NEUROBIOLOGY (2018)
Real-time Genomic Characterization of Advanced Pancreatic Cancer to Enable Precision Medicine
Andrew J. Aguirre et al.
CANCER DISCOVERY (2018)
CDK5 Inhibition Resolves PKA/cAMP-Independent Activation of CREB1 Signaling in Glioma Stem Cells
Subhas Mukherjee et al.
CELL REPORTS (2018)
Tau-Centric Multitarget Approach for Alzheimer's Disease: Development of First-in-Class Dual Glycogen Synthase Kinase 3 beta and Tau-Aggregation Inhibitors
Annachiara Gandini et al.
JOURNAL OF MEDICINAL CHEMISTRY (2018)
Inhibitors of histone acetyltransferases KAT6A/B induce senescence and arrest tumour growth
Jonathan B. Baell et al.
NATURE (2018)
Interplay of pathogenic forms of human tau with different autophagic pathways
Benjamin Caballero et al.
AGING CELL (2018)
Natural and synthetic bioactive inhibitors of glycogen synthase kinase
Imran Khan et al.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2017)
Activation of tumor suppressor protein PP2A inhibits KRAS-driven tumor growth
Jaya Sangodkar et al.
JOURNAL OF CLINICAL INVESTIGATION (2017)
Inhibition of O-GlcNAcase leads to elevation of O-GlcNAc tau and reduction of tauopathy and cerebrospinal fluid tau in rTg4510 mice
Nicholas B. Hastings et al.
MOLECULAR NEURODEGENERATION (2017)
Cytosolic Fc receptor TRIM21 inhibits seeded tau aggregation
William A. McEwan et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2017)
Tau reduction prevents neuronal loss and reverses pathological tau deposition and seeding in mice with tauopathy
Sarah L. DeVos et al.
SCIENCE TRANSLATIONAL MEDICINE (2017)
Personalized In Vitro and In Vivo Cancer Models to Guide Precision Medicine
Chantal Pauli et al.
CANCER DISCOVERY (2017)
Targeting cellular pathways in glioblastoma multiforme
Joshua R. D. Pearson et al.
SIGNAL TRANSDUCTION AND TARGETED THERAPY (2017)
Functional analyses of major cancer-related signaling pathways in Alzheimer's disease etiology
Jianping Guo et al.
BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER (2017)
Advances in Brain Tumor Surgery for Glioblastoma in Adults
Montserrat Lara-Velazquez et al.
BRAIN SCIENCES (2017)
Histone Acetyltransferase KAT6A Upregulates PI3K/AKT Signaling through TRIM24 Binding
Deguan Lv et al.
CANCER RESEARCH (2017)
Efficacy and safety of dinaciclib vs ofatumumab in patients with relapsed/refractory chronic lymphocytic leukemia
Paolo Ghia et al.
BLOOD (2017)
Tau-Directed Immunotherapy: A Promising Strategy for Treating Alzheimer's Disease and Other Tauopathies
Sulana K. Schroeder et al.
JOURNAL OF NEUROIMMUNE PHARMACOLOGY (2016)
Tau pathology-dependent remodelling of cerebral arteries precedes Alzheimer's disease-related microvascular cerebral amyloid angiopathy
Mario Merlini et al.
ACTA NEUROPATHOLOGICA (2016)
Design and synthesis of curcumin derivatives as tau and amyloid β dual aggregation inhibitors
Michiaki Okuda et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2016)
Co-immunoprecipitation with Tau Isoform-specific Antibodies Reveals Distinct Protein Interactions and Highlights a Putative Role for 2N Tau in Disease
Chang Liu et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2016)
Does Valproic Acid or Levetiracetam Improve Survival in Glioblastoma? A Pooled Analysis of Prospective Clinical Trials in Newly Diagnosed Glioblastoma
Caroline Happold et al.
JOURNAL OF CLINICAL ONCOLOGY (2016)
Valproate in Adjuvant Glioblastoma Treatment
Michael F. Fay et al.
JOURNAL OF CLINICAL ONCOLOGY (2016)
miR-186 regulates chemo-sensitivity to paclitaxel via targeting MAPT in non-small cell lung cancer (NSCLC)
Jinjun Ye et al.
MOLECULAR BIOSYSTEMS (2016)
Affinity of Tau antibodies for solubilized pathological Tau species but not their immunogen or insoluble Tau aggregates predicts in vivo and ex vivo efficacy
Erin E. Congdon et al.
MOLECULAR NEURODEGENERATION (2016)
Molecular crosstalk between tumour and brain parenchyma instructs histopathological features in glioblastoma
Sebastien Bougnaud et al.
ONCOTARGET (2016)
Tau Structures
Jesus Avila et al.
FRONTIERS IN AGING NEUROSCIENCE (2016)
Expression, phosphorylation, localization, and microtubule binding of tau in colorectal cell lines
Md Nazmul Huda et al.
APPLIED BIOLOGICAL CHEMISTRY (2016)
Up-regulation of miR-370-3p restores glioblastoma multiforme sensitivity to temozolomide by influencing MGMT expression
Yong-tao Gao et al.
SCIENTIFIC REPORTS (2016)
Nuclear Tau and Its Potential Role in Alzheimer's Disease
Mahmoud Bukar Maina et al.
BIOMOLECULES (2016)
Nuclear Magnetic Resonance Spectroscopy Characterization of Interaction of Tau with DNA and Its Regulation by Phosphorylation
Haoling Qi et al.
BIOCHEMISTRY (2015)
Causes of genome instability: the effect of low dose chemical exposures in modern society
Sabine A. S. Langie et al.
CARCINOGENESIS (2015)
Involvement of 14-3-3 in tubulin instability and impaired axon development is mediated by Tau
Yuyoung Joo et al.
FASEB JOURNAL (2015)
Distinct Therapeutic Mechanisms of Tau Antibodies PROMOTING MICROGLIAL CLEARANCE VERSUS BLOCKING NEURONAL UPTAKE
Kristen E. Funk et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2015)
Analysis of tau post-translational modifications in rTg4510 mice, a model of tau pathology
Lixin Song et al.
MOLECULAR NEURODEGENERATION (2015)
Prefibrillar Tau oligomers alter the nucleic acid protective function of Tau in hippocampal neurons in vivo
Marie Violet et al.
NEUROBIOLOGY OF DISEASE (2015)
Glioblastoma multiforme: Pathogenesis and treatment
Constantinos Alifieris et al.
PHARMACOLOGY & THERAPEUTICS (2015)
Tau immunotherapy for Alzheimer's disease
Jan Torleif Pedersen et al.
TRENDS IN MOLECULAR MEDICINE (2015)
Insights into the clinical value of cyclin-dependent kinase 5 in glioma: a retrospective study
Ruan Yushan et al.
WORLD JOURNAL OF SURGICAL ONCOLOGY (2015)
Aneuploidy and chromosomal instability in cancer: a jackpot to chaos
Maybelline Giam et al.
CELL DIVISION (2015)
Pharmaceutical screen identifies novel target processes for activation of autophagy with a broad translational potential
Santosh Chauhan et al.
NATURE COMMUNICATIONS (2015)
Flubendazole, FDA-approved anthelmintic, targets breast cancer stem-like cells
Zhi-Jie Hou et al.
ONCOTARGET (2015)
Microglial internalization and degradation of pathological tau is enhanced by an anti-tau monoclonal antibody
Wenjie Luo et al.
SCIENTIFIC REPORTS (2015)
PE859, a Novel Tau Aggregation Inhibitor, Reduces Aggregated Tau and Prevents Onset and Progression of Neural Dysfunction In Vivo
Michiaki Okuda et al.
PLOS ONE (2015)
Activation of mTOR: a culprit of Alzheimer's disease?
Zhiyou Cai et al.
NEUROPSYCHIATRIC DISEASE AND TREATMENT (2015)
Modulation of p25 and inflammatory pathways by fisetin maintains cognitive function in Alzheimer's disease transgenic mice
Antonio Currais et al.
AGING CELL (2014)
High-grade glioma: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up
R. Stupp et al.
ANNALS OF ONCOLOGY (2014)
An Overview of Autophagy: Morphology, Mechanism, and Regulation
Katherine R. Parzych et al.
ANTIOXIDANTS & REDOX SIGNALING (2014)
Structure and Mechanism of Action of Tau Aggregation Inhibitors
Katryna Cisek et al.
CURRENT ALZHEIMER RESEARCH (2014)
Quantitative Analysis of Tau-Microtubule Interaction Using FRET
Isabelle L. Di Maio et al.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2014)
Resistance to first line platinum paclitaxel chemotherapy in serous epithelial ovarian cancer: The prediction value of ERCC1 and Tau expression
Karina Dahl Steffensen et al.
INTERNATIONAL JOURNAL OF ONCOLOGY (2014)
Tau promotes neurodegeneration through global chromatin relaxation
Bess Frost et al.
NATURE NEUROSCIENCE (2014)
Phenotypic screening in cancer drug discovery - past, present and future
John G. Moffat et al.
NATURE REVIEWS DRUG DISCOVERY (2014)
Temsirolimus attenuates tauopathy in vitro and in vivo by targeting tau hyperphosphorylation and autophagic clearance
Teng Jiang et al.
NEUROPHARMACOLOGY (2014)
A major role for Tau in neuronal DNA and RNA protection in vivo under physiological and hyperthermic conditions
Marie Violet et al.
FRONTIERS IN CELLULAR NEUROSCIENCE (2014)
X chromosome aneuploidy in the Alzheimer's disease brain
Yuri B. Yurov et al.
MOLECULAR CYTOGENETICS (2014)
Mechanistic Basis of Phenothiazine-Driven Inhibition of Tau Aggregation
Elias Akoury et al.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2013)
Interaction of 14-3-3ζ with Microtubule-Associated Protein Tau within Alzheimer's Disease Neurofibrillary Tangles
Hamid Y. Qureshi et al.
BIOCHEMISTRY (2013)
The Somatic Genomic Landscape of Glioblastoma
Cameron W. Brennan et al.
CELL (2013)
Mutations in MAPT Gene Cause Chromosome Instability and Introduce Copy Number Variations Widely in the Genome
Giacomina Rossi et al.
JOURNAL OF ALZHEIMERS DISEASE (2013)
Two Novel Tau Antibodies Targeting the 396/404 Region Are Primarily Taken Up by Neurons and Reduce Tau Protein Pathology
Jiaping Gu et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2013)
Tau protein as a potential predictive marker in epithelial ovarian cancer patients treated with paclitaxel/platinum first-line chemotherapy
Marta Smoter et al.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2013)
Predictive and prognostic values of Tau and BubR1 protein in prostate cancer and their relationship to the Gleason score
Yalcin Cirak et al.
MEDICAL ONCOLOGY (2013)
Relationship Between Gastric Cancer Tau Protein Expression and Paclitaxel Sensitivity
Qiong Wang et al.
PATHOLOGY & ONCOLOGY RESEARCH (2013)
Lyn Facilitates Glioblastoma Cell Survival under Conditions of Nutrient Deprivation by Promoting Autophagy
Wei Michael Liu et al.
PLOS ONE (2013)
MOZ increases p53 acetylation and premature senescence through its complex formation with PML
Susumu Rokudai et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2013)
Tau degradation: The ubiquitin-proteasome system versus the autophagy-lysosome system
Min Jae Lee et al.
PROGRESS IN NEUROBIOLOGY (2013)
Glial and glioneuronal tumors in adults and children: main genetic alterations and towards a histomolecular classification
Dominique Figarella-Branger et al.
BULLETIN DU CANCER (2013)
Stimulation of autophagy is neuroprotective in a mouse model of human tauopathy
Veronique Schaeffer et al.
AUTOPHAGY (2012)
Degradation of tau protein by autophagy and proteasomal pathways
Yipeng Wang et al.
BIOCHEMICAL SOCIETY TRANSACTIONS (2012)
Going out of the brain: Non-nervous system physiological and pathological functions of Cdk5
Erick Contreras-Vallejos et al.
CELLULAR SIGNALLING (2012)
Effects of PTEN inhibition on regulation of tau phosphorylation in an okadaic acid-induced neurodegeneration model
Zhou Chen et al.
INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE (2012)
Correlation of EGFR, IDH1 and PTEN status with the outcome of patients with recurrent glioblastoma treated in a phase II clinical trial with the EGFR-blocking monoclonal antibody cetuximab
Shasha Lv et al.
INTERNATIONAL JOURNAL OF ONCOLOGY (2012)
Long-term oral lithium treatment attenuates motor disturbance in tauopathy model mice: Implications of autophagy promotion
Kohei Shimada et al.
NEUROBIOLOGY OF DISEASE (2012)
Valproate reduces tau phosphorylation via cyclin-dependent kinase 5 and glycogen synthase kinase 3 signaling pathways
Jiang-Ping Hu et al.
BRAIN RESEARCH BULLETIN (2011)
Nuclear Tau, a Key Player in Neuronal DNA Protection
Audrey Sultan et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2011)
Amyloid-β and tau - a toxic pas de deux in Alzheimer's disease
Lars M. Ittner et al.
NATURE REVIEWS NEUROSCIENCE (2011)
Post-translational modifications of tau protein: Implications for Alzheimer's disease
Ludovic Martin et al.
NEUROCHEMISTRY INTERNATIONAL (2011)
Mechanistic Studies of Antibody-Mediated Clearance of Tau Aggregates Using an ex vivo Brain Slice Model
Pavan K. Krishnamurthy et al.
Frontiers in Psychiatry (2011)
Synergy and antagonism of macroautophagy and chaperone-mediated autophagy in a cell model of pathological tau aggregation
Yipeng Wang et al.
AUTOPHAGY (2010)
The antihelmintic flubendazole inhibits microtubule function through a mechanism distinct from Vinca alkaloids and displays preclinical activity in leukemia and myeloma
Paul A. Spagnuolo et al.
BLOOD (2010)
Integrated Genomic Analysis Identifies Clinically Relevant Subtypes of Glioblastoma Characterized by Abnormalities in PDGFRA, IDH1, EGFR, and NF1
Roel G. W. Verhaak et al.
CANCER CELL (2010)
A randomized phase III study of adjuvant platinum/docetaxel chemotherapy with or without radiation therapy in patients with gastric cancer
Aristotelis Bamias et al.
CANCER CHEMOTHERAPY AND PHARMACOLOGY (2010)
Targeting SRC in glioblastoma tumors and brain metastases Rationale and preclinical studies
Manmeet S. Ahluwalia et al.
CANCER LETTERS (2010)
A Caspase Cleaved Form of Tau Is Preferentially Degraded through the Autophagy Pathway
Philip J. Dolan et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2010)
Hsc70 Rapidly Engages Tau after Microtubule Destabilization
Umesh K. Jinwal et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2010)
Cyclin-dependent Kinase 5 Regulates Endothelial Cell Migration and Angiogenesis
Johanna Liebl et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2010)
Expression and Silencing of the Microtubule-Associated Protein Tau in Breast Cancer Cells
Tatiana Spicakova et al.
MOLECULAR CANCER THERAPEUTICS (2010)
Acetylation of Tau Inhibits Its Degradation and Contributes to Tauopathy
Sang-Won Min et al.
NEURON (2010)
The proline-rich domain of tau plays a role in interactions with actin
Hai Jin He et al.
BMC CELL BIOLOGY (2009)
Fyn and Src Are Effectors of Oncogenic Epidermal Growth Factor Receptor Signaling in Glioblastoma Patients
Kan V. Lu et al.
CANCER RESEARCH (2009)
Mutant Metabolic Enzymes Are at the Origin of Gliomas
Hai Yan et al.
CANCER RESEARCH (2009)
Potential Therapeutic Effect of Glycogen Synthase Kinase 3β Inhibition against Human Glioblastoma
Katsuyoshi Miyashita et al.
CLINICAL CANCER RESEARCH (2009)
Microtubule-Associated Protein Tau in Human Prostate Cancer Cells: Isoforms, Phosphorylation, and Interactions
Skye Souter et al.
JOURNAL OF CELLULAR BIOCHEMISTRY (2009)
The EGFRvIII variant in glioblastoma multiforme
Hui K. Gan et al.
JOURNAL OF CLINICAL NEUROSCIENCE (2009)
Evaluation of Microtubule-Associated Protein-Tau Expression As a Prognostic and Predictive Marker in the NSABP-B 28 Randomized Clinical Trial
Lajos Pusztai et al.
JOURNAL OF CLINICAL ONCOLOGY (2009)
Aneuploidy in the normal, Alzheimer's disease and ataxia-telangiectasia brain: Differential expression and pathological meaning
Ivan Y. Iourov et al.
NEUROBIOLOGY OF DISEASE (2009)
GSK3β Regulates Differentiation and Growth Arrest in Glioblastoma
Serdar Korur et al.
PLOS ONE (2009)
Isoform-specific expression and characterization of 14-3-3 proteins in human glioma tissues discovered by stable isotope labeling with amino acids in cell culture-based proteomic analysis
Shufang Liang et al.
PROTEOMICS CLINICAL APPLICATIONS (2009)
Yes and PI3K bind CD95 to signal invasion of glioblastoma
Susanne Kleber et al.
CANCER CELL (2008)
Glycogen synthase kinase-3 inhibition induces glioma cell death through c-MYC, nuclear factor-κB, and glucose regulation
Svetlana Kotliarova et al.
CANCER RESEARCH (2008)
An unusual member of the Cdk family: Cdk5
Fatema A. Dhariwala et al.
CELLULAR AND MOLECULAR NEUROBIOLOGY (2008)
Phosphorylation regulates tau interactions with Src homology 3 domains of phosphatidylinositol 3-kinase, phospholipase Cγ1, Grb2, and Src family kinases
C. Hugh Reynolds et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2008)
FTDP-17 Mutations in Tau Alter the Regulation of Microtubule Dynamics AN ALTERNATIVE CORE MODEL FOR NORMAL AND PATHOLOGICAL TAU ACTION
Adria C. Leboeuf et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2008)
Histone deacetylase 6 interacts with the microtubule-associated protein tau
Huiping Ding et al.
JOURNAL OF NEUROCHEMISTRY (2008)
Comprehensive genomic characterization defines human glioblastoma genes and core pathways
L. Chin et al.
NATURE (2008)
A potent mechanism-inspired O-GlcNAcase inhibitor that blocks phosphorylation of tau in vivo
Scott A. Yuzwa et al.
NATURE CHEMICAL BIOLOGY (2008)
Lithium inhibits invasion of glioma cells; possible involvement of glycogen synthase kinase-3
Michal O. Nowicki et al.
NEURO-ONCOLOGY (2008)
Cdk5 is essential for adult hippocampal neurogenesis
Diane C. Lagace et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)
Aneuploidy and DNA replication in the normal human brain and Alzheimer's disease
Birgit Mosch et al.
JOURNAL OF NEUROSCIENCE (2007)
Targeting the Raf-MEK-ERK mitogen-activated protein kinase cascade for the treatment of cancer
P. J. Roberts et al.
ONCOGENE (2007)
MAP kinase signalling pathways in cancer
A. S. Dhillon et al.
ONCOGENE (2007)
Tau impacts on growth-factor-stimulated actin remodeling
Vandana M. Sharma et al.
JOURNAL OF CELL SCIENCE (2007)
Regulation of phosphorylation of tau by cyclin-dependent kinase 5 and glycogen synthase kinase-3 at substrate level
Amitabha Sengupta et al.
FEBS LETTERS (2006)
Tau associates with actin in differentiating PC12 cells
Jiang-Zhou Yu et al.
FASEB JOURNAL (2006)
Chemotherapy resistance of glioblastoma stem cells
A. Eramo et al.
CELL DEATH AND DIFFERENTIATION (2006)
Reduced tau expression in gastric cancer can identify candidates for successful paclitaxel treatment
K. Mimori et al.
BRITISH JOURNAL OF CANCER (2006)
Tumor-suppressor PTEN affects tau phosphorylation, aggregation, and binding to microtubules
Xue Zhang et al.
FASEB JOURNAL (2006)
PTEN, a negative regulator of P13 kinase signalling, alters tau phosphorylation in cells by mechanisms independent of GSK-3
Fiona Kerr et al.
FEBS LETTERS (2006)
Hypoxia signalling in cancer and approaches to enforce tumour regression
Jacques Pouyssegur et al.
NATURE (2006)
Reduced glioma infiltration in Src-deficient mice
Caren V. Lund et al.
JOURNAL OF NEURO-ONCOLOGY (2006)
Potent inhibition of platelet-derived growth factor-induced responses in vascular smooth muscle cells by BMS-354825 (dasatinib)
ZM Chen et al.
MOLECULAR PHARMACOLOGY (2006)
Cyclin-dependent protein kinase 5 primes microtubule-associated protein tau site-specifically for glycogen synthase kinase 3β
T Li et al.
BIOCHEMISTRY (2006)
Molecular subclasses of high-grade glioma predict prognosis, delineate a pattern of disease progression, and resemble stages in neurogenesis
HS Phillips et al.
CANCER CELL (2006)
Dasatinib (BMS-354825), a dual SRC/ABL kinase inhibitor, inhibits the kinase activity of wild-type, juxtamembrane, and activation loop mutant KIT Isoforms associated with human malignancies
MM Schittenhelm et al.
CANCER RESEARCH (2006)
Disease-related modifications in tau affect the interaction between Fyn and tau
K Bhaskar et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2005)
Microtubule associated protein (MAP)-Tau - A novel mediator of paclitaxel sensitivity in vitro and in vivo
P Wagner et al.
CELL CYCLE (2005)
Lyn kinase activity is the predominant cellular Src kinase activity in glioblastoma tumor cells
AR Stettner et al.
CANCER RESEARCH (2005)
Microtubule-associated protein tau: A marker of paclitaxel sensitivity in breast cancer
R Rouzier et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)
Post-translational modifications of tau protein in Alzheimer's disease
CX Gong et al.
JOURNAL OF NEURAL TRANSMISSION (2005)
Activation of Akt/PKB, increased phosphorylation of Akt substrates and loss and altered distribution of Akt and PTEN are features of Alzheimer's disease pathology
RJ Griffin et al.
JOURNAL OF NEUROCHEMISTRY (2005)
Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma
R Stupp et al.
NEW ENGLAND JOURNAL OF MEDICINE (2005)
Inability of tau to properly regulate neuronal microtubule dynamics: a loss-of-function mechanism by which tau might mediate neuronal cell death
SC Feinstein et al.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2005)
CHIP and Hsp70 regulate tau ubiquitination, degradation and aggregation
L Petrucelli et al.
HUMAN MOLECULAR GENETICS (2004)
Microtubules as a target for anticancer drugs
MA Jordan et al.
NATURE REVIEWS CANCER (2004)
U-box protein carboxyl terminus of Hsc70-interacting protein (CHIP) mediates poly-ubiquitylation preferentially on four-repeat Tau and is involved in neurodegeneration of tauopathy
S Hatakeyama et al.
JOURNAL OF NEUROCHEMISTRY (2004)
Gene expression profiling of gliomas strongly predicts survival
WA Freije et al.
CANCER RESEARCH (2004)
PTEN function: how normal cells control it and tumour cells lose it
NR Leslie et al.
BIOCHEMICAL JOURNAL (2004)
Promotion of hyperphosphorylation by frontotemporal dementia tau mutations
AD Alonso et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
Gα12 directly interacts with PP2A -: Evidence for Gα12-stimulated PP2A phosphatase activity and dephosphorylation of microtubuleassociated protein, Tau
DG Zhu et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
Pathophysiology of chaperone-mediated autophagy
A Massey et al.
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY (2004)
Tau becomes a more favorable substrate for GSK-3 when it is prephosphorylated by PKA in rat brain
SJ Liu et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
14-3-3 binds to and mediates phosphorylation of microtubule-associated tau protein by Ser9-phosphorylated glycogen synthase kinase 3β in the brain
ZF Yuan et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
Phosphorylation of tau at THR212 and SER214 in human neuronal and glial cultures: The role of Akt
HK Pyo et al.
NEUROSCIENCE (2004)
Src family kinases, key regulators of signal transduction
SJ Parsons et al.
ONCOGENE (2004)
Src kinase activation by direct interaction with the integrin β cytoplasmic domain
EG Arias-Salgado et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2003)
Cdk5 is essential for synaptic vesicle endocytosis
TC Tan et al.
NATURE CELL BIOLOGY (2003)
Tumorigenesis and the angiogenic switch
G Bergers et al.
NATURE REVIEWS CANCER (2003)
Cdk5 is a key factor in tau aggregation and tangle formation in vivo
W Noble et al.
NEURON (2003)
14-3-3 connects glycogen synthase kinase-3β to tau within a brain microtubule-associated tau phosphorylation complex
A Agarwal-Mawal et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
Tau could protect DNA double helix structure
Q Hua et al.
BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS (2003)
Tenascin-C signaling through induction of 14-3-3 tau
D Martin et al.
JOURNAL OF CELL BIOLOGY (2003)
ERM Proteins and Cdk5 in Cellular Senescence
Hai-Su Yang et al.
CELL CYCLE (2003)
Proteasomal degradation of tau protein
DC David et al.
JOURNAL OF NEUROCHEMISTRY (2002)
First tau repeat domain binding to growing and taxol- stabilized microtubules, and serine 262 residue phosphorylation
F Devred et al.
FEBS LETTERS (2002)
Glycogen synthase kinase-3,β is complexed with tau protein in brain microtubules
W Sun et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2002)
Tubulin, actin, and tau protein interactions and the study of their macromolecular assemblies
GA Farias et al.
JOURNAL OF CELLULAR BIOCHEMISTRY (2002)
Regulation of PTEN transcription by p53
V Stambolic et al.
MOLECULAR CELL (2001)
Structural and functional differences between 3-repeat and 4-repeat tau isoforms - Implications for normal tau function and the onset of neurodegenerative disease
BL Goode et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2000)
Selected glimpses into the activation and function of Src kinase
JD Bjorge et al.
ONCOGENE (2000)
Phosphorylation and inactivation of glycogen synthase kinase 3 by protein kinase A
XJ Fang et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2000)
Cell signaling by receptor tyrosine kinases
J Schlessinger
CELL (2000)
p53 is associated with cellular microtubules and is transported to the nucleus by dynein
P Giannakakou et al.
NATURE CELL BIOLOGY (2000)
14-3-3ζ is an effector of tau protein phosphorylation
M Hashiguchi et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2000)
Interaction of tau with the neural membrane cortex is regulated by phosphorylation at sites that are modified in paired helical filaments
T Maas et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2000)
Novel cathepsin D inhibitors block the formation of hyperphosphorylated tau fragments in hippocampus
XN Bi et al.
JOURNAL OF NEUROCHEMISTRY (2000)
分享论文
