4.6 Review

Regulation of Metastasis in Ewing Sarcoma

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Single-cell RNA profiling identifies diverse cellular responses to EWSR1/FLI1 downregulation in Ewing sarcoma cells

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Summary: In this study, the researchers investigated the transcriptional states and phenotypes of cell proliferation and dormancy by suppressing the expression of the EWSR1/FLI1 gene. They found that the dynamics of subpopulations of cells can affect the stem cell characteristics and survival mechanisms of cells, which is of significant importance for understanding the occurrence and development of Ewing sarcoma.

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Summary: The introduction of dose intensified interval compressed therapy has improved event-free survival for localized Ewing sarcoma patients. However, a significant number of patients still experience relapse and die of the disease, with surviving patients often facing debilitating late effects. Traditional clinical features are inadequate for risk stratification, highlighting the need to develop approaches based on molecular features. New technology has allowed the study of multiple molecular biomarkers in Ewing sarcoma, which may enable risk-adapted treatment in the future.

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YAP/TAZ inhibition reduces metastatic potential of Ewing sarcoma cells

Lisa Bierbaumer et al.

Summary: Ewing sarcoma cells exhibit high plasticity and can switch between different functional states under the regulation of EWS-FLI1. Inhibiting the YAP/TAZ pathway has been shown to suppress migration and metastasis of Ewing sarcoma cells.

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Ewing Sarcoma-Diagnosis, Treatment, Clinical Challenges and Future Perspectives

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Summary: Ewing sarcoma is a highly aggressive bone and soft-tissue cancer with a genetically simple yet specific therapeutic target. Current standard treatment involving systemic therapy and local treatment provides a realistic chance of cure for the majority of patients.

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Reactivation of TWIST1 contributes to Ewing sarcoma metastasis

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DNA methylation heterogeneity defines a disease spectrum in Ewing sarcoma

Nathan C. Sheffield et al.

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Role for the EWS domain of EWS/FLI in binding GGAA-microsatellites required for Ewing sarcoma anchorage independent growth

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EWS-FLI1 employs an E2F switch to drive target gene expression

Raphaela Schwentner et al.

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Ewing's sarcoma precursors are highly enriched in embryonic osteochondrogenic progenitors

Miwa Tanaka et al.

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Stress-Induced CXCR4 Promotes Migration and Invasion of Ewing Sarcoma

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LGR5 is expressed by Ewing sarcoma and potentiates Wnt/beta-catenin signaling

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Microsatellites with Macro-Influence in Ewing Sarcoma

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CD99 inhibits neural differentiation of human Ewing sarcoma cells and thereby contributes to oncogenesis

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Caveolin-1 Modulates the Ability of Ewing's Sarcoma to Metastasize

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