☆ 4.6 Review

Recent Advances in Bacteria-Based Cancer Treatment

CANCERS (2022)

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Article Chemistry, Multidisciplinary

Engineered Bacteria for Enhanced Radiotherapy against Breast Carcinoma

Pei Pan et al.

Summary: In this study, an integrated nanosystem composed of engineered bacteria and nanoparticles was developed for sensitizing radiotherapy. The system could target tumor sites and release a radiosensitizer, enhancing the effectiveness of radiotherapy.

ACS NANO (2022)

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Article Chemistry, Multidisciplinary

Neisseria meningitidis Opca Protein/MnO2 Hybrid Nanoparticles for Overcoming the Blood-Brain Barrier to Treat Glioblastoma

Cheng-Yuan Dong et al.

Summary: This study demonstrates a bionic nanotherapeutic system that effectively overcomes the blood-brain barrier and improves the treatment of glioblastoma by loading chemotherapy drugs into modified nanoparticles.

ADVANCED MATERIALS (2022)

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Article Engineering, Biomedical

Engineering bioluminescent bacteria to boost photodynamic therapy and systemic anti-tumor immunity for synergistic cancer treatment

Zhijuan Yang et al.

Summary: This study developed bioluminescent bacteria as an internal light source to enhance photodynamic therapy (PDT). The bioluminescence-triggered PDT showed significant advantages over conventional PDT and could also induce potent antitumor immunity. This research provides a general and highly effective therapeutic approach for diverse cancers with varying light-absorbing capacities and tumor sizes.

BIOMATERIALS (2022)

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Review Oncology

Bugs as drugs: neglected but a promising future therapeutic strategy in cancer

Mithoor Divyashree et al.

Summary: Microbe-based cancer treatment uses tumor-specific infectious microbes to address difficult-to-treat cancers. These microbes can be self-regenerating therapeutics, and scientific research has shown that bacteria can be effective cancer prophylactic and therapeutic agents, as well as ideal carriers for targeted cancer therapy. Advanced molecular engineering techniques have improved the efficacy and reduced adverse effects of bacterial therapy.

FUTURE ONCOLOGY (2022)

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Article Chemistry, Multidisciplinary

Non-viral vectors for RNA delivery

Yi Yan et al.

Summary: RNA-based therapy is a promising strategy for disease treatment, and recent advances in non-viral delivery systems have shown potential in protecting RNA, facilitating cell internalization, and controlled release of therapeutics.

JOURNAL OF CONTROLLED RELEASE (2022)

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Article Chemistry, Multidisciplinary

Microbiotic nanomedicine for tumor-specific chemotherapy-synergized innate/adaptive antitumor immunity

Wencheng Wu et al.

Summary: This study reports a novel microbiotic nanomedicine LOD/TPZ@Lips-LA, which combines lactate oxidase (LOD) and prodrug tirapazamine (TPZ) loaded liposomes anchored on lactobacillus (LA) surface for chemotherapy-synergized antitumor immunity. The nanomedicine induces tumor cell apoptosis through in situ ROS generation and TPZ activation based on LA metabolism, resulting in strong immunogenic cell death (ICD). By regulating biomarker expression, it promotes anti-tumorigenic M1 polarization of innate tumor-associated macrophages and infiltration of adaptive cytotoxic CD8+ T cells, synergistically enhancing the tumor inhibition effects.

NANO TODAY (2022)

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Article Oncology

Anticancer activity of lactic acid bacteria

Katarzyna Garbacz

Summary: Lactic acid bacteria (LAB), naturally occurring in fermented food products and used as probiotics, have bioactive compounds with potential anticancer activity. Research has shown that these compounds can inhibit tumor growth through various mechanisms and have immunomodulatory effects. LAB has promising clinical applications in anticancer therapy.

SEMINARS IN CANCER BIOLOGY (2022)

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Article Biochemical Research Methods

Precise Thermal Regulation of Engineered Bacteria Secretion for Breast Cancer Treatment In Vivo

Lianyue Li et al.

Summary: In this study, heat-sensitive engineered bacteria were constructed to produce therapeutic proteins in response to thermal stimuli. The precise control of their functions was demonstrated in various model organisms, and it was found that heat stimulation could inhibit tumor growth, providing a new approach for the precise control of engineered bacteria in vivo.

ACS SYNTHETIC BIOLOGY (2022)

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Review Food Science & Technology

Cytolysin A (ClyA): A Bacterial Virulence Factor with Potential Applications in Nanopore Technology, Vaccine Development, and Tumor Therapy

Kazunori Murase

Summary: This review provides an overview of the current knowledge about ClyA, including its encoding gene, transcriptional regulation, protein secretion pathway, and assembly mechanism. It highlights the potential applications of ClyA in biotechnology, such as nanopore-based technologies, vaccine development, and anti-tumor agents.

TOXINS (2022)

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Article Biotechnology & Applied Microbiology

Nanocages engineered from Bacillus Calmette-Guerin facilitate protective Vγ2Vδ2 T cell immunity against Mycobacterium tuberculosis infection

Jiang Pi et al.

Summary: Engineering Mycobacterium tuberculosis into nanoscale particles improves the safety and efficacy of the TB vaccine, providing better protection against TB infection.

JOURNAL OF NANOBIOTECHNOLOGY (2022)

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Review Biotechnology & Applied Microbiology

Streptococcal bacterial components in cancer therapy

Zeynab Marzhoseyni et al.

Summary: The incidence of cancer is increasing globally, leading to a need for new treatment strategies. Bacterial therapy, particularly using Streptococcus strains, has shown potential in targeting and fighting cancer. With inherent anti-tumor activity and the ability to activate the immune system, these bacteria are being explored for their role in cancer treatment through mechanisms such as genetic engineering to secrete tumor-specific toxins.

CANCER GENE THERAPY (2022)

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Review Oncology

Bacterial-Based Methods for Cancer Treatment: What We Know and Where We Are

Foad Rommasi

Summary: Cancer, a severe disease caused by the abnormal growth of cells, poses challenges to health and medicine. Traditional cancer treatments like chemotherapy, surgery, and radiotherapy have drawbacks such as side effects and tumor cell resistance. Bacteria, with their potential for non-pathogenicity through genetic manipulation and virulence factors, are being explored as viable options for cancer therapy, despite challenges such as cytotoxic effects and incomplete cancer cell lysis.

ONCOLOGY AND THERAPY (2022)

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Article Chemistry, Multidisciplinary

Intravenous Delivery of Living Listeria monocytogenes Elicits Gasdmermin-Dependent Tumor Pyroptosis and Motivates Anti-Tumor Immune Response

Yao Liu et al.

Summary: In this study, an immunotherapy system based on red blood cell membrane encapsulated Listeria monacytagenes (Lmo@RBC) was developed to address the limitations of Lmo as a cancer vaccine. Lmo@RBC showed low systemic inflammatory response and enhanced accumulation in tumors, resulting in a strong and durable anti-tumor immune response with excellent therapeutic effects.

ACS NANO (2022)

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Article Chemistry, Multidisciplinary

Rapid Surface Display of mRNA Antigens by Bacteria-Derived Outer Membrane Vesicles for a Personalized Tumor Vaccine

Yao Li et al.

Summary: This study utilized bacteria-derived outer membrane vesicles (OMVs) as a delivery platform for mRNA, genetically modified to deliver specific mRNA antigens into dendritic cells, triggering anti-tumor immune responses. The results showed that this platform significantly inhibited tumor progression and achieved 37.5% complete regression in an in vivo model.

ADVANCED MATERIALS (2022)

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Review Pharmacology & Pharmacy

Bacterial cancer therapy: A turning point for new paradigms

Vijayakumar Mayakrishnan et al.

Summary: Cancer treatments have improved significantly, but there is still room for improvement. In recent years, bacteria-based cancer therapy has gained attention for its unique properties, as bacteria can control tumor growth and improve prognosis.

DRUG DISCOVERY TODAY (2022)

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Review Biochemistry & Molecular Biology

Helicobacter pylori Pathogen-Associated Molecular Patterns: Friends or Foes?

Daniela Eletto et al.

Summary: This article discusses how microbial infections are sensed by the host immune system and how H. pylori escapes immune recognition through camouflage.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

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Article Nanoscience & Nanotechnology

Self-Assembly Catalase Nanocomplex Conveyed by Bacterial Vesicles for Oxygenated Photodynamic Therapy and Tumor Immunotherapy

Jiayu Zhang et al.

Summary: This study developed a new nanosystem, CAT-Ce6@OMV-aPDL1, which supports oxygenated photodynamic therapy through self-assembly nanocomplex and enhances antitumoral immunity through coated modified-attenuated Salmonella outer membrane vesicles. The results demonstrated that this nanosystem effectively alleviates hypoxia and stimulates immune responses to inhibit tumor development.

INTERNATIONAL JOURNAL OF NANOMEDICINE (2022)

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Article Multidisciplinary Sciences

A programmable encapsulation system improves delivery of therapeutic bacteria in mice

Tetsuhiro Harimoto et al.

Summary: This study developed a genetically encoded microbial encapsulation system with tunable and dynamic expression of surface capsular polysaccharides to enhance systemic delivery. The system allowed bacteria to temporarily evade immune attack and be effectively cleared in vivo. The results showed that this strategy increased the maximum tolerated dose of bacteria and improved anti-tumor efficacy.

CURRENT SCIENCE (2022)

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Review Oncology

Pseudomonas aeruginosa in Cancer Therapy: Current Knowledge, Challenges and Future Perspectives

Zheng Pang et al.

Summary: Drug resistance, toxicity, and lack of selectivity are major challenges in conventional cancer therapies. Utilizing bacteria as a strategy for cancer treatment, particularly Pseudomonas aeruginosa, shows promising results with high specificity and efficacy.

FRONTIERS IN ONCOLOGY (2022)

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Article Engineering, Biomedical

Antigen-bearing outer membrane vesicles as tumour vaccines produced in situ by ingested genetically engineered bacteria

Yale Yue et al.

Summary: Outer membrane vesicles (OMVs) produced in the intestine by ingested genetically engineered bacteria, which are fused with tumour antigens, can serve as effective oral tumour vaccines in mice. These OMVs can stimulate dendritic cell maturation, inhibit tumour growth, and generate long-term antitumour immunity.

NATURE BIOMEDICAL ENGINEERING (2022)

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Article Engineering, Biomedical

Hydrogel microcapsules containing engineered bacteria for sustained production and release of protein drugs

Chunli Han et al.

Summary: Engineered bacterial microcapsules show potential for durable release of protein drugs, with applications in treating diabetes and preventing tumor growth.

BIOMATERIALS (2022)

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Article Multidisciplinary Sciences

Peptidoglycan maturation controls outer membrane protein assembly

Gideon Mamou et al.

Summary: The spatiotemporal organization of outer membrane proteins (OMPs) in Gram-negative bacteria is modulated by the presence of mature peptidoglycan, which inhibits OMP foldase activity and promotes preferential insertion of OMPs at division sites. This coordination between OMP biogenesis and peptidoglycan maturation represents a potential vulnerability that could be targeted in future antibiotic design.

NATURE (2022)

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Article Medicine, Research & Experimental

Surface-engineered extracellular vesicles for targeted delivery of therapeutic RNAs and peptides for cancer therapy

Migara Kavishka Jayasinghe et al.

Summary: The use of extracellular vesicles (EVs) as drug delivery vectors has gained attention due to their ability to efficiently deliver therapeutic payloads to diseased cells. Surface functionalization methods have been developed to enhance the stability and biocompatibility of EVs, allowing for targeted delivery to cancer cells and improved metastasis suppression. Extensive testing has shown that engineered EVs are biocompatible and safe for repeated dose treatment.

THERANOSTICS (2022)

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Article Nanoscience & Nanotechnology

Novel Engineered Bacterium/Black Phosphorus Quantum Dot Hybrid System for Hypoxic Tumor Targeting and Efficient Photodynamic Therapy

Shuaijie Ding et al.

Summary: In this study, a novel engineered bacterial system was developed to target hypoxic tumor tissues and efficiently mediate photodynamic therapy through the release of oxygen. The system successfully killed tumor cells in vivo, demonstrating good therapeutic efficacy and highlighting new avenues for cancer treatment using black phosphorus quantum dots.

ACS APPLIED MATERIALS & INTERFACES (2021)

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Article Chemistry, Multidisciplinary

Hybrid Vesicles Based on Autologous Tumor Cell Membrane and Bacterial Outer Membrane To Enhance Innate Immune Response and Personalized Tumor Immunotherapy

Mei-Zhen Zou et al.

Summary: A vesicle system designed to enhance innate immune response and amplify personalized immunotherapy effectively inhibits tumor growth and metastasis. In vitro and in vivo experiments demonstrated the potential clinical applications of mTOMV in personalized cancer therapy.

NANO LETTERS (2021)

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Review Immunology

Perspectives on Oncolytic Salmonella in Cancer Immunotherapy-A Promising Strategy

Ding Wang et al.

Summary: Cancer biological therapy, stemming from the spontaneous regression of tumors in patients with streptococcus infection, has evolved into today's immunotherapy. Despite some adverse reactions and selectiveness, substances like Salmonella have been proven to hold promise in antitumor treatment.

FRONTIERS IN IMMUNOLOGY (2021)

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Article Oncology

P. aeruginosa Mediated Necroptosis in Mouse Tumor Cells Induces Long-Lasting Systemic Antitumor Immunity

Jia-long Qi et al.

Summary: The study found that Pseudomonas aeruginosa can inhibit tumor growth by inducing immunogenic cell death, triggering a long-lasting anti-tumor response and reshaping the tumor microenvironment through promoting DC maturation and modulating immune responses.

FRONTIERS IN ONCOLOGY (2021)

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Review Immunology

Clinical Experience and Recent Advances in the Development of Listeria-Based Tumor Immunotherapies

Mariam Oladejo et al.

Summary: Tumor immunotherapy promises to improve patient survival, with Listeria-based vaccines emerging as a promising treatment. Clinical trials have shown Listeria-based vaccines to be effective in activating anti-tumor immunity and eradicating tumors.

FRONTIERS IN IMMUNOLOGY (2021)

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Article Cell Biology

The probiotic L. casei Zhang slows the progression of acute and chronic kidney disease

Han Zhu et al.

Summary: The study demonstrates that oral administration of the probiotic Lactobacillus casei Zhang can correct gut microbial dysbiosis, alleviate kidney injury, and delay the progression of chronic kidney disease. By increasing levels of SCFAs and nicotinamide, L. casei Zhang shows potential as a therapy to reduce renal inflammation and slow the decline of kidney function.

CELL METABOLISM (2021)

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Review Biochemistry & Molecular Biology

Targeting Cytokines, Pathogen-Associated Molecular Patterns, and Damage-Associated Molecular Patterns in Sepsis via Blood Purification

Kazuhiro Moriyama et al.

Summary: Sepsis is a condition characterized by dysregulated immune response to infections, leading to organ dysfunction and even death. Immune system overactivation, triggered by pathogen-associated molecular patterns binding to pattern recognition receptors, results in cellular dysfunction and inflammatory cytokine elevation. Neutrophils, once antimicrobial protectors, can become mediators of tissue injury and organ dysfunction during sepsis.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Article Biochemistry & Molecular Biology

Design of acid-activated cell-penetrating peptides with nuclear localization capacity for anticancer drug delivery

Sujie Huang et al.

Summary: This study established a novel acid-activated CPP, HNLS-3, which demonstrated significant pH-dependent cellular uptake efficiency, endosomal escape ability, and nuclear localization activity. These findings suggest a promising approach for developing efficient CPPs with cancer- and nucleus-targeting properties.

JOURNAL OF PEPTIDE SCIENCE (2021)

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Article Biochemical Research Methods

Engineered hypoxia-responding Escherichia coli carrying cardiac peptide genes, suppresses tumor growth, angiogenesis and metastasis in vivo

Mitra Samadi et al.

Summary: Engineered non-pathogenic E. coli bacteria with hypoxia-responsive promoters were able to selectively accumulate at tumor sites and express specific proteins, leading to suppression of tumor growth and angiogenesis in mice bearing mammary tumors.

JOURNAL OF BIOLOGICAL ENGINEERING (2021)

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Article Multidisciplinary Sciences

Aptamer-assisted tumor localization of bacteria for enhanced biotherapy

Zhongmin Geng et al.

Summary: The study introduces a novel approach of designing tumor-specific aptamer-conjugated bacteria to enhance intratumoral localization and therapeutic efficacy. The surface density of aptamers can be easily adjusted by a simple amidation procedure, leading to increased accumulation of bacteria in tumor tissue. This strategy demonstrates the potential of aptamer-conjugated bacteria for targeted intratumoral localization and improved tumor biotherapy.

NATURE COMMUNICATIONS (2021)

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Article Pharmacology & Pharmacy

Cdk5 knocking out mediated by CRISPR-Cas9 genome editing for PD-L1 attenuation and enhanced antitumor immunity

Huan Deng et al.

ACTA PHARMACEUTICA SINICA B (2020)

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Article Agriculture, Multidisciplinary

Effect of Lactobacillus acidophilus CICC 6074 S-Layer Protein on Colon Cancer HT-29 Cell Proliferation and Apoptosis

Tao Zhang et al.

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2020)

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Article Multidisciplinary Sciences

Mutational signature in colorectal cancer caused by genotoxic pks+E. coli

Cayetano Pleguezuelos-Manzano et al.

NATURE (2020)

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Article Multidisciplinary Sciences

Chemotaxis-driven delivery of nano-pathogenoids for complete eradication of tumors post-phototherapy

Min Li et al.

NATURE COMMUNICATIONS (2020)

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Article Pharmacology & Pharmacy

Doxorubicin-loaded bacterial outer-membrane vesicles exert enhanced anti-tumor efficacy in non-small-cell lung cancer

Kudelaidi Kuerban et al.

ACTA PHARMACEUTICA SINICA B (2020)

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Article Public, Environmental & Occupational Health

Global burden of cancer attributable to infections in 2018: a worldwide incidence analysis

Catherine de Martel et al.

LANCET GLOBAL HEALTH (2020)

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Article Cell Biology

Lactobacilli Have a Niche in the Human Nose

Ilke De Boeck et al.

CELL REPORTS (2020)

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Article Microbiology

Identification of the Molecular Determinants Involved in Antimicrobial Activity of Pseudodesmin A, a Cyclic Lipopeptide From the Viscosin Group

Matthias De Vleeschouwer et al.

FRONTIERS IN MICROBIOLOGY (2020)

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Article Chemistry, Multidisciplinary

Inhibition of Tumor Progression through the Coupling of Bacterial Respiration with Tumor Metabolism

Qi-Wen Chen et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2020)

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Article Chemistry, Multidisciplinary

Prebiotics-Encapsulated Probiotic Spores Regulate Gut Microbiota and Suppress Colon Cancer

Di-Wei Zheng et al.

ADVANCED MATERIALS (2020)

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Article Medicine, Research & Experimental

Imaging of tumor colonization by Escherichia coli using 18F-FDS PET

Sae-Ryung Kang et al.

THERANOSTICS (2020)

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Article Pharmacology & Pharmacy

Prospects and challenges of extracellular vesicle-based drug delivery system: considering cell source

Meng Wanrong et al.

DRUG DELIVERY (2020)

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Article Multidisciplinary Sciences

Bioengineered bacterial vesicles as biological nano-heaters for optoacoustic imaging

Vipul Gujrati et al.

NATURE COMMUNICATIONS (2019)

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Article Chemistry, Multidisciplinary

Unlocking the Potential of Magnetotactic Bacteria as Magnetic Hyperthermia Agents

David Gandia et al.

SMALL (2019)

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Review Microbiology

Bacterial Proteinaceous Compounds With Multiple Activities Toward Cancers and Microbial Infection

Gisele Rodrigues et al.

FRONTIERS IN MICROBIOLOGY (2019)

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Review Biochemistry & Molecular Biology

Bacteria-cancer interactions: bacteria-based cancer therapy

Mai Thi-Quynh Duong et al.

EXPERIMENTAL AND MOLECULAR MEDICINE (2019)

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Article Chemistry, Multidisciplinary

Engineered Bacterial Bioreactor for Tumor Therapy via Fenton-Like Reaction with Localized H2O2 Generation

Jin-Xuan Fan et al.

ADVANCED MATERIALS (2019)

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Article Oncology

A Randomized Phase 2 Study of ADXS11-001 Listeria monocytogenes-Listeriolysin O Immunotherapy With or Without Cisplatin in Treatment of Advanced Cervical Cancer

Partha Basu et al.

INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER (2018)

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Review Microbiology

The human skin microbiome

Allyson L. Byrd et al.

NATURE REVIEWS MICROBIOLOGY (2018)

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Article Multidisciplinary Sciences

Optically-controlled bacterial metabolite for cancer therapy

Di-Wei Zheng et al.

NATURE COMMUNICATIONS (2018)

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Article Oncology

A phase 1 trial extension to assess immunologic efficacy and safety of prime-boost vaccination with VXM01, an oral T cell vaccine against VEGFR2, in patients with advanced pancreatic cancer

Friedrich H. Schmitz-Winnenthal et al.

ONCOIMMUNOLOGY (2018)

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Article Medicine, Research & Experimental

In pursuit of cancer metastasis therapy by bacteria and its biofilms: History or future

Mohd Adnan et al.

MEDICAL HYPOTHESES (2017)

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Article Oncology

Local application of bacteria improves safety of Salmonella-mediated tumor therapy and retains advantages of systemic infection

Dino Kocijancic et al.

ONCOTARGET (2017)

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Review Dentistry, Oral Surgery & Medicine

The oral microbiome and human health

Yoshihisa Yamashita et al.

JOURNAL OF ORAL SCIENCE (2017)

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Article Gastroenterology & Hepatology

Bacterial overgrowth and diversification of microbiota in gastric cancer

Lili Wang et al.

EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY (2016)

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Review Microbiology

Magnetosome biogenesis in magnetotactic bacteria

Rene Uebe et al.

NATURE REVIEWS MICROBIOLOGY (2016)

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Article Genetics & Heredity

Clinical development of TargomiRs, a miRNA mimic-based treatment for patients with recurrent thoracic cancer

Glen Reid et al.

EPIGENOMICS (2016)

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Article Multidisciplinary Sciences

A novel mechanism for the biogenesis of outer membrane vesicles in Gram-negative bacteria

Sandro Roier et al.

NATURE COMMUNICATIONS (2016)

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Article Medicine, Research & Experimental

RGD Peptide Cell-Surface Display Enhances the Targeting and Therapeutic Efficacy of Attenuated Salmonella-mediated Cancer Therapy

Seung-Hwan Park et al.

THERANOSTICS (2016)

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Article Biochemistry & Molecular Biology

Revised Estimates for the Number of Human and Bacteria Cells in the Body

Ron Sender et al.

PLOS BIOLOGY (2016)

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Article Oncology

Neoadjuvant administration of Semliki Forest virus expressing interleukin-12 combined with attenuated Salmonella eradicates breast cancer metastasis and achieves long-term survival in immunocompetent mice

M. Gabriela Kramer et al.

BMC CANCER (2015)

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Article Oncology

Arginine deprivation by arginine deiminase of Streptococcus pyogenes controls primary glioblastoma growth in vitro and in vivo

Tomas Fiedler et al.

CANCER BIOLOGY & THERAPY (2015)

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Article Oncology

Safety and Survival With GVAX Pancreas Prime and Listeria Monocytogenes-Expressing Mesothelin (CRS-207) Boost Vaccines for Metastatic Pancreatic Cancer

Dung T. Le et al.

JOURNAL OF CLINICAL ONCOLOGY (2015)

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Article Medicine, Research & Experimental

Bacille Calmette-Guerin can induce cellular apoptosis of urothelial cancer directly through toll-like receptor 7 activation

Dah-Shyong Yu et al.

KAOHSIUNG JOURNAL OF MEDICAL SCIENCES (2015)

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Article Biology

The human gut resistome

Willem van Schaik

PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES (2015)

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Article Chemistry, Organic

Tailored fragments of roseophilin selectively antagonize Mcl-1 in vitro

Jack D. Bracken et al.

TETRAHEDRON LETTERS (2015)

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Review Microbiology

Pseudomonas Exotoxin A: optimized by evolution for effective killing

Marta Michalska et al.

FRONTIERS IN MICROBIOLOGY (2015)

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Article Chemistry, Multidisciplinary

Bioengineered Bacterial Outer Membrane Vesicles as Cell-Specific Drug-Delivery Vehicles for Cancer Therapy

Vipul Gujrati et al.

ACS NANO (2014)

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Review Microbiology

Bacterial Type III Secretion Systems: Specialized Nanomachines for Protein Delivery into Target Cells

Jorge E. Galan et al.

ANNUAL REVIEW OF MICROBIOLOGY, VOL 68 (2014)

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Review Oncology

Gut Microbiome and Colorectal Adenomas

Santosh Dulal et al.

CANCER JOURNAL (2014)

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Article Multidisciplinary Sciences

Free Glycogen in Vaginal Fluids Is Associated with Lactobacillus Colonization and Low Vaginal pH

Paria Mirmonsef et al.

PLOS ONE (2014)

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Article Oncology

Pseudomonas aeruginosa-mannose-sensitive hemagglutinin inhibits epidermal growth factor receptor signaling pathway activation and induces apoptosis in bladder cancer cells in vitro and in vivo

Lei Chang et al.

UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS (2014)

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Article Hematology

Salmonella engineered to express CD20-targeting antibodies and a drug-converting enzyme can eradicate human lymphomas

Paul E. Massa et al.

BLOOD (2013)

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Article Biochemistry & Molecular Biology

The Anticancer Agent Prodigiosin Is Not a Multidrug Resistance Protein Substrate

Fatemeh Elahian et al.

DNA AND CELL BIOLOGY (2013)

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Article Biotechnology & Applied Microbiology

The Bacterial Magnetosome: A Unique Prokaryotic Organelle

Brian H. Lower et al.

JOURNAL OF MOLECULAR MICROBIOLOGY AND BIOTECHNOLOGY (2013)

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Article Microbiology

The Type VI secretion system - a widespread and versatile cell targeting system

Sarah J. Coulthurst

RESEARCH IN MICROBIOLOGY (2013)

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Article Microbiology

Antibacterial and Anticancer activity of ε-poly-L-lysine (ε-PL) produced by a marine Bacillus subtilis sp.

Nermeen A. El-Sersy et al.

JOURNAL OF BASIC MICROBIOLOGY (2012)

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Article Microbiology

Toxicity of bovicin HC5 against mammalian cell lines and the role of cholesterol in bacteriocin activity

Aline Dias Paiva et al.

MICROBIOLOGY-SGM (2012)

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Article Oncology

A Bioluminescent Transposon Reporter-Trap Identifies Tumor-Specific Microenvironment-Induced Promoters in Salmonella for Conditional Bacterial-Based Tumor Therapy

Kelly Flentie et al.

CANCER DISCOVERY (2012)

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Article Oncology

Nisin, an apoptogenic bacteriocin and food preservative, attenuates HNSCC tumorigenesis via CHAC1

Nam E. Joo et al.

CANCER MEDICINE (2012)

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Review Toxicology

Clostridial Spores for Cancer Therapy: Targeting Solid Tumour Microenvironment

Brittany Umer et al.

JOURNAL OF TOXICOLOGY (2012)

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Article Immunology

Palmitoylation State Impacts Induction of Innate and Acquired Immunity by the Salmonella enterica Serovar Typhimurium msbB Mutant

Qingke Kong et al.

INFECTION AND IMMUNITY (2011)

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Article Immunology

Effect of Deletion of Genes Involved in Lipopolysaccharide Core and O-Antigen Synthesis on Virulence and Immunogenicity of Salmonella enterica Serovar Typhimurium

Qingke Kong et al.

INFECTION AND IMMUNITY (2011)

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Article Biochemistry & Molecular Biology

Turn a diarrhoea toxin into a receptor-mediated therapy for a plethora of CLDN-4-overexpressing cancers

Qin Yao et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2010)

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Review Urology & Nephrology

The Role of Bacillus Calmette-Guerin in the Treatment of Non-Muscle-Invasive Bladder Cancer

Paolo Gontero et al.

EUROPEAN UROLOGY (2010)

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Article Oncology

Tumour-targeted delivery of TRAIL using Salmonella typhimurium enhances breast cancer survival in mice

S. Ganai et al.

BRITISH JOURNAL OF CANCER (2009)

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Article Biochemistry & Molecular Biology

Surfactin Induces Apoptosis and G2/M Arrest in Human Breast Cancer MCF-7 Cells Through Cell Cycle Factor Regulation

Xiaohong Cao et al.

CELL BIOCHEMISTRY AND BIOPHYSICS (2009)

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Article Oncology

Anti-proliferative effects of Bifidobacterium adolescentis SPM0212 extract on human colon cancer cell lines

Do Kyung Lee et al.

BMC CANCER (2008)

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Article Plant Sciences

A prodigiosin from the roseophilin producer Streptomyces griseoviridis

Takashi Kawasaki et al.

JOURNAL OF NATURAL PRODUCTS (2008)

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Article Plant Sciences

Efficient purification of the biosurfactant viscosin from Pseudomonas libanensis strain M9-3 and its physicochemical and biological properties

Harvinder S. Saini et al.

JOURNAL OF NATURAL PRODUCTS (2008)

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Article Oncology

Inhibition of tumor growth using Salmonella expressing Fas ligand

Markus Loeffler et al.

JOURNAL OF THE NATIONAL CANCER INSTITUTE (2008)

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Article Immunology

Optimization of a type III secretion system-based Pseudomonas aeruginosa live vector for antigen delivery

Olivier Epaulard et al.

CLINICAL AND VACCINE IMMUNOLOGY (2008)

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Article Biochemistry & Molecular Biology

Functional antibodies produced by oncolytic clostridia

Arjan J. Groot et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2007)

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Article Biotechnology & Applied Microbiology

Antitumor therapeutic effects of Salmonella typhimurium containing Flt3 Ligand expression plasmids in melanoma-bearing mouse

Won Suck Yoon et al.

BIOTECHNOLOGY LETTERS (2007)

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Article Medicine, Research & Experimental

In vivo antigen delivery by a Salmonella typhimurium type III secretion system for therapeutic cancer vaccines

Hiroyoshi Nishikawa et al.

JOURNAL OF CLINICAL INVESTIGATION (2006)

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Article Immunology

Immune response induced by Salmonella typhimurium defective in ppGpp synthesis

HS Na et al.

VACCINE (2006)

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Article Biochemistry & Molecular Biology

Environmentally controlled invasion of cancer cells by engineered bacteria

JC Anderson et al.

JOURNAL OF MOLECULAR BIOLOGY (2006)

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Review Biotechnology & Applied Microbiology

Overview of bacterial expression systems for heterologous protein production: from molecular and biochemical fundamentals to commercial systems

Kay Terpe

APPLIED MICROBIOLOGY AND BIOTECHNOLOGY (2006)

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Article Toxicology

Pharmacologic and toxicologic evaluation of C-novyi-NT spores

LA Diaz et al.

TOXICOLOGICAL SCIENCES (2005)

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Article Immunology

Fusion to listeriolysin O and delivery by Listeria monocytogenes enhances the immunogenicity of HER-2/neu and reveals subdominant epitopes in the FVB/N mouse

R Singh et al.

JOURNAL OF IMMUNOLOGY (2005)

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Article Immunology

Involvement of Listeria monocytogenes phosphatidylinositol-specific phospholipase C and host protein kinase C in permeabilization of the macrophage phagosome

MA Poussin et al.

INFECTION AND IMMUNITY (2005)

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Article Microbiology

Secretory production of biologically active rat interleukin-2 by Clostridium acetobutylicum DSM792 as tool for anti-tumor treatment

S Barbé et al.

FEMS MICROBIOLOGY LETTERS (2005)

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Article Oncology

AT514, a cyclic depsipeptide from Serratia marcescens, induces apoptosis of B-chronic lymphocytic leukemia cells:: interference with the Akt/NF-κB survival pathway

E Escobar-Díaz et al.

LEUKEMIA (2005)

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Article Multidisciplinary Sciences

Tumor-targeting bacterial therapy with amino acid auxotrophs of GFP-expressing Salmonella typhimurium

M Zhao et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)

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Article Microbiology

Analysis of the genome structure of the nonpathogenic probiotic Escherichia coli strain Nissle 1917

L Grozdanov et al.

JOURNAL OF BACTERIOLOGY (2004)

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Article Biotechnology & Applied Microbiology

Pilot trial of genetically modified, attenuated Salmonella expressing the E-coli cytosine deaminase gene in refractory cancer patients

J Nemunaitis et al.

CANCER GENE THERAPY (2003)

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Letter Oncology

Continuous intravenous administration of live genetically modified Salmonella typhimurium in patients with metastatic melanoma

DM Heimann et al.

JOURNAL OF IMMUNOTHERAPY (2003)

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Article Multidisciplinary Sciences

Combination bacteriolytic therapy for the treatment of experimental tumors

LH Dang et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2001)

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Article Gastroenterology & Hepatology

Claudin-4:: A new target for pancreatic cancer treatment using Clostridium perfringens enterotoxin

P Michl et al.

GASTROENTEROLOGY (2001)

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Article Immunology

Biodistribution and genetic stability of the novel antitumor agent VNP20009, a genetically modified strain of Salmonella typhimurium

C Clairmont et al.

JOURNAL OF INFECTIOUS DISEASES (2000)

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Article Biotechnology & Applied Microbiology

Bifidobacterium longum as a delivery system for cancer gene therapy:: Selective localization and growth in hypoxic tumors

K Yazawa et al.

CANCER GENE THERAPY (2000)

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