期刊
JOURNAL OF CLINICAL MEDICINE
卷 11, 期 21, 页码 -出版社
MDPI
DOI: 10.3390/jcm11216308
关键词
ruxolitinib; hemophagocytic lymphohistiocytosis; liver transplantation
In this article, we report a case of adult HLH triggered by CMV infection shortly after liver transplantation and successfully treated with ruxolitinib combined with a modified HLH-2004 treatment strategy.
Hemophagocytic lymphohistiocytosis (HLH) is a rare but potentially fatal hyperinflammatory disorder characterized by dysfunctional cytotoxic T and natural killer cells. Liver transplantation is a predisposing factor for HLH. High mortality rates were reported in 40 cases of HLH following liver transplantation in adults and children. Herein, we describe a case of adult HLH triggered by cytomegalovirus (CMV) infection shortly after liver transplantation. The patient was successfully treated with ruxolitinib combined with a modified HLH-2004 treatment strategy. Our case is the first to report the successful use of ruxolitinib with a modified HLH-2004 strategy to treat HLH in a solid organ transplantation recipient.
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