Stem Cells in Regenerative Medicine

Review Cell & Tissue Engineering

Role of hypoxia preconditioning in therapeutic potential of mesenchymal stem-cell-derived extracellular vesicles

Victoria Pulido-Escribano et al.

Summary: Mesenchymal stem cells (MSC) have gained significant attention in cell therapy due to their properties, including high expansion and differentiation capabilities, low immunogenicity, and modulation of biological processes. The regenerative effect of MSC is partly attributed to their paracrine activity, particularly the secretion of extracellular vesicles (EV). These EV contain various molecules that can induce physiological changes in recipient cells. Preconditioning MSC under hypoxia has been shown to enhance the regenerative capacity of EV, making it an attractive strategy for clinical use in regenerative medicine.

WORLD JOURNAL OF STEM CELLS (2022)

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Review Cell & Tissue Engineering

Influence of Dipeptidyl Peptidase-4 (DPP4) on Mesenchymal Stem-Cell (MSC) Biology: Implications for Regenerative Medicine - Review

Barbara Torrecillas-Baena et al.

Summary: DPP4 and its inhibitors are important for diabetes treatment, but their potential effects in regenerative medicine, including on MSC and their differentiation, immunomodulation, and mobilization capacities, should be further explored.

STEM CELL REVIEWS AND REPORTS (2022)

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Review Cell & Tissue Engineering

Role of Stromal Cell-Derived Factor-1 in Endothelial Progenitor Cell-Mediated Vascular Repair and Regeneration

Ji-Hua Li et al.

Summary: Endothelial progenitor cells (EPCs) play a crucial role in vascular repair and neovascularization, but their therapeutic efficacy in clinical studies varies. The effectiveness of EPCs is closely associated with the number of cells recruited to ischemic regions, their functional abilities, and survival in injury tissues.

TISSUE ENGINEERING AND REGENERATIVE MEDICINE (2021)

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Review Cell Biology

Mesenchymal Stem Cells, Bioactive Factors, and Scaffolds in Bone Repair: From Research Perspectives to Clinical Practice

Sandra Stamnitz et al.

Summary: Mesenchymal stem cell-based therapies show promise in bone tissue regeneration, but cell tracking and maintenance in the injury site pose challenges. Seeding cells onto a biocompatible scaffold may offer a potential solution. The development of bone tissue engineering involves optimizing various variables like stem cell source, osteogenic molecular factors, scaffold design, and suitable animal models.

CELLS (2021)

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Review Cell & Tissue Engineering