4.7 Article

Single-cell RNA sequencing highlights the functional role of human endogenous retroviruses in gallbladder cancer

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Microbiology

HERV-K and HERV-H Env Proteins Induce a Humoral Response in Prostate Cancer Patients

Maria Antonietta Manca et al.

Summary: The study found a significant antibody response against HERV-K and HERV-H in patients with prostate cancer, providing additional evidence of the association between these endogenous retroviruses and prostate cancer, and highlighting their potential as biomarkers for the disease.

PATHOGENS (2022)

Article Multidisciplinary Sciences

Single-cell RNA-seq reveals cell type-specific molecular and genetic associations to lupus

Richard K. Perez et al.

Summary: By using mux-seq technology, we conducted extensive single-cell RNA sequencing on peripheral blood cells from SLE patients and healthy individuals. We found increased expression of type 1 interferon-stimulated genes in monocytes, reduced naive CD4(+) T cells, and expanded cytotoxic CD8(+) T cells in SLE patients. The cell type-specific expression features could predict the case-control status and classify patients into two molecular subtypes. Furthermore, we linked SLE-associated genetic variants to cell type-specific expression using genotyping data.

SCIENCE (2022)

Review Medicine, General & Internal

Human endogenous retrovirus-H long terminal repeat-associating 2: The next immune checkpoint for antitumour therapy

Honggang Ying et al.

Summary: This review summarizes the expression profile of HHLA2 in human cancers, its association with cancer prognosis and clinical features, and its dual roles in regulating cancer immune response. Manipulating the interaction between HHLA2-KIR3DL3/TMIGD2 holds promise for precision cancer immunotherapy.

EBIOMEDICINE (2022)

Article Biochemistry & Molecular Biology

Single-cell RNA-seq reveals the genesis and heterogeneity of tumor microenvironment in pancreatic undifferentiated carcinoma with osteoclast-like giant-cells

Xinbo Wang et al.

Summary: The study used single-cell RNA sequencing to analyze the unique tumor microenvironment of undifferentiated carcinoma with osteoclast-like giant cells (UCOGCP) and found that UCOGCP sample displayed distinct distribution patterns in different cell clusters. Functional analysis showed that OGCs cluster was enriched in antigen presentation, immune response, and stem cell differentiation.

MOLECULAR CANCER (2022)

Article Biochemistry & Molecular Biology

Transcript assembly improves expression quantification of transposable elements in single-cell RNA-seq data

Wanqing Shao et al.

Summary: Researchers developed a pipeline for quantifying TE expression in single-cell RNA-seq data, successfully capturing the expression profile of endogenous retroviruses in mouse embryonic stem cells, and revealing 146 TE-containing ncRNA transcripts with substantial tissue specificity in early mouse embryonic development.

GENOME RESEARCH (2021)

Review Oncology

Human endogenous retroviruses in cancer: Expression, regulation and function

Yuan Gao et al.

Summary: This review examines the expression patterns and regulatory mechanisms of HERVs in cancer, highlighting their dual roles in either suppressing or promoting cancer through immune activation or immune suppression. HERV env gene plays a key role in promoting carcinogenesis in certain malignant tumors, and targeting ENV proteins could be a potential future antitumor treatment approach.

ONCOLOGY LETTERS (2021)

Review Medical Laboratory Technology

Roles of matrix metalloproteinase-7 (MMP-7) in cancer

Hai-Yang Liao et al.

Summary: MMP-7 is a crucial proteolytic enzyme involved in regulating various human pathophysiological processes, especially in the occurrence and development of cancers. It could serve as a potential tumor biomarker and therapeutic target, providing new diagnostic and prognostic considerations for cancer patients.

CLINICAL BIOCHEMISTRY (2021)

Article Multidisciplinary Sciences

Identifying transposable element expression dynamics and heterogeneity during development at the single-cell level with a processing pipeline scTE

Jiangping He et al.

Summary: This study developed a pipeline to quantify TE expression from single cell data, showing dynamic expression of TEs in various biological contexts including embryonic stem cells and somatic cells. The results demonstrate the important role of TEs in cell heterogeneity.

NATURE COMMUNICATIONS (2021)

Article Oncology

Single-cell dissection of cellular components and interactions shaping the tumor immune phenotypes in ovarian cancer

Milena Hornburg et al.

Summary: This study provides a detailed analysis of distinct T cell infiltration patterns in ovarian tumors, revealing the impact on responses to cancer immunotherapies and the underlying key determinants and biology of tumor immune phenotypes. The research highlights potential molecular mechanisms shaping these phenotypes and may inform therapeutic strategies for enhancing clinical benefit from cancer immunotherapies.

CANCER CELL (2021)

Article Oncology

Locus-Specific Characterization of Human Endogenous Retrovirus Expression in Prostate, Breast, and Colon Cancers

Margaret C. Steiner et al.

Summary: Research implicates that HERVs are involved in various cancers, with differential expression identified in prostate, breast, and colon cancers. The study highlights potential biomarkers and therapeutic targets in these cancers, providing insights into the role of HERVs in cancer pathogenesis.

CANCER RESEARCH (2021)

Review Pharmacology & Pharmacy

Targeted therapies for gallbladder cancer: an overview of agents in preclinical and clinical development

Stefania De Lorenzo et al.

Summary: Gallbladder cancer is a rare malignancy with poor prognosis, often requiring chemotherapy due to limited surgical options. Recent studies have explored new molecular targets and therapies, showing potential for improved outcomes. The ongoing trials and future research may lead to significant advancements in systemic treatments for gallbladder cancer.

EXPERT OPINION ON INVESTIGATIONAL DRUGS (2021)

Review Oncology

Molecular Targets and Emerging Therapies for Advanced Gallbladder Cancer

Matteo Canale et al.

Summary: Biliary tract cancers, with gallbladder cancer being the most common type, have poor prognosis and slow progress in precision medicine and immunotherapy research. More attention and research are needed to explore new treatment strategies.

CANCERS (2021)

Review Oncology

Human Endogenous Retrovirus Reactivation: Implications for Cancer Immunotherapy

Annacarmen Petrizzo et al.

Summary: Human endogenous retroviruses (HERVs) are integrated in our genome and play a crucial role in cancer immunotherapy. Reactivation of HERVs in cancer cells can lead to antiviral defense response, production of immune targets, and implications for therapeutic targets or prognosis.

CANCERS (2021)

Review Biology

Mobile genomics: tools and techniques for tackling transposons

Kathryn O'Neill et al.

PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES (2020)

Article Multidisciplinary Sciences

Expanded encyclopaedias of DNA elements in the human and mouse genomes

Jill E. Moore et al.

NATURE (2020)

Review Genetics & Heredity

Measuring and interpreting transposable element expression

Sophie Lanciano et al.

NATURE REVIEWS GENETICS (2020)

Article Multidisciplinary Sciences

Endogenous retroviruses drive KRAB zinc-finger protein family expression for tumor suppression

Jumpei Ito et al.

SCIENCE ADVANCES (2020)

Article Multidisciplinary Sciences

Human endogenous retroviruses form a reservoir of T cell targets in hematological cancers

Sunil Kumar Saini et al.

NATURE COMMUNICATIONS (2020)

Review Biochemistry & Molecular Biology

Overview of current targeted therapy in gallbladder cancer

Xiaoling Song et al.

SIGNAL TRANSDUCTION AND TARGETED THERAPY (2020)

Article Oncology

A framework for advancing our understanding of cancer-associated fibroblasts

Erik Sahai et al.

NATURE REVIEWS CANCER (2020)

Article Endocrinology & Metabolism

Selenium detoxification is required for cancer-cell survival

Anne E. Carlisle et al.

NATURE METABOLISM (2020)

Review Biochemistry & Molecular Biology

Crosstalk between the lncRNA UCA1 and microRNAs in cancer

Wei Xuan et al.

FEBS LETTERS (2019)

Review Virology

Expressional activation and functional roles of human endogenous retroviruses in cancers

Mengwen Zhang et al.

REVIEWS IN MEDICAL VIROLOGY (2019)

Article Biochemistry & Molecular Biology

Autophagy induced by overexpression of DCTPP1 promotes tumor progression and predicts poor clinical outcome in prostate cancer

Jianming Lu et al.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2018)

Article Immunology

Human endogenous retrovirus env genes: Potential blood biomarkers in lung cancer

Mokhtar Zare et al.

MICROBIAL PATHOGENESIS (2018)

Article Biotechnology & Applied Microbiology

Integrating single-cell transcriptomic data across different conditions, technologies, and species

Andrew Butler et al.

NATURE BIOTECHNOLOGY (2018)

Article Biochemistry & Molecular Biology

Global characterization of T cells in non-small-cell lung cancer by single-cell sequencing

Xinyi Guo et al.

NATURE MEDICINE (2018)

Review Microbiology

HERVs New Role in Cancer: From Accused Perpetrators to Cheerful Protectors

Norbert Bannert et al.

FRONTIERS IN MICROBIOLOGY (2018)

Article Medicine, General & Internal

Gallbladder Cancer

Ioana Baiu et al.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2018)

Review Genetics & Heredity

Computational tools to unmask transposable elements

Patricia Goerner-Potvin et al.

NATURE REVIEWS GENETICS (2018)

Article Medicine, Research & Experimental

Endogenous retroviral signatures predict immunotherapy response in clear cell renal cell carcinoma

Christof C. Smith et al.

JOURNAL OF CLINICAL INVESTIGATION (2018)

Article Multidisciplinary Sciences

The chromatin accessibility landscape of primary human cancers

M. Ryan Corces et al.

SCIENCE (2018)

Article Biochemistry & Molecular Biology

Multi-omics of 34 colorectal cancer cell lines - a resource for biomedical studies

Kaja C. G. Berg et al.

MOLECULAR CANCER (2017)

Article Multidisciplinary Sciences

CDK4/6 inhibition triggers anti-tumour immunity

Shom Goel et al.

NATURE (2017)

Article Biochemical Research Methods

Reversed graph embedding resolves complex single-cell trajectories

Xiaojie Qiu et al.

NATURE METHODS (2017)

Article Mathematical & Computational Biology

GeneHancer: genome-wide integration of enhancers and target genes in GeneCards

Simon Fishilevich et al.

DATABASE-THE JOURNAL OF BIOLOGICAL DATABASES AND CURATION (2017)

Review Immunology

B cell regulation in cancer and anti-Xtumor immunity

Anushruti Sarvaria et al.

CELLULAR & MOLECULAR IMMUNOLOGY (2017)

Article Biochemical Research Methods

Tissue-specific regulatory circuits reveal variable modular perturbations across complex diseases

Daniel Marbach et al.

NATURE METHODS (2016)

Review Oncology

The role of myeloid cells in cancer therapies

Camilla Engblom et al.

NATURE REVIEWS CANCER (2016)

Article Biochemistry & Molecular Biology

Inhibiting DNA Methylation Causes an Interferon Response in Cancer via dsRNA Including Endogenous Retroviruses

Katherine B. Chiappinelli et al.

Review Immunology

The generation of antibody-secreting plasma cells

Stephen L. Nutt et al.

NATURE REVIEWS IMMUNOLOGY (2015)

Article Biotechnology & Applied Microbiology

Transcriptional landscape of repetitive elements in normal and cancer human cells

Steven W. Criscione et al.

BMC GENOMICS (2014)

Review Cell Biology

In search of the determinants of enhancer-promoter interaction specificity

Joris van Arensbergen et al.

TRENDS IN CELL BIOLOGY (2014)

Article Biochemical Research Methods

STAR: ultrafast universal RNA-seq aligner

Alexander Dobin et al.

BIOINFORMATICS (2013)

Review Genetics & Heredity

Repetitive DNA and next-generation sequencing: computational challenges and solutions

Todd J. Treangen et al.

NATURE REVIEWS GENETICS (2012)

Article Biochemistry & Molecular Biology

Derepression of an endogenous long terminal repeat activates the CSF1R proto-oncogene in human lymphoma

Bjoern Lamprecht et al.

NATURE MEDICINE (2010)

Review Oncology

Carcinoma of the gallbladder

S Misra et al.

LANCET ONCOLOGY (2003)

Review Multidisciplinary Sciences

Initial sequencing and analysis of the human genome

ES Lander et al.

NATURE (2001)