☆ 4.7 Review

Substance use and common contributors to morbidity: A genetics perspective

EBIOMEDICINE (2022)

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Review Biochemistry & Molecular Biology

Closing the brain-heart loop: Towards more holistic models of addiction and addiction recovery

David Eddie et al.

Summary: The research aims to understand the brain structures and pathways involved in addiction and addiction recovery. It highlights the importance of sensory and visceral information streams in linking context and state to addictive processes. The study describes the overlap between addiction circuitry and the neural network that regulates cardiovascular activity and receives feedback from peripheral cardiovascular processes. The need for studies on neural and peripheral cardiovascular signal integration during internal states and environmental contexts that drive addictive behaviors is emphasized.

ADDICTION BIOLOGY (2022)

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Article Biochemistry & Molecular Biology

Genetic liability for substance use associated with medical comorbidities in electronic health records of African- and European-ancestry individuals

Emily E. Hartwell et al.

Summary: This study investigated the relationship between SUD PRS and primary phenotypes, finding associations but not diagnostic predictability. PheWAS analysis revealed cross-trait associations in psychiatric disorders and medical conditions.

ADDICTION BIOLOGY (2022)

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Editorial Material Psychiatry

Identifying and Reducing Bias in Genome-Wide Association Studies of Alcohol-Related Traits

Henry R. Kranzler et al.

AMERICAN JOURNAL OF PSYCHIATRY (2022)

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Article Psychiatry

Item-Level Genome-Wide Association Study of the Alcohol Use Disorders Identification Test in Three Population-Based Cohorts

Travis T. Mallard et al.

Summary: This study utilized genomic structural equation modeling to explore the genetics of alcohol consumption and problematic consequences as measured by the Alcohol Use Disorders Identification Test (AUDIT). Through a large-scale GWAS and multivariate approach, the authors identified genetic correlations among the AUDIT items and constructed an aggregate measure strongly associated with alcohol dependence.

AMERICAN JOURNAL OF PSYCHIATRY (2022)

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Article Multidisciplinary Sciences

Cannabidiol inhibits SARS-CoV-2 replication through induction of the host ER stress and innate immune responses

Long Chi Nguyen et al.

Summary: This study found that cannabidiol (CBD) can inhibit the infection of SARS-CoV-2 in cells and mice, potentially making it a preventative agent for early-stage SARS-CoV-2 infection. The study also discovered that CBD inhibits SARS-CoV-2 replication partially by regulating the host cell's endoplasmic reticulum stress response and interferon signaling pathways. However, the current use of non-medical formulations for prevention or treatment is not recommended.

SCIENCE ADVANCES (2022)

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Review Substance Abuse

Changes in alcohol use during the COVID-19 pandemic and previous pandemics: A systematic review

Ivneet Sohi et al.

Summary: The objective of this study is to summarize the research on the relationships between exposure to the COVID-19 pandemic or previous pandemics and changes in alcohol use. The study found that there was a significant decrease in alcohol consumption in Australia and a significant increase in alcohol use frequency in the United States. The frequency of heavy episodic drinking (HED) decreased significantly in Australia and Spain but not in the United States. There was a significant increase in the proportion of people with problematic alcohol use in the United Kingdom.

ALCOHOL-CLINICAL AND EXPERIMENTAL RESEARCH (2022)

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Article Public, Environmental & Occupational Health

Alcohol use and the COVID-19 pandemic: Historical trends in drinking, contexts, and reasons for use among US adults

Megan E. Patrick et al.

Summary: This study examined changes in drinking trends among young and middle-aged adults in the United States before and during the COVID-19 pandemic. The results showed a decrease in alcohol use prevalence and an increase in daily alcohol use prevalence during 2020. There were also changes in alcohol use frequency and reasons. Among college students, there was a significant deviation from expected historical trends in alcohol use prevalence. Age and college status had a moderating effect on alcohol use patterns.

SOCIAL SCIENCE & MEDICINE (2022)

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Article Public, Environmental & Occupational Health

Reduced alcohol consumption during the COVID-19 pandemic: Analyses of 17 000 patients seeking primary health care in Colombia and Mexico

Jakob Manthey et al.

Summary: During the COVID-19 pandemic, the alcohol consumption among primary health care patients in Colombia and Mexico showed changes. The number of patients having their alcohol consumption measured decreased in both countries during the pandemic. Each month of the pandemic was associated with a decrease in the mean AUDIT-C score in Colombia and Mexico. The proportion of heavy drinking patients declined in Colombia but remained unchanged in Mexico.

JOURNAL OF GLOBAL HEALTH (2022)

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Article Medicine, General & Internal

Association of Habitual Alcohol Intake With Risk of Cardiovascular Disease

Kiran J. Biddinger et al.

Summary: Observational studies have suggested cardiovascular benefits associated with light alcohol consumption, while genetic analyses have indicated a possible causal link between alcohol intake and increased cardiovascular disease risk. This cohort study using the UK Biobank examined the association of habitual alcohol intake with cardiovascular disease risk, showing that light to moderate alcohol consumption was associated with healthier lifestyle factors, but genetic predisposition to alcohol intake was associated with increased risk of hypertension and coronary artery disease across different levels of intake.

JAMA NETWORK OPEN (2022)

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Article Biochemistry & Molecular Biology

Genome-wide association study in individuals of European and African ancestry and multi-trait analysis of opioid use disorder identifies 19 independent genome-wide significant risk loci

Joseph D. Deak et al.

Summary: Despite the significant impact of opioid use disorder (OUD), previous genome-wide association studies (GWAS) of OUD have identified a limited number of susceptibility loci. In this large-scale GWAS study, researchers optimized genetic informativeness by performing multi-trait analysis of GWAS (MTAG) with genetically correlated substance use disorders (SUDs) in individuals of European and African ancestry. The study identified several genetic associations with OUD, including variants in the OPRM1 gene and a variant in the FURIN gene, as well as 18 genome-wide significant loci associated with OUD-MTAG.

MOLECULAR PSYCHIATRY (2022)

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Editorial Material Neurosciences

Cross-ancestry genomic research: time to close the gap

Elizabeth G. Atkinson et al.

NEUROPSYCHOPHARMACOLOGY (2022)

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Article Medicine, Research & Experimental

Multivariable Mendelian Randomization and Mediation

Eleanor Sanderson

Summary: Mendelian randomization (MR) uses genetic variants to estimate the causal effect of exposure on outcome, while mediation analysis decomposes the effects of exposure on outcome into direct effects and effects via mediating variables. Multivariable MR (MVMR) extends MR to multiple exposures, allowing for estimation of effects on a single outcome and mediation analysis.

COLD SPRING HARBOR PERSPECTIVES IN MEDICINE (2021)

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Article Biochemistry & Molecular Biology

COVID-19 risk and outcomes in patients with substance use disorders: analyses from electronic health records in the United States

Quan Qiu Wang et al.

Summary: This study identified individuals with SUD, especially those with OUD and African Americans, as having an increased risk for COVID-19 and worse outcomes. Screening and treating individuals with SUD is crucial in controlling the pandemic and ensuring healthcare support without disparities.

MOLECULAR PSYCHIATRY (2021)

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Article Health Care Sciences & Services

The Opioid Epidemic Within the COVID-19 Pandemic: Drug Testing in 2020

Justin K. Niles et al.

Summary: The study revealed that drug testing for prescription and illicit drugs decreased during the COVID-19 pandemic, while positivity for non-prescribed fentanyl and heroin increased. Particularly, there was a significant increase in non-prescribed fentanyl positivity among patients positive for other drugs, indicating a rise in dangerous drug combinations.

POPULATION HEALTH MANAGEMENT (2021)

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Article Medicine, General & Internal

Construct validity and reproducibility of the Prescription Opioid Misuse And Abuse Questionnaire (POMAQ)

Karin S. Coyne et al.

Summary: The Prescription Opioid Misuse and Abuse Questionnaire showed evidence of construct validity and reproducibility in identifying prescription opioid abuse and misuse among chronic pain patients. Results indicated high agreement between the questionnaire responses and validated measures as well as objective information from hair and urine drug screens. The questionnaire also demonstrated excellent test-retest reliability, with high percentage agreement between administrations.

CURRENT MEDICAL RESEARCH AND OPINION (2021)

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Article Substance Abuse

Genomic relationships across psychiatric disorders including substance use disorders

Abdel Abdellaoui et al.

Summary: The study investigated genetic associations and latent genetic structure among psychiatric disorders, finding significant genetic correlations between alcohol and nicotine dependence with other disorders, while cannabis use disorder was only associated with ADHD. Including substance use disorders in the factor analysis led to changes in the underlying genetic factor structure, emphasizing the importance of cautious interpretation of the identified structures.

DRUG AND ALCOHOL DEPENDENCE (2021)

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Article Psychiatry

An organization- and category-level comparison of diagnostic requirements for mental disorders in ICD-11 and DSM-5

Michael B. First et al.

Summary: While the organization of ICD-11 and DSM-5 in mental disorder classification is substantially similar, there are significant differences, including certain disorder categories exclusive to each system. Out of 103 diagnostic entities appearing in both ICD-11 and DSM-5, 20 were rated as having major differences, indicating divergent interpretations and uses of evidence. The efforts towards harmonization have resulted in closer alignment between ICD and DSM, but differences remain based on priorities and interpretations, enabling empirical comparisons and advancements in the field.

WORLD PSYCHIATRY (2021)

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Article Multidisciplinary Sciences

Genome-wide analyses of behavioural traits are subject to bias by misreports and longitudinal changes

Angli Xue et al.

Summary: Genome-wide association studies have identified genetic variants associated with human behavioral traits, but misreporting and reduction of alcohol consumption due to disease burden can lead to biased associations. After correcting for these biases, genetic correlations between alcohol consumption and diseases previously reported as negative become positive or non-significant. These findings emphasize the importance of considering longitudinal changes and misreporting when analyzing self-reported behavioral traits in biobank data.

NATURE COMMUNICATIONS (2021)

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Article Biochemistry & Molecular Biology

The evolution of group differences in changing environments

Arbel Harpak et al.

Summary: The evolution of complex traits in humans is influenced by selection pressures that are largely unknown, and the discussion around group differences in traits focuses on whether they are genetically based or influenced by environmental factors. One plausible alternative suggests that many complex traits evolve under stabilizing selection, even when faced with shifting environmental effects, which challenges the assumption that trait differences among groups are solely due to genetic factors.

PLOS BIOLOGY (2021)

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Review Psychiatry

Gray and white matter morphology in substance use disorders: a neuroimaging systematic review and meta-analysis

Victor Pando-Naude et al.

Summary: Substance use disorders (SUDs) are characterized by a compulsion to seek and consume substances, which may lead to morphological changes in neural circuits. VBM studies show convergence and divergence in brain regions and volume effects, providing insights into disease progression and therapeutic approaches.

TRANSLATIONAL PSYCHIATRY (2021)

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Article Psychiatry

Quality of Life and Its Correlates in Alcohol Use Disorder Patients With and Without Depression in China

Hui Huang et al.

Summary: This study aimed to investigate the quality of life (QOL) and its correlates in AUD patients with and without depression in China. The research found that AUD patients with depression had lower QOL compared to those without depression, but were more willing to have alcohol-related treatment.

FRONTIERS IN PSYCHIATRY (2021)

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Article Biochemistry & Molecular Biology

Genome-wide association study of problematic opioid prescription use in 132,113 23andMe research participants of European ancestry

Sandra Sanchez-Roige et al.

Summary: This study aims to explore the genetic basis of opioid misuse when not prescribed, confirming that opioid abuse may be a heritable risk factor for opioid use disorder. The research found that opioid misuse is associated with many other genetic factors, including alcohol dependence, smoking, and mental disorders.

MOLECULAR PSYCHIATRY (2021)

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Article Substance Abuse

The impact of removing former drinkers from genome-wide association studies of AUDIT-C

Cecilia Dao et al.

Summary: By differentiating between former drinkers and lifelong abstainers, the study aimed to improve the genome-wide association results of the Alcohol Use Disorders Identification Test-Consumption (AUDIT-C). Removing former drinkers resulted in a stronger association with a specific polymorphism, more significant SNPs, and genomic loci. There were significant differences in polygenic risk scores for related diseases between former drinkers and lifelong abstainers.

ADDICTION (2021)

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Article Substance Abuse

Alcohol and cigarette smoking consumption as genetic proxies for alcohol misuse and nicotine dependence

Sandra Sanchez-Roige et al.

Summary: The study investigated the role of consumption phenotypes as genetic proxies for alcohol misuse and nicotine dependence. Results showed that smoking consumption and dependence phenotypes were strongly negatively associated with numerous diseases, while the genetic association patterns of alcohol consumption diverged from those of alcohol misuse.

DRUG AND ALCOHOL DEPENDENCE (2021)

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Article Genetics & Heredity

Host Genetic Liability for Severe COVID-19 Associates with Alcohol Drinking Behavior and Diabetic Outcomes in Participants of European Descent

Frank R. Wendt et al.

Summary: By analyzing large-scale genomic data, we found genetic correlations and putative causality between COVID-19 infection and depressive symptoms, metformin use, and alcohol drinking status. The study also identified COVID-19 risk loci associated with various hematologic biomarkers, providing insights into genetic contributions to the disease and potential long-term health effects.

FRONTIERS IN GENETICS (2021)

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Article Oncology

Cannabis Use, Pulmonary Function, and Lung Cancer Susceptibility: A Mendelian Randomization Study

Sebastian-Edgar Baumeister et al.

Summary: This study used Mendelian randomization to assess the impact of genetic propensity for lifetime cannabis use and cannabis use disorder on pulmonary function and lung cancer. Results suggest a potential causal association between genetic liability for cannabis use and the risk of squamous cell carcinoma.

JOURNAL OF THORACIC ONCOLOGY (2021)

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Article Medicine, General & Internal

Assessment of Stimulant Use and Cardiovascular Event Risks Among Older Adults

Mina Tadrous et al.

Summary: A cohort study found that stimulant use was associated with an early increase in cardiovascular events among older adults, with no association for long-term use.

JAMA NETWORK OPEN (2021)

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Article Biology

Smoking is significantly associated with increased risk of COVID-19 and other respiratory infections

Daniel B. Rosoff et al.

Summary: The study found a significant association between smoking and various respiratory infections, including COVID-19 infection risk. This association remained strong even after considering other substance use behaviors and cardiometabolic risk factors, emphasizing the importance of smoking prevention programs for public health benefits during the COVID-19 pandemic.

COMMUNICATIONS BIOLOGY (2021)

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Article Cardiac & Cardiovascular Systems

Opioid Use and Its Relationship to Cardiovascular Disease and Brain Health: A Presidential Advisory From the American Heart Association

Sheryl L. Chow et al.

Summary: The misuse of opioids remains widespread, leading to dependence and an increase in drug overdoses that has significantly reduced life expectancy in the United States. Commonly used opioids for pain management in cardiovascular disease and stroke patients may have unwanted effects on critical medications, necessitating the search for more effective care approaches.

CIRCULATION (2021)

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Article Medicine, General & Internal

Estimating global burden of COVID-19 with disability-adjusted life years and value of statistical life metrics

Chiao-Yun Fan et al.

Summary: The study quantified the impact of the COVID-19 pandemic on global health and economic loss using disability-adjusted life years (DALYs) and value of statistical life (VSL) metrics. It was found that developed economies particularly suffered significant health and life value loss, with disparities even at the same level of human development index.

JOURNAL OF THE FORMOSAN MEDICAL ASSOCIATION (2021)

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Article Medicine, General & Internal

A time of crisis for the opioid epidemic in the USA

The Lancet

LANCET (2021)

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Review Genetics & Heredity

Advancing the use of genome-wide association studies for drug repurposing

William R. Reay et al.

Summary: Genome-wide association studies have provided important biological insights into complex diseases, offering opportunities for drug repurposing. Leveraging common variant genetics through approaches such as single-loci mapping to drug targets, transcriptome-wide association studies, gene-set association, causal inference by Mendelian randomization, and polygenic scoring, researchers aim to identify new treatment options more efficiently.

NATURE REVIEWS GENETICS (2021)

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Article Neurosciences

Choosing appropriate language to reduce the stigma around mental illness and substance use disorders

Nora D. Volkow et al.

NEUROPSYCHOPHARMACOLOGY (2021)

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Article Multidisciplinary Sciences

Alcohol use and cardiometabolic risk in the UK Biobank: A Mendelian randomization study

Joanna Lankester et al.

Summary: Observational studies suggest a complex relationship between alcohol use and cardiometabolic traits, with some positive associations with certain diseases. Using Mendelian randomization, this study found positive associations between alcohol consumption and high blood pressure, hemorrhagic stroke, and atrial fibrillation, while the relationship with myocardial infarction and type 2 diabetes was influenced by other factors. Results suggest a harmful or null effect of alcohol on cardiometabolic health, indicating that moderate alcohol use should not be promoted as part of a healthy lifestyle.

PLOS ONE (2021)

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Article Multidisciplinary Sciences

Protein-coding repeat polymorphisms strongly shape diverse human phenotypes

Ronen E. Mukamel et al.

Summary: This study utilized whole-exome sequencing data to estimate VNTR lengths and impute VNTR alleles into single-nucleotide polymorphism haplotypes, identifying strong associations of common variants with human phenotypes like height, hair morphology, and biomarkers of health. Accounting for large-effect VNTRs enabled further fine-mapping of associations to many more protein-coding mutations in the same genes. These findings point to hidden effects of highly polymorphic common structural variants that have not been previously analyzed at the molecular level.

SCIENCE (2021)

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Article Biology

Mendelian randomization analysis provides causality of smoking on the expression of ACE2, a putative SARS-CoV-2 receptor

Hui Liu et al.

Summary: The study revealed that genetically predicted smoking significantly increased ACE2 expression in the thyroid and other tissues, as well as the risk of COVID-19 onset. No significant results were observed for genetically predicted alcohol consumption.

ELIFE (2021)

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Review Public, Environmental & Occupational Health

Nordic Health Registry-Based Research: A Review of Health Care Systems and Key Registries

Kristina Laugesen et al.

Summary: The Nordic countries provide unique opportunities for joint health registry-based research, but challenges such as cross-border data sharing hinder the full exploitation of their potential. Clear legal pathways and practical frameworks are needed for future collaboration.

CLINICAL EPIDEMIOLOGY (2021)

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Article Genetics & Heredity

Novel characterization of the multivariate genetic architecture of internalizing psychopathology and alcohol use

Sarah M. C. Colbert et al.

Summary: Genetic correlations between alcohol use and internalizing psychopathology vary depending on the measure of alcohol use. Problematic alcohol use (PAU) shows positive genetic correlation with internalizing psychopathology, while alcohol consumption shows a range from not significantly correlated to moderately negatively correlated. The study identified different genetic relationships, with 14 significant regions of positive genetic covariance between PAU and internalizing psychopathology, and 12 regions of significant genetic covariance (positive and negative) between consumption factors and internalizing psychopathology.

AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS (2021)

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Article Substance Abuse

The Association Between Alcohol Consumption and Pain Interference in a Nationally Representative Sample: The Moderating Roles of Gender and Alcohol Use Disorder Symptomatology

Ellen W. Yeung et al.

ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH (2020)

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Review Neurosciences

Endogenous Opioids at the Intersection of Opioid Addiction, Pain, and Depression: The Search for a Precision Medicine Approach

Michael A. Emery et al.

ANNUAL REVIEW OF NEUROSCIENCE, VOL 43 (2020)

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Review Public, Environmental & Occupational Health

The protective effect of alcohol consumption on the incidence of cardiovascular diseases: is it real? A systematic review and meta-analysis of studies conducted in community settings

Seok-Joon Yoon et al.

BMC PUBLIC HEALTH (2020)

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Leveraging genome-wide data to investigate differences between opioid use vs. opioid dependence in 41,176 individuals from the Psychiatric Genomics Consortium

Renato Polimanti et al.

MOLECULAR PSYCHIATRY (2020)

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Genome-wide rare variant analysis for thousands of phenotypes in over 70,000 exomes from two cohorts

Elizabeth T. Cirulli et al.

NATURE COMMUNICATIONS (2020)

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Genome-Wide Association Study of Opioid Cessation

Jiayi W. Cox et al.

JOURNAL OF CLINICAL MEDICINE (2020)

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Alcohol Use Disorder and Risk of Suicide in a Swedish Population-Based Cohort

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AMERICAN JOURNAL OF PSYCHIATRY (2020)

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Chronic non-cancer pain among adults with substance use disorders: Prevalence, characteristics, and association with opioid overdose and healthcare utilization

William S. John et al.

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Emerging phenotyping strategies will advance our understanding of psychiatric genetics

Sandra Sanchez-Roige et al.

NATURE NEUROSCIENCE (2020)

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Genome-wide meta-analysis of problematic alcohol use in 435,563 individuals yields insights into biology and relationships with other traits

Hang Zhou et al.

NATURE NEUROSCIENCE (2020)

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Article Psychiatry

Association of OPRM1 Functional Coding Variant With Opioid Use Disorder A Genome-Wide Association Study

Hang Zhou et al.

JAMA PSYCHIATRY (2020)

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Article Psychiatry

Substance Use Disorders and COVID-19: Multi-Faceted Problems Which Require Multi-Pronged Solutions

Wossenseged Birhane Jemberie et al.

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Discovery of 318 new risk loci for type 2 diabetes and related vascular outcomes among 1.4 million participants in a multi-ancestry meta-analysis

Marijana Vujkovic et al.

NATURE GENETICS (2020)

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Article Substance Abuse

Genome-wide association analysis of opioid use disorder: A novel approach using clinical data

Wenyu Song et al.

DRUG AND ALCOHOL DEPENDENCE (2020)

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Article Substance Abuse

Stigma: how it affects the substance use disorder patient

Janet Zwick et al.

SUBSTANCE ABUSE TREATMENT PREVENTION AND POLICY (2020)

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A large-scale genome-wide association study meta-analysis of cannabis use disorder

Emma C. Johnson et al.

LANCET PSYCHIATRY (2020)

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Article Multidisciplinary Sciences

Expanding the genetic architecture of nicotine dependence and its shared genetics with multiple traits

Bryan C. Quach et al.

NATURE COMMUNICATIONS (2020)

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Article Substance Abuse

Medical Burden of Disease Among Individuals in Recovery From Alcohol and Other Drug Problems in the United States: Findings From the National Recovery Survey

David Eddie et al.

JOURNAL OF ADDICTION MEDICINE (2019)

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Article Multidisciplinary Sciences

Genome-wide association study of alcohol consumption and use disorder in 274,424 individuals from multiple populations

Henry R. Kranzler et al.

NATURE COMMUNICATIONS (2019)

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Review Psychiatry

Neurocognitive Precursors of Substance Misuse Corresponding to Risk, Resistance, and Resilience Pathways: Implications for Prevention Science

Emma Jane Rose et al.

FRONTIERS IN PSYCHIATRY (2019)

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Article Psychology, Biological

Genomic structural equation modelling provides insights into the multivariate genetic architecture of complex traits

Andrew D. Grotzinger et al.

NATURE HUMAN BEHAVIOUR (2019)

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Article Psychiatry

Genome-Wide Association Study Meta-Analysis of the Alcohol Use Disorders Identification Test (AUDIT) in Two Population-Based Cohorts

Sandra Sanchez-Roige et al.

AMERICAN JOURNAL OF PSYCHIATRY (2019)

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Article Genetics & Heredity

Association studies of up to 1.2 million individuals yield new insights into the genetic etiology of tobacco and alcohol use

Mengzhen Liu et al.

NATURE GENETICS (2019)

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Article Anesthesiology

Self-reported cumulative medical opioid exposure and subjective responses on first use of opioids predict analgesic and subjective responses to placebo-controlled opioid administration

Stephen Bruehl et al.

REGIONAL ANESTHESIA AND PAIN MEDICINE (2019)

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Article Biochemistry & Molecular Biology

Genome-wide association study of alcohol use disorder identification test (AUDIT) scores in 20 328 research participants of European ancestry

Sandra Sanchez-Roige et al.

ADDICTION BIOLOGY (2019)

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Review Medicine, Research & Experimental

The effects of cigarette smoking extracts on cell cycle and tumor spread: novel evidence

Aldo Pezzuto et al.

FUTURE SCIENCE OA (2019)

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Review Clinical Neurology

Substance-related disorders: A review of prevalence and correlates among patients with chronic pain

Marc O. Martel et al.

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Review Anesthesiology

Depression in chronic pain: might opioids be responsible?

Graham Mazereeuw et al.

PAIN (2018)

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Review Psychiatry

Clinical characteristics of primary psychotic disorders with concurrent substance abuse and substance-induced psychotic disorders: A systematic review

Lorna Wilson et al.

SCHIZOPHRENIA RESEARCH (2018)

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Drug dependence in patients with chronic pain A retrospective study

Tomoko Tetsunaga et al.

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Transancestral GWAS of alcohol dependence reveals common genetic underpinnings with psychiatric disorders

Raymond K. Walters et al.

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The global burden of disease attributable to alcohol and drug use in 195 countries and territories, 1990-2016: a systematic analysis for the Global Burden of Disease Study 2016

Louisa Degenhardt et al.

LANCET PSYCHIATRY (2018)

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Review Substance Abuse

Cigarette smoking and depression comorbidity: systematic review and proposed theoretical model

Amanda R. Mathew et al.

ADDICTION (2017)

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Analysis of genome-wide association data highlights candidates for drug repositioning in psychiatry

Hon-Cheong So et al.

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Comorbidity of Alcohol Use Disorder and Chronic Pain: Genetic Influences on Brain Reward and Stress Systems

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Current Challenges and New Opportunities for Gene-Environment Interaction Studies of Complex Diseases

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AMERICAN JOURNAL OF EPIDEMIOLOGY (2017)

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Cannabis and Depression: A Twin Model Approach to Co-morbidity

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BEHAVIOR GENETICS (2017)

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Review Substance Abuse

The relationship between different dimensions of alcohol use and the burden of diseasean update

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ADDICTION (2017)

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Review Psychology, Developmental

Annual Research Review: On the developmental neuropsychology of substance use disorders

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Common Brain Mechanisms of Chronic Pain and Addiction

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Article Substance Abuse

Pain as a predictor of heavy drinking and any drinking lapses in the COMBINE study and the UK Alcohol Treatment Trial

Katie Witkiewitz et al.

ADDICTION (2015)

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Higher usual alcohol consumption was associated with a lower 41-y mortality risk from coronary artery disease in men independent of genetic and common environmental factors: the prospective NHLBI Twin Study

Jun Dai et al.

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Cannabis Smoking and Diabetes Mellitus Results from Meta-analysis with Eight Independent Replication Samples

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LD Score regression distinguishes confounding from polygenicity in genome-wide association studies

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NATURE GENETICS (2015)

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Review Public, Environmental & Occupational Health

The Danish National Patient Registry: a review of content, data quality, and research potential

Morten Schmidt et al.

CLINICAL EPIDEMIOLOGY (2015)

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Article Behavioral Sciences

Genetic and Environmental Risk Factors for Illicit Substance Use and Use Disorders: Joint Analysis of Self and Co-twin Ratings

Eivind Ystrom et al.

BEHAVIOR GENETICS (2014)

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Review Psychology, Developmental

Research Review: Polygenic methods and their application to psychiatric traits

Naomi R. Wray et al.

JOURNAL OF CHILD PSYCHOLOGY AND PSYCHIATRY (2014)

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Article Multidisciplinary Sciences

Common genetic variants associated with cognitive performance identified using the proxy-phenotype method

Cornelius A. Rietveld et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2014)

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Review Psychiatry

DSM-5 Criteria for Substance Use Disorders: Recommendations and Rationale

Deborah S. Hasin et al.

AMERICAN JOURNAL OF PSYCHIATRY (2013)

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Review Substance Abuse

Stigma among health professionals towards patients with substance use disorders and its consequences for healthcare delivery: Systematic review

Leonieke C. van Boekel et al.

DRUG AND ALCOHOL DEPENDENCE (2013)

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Article Genetics & Heredity

A Subset-Based Approach Improves Power and Interpretation for the Combined Analysis of Genetic Association Studies of Heterogeneous Traits

Samsiddhi Bhattacharjee et al.

AMERICAN JOURNAL OF HUMAN GENETICS (2012)

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Article Substance Abuse

Cannabis and depression: An integrative data analysis of four Australasian cohorts

L. John Horwood et al.

DRUG AND ALCOHOL DEPENDENCE (2012)

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Article Clinical Neurology

A twin study of depression and nicotine dependence: Shared liability or causal relationship?

Alexis C. Edwards et al.

JOURNAL OF AFFECTIVE DISORDERS (2012)

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Review Substance Abuse

Alcohol and depression

Joseph M. Boden et al.

ADDICTION (2011)

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Article Genetics & Heredity

GCTA: A Tool for Genome-wide Complex Trait Analysis

Jian Yang et al.

AMERICAN JOURNAL OF HUMAN GENETICS (2011)

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Article Clinical Neurology

Association Between Substance Use Disorder Status and Pain-Related Function Following 12 Months of Treatment in Primary Care Patients With Musculoskeletal Pain

Benjamin J. Morasco et al.

JOURNAL OF PAIN (2011)

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Review Cardiac & Cardiovascular Systems

Cardiovascular Effects of Cocaine

Bryan G. Schwartz et al.

CIRCULATION (2010)

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Article Substance Abuse

An improved brief measure of cannabis misuse: The Cannabis Use Disorders Identification Test-Revised (CUDIT-R)

Simon J. Adamson et al.

DRUG AND ALCOHOL DEPENDENCE (2010)

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Article Psychology, Clinical

Prescription Opioid Misuse Index: A brief questionnaire to assess misuse

Janet S. Knisely et al.

JOURNAL OF SUBSTANCE ABUSE TREATMENT (2008)

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Review Psychiatry

Prevalence, correlates, disability, and comorbidity of DSM-IV alcohol abuse and dependence in the United States -: Results from the National Epidemiologic Survey on Alcohol and Related Conditions

Deborah S. Hasin et al.

ARCHIVES OF GENERAL PSYCHIATRY (2007)

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Article Anesthesiology

Development and validation of the current opioid misuse measure

Stephen F. Butler et al.

PAIN (2007)

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Article Anesthesiology

Predicting aberrant behaviors in opioid-treated patients: Preliminary validation of the opioid risk tool

LR Webster et al.

PAIN MEDICINE (2005)

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Article Substance Abuse

Evaluation of the Drug Use Disorders Identification Test (DUDIT) in criminal justice and detoxification settings and in a Swedish population sample

AH Berman et al.

EUROPEAN ADDICTION RESEARCH (2005)

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Review Medicine, General & Internal

Treatment of depression in patients with alcohol or other drug dependence - A meta-analysis

EV Nunes et al.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2004)

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Article Psychiatry

Sex-specific genetic influences on the comorbidity of alcoholism and major depression in a population-based sample of US twins

CA Prescott et al.

ARCHIVES OF GENERAL PSYCHIATRY (2000)

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