TSNAdb v2.0: The Updated Version of Tumor-specific Neoantigen Database

In recent years, neoantigens have been recognized as ideal targets for tumor immunotherapy. With the development of neoantigen-based tumor immunotherapy, comprehensive neoantigen databases are urgently needed to meet the growing demand for clinical studies. We have built the tumor-specific neoantigen database (TSNAdb) previously, which has attracted much attention. In this study, we provide TSNAdb v2.0, an updated version of the TSNAdb. TSNAdb v2.0 offers several new features, including (1) adopting more stringent criteria for neoantigen identification, (2) providing predicted neoantigens derived from three types of somatic mutations, and (3) collecting experimentally validated neoantigens and dividing them according to the experimental level. TSNAdb v2.0 is freely available at https://pgx.zju.edu.cn/tsnadb/.

Automated summary

In this study, the authors present an updated version, TSNAdb v2.0, of the tumor-specific neoantigen database (TSNAdb). This version offers new features, including stricter criteria for neoantigen identification, predicted neoantigens derived from three types of somatic mutations, and the collection of experimentally validated neoantigens categorized according to experimental level.