期刊
SCIENCE ADVANCES
卷 8, 期 40, 页码 -出版社
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/sciadv.abn4316
关键词
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资金
- John D. and Catherine T. MacArthur Foundation Research Network on Early Experience and Brain Development
- NIH [R01-MH091363, K01-MH092526, K01-MH092555, RO1-MH115004]
This article provides evidence from a longitudinal study that psychosocial deprivation in early childhood can lead to changes in cortical development, particularly in the prefrontal cortex and white matter tracts connecting the prefrontal and parietal cortex. This finding highlights the importance of early placement into family-based care to mitigate the lasting neurodevelopmental consequences associated with early-life deprivation.
Hypotheses concerning the biologic embedding of early adversity via developmental neuroplasticity mechanisms have been proposed on the basis of experimental studies in animals. However, no studies have demonstrated a causal link between early adversity and neural development in humans. Here, we present evidence from a randomized controlled trial linking psychosocial deprivation in early childhood to changes in cortical development from childhood to adolescence using longitudinal data from the Bucharest Early Intervention Project. Changes in cortical structure due to randomization to foster care were most pronounced in the lateral and medial prefrontal cortex and in white matter tracts connecting the prefrontal and parietal cortex. Demonstrating the causal impact of exposure to deprivation on the development of neural structure highlights the importance of early placement into family-based care to mitigate lasting neurodevelopmental consequences associated with early-life deprivation.
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