4.6 Review

An Overview of Clinical Development of Agents for Metastatic or Advanced Breast Cancer Without ERBB2 Amplification (HER2-Low)

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ERBB2-Low Breast Cancer-Is It a Fact or Fiction, and Do We Have the Right Assay?

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Summary: The current standard ERBB2 IHC assay may not be suitable for selecting patients with low ERBB2 positivity for treatment with T-DXd, as the accuracy of scoring for ERBB2 INC in the low range (0 and 1+) was poor in this study, raising the risk of misassigning patients for treatment with T-DXd.

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Trastuzumab Deruxtecan in Previously Treated HER2-Low Advanced Breast Cancer

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Clinical, pathological, and PAM50 gene expression features of HER2-low breast cancer

Francesco Schettini et al.

Summary: Novel antibody-drug conjugates targeting HER2 have shown high activity in HER2-negative breast cancer with low HER2 expression, but the clinical and molecular characteristics of HER2-low breast cancer remain unclear. This study reveals that HER2-low is more common in HR-positive disease than in TNBC, and emphasizes the significant biological heterogeneity of HER2-low BC, highlighting the importance of reproducible and sensitive assays for measuring low HER2 expression.

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HER2-low status and response to neoadjuvant chemotherapy in HER2 negative early breast cancer

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Prevalence of HER2 low in breast cancer subtypes using the VENTANA anti-HER2/neu (4B5) assay.

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