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Caution Regarding Assessment of Toxic Effects and Survival in Treatment De-escalation With Radiotherapy vs Transoral Surgery for Human Papillomavirus-Associated Oropharyngeal Cancer Reply

JAMA ONCOLOGY (2022)

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Article Oncology

Phase II Randomized Trial of Transoral Surgery and Low-Dose Intensity Modulated Radiation Therapy in Resectable p16+Locally Advanced Oropharynx Cancer: An ECOG-ACRIN Cancer Research Group Trial (E3311)

Robert L. Ferris et al.

Summary: This study aimed to investigate the efficacy and safety of primary transoral surgery (TOS) and reduced postoperative radiation therapy (RT) in intermediate-risk patients with human papillomavirus-associated oropharynx cancer (HPV+ OPC). The results showed that TOS and reduced RT achieved favorable oncologic outcomes and functional outcomes in intermediate-risk HPV+ OPC patients.

JOURNAL OF CLINICAL ONCOLOGY (2022)

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Article Oncology

Assessment of Toxic Effects and Survival in Treatment Deescalation With Radiotherapy vs Transoral Surgery for HPV-Associated Oropharyngeal Squamous Cell Carcinoma The ORATOR2 Phase 2 Randomized Clinical Trial

David A. Palma et al.

Summary: This study compares the treatment outcomes of primary radiotherapy and transoral surgery for HPV-related oropharyngeal squamous cell carcinomas. The results show that transoral surgery is associated with unacceptable toxic effects, but both treatment approaches result in good swallowing outcomes at 1 year.

JAMA ONCOLOGY (2022)

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Article Oncology

Randomized Trial of Radiotherapy Versus Transoral Robotic Surgery for Oropharyngeal Squamous Cell Carcinoma: Long-Term Results of the ORATOR Trial

Anthony C. Nichols et al.

Summary: The study found that for early-stage OPSCC, radiotherapy performed better in terms of long-term swallowing quality of life compared to transoral robotic surgery plus neck dissection, although this difference decreases over time. Some differences in QOL concerns gradually resolved in the long term, but it is worth noting that TORS patients started using more nutritional supplements at 3 years, and dry mouth scores increased over time in RT patients.

JOURNAL OF CLINICAL ONCOLOGY (2022)

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Article Otorhinolaryngology

Transoral robotic surgery

Gregory S. Weinstein et al.

ARCHIVES OF OTOLARYNGOLOGY-HEAD & NECK SURGERY (2007)

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