期刊
CHEMISTRYSELECT
卷 7, 期 33, 页码 -出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/slct.202202650
关键词
Chromone; tert-Valeric Acid; Decarboxylation coupling reaction
资金
- National Natural Science Foundation of China [22101126]
- Natural Science Foundation of Hunan Province [2020JJ5475]
- Undergraduate Training Programs for Innovative and Entrepreneurship in Hunan Province [S202110555255]
- University of South China [X202210555165]
- fund of Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study
In this work, a silver-catalyzed and regioselective alkylation of chromones with alkyl carboxylic acids under mild conditions is reported. Various alkyl groups, including tert-butyl, cyclohexyl, and adamantyl, can be successfully introduced at the C2 site of chromones with moderate to good yields. A gram-scale experiment was conducted, and a plausible mechanism was proposed.
Herein, we report a silver-catalyzed regioselective alkylation of chromones with alkyl carboxylic acids under mild conditions. Various alkyl groups including tert-butyl, cyclohexyl especially adamantyl could be successfully installed at C2 site of chromones in moderate to good yields. A gram-scale experiment was conducted and a plausible mechanism was proposed.
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